GREMLIN Database
Gemini_coat - Geminivirus coat protein/nuclear export factor BR1 family
PFAM: PF00844 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 244 (239)
Sequences: 635 (345)
Seq/√Len: 22.3
META: 0.271

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_R213_N5.9581.00
71_C74_D4.9831.00
116_M162_K4.9461.00
94_L119_L4.8581.00
50_Q53_E3.9401.00
48_K53_E3.6381.00
125_P214_A3.5211.00
48_K51_S3.1971.00
129_T207_Y2.7590.99
207_Y213_N2.7090.99
203_E209_N2.6320.99
40_R43_R2.6300.99
118_V137_F2.3550.97
17_F21_T2.2430.96
5_N8_S2.2040.96
195_F213_N2.1070.95
16_P21_T2.0420.94
8_S11_S1.9420.92
71_C216_L1.9060.91
16_P20_S1.8950.91
151_N154_R1.8820.91
22_N26_A1.8730.90
8_S15_A1.8280.89
11_S15_A1.8260.89
24_K28_G1.7960.88
122_D157_F1.7440.87
8_S13_A1.7260.86
127_G130_P1.7170.86
9_R12_R1.7020.86
122_D156_R1.6960.85
6_F15_A1.6730.85
208_E238_F1.6590.84
117_F217_L1.6530.84
229_Y232_L1.6510.84
76_T204_A1.6350.83
7_D11_S1.6230.83
6_F13_A1.6180.82
137_F159_V1.6180.82
235_R240_D1.5800.81
11_S14_R1.5550.80
80_G87_K1.5390.79
13_A16_P1.4960.77
8_S12_R1.4850.77
161_R190_N1.4850.77
200_N203_E1.4790.76
92_K208_E1.4780.76
98_G125_P1.4550.75
194_N197_V1.4370.74
91_L94_L1.4320.74
7_D17_F1.4150.73
5_N18_K1.4100.73
5_N12_R1.4030.72
17_F119_L1.4000.72
6_F21_T1.3990.72
7_D15_A1.3920.72
71_C210_I1.3800.71
123_R158_Q1.3690.70
7_D12_R1.3620.70
6_F12_R1.3570.70
7_D13_A1.3540.69
207_Y216_L1.3530.69
75_P89_I1.3390.69
12_R17_F1.3280.68
93_S208_E1.3130.67
26_A119_L1.3090.67
136_L147_L1.3080.67
10_R15_A1.3010.66
120_V218_Y1.2990.66
7_D21_T1.2970.66
235_R238_F1.2910.66
133_F137_F1.2820.65
143_S147_L1.2740.65
77_R87_K1.2650.64
23_K26_A1.2630.64
127_G132_T1.2540.63
228_V231_T1.2510.63
209_N216_L1.2430.63
37_R130_P1.2240.61
200_N204_A1.2170.61
11_S16_P1.2150.61
5_N13_A1.2120.61
7_D16_P1.2060.60
126_H212_K1.1960.60
137_F216_L1.1920.59
136_L157_F1.1810.59
9_R13_A1.1580.57
118_V159_V1.1550.57
75_P205_G1.1440.56
127_G199_Y1.1390.56
118_V162_K1.1390.56
76_T200_N1.1250.55
14_R18_K1.1170.54
207_Y214_A1.1150.54
121_R195_F1.1130.54
25_R30_R1.1010.53
35_K41_M1.0990.53
77_R81_E1.0960.53
217_L236_V1.0900.52
49_V52_F1.0850.52
147_L150_K1.0850.52
20_S23_K1.0850.52
20_S28_G1.0840.52
69_V136_L1.0810.52
5_N9_R1.0760.52
18_K21_T1.0720.51
20_S42_Y1.0610.51
10_R13_A1.0560.50
37_R42_Y1.0510.50
10_R24_K1.0230.48
12_R16_P1.0210.48
8_S16_P1.0150.47
94_L236_V1.0080.47
211_T214_A1.0050.47
28_G217_L1.0030.47
29_K167_V0.9990.46
92_K123_R0.9860.45
123_R151_N0.9850.45
95_Y159_V0.9830.45
199_Y208_E0.9830.45
