GREMLIN Database
PYRF - Orotidine 5'-phosphate decarboxylase
UniProt: Q9P9M3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (253)
Sequences: 1664 (1013)
Seq/√Len: 63.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_S237_G4.6461.00
41_W76_E4.4291.00
160_R168_E3.7211.00
255_A258_T3.2781.00
44_N77_T3.1521.00
54_H253_G3.1461.00
92_A114_I2.9891.00
78_V88_V2.9741.00
44_N65_Y2.8921.00
90_L108_L2.8611.00
49_D80_Y2.8291.00
53_E253_G2.7631.00
170_A182_L2.6131.00
215_D218_A2.6101.00
90_L111_V2.3391.00
139_L142_T2.2911.00
62_A90_L2.2811.00
126_Q130_T2.2761.00
42_A46_R2.2601.00
101_A128_F2.2561.00
45_R80_Y2.2511.00
65_Y77_T2.1931.00
161_R164_E2.1921.00
102_R130_T2.1601.00
170_A180_V2.1121.00
56_A231_L2.1031.00
57_V89_L2.0691.00
47_I51_T2.0621.00
114_I136_V1.9971.00
137_F181_G1.8871.00
62_A108_L1.8331.00
150_F169_R1.8071.00
110_H134_A1.7871.00
174_N178_G1.7450.99
75_R79_A1.7090.99
10_R13_A1.7080.99
160_R165_H1.6830.99
51_T58_F1.6800.99
168_E198_R1.6620.99
140_C182_L1.6500.99
141_R147_G1.6190.99
167_A182_L1.6120.99
58_F81_A1.5940.99
68_S72_R1.5790.99
68_S75_R1.5790.99
20_V238_V1.5780.99
169_R172_E1.5660.99
9_A13_A1.5640.99
164_E194_A1.5630.99
62_A92_A1.5570.99
81_A86_V1.5540.99
74_L90_L1.5490.99
141_R152_H1.5410.99
251_A254_D1.5210.99
119_Y166_V1.5120.99
22_L44_N1.4970.98
118_P166_V1.4780.98
150_F162_L1.4720.98
116_V136_V1.4570.98
78_V111_V1.4540.98
257_R261_E1.4510.98
40_R73_A1.4420.98
48_I77_T1.4130.98
66_E94_R1.4090.98
116_V128_F1.4000.98
67_D70_G1.3880.97
242_G247_A1.3780.97
140_C167_A1.3610.97
129_L136_V1.3530.97
46_R248_W1.3520.97
136_V180_V1.3520.97
124_A146_G1.3220.97
69_D72_R1.3180.96
15_D53_E1.3030.96
116_V138_V1.2840.96
58_F86_V1.2810.96
242_G245_G1.2780.96
241_A252_A1.2660.96
41_W45_R1.2630.95
126_Q173_W1.2580.95
138_V170_A1.2540.95
62_A71_W1.2410.95
55_A86_V1.2400.95
90_L114_I1.2310.95
154_E161_R1.2270.95
45_R77_T1.2230.95
71_W108_L1.2120.94
253_G257_R1.2100.94
234_S255_A1.2070.94
46_R249_A1.1920.94
51_T81_A1.1840.94
122_E166_V1.1800.94
251_A255_A1.1780.93
30_P35_D1.1690.93
25_D99_N1.1670.93
25_D28_R1.1570.93
19_S57_V1.1400.92
154_E159_D1.1330.92
53_E86_V1.1330.92
234_S238_V1.1290.92
15_D86_V1.1190.92
164_E168_E1.1040.91
78_V82_H1.1030.91
195_I199_V1.0950.91
209_V234_S1.0900.90
206_V214_G1.0880.90
190_D194_A1.0730.90
174_N179_D1.0680.90
66_E107_I1.0610.89
47_I239_I1.0600.89
60_P74_L1.0510.89
37_E73_A1.0460.89
92_A108_L1.0420.88
11_I231_L1.0410.88
88_V111_V1.0370.88
209_V216_A1.0290.88
141_R191_E1.0210.87
44_N73_A1.0130.87
38_L41_W1.0100.87
36_A42_A1.0040.86
82_H88_V0.9950.86
237_G259_L0.9940.86
252_A256_A0.9940.86
122_E173_W0.9910.86
120_L124_A0.9870.85
165_H169_R0.9840.85
20_V55_A0.9780.85
10_R55_A0.9700.84
