Q9HT04 - HALSA - GREMLIN Contacts

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Q9HT04 - Uncharacterized protein

UniProt:	Q9HT04	Sequences: MTRRSRVGAGLAAIVLALAAVSAAAPIAGAQSAGSGAVSVTIGDVDVSPANPTTGTQVLITPSINNSGSASGSARVNEVTLRGDGLLATEDSLGRLGAGDSIEVPLSSTFTEPGDHQLSVHVRGLNPDGSVFYVQRSVYVTVDDRTSDVGVSARTTATNGSTDIQATITQYGTIPIKSGELQVVSDGRIVERAPVANVSESDSANVTFDGASIPSGELVIRGEYTLDDEHSTHTTNTTLTYQPQRSADVALTGVEASGGGTTYTISGDAANLGSADAASVRVNAVGDGLSANGGYFVGKIETSEFATFDMTVQADSAVDEIPITVNYSADGQRYSDVVTVDVSGASSGSATSPERAPGQQQKRAPSPSNGASGGGLPLFKIGGAVAVIAIVVVVVRRWRNP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	401 (316)
Sequences:	564 (528)
Seq/√Len:	29.7

HALSA - Q9HT04 Q9HPT8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
267_G	308_F	7.400	1.00
218_L	224_Y	4.614	1.00
218_L	226_L	3.692	1.00
172_G	176_I	3.487	1.00
175_P	200_E	3.313	1.00
270_A	305_F	3.173	1.00
276_D	302_T	3.172	1.00
170_Q	271_N	3.145	1.00
321_I	327_Y	3.012	1.00
295_Y	308_F	2.921	1.00
55_G	66_N	2.848	1.00
60_I	164_I	2.825	1.00
66_N	170_Q	2.739	1.00
168_I	300_I	2.637	1.00
273_G	277_A	2.604	1.00
183_V	220_I	2.581	1.00
61_T	105_P	2.546	0.99
40_V	102_I	2.448	0.99
198_V	203_S	2.416	0.99
53_T	56_T	2.336	0.99
227_D	320_E	2.290	0.99
117_Q	139_Y	2.280	0.99
291_A	310_M	2.248	0.99
106_L	111_T	2.213	0.98
45_V	60_I	2.148	0.98
121_H	135_Q	2.136	0.98
110_F	259_G	2.106	0.98
187_G	190_V	2.093	0.98
93_L	96_L	2.057	0.97
269_A	303_S	2.011	0.97
251_L	301_E	2.004	0.97
60_I	220_I	2.004	0.97
208_F	310_M	1.969	0.97
329_A	332_Q	1.960	0.97
118_L	220_I	1.956	0.97
269_A	300_I	1.939	0.96
282_V	308_F	1.919	0.96
201_S	301_E	1.869	0.95
142_V	187_G	1.863	0.95
117_Q	137_S	1.847	0.95
99_G	201_S	1.843	0.95
142_V	200_E	1.832	0.95
66_N	94_G	1.829	0.95
166_A	267_G	1.824	0.95
170_Q	273_G	1.818	0.95
279_S	328_S	1.792	0.94
164_I	327_Y	1.744	0.93
116_H	218_L	1.712	0.93
195_V	198_V	1.705	0.93
147_S	151_V	1.695	0.92
210_G	334_Y	1.661	0.92
164_I	220_I	1.660	0.92
260_G	271_N	1.626	0.91
220_I	226_L	1.625	0.91
99_G	200_E	1.564	0.89
114_G	179_G	1.562	0.89
322_P	325_V	1.553	0.89
256_A	325_V	1.549	0.88
268_D	305_F	1.547	0.88
273_G	327_Y	1.542	0.88
121_H	223_E	1.503	0.87
284_A	325_V	1.502	0.87
145_R	284_A	1.489	0.86
241_Y	279_S	1.470	0.86
282_V	298_G	1.468	0.86
284_A	302_T	1.457	0.85
201_S	234_T	1.455	0.85
316_S	351_T	1.452	0.85
133_Y	265_I	1.451	0.85
120_V	222_G	1.444	0.85
156_T	288_G	1.403	0.83
273_G	298_G	1.394	0.82
179_G	224_Y	1.391	0.82
178_S	279_S	1.377	0.82
110_F	212_S	1.346	0.80
62_P	106_L	1.329	0.79
267_G	295_Y	1.327	0.79
63_S	101_S	1.313	0.78
222_G	251_L	1.313	0.78
327_Y	335_S	1.311	0.78
321_I	337_V	1.305	0.78
201_S	302_T	1.305	0.78
105_P	183_V	1.290	0.77
60_I	121_H	1.273	0.76
271_N	298_G	1.267	0.76
