GREMLIN Database
Ependymin - Ependymin
PFAM: PF00811 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 127 (121)
Sequences: 671 (577)
Seq/√Len: 52.5
META: 0.58

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_V30_K6.0911.00
18_M31_S3.6661.00
21_I126_E3.0371.00
12_L15_E3.0311.00
66_V92_V2.8921.00
51_E67_N2.7511.00
85_T92_V2.6891.00
124_P127_C2.6411.00
119_N122_I2.3561.00
12_L123_P2.1951.00
114_G117_D2.0661.00
21_I124_P2.0101.00
54_I109_F2.0101.00
42_I89_C1.8670.99
10_L21_I1.8300.99
10_L123_P1.7990.99
48_F69_W1.7710.99
43_P46_A1.7230.99
55_G89_C1.7190.99
22_D25_T1.6780.99
51_E86_E1.6680.99
49_L70_S1.5920.98
9_V21_I1.5610.98
5_E22_D1.5280.97
93_S107_S1.4960.97
85_T88_G1.4760.97
42_I84_V1.4710.97
71_G84_V1.3090.94
35_G111_V1.3050.94
54_I93_S1.2970.93
20_E29_T1.2950.93
112_V118_P1.2850.93
37_F111_V1.2680.93
89_C111_V1.2420.92
69_W111_V1.2300.91
27_T101_T1.2260.91
43_P89_C1.2110.91
121_F124_P1.1700.89
21_I125_S1.1660.89
13_Y99_N1.1460.88
56_S113_L1.1270.87
23_L122_I1.1220.87
33_L61_G1.1160.87
47_T97_F1.1100.86
64_L76_G1.1100.86
9_V20_E1.1070.86
43_P80_Y1.1040.86
11_L14_K1.0960.86
52_F109_F1.0950.86
37_F42_I1.0930.86
27_T48_F1.0790.85
12_L41_C1.0670.84
55_G85_T1.0630.84
39_P117_D1.0460.83
53_T110_N1.0310.82
18_M108_F1.0170.81
41_C91_P1.0120.81
50_G108_F1.0120.81
11_L18_M1.0070.81
52_F68_T1.0060.80
85_T89_C0.9870.79
121_F127_C0.9710.78
46_A72_R0.9510.77
111_V121_F0.9420.76
73_F76_G0.9240.74
85_T117_D0.9220.74
13_Y22_D0.9050.73
87_D110_N0.9040.73
38_R64_L0.8930.72
67_N86_E0.8920.72
63_G90_I0.8870.71
42_I67_N0.8870.71
81_V107_S0.8840.71
89_C115_I0.8830.71
26_K82_G0.8690.70
26_K126_E0.8560.69
17_V32_P0.8540.68
75_D78_G0.8530.68
19_Y30_K0.8500.68
123_P126_E0.8500.68
38_R94_E0.8430.67
91_P114_G0.8400.67
5_E9_V0.8390.67
37_F69_W0.8270.66
28_C127_C0.8260.66
44_P125_S0.8250.66
16_G32_P0.8210.65
13_Y29_T0.8170.65
69_W85_T0.8150.65
42_I92_V0.8120.65
80_Y96_F0.8080.64
84_V115_I0.7980.63
29_T108_F0.7950.63
65_L123_P0.7930.63
117_D120_V0.7840.62
112_V117_D0.7790.61
35_G125_S0.7520.59
48_F100_K0.7470.58
82_G110_N0.7450.58
62_E67_N0.7410.57
53_T57_S0.7280.56
39_P69_W0.7210.55
55_G64_L0.7200.55
52_F66_V0.7190.55
50_G68_T0.7160.55
66_V71_G0.7150.55
87_D111_V0.7120.54
42_I46_A0.7110.54
21_I42_I0.7040.54
34_T119_N0.6980.53
20_E105_T0.6970.53
45_N56_S0.6960.53
30_K104_V0.6890.52
80_Y84_V0.6880.52
13_Y47_T0.6830.51
89_C114_G0.6820.51
10_L57_S0.6730.50
28_C124_P0.6680.50
26_K110_N0.6680.50
65_L86_E0.6680.50
32_P125_S0.6630.49
69_W74_P0.6620.49
46_A90_I0.6600.49
41_C84_V0.6590.49
43_P85_T0.6580.49
22_D37_F0.6540.48
64_L78_G0.6520.48
115_I125_S0.6460.48
67_N73_F0.6390.47
74_P96_F0.6310.46
52_F72_R0.6300.46
9_V16_G0.6280.46
48_F67_N0.6270.46
8_D12_L0.6220.45
35_G121_F0.6130.44
66_V90_I0.6130.44
7_F11_L0.6110.44
41_C56_S0.6090.44
24_K68_T0.6090.44
20_E69_W0.6060.43
57_S66_V0.6020.43
54_I57_S0.6000.43
98_S101_T0.6000.43
6_F9_V0.5990.43
24_K79_T0.5980.43
51_E83_T0.5980.43
63_G76_G0.5960.42
53_T65_L0.5910.42
46_A116_S0.5880.42
66_V91_P0.5870.41
20_E92_V0.5860.41
112_V116_S0.5850.41
54_I111_V0.5850.41
46_A80_Y0.5750.40
68_T109_F0.5730.40
66_V104_V0.5650.39
54_I110_N0.5610.39
25_T93_S0.5570.38
62_E110_N0.5560.38
53_T56_S0.5540.38
42_I85_T0.5540.38
45_N98_S0.5520.38
56_S69_W0.5490.38
44_P100_K0.5400.37
17_V101_T0.5390.37
26_K46_A0.5370.36
10_L13_Y0.5370.36
69_W103_F0.5340.36
13_Y21_I0.5340.36
45_N122_I0.5230.35
18_M51_E0.5230.35
93_S109_F0.5200.35
29_T36_P0.5190.35
60_P115_I0.5180.35
26_K120_V0.5160.34
46_A94_E0.5140.34
56_S62_E0.5130.34
27_T122_I0.5100.34
26_K32_P0.5050.33
48_F57_S0.5020.33
65_L69_W0.5020.33
48_F119_N0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bmzA 2 0.9134 19.8 0.899 Contact Map
2ab9A 1 0.2441 12.9 0.907 Contact Map
4ixjA 1 0.4331 2.3 0.935 Contact Map
4mxtA 2 0.9055 2.1 0.936 Contact Map
3zleA 3 0.9685 2.1 0.936 Contact Map
1vazA 1 0.5433 1.9 0.938 Contact Map
2yzyA 1 0.8031 1.8 0.939 Contact Map
3gfuC 1 0.2441 1.7 0.94 Contact Map
3emwA 1 0.4252 1.5 0.941 Contact Map
4yivA 1 0.9685 1.4 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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