162_K168_T0.9750.45
103_D167_V0.9750.45
21_T26_A0.9740.45
118_V218_Y0.9720.44
16_P35_K0.9720.44
153_L157_F0.9660.44
87_K194_N0.9650.44
127_G135_E0.9640.44
125_P207_Y0.9550.43
111_H114_V0.9530.43
27_W32_M0.9410.42
12_R15_A0.9360.42
182_E185_S0.9340.42
76_T205_G0.9250.41
209_N218_Y0.9180.41
204_A208_E0.9150.41
25_R29_K0.9120.40
11_S20_S0.9080.40
30_R34_R0.9050.40
97_K148_T0.9010.40
88_R155_D0.8990.40
7_D10_R0.8960.39
59_P62_D0.8940.39
221_W226_N0.8940.39
36_P40_R0.8940.39
192_W197_V0.8940.39
136_L216_L0.8920.39
78_G238_F0.8840.39
230_A233_K0.8830.39
9_R15_A0.8770.38
5_N16_P0.8750.38
110_N167_V0.8730.38
13_A21_T0.8700.38
59_P94_L0.8690.38
131_G134_D0.8680.38
6_F11_S0.8640.37
144_P147_L0.8610.37
186_V190_N0.8580.37
87_K162_K0.8530.37
88_R196_K0.8430.36
125_P133_F0.8360.36
10_R14_R0.8360.36
21_T37_R0.8290.35
148_T189_F0.8240.35
11_S21_T0.8240.35
55_N100_V0.8230.35
95_Y187_R0.8230.35
142_N147_L0.8200.35
118_V144_P0.8180.34
107_K243_V0.8160.34
119_L217_L0.8150.34
221_W224_A0.8130.34
120_V129_T0.8050.34
169_G182_E0.8040.34
12_R22_N0.8010.33
149_V214_A0.8000.33
69_V218_Y0.7980.33
86_G240_D0.7900.33
15_A22_N0.7830.32
134_D213_N0.7820.32
65_N70_T0.7800.32
15_A23_K0.7770.32
47_C50_Q0.7720.32
6_F23_K0.7710.32
163_F198_V0.7660.31
7_D157_F0.7660.31
96_F119_L0.7650.31
93_S168_T0.7640.31
9_R21_T0.7590.31
237_Y240_D0.7580.31
73_S91_L0.7560.31
5_N21_T0.7550.31
88_R126_H0.7550.31
93_S98_G0.7540.31
12_R21_T0.7510.30
203_E206_K0.7500.30
84_R122_D0.7490.30
79_K207_Y0.7490.30
159_V171_K0.7490.30
81_E187_R0.7440.30
10_R27_W0.7430.30
17_F20_S0.7390.30
5_N10_R0.7380.30
134_D139_M0.7320.29
26_A167_V0.7300.29
8_S17_F0.7260.29
33_R37_R0.7250.29
19_R28_G0.7200.29
27_W42_Y0.7170.28
19_R26_A0.7150.28
17_F23_K0.7130.28
228_V238_F0.7130.28
218_Y222_T0.7110.28
162_K212_K0.7070.28
6_F16_P0.7040.28
26_A32_M0.7040.28
11_S17_F0.7030.28
27_W30_R0.7030.28
173_T180_G0.7030.28
33_R40_R0.6970.27
224_A227_P0.6960.27
100_V231_T0.6960.27
97_K187_R0.6960.27
105_N127_G0.6960.27
38_M43_R0.6920.27
29_K32_M0.6910.27
9_R16_P0.6860.27
128_A138_G0.6850.27
16_P45_P0.6840.27
130_P136_L0.6840.27
89_I195_F0.6830.27
89_I206_K0.6760.26
132_T137_F0.6750.26
97_K234_I0.6740.26
239_Y242_Y0.6730.26
8_S14_R0.6730.26
55_N128_A0.6680.26
115_V213_N0.6670.26
14_R17_F0.6660.26
15_A19_R0.6630.26
209_N213_N0.6600.25
92_K237_Y0.6600.25
8_S23_K0.6590.25
96_F100_V0.6580.25
28_G37_R0.6570.25
35_K106_I0.6560.25
34_R40_R0.6550.25
61_F69_V0.6540.25
23_K37_R0.6530.25
9_R14_R0.6510.25
136_L168_T0.6510.25
187_R190_N0.6500.25
146_T215_L0.6480.25
