GREMLIN Database
FliP - FliP family
PFAM: PF00813 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 191 (191)
Sequences: 14544 (7034)
Seq/√Len: 509.0
META: 0.852

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_Q65_E4.3171.00
62_I88_L3.7861.00
85_S119_L3.6261.00
63_Y68_Q3.4281.00
76_T79_E3.1081.00
62_I66_A2.6661.00
65_E83_R2.6601.00
61_Q90_E2.5741.00
68_Q72_A2.5571.00
21_I54_V2.4541.00
102_A106_D2.2571.00
93_L114_P2.1771.00
60_D64_E2.1711.00
89_R119_L2.1691.00
67_L71_L2.1471.00
14_M127_V2.0561.00
75_I83_R2.0551.00
39_P42_V1.9961.00
31_A142_F1.9781.00
113_T116_D1.9631.00
83_R86_E1.9521.00
82_E85_S1.9341.00
93_L122_L1.9171.00
56_A59_F1.9171.00
110_E118_P1.9081.00
66_A84_A1.8381.00
105_V111_P1.7841.00
117_V122_L1.7651.00
64_E68_Q1.7591.00
79_E83_R1.7361.00
21_I50_L1.7351.00
97_R100_D1.7251.00
90_E94_K1.7201.00
104_F128_I1.7111.00
79_E82_E1.6861.00
68_Q71_L1.5851.00
63_Y67_L1.5591.00
29_R40_N1.5421.00
89_R93_L1.5361.00
21_I25_L1.5321.00
97_R133_T1.5301.00
22_V43_L1.4841.00
91_F126_F1.4681.00
23_I131_L1.4481.00
56_A120_R1.4441.00
61_Q64_E1.4271.00
132_K136_Q1.4251.00
15_M123_I1.4231.00
58_V61_Q1.4171.00
96_T101_L1.4021.00
112_A116_D1.3631.00
77_Q81_L1.3551.00
129_S133_T1.3521.00
44_I47_A1.3491.00
24_V191_L1.3481.00
63_Y66_A1.3181.00
4_V11_I1.3141.00
147_V151_V1.2971.00
27_F175_L1.2911.00
119_L123_I1.2681.00
111_P116_D1.2671.00
49_F123_I1.2551.00
81_L85_S1.2461.00
17_S54_V1.2441.00
65_E86_E1.2281.00
14_M45_G1.2231.00
22_V39_P1.2141.00
52_F56_A1.2131.00
4_V8_A1.1991.00
19_T22_V1.1901.00
56_A60_D1.1791.00
60_D120_R1.1711.00
98_E102_A1.1711.00
110_E120_R1.1671.00
85_S89_R1.1621.00
105_V108_A1.1201.00
128_I188_V1.1091.00
75_I79_E1.1061.00
10_A14_M1.1061.00
110_E121_V1.1021.00
99_K185_N1.0951.00
7_L10_A1.0921.00
22_V44_I1.0881.00
105_V110_E1.0811.00
105_V121_V1.0781.00
15_M88_L1.0781.00
34_T37_T1.0741.00
93_L119_L1.0651.00
86_E90_E1.0641.00
136_Q140_L1.0631.00
78_E82_E1.0391.00
182_D185_N1.0301.00
81_L119_L1.0231.00
26_S30_Q1.0191.00
108_A121_V1.0131.00
103_L185_N1.0001.00
93_L101_L0.9971.00
13_I41_Q0.9971.00
19_T23_I0.9941.00
30_Q36_Q0.9841.00
84_A87_P0.9811.00
49_F124_P0.9801.00
121_V125_A0.9771.00
185_N189_G0.9741.00
111_P117_V0.9701.00
93_L117_V0.9631.00
157_M163_M0.9531.00
25_L28_L0.9441.00
89_R122_L0.9441.00
8_A14_M0.9391.00
70_Y80_A0.9271.00
17_S21_I0.9251.00
86_E89_R0.9241.00
24_V137_I0.9181.00
89_R115_E0.9171.00
62_I84_A0.9051.00
100_D132_K0.9031.00
22_V47_A0.8961.00
118_P121_V0.8951.00
4_V7_L0.8921.00
48_L52_F0.8761.00
28_L141_I0.8751.00
25_L47_A0.8711.00
82_E86_E0.8641.00
81_L84_A0.8631.00
15_M92_M0.8611.00
43_L47_A0.8601.00
83_R87_P0.8581.00
59_F88_L0.8431.00
30_Q33_G0.8401.00
86_E115_E0.8391.00
7_L11_I0.8341.00
45_G127_V0.8301.00
27_F34_T0.8301.00
63_Y72_A0.8271.00
132_K182_D0.8241.00
15_M19_T0.8151.00
111_P114_P0.8131.00
70_Y77_Q0.8081.00
59_F63_Y0.7971.00
154_S157_M0.7901.00
128_I185_N0.7901.00
61_Q87_P0.7881.00
96_T122_L0.7871.00
176_L188_V0.7771.00
6_S10_A0.7721.00
96_T133_T0.7701.00
66_A75_I0.7701.00
40_N43_L0.7701.00
66_A83_R0.7621.00
14_M19_T0.7621.00
101_L117_V0.7571.00
