GREMLIN Database
Q9HT04 - Uncharacterized protein
UniProt: Q9HT04 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 401 (316)
Sequences: 564 (528)
Seq/√Len: 29.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
267_G308_F7.4001.00
218_L224_Y4.6141.00
218_L226_L3.6921.00
172_G176_I3.4871.00
175_P200_E3.3131.00
270_A305_F3.1731.00
276_D302_T3.1721.00
170_Q271_N3.1451.00
321_I327_Y3.0121.00
295_Y308_F2.9211.00
55_G66_N2.8481.00
60_I164_I2.8251.00
66_N170_Q2.7391.00
168_I300_I2.6371.00
273_G277_A2.6041.00
183_V220_I2.5811.00
61_T105_P2.5460.99
40_V102_I2.4480.99
198_V203_S2.4160.99
53_T56_T2.3360.99
227_D320_E2.2900.99
117_Q139_Y2.2800.99
291_A310_M2.2480.99
106_L111_T2.2130.98
45_V60_I2.1480.98
121_H135_Q2.1360.98
110_F259_G2.1060.98
187_G190_V2.0930.98
93_L96_L2.0570.97
269_A303_S2.0110.97
251_L301_E2.0040.97
60_I220_I2.0040.97
208_F310_M1.9690.97
329_A332_Q1.9600.97
118_L220_I1.9560.97
269_A300_I1.9390.96
282_V308_F1.9190.96
201_S301_E1.8690.95
142_V187_G1.8630.95
117_Q137_S1.8470.95
99_G201_S1.8430.95
142_V200_E1.8320.95
66_N94_G1.8290.95
166_A267_G1.8240.95
170_Q273_G1.8180.95
279_S328_S1.7920.94
164_I327_Y1.7440.93
116_H218_L1.7120.93
195_V198_V1.7050.93
147_S151_V1.6950.92
210_G334_Y1.6610.92
164_I220_I1.6600.92
260_G271_N1.6260.91
220_I226_L1.6250.91
99_G200_E1.5640.89
114_G179_G1.5620.89
322_P325_V1.5530.89
256_A325_V1.5490.88
268_D305_F1.5470.88
273_G327_Y1.5420.88
121_H223_E1.5030.87
284_A325_V1.5020.87
145_R284_A1.4890.86
241_Y279_S1.4700.86
282_V298_G1.4680.86
284_A302_T1.4570.85
201_S234_T1.4550.85
316_S351_T1.4520.85
133_Y265_I1.4510.85
120_V222_G1.4440.85
156_T288_G1.4030.83
273_G298_G1.3940.82
179_G224_Y1.3910.82
178_S279_S1.3770.82
110_F212_S1.3460.80
62_P106_L1.3290.79
267_G295_Y1.3270.79
63_S101_S1.3130.78
222_G251_L1.3130.78
327_Y335_S1.3110.78
321_I337_V1.3050.78
201_S302_T1.3050.78
105_P183_V1.2900.77
60_I121_H1.2730.76
271_N298_G1.2670.76
69_S244_Q1.2640.76
273_G300_I1.2630.76
303_S309_D1.2530.75
183_V284_A1.2490.75
37_A40_V1.2440.74
124_G226_L1.2360.74
242_Q269_A1.2340.74
59_L105_P1.2340.74
300_I306_A1.2270.73
62_P220_I1.2100.72
58_V118_L1.2080.72
174_I275_A1.2060.72
176_I320_E1.1870.71
346_S350_A1.1770.70
228_D231_S1.1720.70
168_I224_Y1.1660.70
280_V331_G1.1530.69
168_I181_L1.1520.69
69_S342_V1.1500.68
38_V45_V1.1440.68
85_G159_N1.1400.68
104_V175_P1.1400.68
58_V108_S1.1270.67
85_G140_V1.1200.66
81_L138_V1.1190.66
90_E118_L1.1180.66
78_E325_V1.1160.66
331_G334_Y1.1150.66
206_V222_G1.1130.66
267_G277_A1.1100.66
111_T321_I1.1100.66