93_S160_L0.6480.25
205_G213_N0.6470.25
91_L160_L0.6470.25
60_R225_S0.6400.24
6_F10_R0.6340.24
17_F22_N0.6290.24
5_N11_S0.6280.24
97_K164_K0.6280.24
16_P26_A0.6280.24
203_E219_Y0.6270.24
5_N17_F0.6260.24
116_M137_F0.6230.24
144_P150_K0.6220.23
25_R72_I0.6220.23
41_M45_P0.6190.23
37_R73_S0.6190.23
32_M35_K0.6180.23
18_K26_A0.6180.23
18_K23_K0.6170.23
227_P231_T0.6160.23
124_R212_K0.6160.23
187_R192_W0.6160.23
38_M45_P0.6150.23
73_S78_G0.6140.23
36_P42_Y0.6130.23
27_W35_K0.6130.23
23_K28_G0.6110.23
7_D23_K0.6110.23
58_G214_A0.6090.23
124_R150_K0.6050.23
11_S157_F0.6040.23
9_R23_K0.6040.23
84_R156_R0.6030.23
127_G232_L0.6030.23
11_S23_K0.6020.23
46_P158_Q0.6020.23
33_R43_R0.6010.22
164_K205_G0.5990.22
61_F103_D0.5930.22
79_K197_V0.5920.22
154_R200_N0.5920.22
71_C111_H0.5850.22
46_P51_S0.5850.22
207_Y219_Y0.5820.22
223_S230_A0.5820.22
39_Y43_R0.5810.22
15_A18_K0.5800.21
134_D153_L0.5800.21
26_A42_Y0.5790.21
194_N199_Y0.5740.21
223_S228_V0.5730.21
70_T142_N0.5730.21
102_M113_G0.5710.21
173_T176_V0.5690.21
88_R98_G0.5670.21
33_R36_P0.5660.21
73_S76_T0.5640.21
106_I148_T0.5630.21
70_T114_V0.5630.21
82_T213_N0.5630.21
64_S73_S0.5620.21
20_S31_P0.5610.21
225_S228_V0.5580.20
38_M41_M0.5580.20
7_D159_V0.5570.20
110_N189_F0.5550.20
21_T43_R0.5550.20
165_R189_F0.5530.20
214_A238_F0.5530.20
134_D138_G0.5520.20
9_R20_S0.5490.20
110_N113_G0.5490.20
51_S64_S0.5480.20
20_S215_L0.5450.20
7_D22_N0.5430.20
26_A41_M0.5430.20
64_S107_K0.5420.20
65_N134_D0.5420.20
28_G35_K0.5420.20
10_R18_K0.5410.20
64_S113_G0.5400.20
125_P137_F0.5370.20
74_D202_S0.5350.19
7_D20_S0.5330.19
13_A36_P0.5290.19
140_R144_P0.5290.19
81_E154_R0.5270.19
223_S226_N0.5260.19
233_K236_V0.5260.19
33_R41_M0.5250.19
83_N196_K0.5220.19
159_V165_R0.5210.19
181_K189_F0.5210.19
115_V165_R0.5190.19
36_P98_G0.5180.19
195_F198_V0.5150.19
113_G116_M0.5140.19
184_L197_V0.5140.19
229_Y239_Y0.5090.18
204_A209_N0.5090.18
76_T83_N0.5090.18
133_F175_M0.5080.18
45_P59_P0.5080.18
196_K213_N0.5030.18
21_T25_R0.5020.18
188_R192_W0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vtze 8 0.75 99.4 0.757 Contact Map
1f2nA 12 0.7008 4.6 0.962 Contact Map
3zqxA 1 0.2049 4.6 0.962 Contact Map
1c8nA 8 0.7746 4.2 0.963 Contact Map
4htvB 1 0.0287 4.2 0.963 Contact Map
1opoA 7 0.7213 3.8 0.963 Contact Map
4llfA 8 0.7828 3.3 0.965 Contact Map
2tbvA 9 0.7992 3.3 0.965 Contact Map
4fp5D 3 0.209 2.1 0.968 Contact Map
4b97A 1 0.209 2.1 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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