152_V173_F0.7551.00
20_R23_I0.7521.00
62_I87_P0.7421.00
37_T134_A0.7421.00
29_R38_P0.7391.00
53_F107_L0.7361.00
100_D103_L0.7261.00
40_N44_I0.7241.00
148_I177_L0.7191.00
108_A120_R0.7191.00
19_T127_V0.7181.00
103_L106_D0.7171.00
93_L96_T0.7141.00
99_K102_A0.7141.00
103_L107_L0.6961.00
87_P90_E0.6951.00
11_I15_M0.6941.00
19_T42_V0.6931.00
123_I127_V0.6901.00
59_F67_L0.6901.00
103_L189_G0.6891.00
104_F121_V0.6881.00
164_L169_I0.6871.00
133_T136_Q0.6851.00
154_S165_P0.6851.00
163_M166_P0.6841.00
96_T129_S0.6801.00
147_V150_L0.6751.00
17_S126_F0.6741.00
179_V182_D0.6741.00
98_E114_P0.6731.00
52_F120_R0.6691.00
100_D128_I0.6671.00
97_R132_K0.6671.00
111_P118_P0.6621.00
97_R136_Q0.6621.00
92_M95_Q0.6611.00
46_L188_V0.6611.00
22_V26_S0.6601.00
2_L6_S0.6571.00
34_T175_L0.6551.00
150_L156_L0.6551.00
85_S88_L0.6541.00
176_L180_L0.6541.00
18_F44_I0.6541.00
53_F108_A0.6541.00
27_F138_G0.6511.00
97_R129_S0.6481.00
185_N188_V0.6451.00
58_V62_I0.6431.00
62_I65_E0.6371.00
50_L107_L0.6371.00
27_F35_Q0.6351.00
120_R124_P0.6341.00
30_Q37_T0.6331.00
50_L188_V0.6301.00
26_S134_A0.6261.00
41_Q44_I0.6201.00
39_P156_L0.6171.00
142_F171_L0.6171.00
92_M96_T0.6141.00
80_A84_A0.6131.00
12_L48_L0.6121.00
59_F62_I0.6091.00
7_L13_I0.6091.00
130_E133_T0.6081.00
26_S36_Q0.6071.00
25_L46_L0.6030.99
41_Q45_G0.6020.99
103_L124_P0.6010.99
30_Q155_V0.6000.99
103_L128_I0.6000.99
24_V134_A0.5970.99
75_I80_A0.5960.99
55_M91_F0.5920.99
162_M165_P0.5890.99
70_Y75_I0.5860.99
102_A105_V0.5850.99
25_L188_V0.5840.99
34_T38_P0.5810.99
23_I27_F0.5800.99
17_S51_T0.5790.99
105_V117_V0.5770.99
25_L187_L0.5760.99
112_A115_E0.5760.99
76_T82_E0.5750.99
95_Q107_L0.5720.99
101_L122_L0.5710.99
52_F59_F0.5680.99
73_G76_T0.5670.99
164_L170_S0.5660.99
106_D189_G0.5660.99
114_P117_V0.5650.99
148_I173_F0.5630.99
109_K112_A0.5630.99
128_I132_K0.5610.99
88_L92_M0.5610.99
117_V121_V0.5580.99
29_R43_L0.5570.99
73_G77_Q0.5560.99
74_E109_K0.5550.99
186_L189_G0.5540.99
161_M166_P0.5530.99
95_Q133_T0.5490.99
153_A164_L0.5480.99
140_L164_L0.5460.99
51_T55_M0.5440.99
10_A13_I0.5430.99
72_A82_E0.5430.99
173_F177_L0.5420.99
102_A111_P0.5400.99
154_S158_S0.5370.99
104_F124_P0.5340.99
54_V91_F0.5340.99
159_M162_M0.5320.99
66_A80_A0.5320.99
55_M58_V0.5310.99
181_V185_N0.5290.99
11_I14_M0.5260.99
185_N190_S0.5240.99
114_P122_L0.5200.98
51_T59_F0.5190.98
15_M59_F0.5170.98
74_E112_A0.5170.98
100_D129_S0.5140.98
159_M167_V0.5080.98
54_V139_F0.5070.98
85_S92_M0.5050.98
106_D114_P0.5040.98
77_Q85_S0.5040.98
30_Q168_M0.5030.98
33_G36_Q0.5010.98
171_L175_L0.5010.98
16_T51_T0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ww9B 1 0.3089 3.8 0.968 Contact Map
1w53A 2 0.4398 3.4 0.968 Contact Map
1rh5B 1 0.288 3.1 0.969 Contact Map
2f6mA 1 0.3298 2.6 0.97 Contact Map
4fdyA 1 0.3141 2.2 0.971 Contact Map
1mhsA 2 0.4869 1.6 0.974 Contact Map
4owtA 1 0.4921 1.6 0.974 Contact Map
3aqpA 1 0.2618 1.5 0.974 Contact Map
3mp7B 1 0.2775 1.5 0.974 Contact Map
4dx5A 3 0.3403 1.5 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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