38_V88_A1.1050.65
260_G264_T1.0920.64
118_L168_I1.0900.64
164_I265_I1.0870.64
319_D322_P1.0840.64
62_P313_Q1.0830.64
96_L313_Q1.0810.64
117_Q140_V1.0690.63
120_V125_L1.0670.63
297_V322_P1.0630.62
101_S172_G1.0600.62
284_A310_M1.0550.62
288_G322_P1.0500.61
180_E311_T1.0460.61
306_A309_D1.0430.61
106_L160_G1.0430.61
251_L265_I1.0420.61
198_V280_V1.0390.60
166_A239_L1.0350.60
179_G196_A1.0260.59
181_L339_T1.0250.59
76_V128_D1.0240.59
279_S298_G1.0240.59
280_V285_V1.0220.59
185_S206_V1.0210.59
181_L291_A1.0210.59
96_L205_N1.0160.59
210_G276_D1.0140.59
228_D233_H1.0110.58
121_H152_S1.0090.58
162_T270_A1.0010.58
253_G256_A0.9940.57
314_A318_V0.9920.57
219_V342_V0.9860.56
260_G341_D0.9820.56
62_P283_N0.9810.56
194_P240_T0.9810.56
162_T263_Y0.9790.56
226_L327_Y0.9770.56
64_I163_D0.9760.56
174_I259_G0.9740.55
210_G244_Q0.9730.55
116_H259_G0.9720.55
337_V346_S0.9700.55
59_L330_D0.9670.55
103_E107_S0.9610.54
96_L340_V0.9590.54
34_G269_A0.9580.54
183_V253_G0.9560.54
248_D251_L0.9510.54
222_G226_L0.9500.54
120_V278_A0.9470.53
191_E217_E0.9420.53
35_S122_V0.9360.52
177_K262_T0.9310.52
48_S110_F0.9300.52
124_G296_F0.9280.52
243_P340_V0.9270.52
96_L334_Y0.9260.52
56_T144_D0.9240.52
93_L163_D0.9200.51
185_S190_V0.9150.51
185_S218_L0.9140.51
115_D202_D0.9140.51
67_S98_A0.9090.50
170_Q303_S0.9070.50
62_P267_G0.9070.50
145_R179_G0.9060.50
122_V128_D0.9050.50
233_H241_Y0.9020.50
347_S350_A0.9010.50
198_V326_N0.9010.50
34_G140_V0.8960.49
65_N234_T0.8950.49
255_E316_S0.8930.49
120_V206_V0.8920.49
70_A135_Q0.8910.49
114_G142_V0.8890.49
93_L103_E0.8860.49
39_S45_V0.8850.48
125_L142_V0.8820.48
321_I340_V0.8800.48
81_L174_I0.8760.48
149_V166_A0.8740.48
103_E179_G0.8660.47
191_E195_V0.8660.47
342_V345_A0.8640.47
238_T303_S0.8600.46
272_L302_T0.8590.46
109_T137_S0.8560.46
80_T89_T0.8530.46
282_V295_Y0.8530.46
164_I202_D0.8520.46
334_Y339_T0.8520.46
316_S320_E0.8510.46
274_S311_T0.8500.46
278_A342_V0.8490.46
303_S306_A0.8460.45
88_A106_L0.8440.45
138_V156_T0.8430.45
190_V205_N0.8380.45
67_S198_V0.8380.45
73_S77_N0.8370.45
262_T266_S0.8340.44
277_A339_T0.8310.44
270_A296_F0.8300.44
45_V118_L0.8260.44
140_V200_E0.8260.44
147_S226_L0.8250.44
63_S215_S0.8240.44
195_V231_S0.8240.44
114_G297_V0.8140.43
141_T186_D0.8140.43
156_T303_S0.8140.43
261_T333_R0.8130.43
322_P331_G0.8110.43
268_D307_T0.8090.42
76_V87_L0.8090.42
66_N74_A0.8050.42
136_R213_I0.8030.42
173_T176_I0.8000.42
60_I120_V0.7980.42
247_A328_S0.7960.41
181_L222_G0.7950.41
216_G244_Q0.7940.41
252_T270_A0.7930.41
110_F118_L0.7930.41
86_L201_S0.7890.41
