GREMLIN Database
Q9UWF7 - Uncharacterized protein
UniProt: Q9UWF7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 163 (152)
Sequences: 660 (487)
Seq/√Len: 39.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_R68_I5.6601.00
21_L53_A5.3231.00
126_T129_T4.2061.00
95_V98_V4.1421.00
33_R70_L4.0501.00
91_H121_P3.7431.00
59_E71_N2.7591.00
26_I64_I2.7241.00
26_I32_D2.7221.00
122_R126_T2.5681.00
50_R54_S2.3811.00
122_R130_Y2.0900.99
6_D36_D1.9110.98
9_L42_A1.8960.98
30_Q69_L1.8550.98
21_L64_I1.8330.98
108_S153_L1.7340.97
110_I127_I1.7000.97
88_L134_M1.6960.97
125_R129_T1.6280.96
105_L110_I1.6020.95
14_A28_T1.5650.95
92_Q130_Y1.5610.95
41_D93_R1.5520.94
42_A45_A1.5490.94
125_R128_R1.4710.93
38_A45_A1.4650.92
146_S149_R1.4640.92
88_L139_V1.4560.92
114_Y121_P1.4410.92
17_V26_I1.4180.91
33_R66_D1.4170.91
21_L26_I1.3820.90
126_T130_Y1.3790.90
22_D25_V1.3770.90
26_I66_D1.3750.90
111_Y124_K1.3380.89
6_D39_A1.3090.87
105_L109_E1.3050.87
91_H114_Y1.2940.87
118_V121_P1.2730.86
95_V99_V1.2610.85
16_R20_G1.2320.84
27_T63_R1.2310.84
48_I76_A1.2040.83
88_L137_Y1.2040.83
40_G43_R1.1950.82
10_H32_D1.1710.81
111_Y125_R1.1450.79
138_N151_Y1.1420.79
144_G151_Y1.1410.79
44_L89_I1.1400.79
96_Y113_H1.1400.79
116_R119_D1.1280.78
4_Y12_I1.1260.78
10_H14_A1.1260.78
20_G38_A1.1150.77
42_A46_I1.1150.77
52_A69_L1.1080.77
114_Y118_V1.0980.76
5_H8_Q1.0970.76
91_H94_L1.0830.75
106_G154_V1.0550.73
34_I48_I1.0450.73
10_H27_T1.0430.72
21_L25_V1.0420.72
87_S133_K1.0300.71
135_T142_A1.0260.71
53_A80_I1.0220.71
147_R151_Y1.0160.70
56_A68_I1.0160.70
76_A141_E1.0150.70
29_N32_D1.0100.70
94_L139_V0.9840.68
4_Y16_R0.9780.67
96_Y99_V0.9750.67
37_A70_L0.9650.66
41_D48_I0.9570.66
124_K142_A0.9560.66
32_D90_P0.9500.65
10_H31_L0.9470.65
7_E10_H0.9370.64
151_Y154_V0.9330.64
59_E68_I0.9330.64
8_Q45_A0.9300.63
13_L31_L0.9250.63
146_S151_Y0.9170.62
77_R125_R0.8980.61
89_I92_Q0.8970.61
66_D85_L0.8860.60
132_S139_V0.8770.59
3_K89_I0.8700.58
12_I16_R0.8640.58
59_E129_T0.8620.58
41_D44_L0.8590.57
53_A64_I0.8500.57
24_D28_T0.8500.57
47_G50_R0.8490.56
26_I30_Q0.8480.56
48_I51_T0.8480.56
41_D139_V0.8210.54
58_R77_R0.8200.54
102_H132_S0.8200.54
67_D71_N0.8150.53
14_A27_T0.8070.53
128_R154_V0.8030.52
22_D143_E0.7930.51
8_Q18_K0.7920.51
107_P127_I0.7840.51
89_I130_Y0.7780.50
51_T54_S0.7700.49
85_L153_L0.7630.49
25_V28_T0.7620.49
41_D85_L0.7580.48
8_Q32_D0.7540.48
99_V140_L0.7530.48
37_A93_R0.7510.48
96_Y123_T0.7490.47
55_K152_S0.7390.46
135_T154_V0.7310.46
58_R75_D0.7240.45
