GREMLIN Database
Chitin_bind_4 - Insect cuticle protein
PFAM: PF00379 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 54 (52)
Sequences: 4765 (3039)
Seq/√Len: 421.4
META: 0.332

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_D41_R3.1231.00
37_D43_R2.8211.00
32_S46_T2.6681.00
36_V42_T2.5801.00
34_S44_T2.5081.00
33_Y45_V2.4141.00
28_V50_D1.8951.00
32_S44_T1.8921.00
48_T52_N1.7651.00
35_Y43_R1.7131.00
34_S42_T1.6341.00
3_F13_T1.6031.00
1_Y29_V1.5181.00
22_E25_D1.3941.00
1_Y15_E1.3851.00
5_Y13_T1.3381.00
7_V11_I1.3241.00
21_E24_D1.1831.00
29_V47_Y1.1261.00
33_Y47_Y1.0911.00
14_Q17_G1.0671.00
35_Y38_P1.0431.00
30_K48_T1.0291.00
33_Y54_F1.0131.00
12_S34_S0.9921.00
35_Y39_D0.9791.00
47_Y54_F0.9651.00
24_D28_V0.9631.00
36_V41_R0.9331.00
6_E12_S0.9281.00
24_D27_G0.9171.00
21_E25_D0.9051.00
3_F47_Y0.9021.00
2_S23_E0.8611.00
4_S32_S0.8461.00
18_R30_K0.8391.00
28_V51_E0.8201.00
13_T47_Y0.8111.00
30_K46_T0.7701.00
37_D42_T0.7471.00
23_E27_G0.7431.00
5_Y11_I0.7331.00
14_Q18_R0.7191.00
2_S16_E0.7071.00
18_R27_G0.6951.00
26_G51_E0.6841.00
39_D43_R0.6811.00
25_D30_K0.6751.00
45_V54_F0.6701.00
18_R24_D0.6480.99
7_V10_G0.6470.99
22_E26_G0.6310.99
3_F33_Y0.6300.99
49_A52_N0.6250.99
25_D28_V0.6250.99
7_V13_T0.5900.99
14_Q32_S0.5760.99
37_D54_F0.5740.99
23_E26_G0.5730.98
28_V48_T0.5720.98
21_E27_G0.5700.98
2_S22_E0.5660.98
29_V49_A0.5590.98
8_S15_E0.5580.98
4_S14_Q0.5550.98
35_Y54_F0.5520.98
38_P41_R0.5490.98
25_D41_R0.5480.98
26_G29_V0.5390.98
5_Y54_F0.5380.98
10_G13_T0.5350.98
9_D40_G0.5290.97
48_T51_E0.5260.97
16_E30_K0.5240.97
18_R28_V0.5230.97
7_V38_P0.5200.97
31_G53_G0.5070.97
35_Y42_T0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2g5dA 1 0.9815 13.2 0.8 Contact Map
2pnwA 1 0.9815 8.3 0.817 Contact Map
3czbA 2 0.9815 3.8 0.845 Contact Map
3klkA 1 0.4074 2.8 0.855 Contact Map
4r3oE 1 0.4815 2.5 0.859 Contact Map
2kt7A 1 0.3333 2.3 0.861 Contact Map
1rypE 1 0.463 2.3 0.861 Contact Map
3mfbA 1 0.9815 2.3 0.862 Contact Map
3a24A 1 0.4259 1.7 0.87 Contact Map
1xqaA 2 0.8148 1.7 0.871 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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