74_L111_V0.9690.84
81_A214_G0.9640.84
254_D257_R0.9590.84
141_R188_A0.9570.84
71_W90_L0.9560.84
209_V232_V0.9520.83
20_V51_T0.9470.83
158_Y161_R0.9440.83
68_S71_W0.9420.83
258_T262_R0.9420.83
17_V220_V0.9410.83
129_L173_W0.9330.82
250_A254_D0.9320.82
148_M188_A0.9280.82
123_D126_Q0.9220.81
146_G149_D0.9200.81
62_A74_L0.9160.81
122_E129_L0.9150.81
117_N124_A0.9120.81
57_V231_L0.9110.81
138_V180_V0.9100.80
38_L42_A0.9090.80
182_L204_F0.9040.80
51_T252_A0.9020.80
182_L199_V0.9010.80
34_Q39_P0.8960.79
37_E40_R0.8910.79
54_H257_R0.8850.79
48_I81_A0.8830.78
28_R239_I0.8820.78
123_D173_W0.8750.78
147_G174_N0.8750.78
194_A197_E0.8720.78
155_L158_Y0.8710.77
28_R240_F0.8670.77
52_H86_V0.8650.77
145_E148_M0.8500.76
41_W80_Y0.8480.76
200_P204_F0.8460.75
141_R189_P0.8440.75
36_A39_P0.8430.75
9_A12_E0.8320.74
20_V47_I0.8320.74
215_D219_A0.8310.74
88_V113_A0.8300.74
245_G252_A0.8280.74
155_L165_H0.8230.73
8_G227_D0.8210.73
72_R75_R0.8200.73
125_L138_V0.8190.73
148_M152_H0.8150.73
112_D134_A0.8120.72
196_R199_V0.8120.72
140_C170_A0.8110.72
207_P210_G0.8090.72
74_L108_L0.8070.72
191_E194_A0.8050.72
206_V230_G0.8050.72
89_L233_N0.8020.71
189_P222_Y0.8000.71
254_D258_T0.8000.71
212_Q236_R0.7980.71
117_N139_L0.7940.71
214_G218_A0.7870.70
64_F99_N0.7860.70
234_S259_L0.7830.70
22_L65_Y0.7740.69
152_H188_A0.7670.68
137_F203_P0.7610.67
20_V233_N0.7600.67
155_L159_D0.7570.67
77_T80_Y0.7540.67
217_E262_R0.7520.66
122_E170_A0.7510.66
224_L229_V0.7500.66
167_A204_F0.7500.66
81_A88_V0.7490.66
164_E198_R0.7440.66
183_V207_P0.7440.66
129_L180_V0.7420.65
150_F166_V0.7410.65
108_L141_R0.7400.65
214_G222_Y0.7380.65
10_R85_G0.7290.64
256_A260_R0.7230.63
108_L114_I0.7230.63
247_A250_A0.7220.63
154_E158_Y0.7210.63
78_V110_H0.7180.63
227_D230_G0.7180.63
116_V129_L0.7170.63
218_A221_E0.7160.63
109_A128_F0.7160.63
152_H191_E0.7140.62
158_Y165_H0.7130.62
138_V171_A0.7130.62
92_A95_A0.7110.62
153_L162_L0.7070.62
122_E149_D0.7060.62
22_L77_T0.7060.62
53_E257_R0.7030.61
51_T86_V0.6980.61
182_L200_P0.6950.60
174_N202_L0.6920.60
147_G189_P0.6890.60
125_L146_G0.6830.59
67_D107_I0.6810.59
114_I118_P0.6810.59
24_P65_Y0.6800.59
35_D106_E0.6790.59
87_P135_G0.6780.58
38_L76_E0.6760.58
95_A124_A0.6710.58
101_A116_V0.6670.57
199_V202_L0.6670.57
165_H168_E0.6660.57
8_G12_E0.6650.57
248_W252_A0.6650.57
155_L160_R0.6640.57
149_D169_R0.6630.57
60_P98_G0.6600.56
153_L165_H0.6580.56
170_A173_W0.6580.56
82_H110_H0.6530.56
119_Y163_Y0.6510.55
193_Q221_E0.6500.55
9_A72_R0.6490.55
24_P240_F0.6470.55
224_L230_G0.6460.55
7_L11_I0.6460.55
51_T109_A0.6430.55
99_N102_R0.6430.55
99_N120_L0.6420.54
253_G256_A0.6410.54
104_Y183_V0.6410.54
27_E34_Q0.6370.54
210_G236_R0.6350.54
192_L222_Y0.6340.53