57_D124_K0.7230.45
20_G53_A0.7220.45
89_I127_I0.7200.45
126_T137_Y0.7180.45
150_E153_L0.7170.44
89_I126_T0.7120.44
21_L61_R0.7050.43
47_G64_I0.7040.43
85_L131_L0.7030.43
52_A136_Q0.7020.43
12_I46_I0.6930.42
69_L112_D0.6920.42
10_H35_A0.6910.42
77_R99_V0.6910.42
82_Q85_L0.6860.42
33_R129_T0.6860.42
51_T79_Q0.6800.41
115_K139_V0.6790.41
44_L133_K0.6780.41
135_T140_L0.6780.41
30_Q64_I0.6770.41
22_D60_S0.6760.41
98_V109_E0.6740.41
123_T129_T0.6730.41
19_G93_R0.6730.41
3_K6_D0.6720.40
20_G134_M0.6720.40
12_I38_A0.6690.40
48_I107_P0.6680.40
51_T123_T0.6670.40
5_H39_A0.6620.40
54_S125_R0.6610.39
69_L102_H0.6610.39
61_R115_K0.6600.39
8_Q69_L0.6590.39
5_H36_D0.6590.39
13_L80_I0.6580.39
10_H28_T0.6540.39
108_S124_K0.6510.39
42_A114_Y0.6510.39
102_H105_L0.6490.38
11_D57_D0.6460.38
17_V49_L0.6460.38
98_V140_L0.6430.38
21_L49_L0.6430.38
70_L91_H0.6410.38
18_K23_Q0.6260.36
92_Q137_Y0.6100.35
55_K72_A0.6050.35
131_L137_Y0.6030.35
51_T92_Q0.6010.34
30_Q98_V0.6010.34
5_H63_R0.5990.34
18_K101_E0.5940.34
66_D70_L0.5920.34
29_N37_A0.5910.34
60_S71_N0.5900.34
41_D107_P0.5890.33
25_V32_D0.5890.33
57_D152_S0.5890.33
39_A42_A0.5880.33
98_V116_R0.5860.33
46_I81_K0.5850.33
3_K38_A0.5840.33
36_D85_L0.5800.33
60_S116_R0.5800.33
124_K128_R0.5780.33
11_D64_I0.5780.33
64_I145_T0.5770.32
3_K17_V0.5740.32
111_Y126_T0.5740.32
133_K137_Y0.5730.32
111_Y130_Y0.5720.32
8_Q90_P0.5670.32
107_P142_A0.5590.31
78_A84_N0.5520.30
14_A17_V0.5500.30
27_T67_D0.5490.30
86_D140_L0.5480.30
101_E112_D0.5460.30
146_S152_S0.5450.30
83_K117_K0.5420.30
93_R97_D0.5420.30
82_Q86_D0.5420.30
41_D47_G0.5370.29
41_D87_S0.5360.29
7_E11_D0.5340.29
59_E87_S0.5330.29
95_V113_H0.5320.29
50_R79_Q0.5300.29
13_L134_M0.5290.29
79_Q139_V0.5260.29
29_N142_A0.5240.28
113_H118_V0.5240.28
52_A79_Q0.5200.28
97_D117_K0.5180.28
10_H74_E0.5160.28
6_D66_D0.5150.28
20_G61_R0.5140.28
38_A42_A0.5140.28
35_A114_Y0.5120.27
53_A121_P0.5090.27
83_K111_Y0.5060.27
50_R64_I0.5030.27
85_L143_E0.5020.27
143_E154_V0.5010.27
103_G113_H0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qbyA 1 0.9816 99.9 0.533 Contact Map
1w5sA 1 0.9509 99.9 0.536 Contact Map
2v1uA 1 1 99.9 0.553 Contact Map
2qbyB 1 0.9693 99.8 0.569 Contact Map
4xgcA 1 0.9325 99.8 0.575 Contact Map
1fnnA 1 0.9571 99.8 0.585 Contact Map
4xgcD 1 0.9571 99.8 0.601 Contact Map
3ja87 1 0.5031 99.1 0.742 Contact Map
4fdgB 1 0.4847 99 0.75 Contact Map
3ja84 1 0.5031 99 0.751 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0071 seconds.