GREMLIN Database
RL18E - 50S ribosomal protein L18e
UniProt: Q9V2W0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 117 (113)
Sequences: 179 (137)
Seq/√Len: 12.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_A73_K5.9341.00
29_D33_R3.8350.99
49_I75_V3.4560.99
49_I65_V3.3560.98
50_E72_R3.1740.97
33_R42_A2.6420.93
90_I95_G2.5210.91
57_E114_R2.3780.88
96_E106_Q2.3570.88
100_L103_A2.1960.84
50_E73_K2.0800.80
65_V82_F1.8130.70
82_F97_A1.7940.69
60_I97_A1.7170.65
67_G85_S1.6680.63
103_A113_V1.6300.61
16_K35_E1.6060.60
65_V90_I1.5840.59
56_D60_I1.5750.58
47_S52_Y1.5320.56
29_D42_A1.4420.52
55_E73_K1.4260.51
26_V115_V1.3600.47
52_Y82_F1.3180.45
20_R35_E1.3160.45
18_V22_S1.3120.45
47_S51_R1.3090.45
107_N110_G1.3050.44
87_A91_E1.2780.43
35_E80_V1.2760.43
77_V95_G1.2640.42
78_A100_L1.2470.42
43_E61_V1.2460.41
8_L32_D1.2420.41
12_I34_L1.2350.41
24_A108_P1.2180.40
49_I52_Y1.2130.40
43_E57_E1.2100.40
18_V104_V1.1990.39
5_S30_V1.1950.39
26_V50_E1.1940.39
47_S70_A1.1870.39
13_A46_L1.1700.38
75_V82_F1.1660.38
8_L25_D1.1400.36
44_V116_I1.1230.35
84_S88_T1.1140.35
30_V75_V1.1090.35
38_R89_K1.0760.33
44_V111_T1.0750.33
9_S13_A1.0600.33
6_P57_E1.0110.30
41_H80_V0.9960.30
29_D74_S0.9940.30
102_Q109_D0.9580.28
37_P48_R0.9490.28
13_A16_K0.9480.28
19_A24_A0.9420.27
18_V24_A0.9400.27
5_S64_K0.9350.27
61_V116_I0.9290.27
51_R71_L0.9250.27
56_D104_V0.9240.27
103_A107_N0.9050.26
43_E101_E0.9020.26
7_R101_E0.8880.25
79_A82_F0.8840.25
74_S102_Q0.8760.25
10_S116_I0.8760.25
21_D58_T0.8750.25
75_V87_A0.8680.24
103_A108_P0.8440.24
32_D92_H0.8420.23
50_E71_L0.8220.23
32_D88_T0.8190.23
53_A72_R0.8050.22
32_D40_T0.8050.22
58_T105_E0.8040.22
54_S73_K0.8020.22
7_R11_L0.8020.22
111_T115_V0.8010.22
48_R80_V0.7990.22
58_T88_T0.7980.22
41_H48_R0.7970.22
78_A111_T0.7960.22
11_L99_H0.7960.22
100_L115_V0.7800.21
40_T46_L0.7780.21
95_G113_V0.7740.21
34_L79_A0.7710.21
11_L37_P0.7710.21
105_E109_D0.7710.21
32_D39_S0.7590.20
78_A103_A0.7530.20
18_V48_R0.7500.20
10_S20_R0.7490.20
11_L101_E0.7480.20
30_V61_V0.7430.20
14_E44_V0.7390.20
5_S95_G0.7270.19
109_D112_D0.7170.19
25_D30_V0.7160.19
55_E74_S0.7070.19
4_T39_S0.6990.19
55_E99_H0.6970.18
87_A112_D0.6940.18
54_S113_V0.6940.18
91_E96_E0.6830.18
5_S98_V0.6750.18
30_V40_T0.6680.18
43_E78_A0.6620.17
51_R68_S0.6560.17
6_P9_S0.6520.17
20_R28_H0.6500.17
78_A107_N0.6500.17
21_D81_D0.6440.17
10_S32_D0.6410.17
36_K59_V0.6370.17
61_V65_V0.6330.17
72_R80_V0.6320.17
45_N89_K0.6310.16
82_F90_I0.6310.16
58_T72_R0.6290.16
74_S88_T0.6280.16
84_S103_A0.6240.16
91_E112_D0.6220.16
32_D41_H0.6140.16
26_V101_E0.6130.16
60_I103_A0.6000.16
58_T76_T0.5980.16
12_I71_L0.5950.15
21_D116_I0.5940.15
48_R51_R0.5930.15
25_D115_V0.5930.15
46_L81_D0.5910.15
23_G30_V0.5880.15
51_R93_A0.5880.15
73_K76_T0.5880.15
44_V82_F0.5860.15
11_L80_V0.5850.15
10_S18_V0.5850.15
17_S41_H0.5820.15
23_G59_V0.5810.15
48_R56_D0.5740.15
19_A116_I0.5740.15
54_S105_E0.5730.15
28_H98_V0.5700.15
92_H112_D0.5690.15
13_A35_E0.5680.15
46_L58_T0.5620.15
54_S68_S0.5620.15
42_A57_E0.5590.15
53_A59_V0.5590.15
57_E73_K0.5500.14
87_A98_V0.5490.14
16_K36_K0.5470.14
46_L102_Q0.5440.14
8_L60_I0.5400.14
19_A55_E0.5380.14
45_N95_G0.5310.14
62_P114_R0.5270.14
53_A114_R0.5260.14
106_Q111_T0.5190.14
14_E36_K0.5180.14
72_R101_E0.5160.13
88_T105_E0.5150.13
39_S61_V0.5080.13
22_S26_V0.5070.13
15_L108_P0.5070.13
38_R96_E0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vq8O 1 0.9829 100 0.418 Contact Map
3j21P 1 1 100 0.419 Contact Map
1vx7S 1 1 100 0.438 Contact Map
3j61Q 1 1 100 0.438 Contact Map
4w20Q 1 1 100 0.44 Contact Map
4ujrD 1 1 100 0.441 Contact Map
4a17N 1 1 100 0.441 Contact Map
3j39Q 1 1 100 0.442 Contact Map
3zf7I 1 1 100 0.452 Contact Map
1vq8L 1 0.812 99.4 0.723 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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