GREMLIN Database
ER_lumen_recept - ER lumen protein retaining receptor
PFAM: PF00810 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 141 (141)
Sequences: 1422 (873)
Seq/√Len: 73.5
META: 0.425

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_H82_F4.2021.00
11_E48_R4.0691.00
14_A41_L3.9891.00
19_T94_F3.6311.00
18_V41_L3.4541.00
93_T97_Y2.7121.00
122_H125_F2.3421.00
123_Y127_L2.2861.00
8_K11_E2.1751.00
130_Y134_Y2.1661.00
11_E64_I2.0981.00
42_Y46_L2.0651.00
75_A94_F2.0001.00
132_A136_L1.9771.00
13_Y17_F1.9631.00
117_E120_T1.9341.00
7_L44_I1.8881.00
15_L19_T1.8671.00
13_Y16_V1.8221.00
18_V37_I1.8091.00
87_F91_L1.7031.00
35_F39_S1.6591.00
9_T13_Y1.6581.00
78_F97_Y1.6501.00
9_T124_V1.6291.00
7_L48_R1.5970.99
28_Y33_K1.5770.99
44_I48_R1.5580.99
29_N33_K1.5540.99
33_K36_F1.5270.99
63_R66_Y1.4810.99
34_I38_A1.4580.99
33_K37_I1.4550.99
26_T88_L1.4540.99
55_Y60_D1.4180.99
56_D59_L1.3540.98
80_P93_T1.3500.98
134_Y137_N1.3020.98
116_V121_S1.2680.97
67_L101_V1.2450.97
80_P89_E1.2310.97
130_Y137_N1.2250.96
40_S44_I1.2020.96
27_T88_L1.1980.96
128_G131_R1.1830.96
16_V21_Y1.1650.95
118_N121_S1.1580.95
7_L11_E1.1470.95
131_R138_W1.1470.95
79_H97_Y1.1410.95
79_H83_T1.1280.94
2_C55_Y1.1220.94
65_E68_L1.1150.94
33_K134_Y1.1040.94
17_F23_D1.1030.94
122_H126_A1.1000.94
28_Y32_M1.0930.93
25_F28_Y1.0870.93
116_V124_V1.0850.93
86_F90_I1.0700.93
21_Y24_L1.0690.93
9_T17_F1.0650.93
23_D29_N1.0610.92
72_A94_F1.0550.92
73_V77_L1.0450.92
14_A44_I1.0260.91
20_R23_D1.0150.91
2_C47_M1.0100.90
76_L90_I1.0080.90
68_L94_F0.9900.89
44_I118_N0.9800.89
31_V35_F0.9710.89
49_F52_K0.9650.88
34_I129_L0.9430.87
11_E15_L0.9380.87
137_N140_Y0.9330.86
1_S4_G0.9200.86
16_V28_Y0.9180.86
89_E92_W0.9110.85
70_P74_L0.9100.85
9_T127_L0.9090.85
75_A97_Y0.8900.84
10_Q23_D0.8670.82
78_F93_T0.8660.82
24_L29_N0.8630.82
107_L111_Q0.8540.81
12_L127_L0.8530.81
30_T34_I0.8480.81
11_E44_I0.8480.81
7_L135_I0.8440.80
16_V20_R0.8430.80
21_Y25_F0.8420.80
110_L123_Y0.8340.80
95_S98_L0.8300.79
13_Y43_I0.8280.79
119_I124_V0.8270.79
127_L131_R0.8150.78
132_A141_R0.8120.78
7_L12_L0.8110.78
13_Y32_M0.8110.78
68_L72_A0.8100.78
25_F29_N0.8060.77
133_L136_L0.8050.77
131_R134_Y0.8040.77
116_V119_I0.7980.77
28_Y36_F0.7950.76
40_S114_G0.7940.76
97_Y125_F0.7940.76
38_A58_E0.7920.76
24_L30_T0.7920.76
37_I41_L0.7810.75
92_W95_S0.7770.75
66_Y111_Q0.7730.74