139_L166_V0.6340.53
52_H84_K0.6330.53
167_A191_E0.6320.53
196_R230_G0.6320.53
171_A201_E0.6320.53
207_P236_R0.6310.53
62_A114_I0.6310.53
7_L57_V0.6300.53
208_G236_R0.6290.53
31_E34_Q0.6280.53
45_R49_D0.6280.53
63_A94_R0.6260.53
147_G151_Q0.6250.52
6_E112_D0.6230.52
47_I167_A0.6220.52
207_P212_Q0.6200.52
94_R104_Y0.6190.52
104_Y235_T0.6150.51
92_A107_I0.6130.51
216_A255_A0.6130.51
50_A249_A0.6110.51
61_N99_N0.6110.51
50_A250_A0.6090.51
77_T81_A0.6090.51
188_A191_E0.6080.50
64_F107_I0.6040.50
133_E179_D0.6040.50
69_D75_R0.6040.50
48_I51_T0.6040.50
182_L202_L0.6020.50
147_G219_A0.6020.50
190_D193_Q0.6020.50
32_D246_S0.6020.50
18_V256_A0.6000.50
66_E70_G0.5990.49
63_A104_Y0.5970.49
250_A253_G0.5960.49
245_G248_W0.5940.49
158_Y175_A0.5940.49
92_A111_V0.5920.49
18_V259_L0.5870.48
28_R43_F0.5860.48
167_A170_A0.5860.48
167_A199_V0.5850.48
255_A259_L0.5840.48
183_V210_G0.5830.48
26_M35_D0.5820.47
76_E80_Y0.5810.47
74_L192_L0.5810.47
48_I84_K0.5800.47
105_A127_P0.5800.47
158_Y217_E0.5790.47
152_H189_P0.5790.47
54_H256_A0.5790.47
161_R194_A0.5780.47
143_S187_T0.5780.47
207_P213_G0.5780.47
66_E181_G0.5770.47
24_P60_P0.5760.47
6_E10_R0.5740.47
122_E126_Q0.5720.46
258_T261_E0.5720.46
26_M40_R0.5710.46
74_L92_A0.5690.46
61_N64_F0.5640.45
64_F240_F0.5620.45
61_N135_G0.5620.45
167_A195_I0.5580.45
47_I81_A0.5570.45
79_A197_E0.5560.44
238_V241_A0.5540.44
226_D246_S0.5520.44
124_A149_D0.5490.44
120_L233_N0.5480.44
48_I80_Y0.5480.44
237_G255_A0.5450.43
113_A133_E0.5420.43
133_E245_G0.5410.43
40_R44_N0.5400.43
29_L35_D0.5370.42
67_D103_Q0.5350.42
7_L203_P0.5340.42
87_P90_L0.5340.42
123_D169_R0.5330.42
13_A85_G0.5330.42
37_E72_R0.5330.42
11_I141_R0.5320.42
80_Y83_G0.5320.42
93_K96_D0.5320.42
206_V233_N0.5310.42
57_V232_V0.5300.42
27_E72_R0.5300.42
31_E35_D0.5280.41
79_A257_R0.5270.41
26_M30_P0.5250.41
214_G234_S0.5230.41
233_N237_G0.5220.41
259_L262_R0.5180.40
79_A133_E0.5170.40
193_Q197_E0.5160.40
41_W77_T0.5150.40
187_T212_Q0.5150.40
28_R64_F0.5150.40
214_G241_A0.5130.40
51_T55_A0.5120.40
94_R183_V0.5110.39
237_G240_F0.5080.39
150_F153_L0.5070.39
155_L161_R0.5060.39
139_L170_A0.5040.39
63_A66_E0.5030.39
24_P28_R0.5010.38
62_A88_V0.5000.38
224_L228_G0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n3mA 2 0.9775 100 0.361 Contact Map
2ffcA 2 0.9738 100 0.368 Contact Map
3r89A 2 0.985 100 0.371 Contact Map
4mjzA 2 0.9738 100 0.373 Contact Map
3v75A 2 0.9738 100 0.376 Contact Map
2fdsA 2 0.9625 100 0.376 Contact Map
3qw4B 4 0.9438 100 0.414 Contact Map
3qw3A 2 0.9176 100 0.436 Contact Map
3gdmA 2 0.8464 100 0.586 Contact Map
3ewwA 2 0.8352 100 0.691 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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