40_V66_N0.7880.41
38_V331_G0.7870.41
186_D254_V0.7860.41
282_V305_F0.7850.41
63_S256_A0.7820.40
57_Q110_F0.7770.40
270_A322_P0.7730.40
103_E205_N0.7710.40
42_I52_P0.7690.39
162_T274_S0.7680.39
160_G173_T0.7660.39
93_L161_S0.7650.39
170_Q198_V0.7640.39
322_P337_V0.7620.39
126_N132_F0.7620.39
347_S352_S0.7610.39
179_G230_H0.7600.39
56_T59_L0.7590.39
207_T329_A0.7580.39
54_T158_T0.7550.38
269_A338_V0.7550.38
36_G40_V0.7540.38
156_T312_V0.7530.38
48_S95_R0.7510.38
201_S275_A0.7490.38
96_L301_E0.7480.38
185_S241_Y0.7450.38
67_S81_L0.7420.37
341_D348_G0.7400.37
78_E81_L0.7390.37
119_S135_Q0.7390.37
254_V297_V0.7380.37
194_P266_S0.7350.37
335_S346_S0.7330.37
65_N78_E0.7320.37
76_V139_Y0.7320.37
49_P216_G0.7310.37
223_E265_I0.7310.37
116_H183_V0.7310.37
194_P227_D0.7310.37
220_I276_D0.7290.36
222_G314_A0.7280.36
116_H124_G0.7280.36
69_S118_L0.7270.36
147_S153_A0.7260.36
84_D168_I0.7260.36
334_Y351_T0.7260.36
159_N260_G0.7240.36
191_E264_T0.7220.36
169_T203_S0.7210.36
185_S226_L0.7180.36
114_G298_G0.7160.35
148_D265_I0.7140.35
295_Y309_D0.7140.35
349_S352_S0.7130.35
168_I269_A0.7070.35
122_V166_A0.7060.35
120_V149_V0.7060.35
164_I298_G0.7060.35
87_L284_A0.7040.35
36_G48_S0.7040.35
112_E200_E0.7030.35
342_V348_G0.7030.35
66_N298_G0.7020.34
96_L272_L0.7010.34
95_R207_T0.7000.34
318_V349_S0.7000.34
96_L151_V0.7000.34
218_L222_G0.6980.34
197_N250_A0.6940.34
66_N139_Y0.6920.34
73_S76_V0.6900.34
226_L297_V0.6850.33
289_L313_Q0.6850.33
192_R234_T0.6840.33
68_G102_I0.6840.33
61_T211_A0.6830.33
77_N144_D0.6830.33
224_Y314_A0.6820.33
132_F148_D0.6790.33
116_H336_D0.6790.33
297_V349_S0.6770.33
253_G284_A0.6760.33
51_N56_T0.6720.32
277_A280_V0.6720.32
52_P120_V0.6710.32
56_T255_E0.6710.32
103_E112_E0.6710.32
204_A340_V0.6700.32
251_L291_A0.6690.32
267_G282_V0.6650.32
186_D221_R0.6640.32
219_V302_T0.6630.32
315_D320_E0.6630.32
288_G304_E0.6620.32
284_A294_G0.6610.32
114_G281_R0.6610.32
120_V165_Q0.6550.31
64_I168_I0.6540.31
265_I295_Y0.6520.31
40_V45_V0.6520.31
60_I113_P0.6500.31
34_G38_V0.6490.31
64_I140_V0.6480.31
52_P306_A0.6480.31
118_L164_I0.6470.31
343_S350_A0.6460.31
156_T240_T0.6440.30
104_V195_V0.6420.30
187_G197_N0.6410.30
166_A209_D0.6390.30
145_R222_G0.6390.30
41_T45_V0.6390.30
38_V199_S0.6380.30
138_V262_T0.6350.30
60_I155_T0.6350.30
338_V346_S0.6350.30
195_V206_V0.6340.30
196_A237_T0.6330.30
120_V216_G0.6300.30
116_H298_G0.6260.29
148_D250_A0.6250.29
279_S296_F0.6230.29
96_L350_A0.6220.29
97_G307_T0.6210.29
58_V220_I0.6200.29
245_R277_A0.6200.29
62_P138_V0.6190.29
