GREMLIN Database
Cys_rich_FGFR - Cysteine rich repeat
PFAM: PF00839 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 58 (55)
Sequences: 3004 (2348)
Seq/√Len: 316.7
META: 0.522

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_I46_V5.8031.00
53_N56_D3.2931.00
21_D24_L2.3371.00
18_Y32_I2.2591.00
42_G45_R1.9211.00
35_F53_N1.8591.00
31_D34_K1.7521.00
8_F11_Q1.7291.00
6_E10_L1.7201.00
6_E9_R1.6961.00
18_Y46_V1.6931.00
39_V45_R1.5911.00
11_Q14_L1.5321.00
47_L51_K1.5141.00
4_R9_R1.4231.00
7_L14_L1.2161.00
31_D35_F1.1391.00
25_A29_K1.1061.00
41_P45_R1.1001.00
51_K54_K1.0511.00
42_G46_V1.0341.00
48_E52_E1.0291.00
10_L13_Q1.0001.00
29_K33_E0.9971.00
6_E24_L0.9781.00
48_E51_K0.9621.00
26_K33_E0.9601.00
11_Q15_A0.9591.00
17_D24_L0.9531.00
32_I47_L0.9451.00
5_A9_R0.9411.00
23_E27_A0.8971.00
5_A29_K0.8851.00
39_V42_G0.8441.00
11_Q51_K0.8201.00
9_R12_E0.8141.00
10_L14_L0.8011.00
4_R8_F0.7991.00
47_L54_K0.7891.00
12_E15_A0.7881.00
30_D34_K0.7861.00
10_L23_E0.7831.00
16_E22_P0.7821.00
16_E20_L0.7811.00
18_Y22_P0.7600.99
35_F52_E0.7490.99
38_D42_G0.7410.99
2_E34_K0.6960.99
7_L10_L0.6950.99
46_V50_L0.6860.99
25_A37_S0.6810.99
23_E52_E0.6760.99
3_C50_L0.6730.99
35_F45_R0.6600.98
7_L31_D0.6580.98
20_L23_E0.6500.98
13_Q51_K0.6440.98
44_G48_E0.6420.98
8_F12_E0.6190.98
35_F38_D0.6150.98
24_L47_L0.6090.97
22_P26_K0.6020.97
13_Q20_L0.5980.97
14_L20_L0.5910.97
18_Y24_L0.5870.97
4_R7_L0.5820.97
17_D21_D0.5770.96
3_C28_C0.5680.96
12_E16_E0.5540.95
2_E5_A0.5490.95
40_P52_E0.5490.95
28_C36_C0.5400.95
19_R26_K0.5360.95
2_E15_A0.5300.94
15_A24_L0.5290.94
28_C49_C0.5260.94
7_L44_G0.5240.94
29_K56_D0.5170.94
13_Q43_E0.5130.93
27_A30_D0.5100.93
21_D26_K0.5020.93
43_E55_D0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oj7A 3 0.6897 6.4 0.805 Contact Map
2fp1A 2 0.7241 5.3 0.812 Contact Map
3bq3A 2 0.569 3.8 0.825 Contact Map
2q13A 2 0.9483 3.3 0.829 Contact Map
2vrwB 1 0.6034 2.7 0.837 Contact Map
2r17C 1 0.7586 2.4 0.842 Contact Map
1chcA 1 0.431 2 0.847 Contact Map
2db6A 1 0.7241 2 0.849 Contact Map
2i5oA 1 0.4655 1.7 0.855 Contact Map
2ennA 1 0.6897 1.7 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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