61_T112_R0.7720.74
137_N141_R0.7710.74
50_K117_E0.7680.74
27_T80_P0.7630.73
14_A126_A0.7610.73
116_V122_H0.7510.72
22_L25_F0.7460.72
9_T12_L0.7420.71
33_K130_Y0.7380.71
17_F33_K0.7360.71
89_E96_I0.7350.71
75_A90_I0.7290.70
117_E128_G0.7220.69
8_K60_D0.7200.69
17_F70_P0.7180.69
79_H93_T0.7180.69
15_L68_L0.7170.69
71_C97_Y0.7170.69
13_Y99_E0.7150.68
82_F89_E0.7130.68
42_Y45_Y0.7110.68
36_F130_Y0.7100.68
75_A86_F0.7020.67
75_A133_L0.6990.67
52_K100_A0.6880.65
49_F53_S0.6870.65
1_S124_V0.6840.65
81_K87_F0.6830.65
95_S99_E0.6820.65
40_S58_E0.6740.64
74_L97_Y0.6740.64
30_T96_I0.6710.63
34_I39_S0.6680.63
36_F134_Y0.6680.63
75_A82_F0.6670.63
54_T93_T0.6610.62
17_F21_Y0.6570.62
90_I93_T0.6530.61
28_Y95_S0.6520.61
53_S115_E0.6470.61
51_Y127_L0.6430.60
104_L108_F0.6290.59
117_E121_S0.6250.58
135_I141_R0.6240.58
17_F40_S0.6200.57
28_Y37_I0.6180.57
107_L120_T0.6150.57
23_D28_Y0.6130.57
12_L71_C0.6120.56
8_K17_F0.6110.56
29_N36_F0.6090.56
120_T123_Y0.6090.56
36_F141_R0.6080.56
61_T113_T0.6080.56
37_I43_I0.6060.56
114_G122_H0.6050.56
21_Y28_Y0.6040.55
92_W98_L0.6030.55
43_I119_I0.5970.55
35_F47_M0.5950.54
66_Y112_R0.5940.54
45_Y49_F0.5900.54
92_W138_W0.5890.54
101_V104_L0.5880.54
5_I109_M0.5870.53
31_V62_F0.5810.53
20_R95_S0.5810.53
66_Y70_P0.5770.52
22_L88_L0.5750.52
114_G118_N0.5740.52
10_Q21_Y0.5730.52
16_V19_T0.5730.52
123_Y131_R0.5720.52
53_S112_R0.5690.51
92_W134_Y0.5650.51
36_F40_S0.5580.50
2_C5_I0.5560.50
66_Y81_K0.5500.49
92_W102_A0.5460.48
35_F41_L0.5430.48
7_L65_E0.5410.48
104_L121_S0.5390.47
1_S8_K0.5390.47
19_T31_V0.5370.47
68_L98_L0.5370.47
104_L133_L0.5340.47
61_T133_L0.5320.47
16_V24_L0.5290.46
71_C125_F0.5220.45
81_K88_L0.5200.45
31_V91_L0.5180.45
17_F20_R0.5180.45
60_D70_P0.5160.45
67_L113_T0.5120.44
74_L104_L0.5090.44
23_D33_K0.5090.44
108_F112_R0.5040.43
27_T30_T0.5020.43
24_L37_I0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x5mA 2 0.4043 94.9 0.832 Contact Map
4qncA 2 0.3901 94.8 0.833 Contact Map
4rngA 2 0.3972 88.5 0.861 Contact Map
4qndA 2 0.4539 81.9 0.873 Contact Map
4qtnA 3 0.9078 3.3 0.943 Contact Map
4xesA 1 0.5035 1.5 0.953 Contact Map
3w8iB 1 0.1277 1.2 0.955 Contact Map
2rddB 1 0.2624 1.1 0.956 Contact Map
2xyyA 9 0.2837 1 0.957 Contact Map
4grvA 1 0.4752 1 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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