247_A327_Y0.6190.29
148_D308_F0.6180.29
268_D309_D0.6150.29
76_V282_V0.6140.29
67_S210_G0.6140.29
215_S218_L0.6120.28
172_G270_A0.6120.28
102_I341_D0.6120.28
247_A294_G0.6110.28
42_I129_G0.6100.28
186_D267_G0.6100.28
141_T255_E0.6070.28
178_S227_D0.6060.28
171_Y249_V0.6030.28
120_V211_A0.6000.28
35_S69_S0.5970.27
112_E143_D0.5970.27
66_N300_I0.5960.27
281_R296_F0.5960.27
169_T252_T0.5920.27
35_S39_S0.5910.27
252_T318_V0.5910.27
176_I179_G0.5880.27
169_T238_T0.5880.27
198_V216_G0.5860.27
186_D269_A0.5860.27
62_P87_L0.5860.27
245_R328_S0.5830.27
90_E283_N0.5830.27
83_G153_A0.5790.26
38_V42_I0.5770.26
260_G268_D0.5770.26
83_G148_D0.5760.26
35_S44_D0.5750.26
54_T308_F0.5740.26
241_Y284_A0.5700.26
52_P96_L0.5680.26
298_G308_F0.5670.26
147_S211_A0.5660.26
81_L115_D0.5640.25
56_T141_T0.5640.25
124_G147_S0.5630.25
162_T344_G0.5620.25
156_T243_P0.5610.25
247_A337_V0.5580.25
148_D153_A0.5570.25
111_T173_T0.5560.25
179_G205_N0.5540.25
97_G140_V0.5530.25
266_S314_A0.5530.25
77_N80_T0.5510.25
204_A207_T0.5490.25
245_R272_L0.5490.25
155_T191_E0.5480.24
147_S294_G0.5480.24
171_Y267_G0.5480.24
65_N217_E0.5480.24
207_T335_S0.5470.24
45_V183_V0.5450.24
167_T239_L0.5450.24
71_S166_A0.5440.24
129_G146_T0.5400.24
111_T200_E0.5400.24
300_I304_E0.5360.24
73_S78_E0.5350.24
164_I186_D0.5350.24
196_A206_V0.5300.23
267_G281_R0.5300.23
305_F308_F0.5280.23
60_I321_I0.5280.23
282_V287_D0.5280.23
323_I327_Y0.5270.23
163_D167_T0.5270.23
88_A230_H0.5260.23
295_Y305_F0.5250.23
61_T69_S0.5250.23
81_L171_Y0.5250.23
45_V53_T0.5240.23
221_R275_A0.5230.23
55_G58_V0.5210.23
60_I185_S0.5210.23
111_T251_L0.5210.23
159_N303_S0.5200.23
34_G37_A0.5170.23
189_I244_Q0.5170.23
65_N101_S0.5170.23
266_S317_A0.5140.23
84_D93_L0.5140.23
107_S250_A0.5140.23
217_E240_T0.5130.22
64_I155_T0.5120.22
270_A307_T0.5090.22
150_G342_V0.5080.22
78_E195_V0.5050.22
136_R141_T0.5050.22
96_L307_T0.5040.22
164_I182_Q0.5030.22
170_Q200_E0.5020.22
65_N152_S0.5010.22
152_S316_S0.5000.22
162_T297_V0.5000.22
47_V60_I0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iduA 1 0.2818 98.5 0.852 Contact Map
3j8f7 1 0.6983 98.5 0.853 Contact Map
2l0dA 1 0.2668 98.3 0.86 Contact Map
2qsvA 1 0.4938 98.3 0.86 Contact Map
2kutA 1 0.2618 98.2 0.862 Contact Map
2q3zA 2 0.5062 98.1 0.868 Contact Map
4e9lA 1 0.7456 97.9 0.873 Contact Map
4ktyA 1 0.5112 97.9 0.873 Contact Map
1l9mA 2 0.5436 97.9 0.874 Contact Map
4liqE 1 0.8229 97.7 0.879 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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