69_S	244_Q	1.264	0.76
273_G	300_I	1.263	0.76
303_S	309_D	1.253	0.75
183_V	284_A	1.249	0.75
37_A	40_V	1.244	0.74
124_G	226_L	1.236	0.74
242_Q	269_A	1.234	0.74
59_L	105_P	1.234	0.74
300_I	306_A	1.227	0.73
62_P	220_I	1.210	0.72
58_V	118_L	1.208	0.72
174_I	275_A	1.206	0.72
176_I	320_E	1.187	0.71
346_S	350_A	1.177	0.70
228_D	231_S	1.172	0.70
168_I	224_Y	1.166	0.70
280_V	331_G	1.153	0.69
168_I	181_L	1.152	0.69
69_S	342_V	1.150	0.68
38_V	45_V	1.144	0.68
85_G	159_N	1.140	0.68
104_V	175_P	1.140	0.68
58_V	108_S	1.127	0.67
85_G	140_V	1.120	0.66
81_L	138_V	1.119	0.66
90_E	118_L	1.118	0.66
78_E	325_V	1.116	0.66
331_G	334_Y	1.115	0.66
206_V	222_G	1.113	0.66
267_G	277_A	1.110	0.66
111_T	321_I	1.110	0.66
38_V	88_A	1.105	0.65
260_G	264_T	1.092	0.64
118_L	168_I	1.090	0.64
164_I	265_I	1.087	0.64
319_D	322_P	1.084	0.64
62_P	313_Q	1.083	0.64
96_L	313_Q	1.081	0.64
117_Q	140_V	1.069	0.63
120_V	125_L	1.067	0.63
297_V	322_P	1.063	0.62
101_S	172_G	1.060	0.62
284_A	310_M	1.055	0.62
288_G	322_P	1.050	0.61
180_E	311_T	1.046	0.61
306_A	309_D	1.043	0.61
106_L	160_G	1.043	0.61
251_L	265_I	1.042	0.61
198_V	280_V	1.039	0.60
166_A	239_L	1.035	0.60
179_G	196_A	1.026	0.59
181_L	339_T	1.025	0.59
76_V	128_D	1.024	0.59
279_S	298_G	1.024	0.59
280_V	285_V	1.022	0.59
185_S	206_V	1.021	0.59
181_L	291_A	1.021	0.59
96_L	205_N	1.016	0.59
210_G	276_D	1.014	0.59
228_D	233_H	1.011	0.58
121_H	152_S	1.009	0.58
162_T	270_A	1.001	0.58
253_G	256_A	0.994	0.57
314_A	318_V	0.992	0.57
219_V	342_V	0.986	0.56
260_G	341_D	0.982	0.56
62_P	283_N	0.981	0.56
194_P	240_T	0.981	0.56
162_T	263_Y	0.979	0.56
226_L	327_Y	0.977	0.56
64_I	163_D	0.976	0.56
174_I	259_G	0.974	0.55
210_G	244_Q	0.973	0.55
116_H	259_G	0.972	0.55
337_V	346_S	0.970	0.55
59_L	330_D	0.967	0.55
103_E	107_S	0.961	0.54
96_L	340_V	0.959	0.54
34_G	269_A	0.958	0.54
183_V	253_G	0.956	0.54
248_D	251_L	0.951	0.54
222_G	226_L	0.950	0.54
120_V	278_A	0.947	0.53
191_E	217_E	0.942	0.53
35_S	122_V	0.936	0.52
177_K	262_T	0.931	0.52
48_S	110_F	0.930	0.52
124_G	296_F	0.928	0.52
243_P	340_V	0.927	0.52
96_L	334_Y	0.926	0.52
56_T	144_D	0.924	0.52
93_L	163_D	0.920	0.51
185_S	190_V	0.915	0.51
185_S	218_L	0.914	0.51
115_D	202_D	0.914	0.51
67_S	98_A	0.909	0.50
170_Q	303_S	0.907	0.50
62_P	267_G	0.907	0.50
145_R	179_G	0.906	0.50
122_V	128_D	0.905	0.50
233_H	241_Y	0.902	0.50
347_S	350_A	0.901	0.50
198_V	326_N	0.901	0.50
34_G	140_V	0.896	0.49
65_N	234_T	0.895	0.49
255_E	316_S	0.893	0.49
120_V	206_V	0.892	0.49
70_A	135_Q	0.891	0.49
114_G	142_V	0.889	0.49
93_L	103_E	0.886	0.49
39_S	45_V	0.885	0.48
125_L	142_V	0.882	0.48
321_I	340_V	0.880	0.48
81_L	174_I	0.876	0.48
149_V	166_A	0.874	0.48
103_E	179_G	0.866	0.47
191_E	195_V	0.866	0.47
342_V	345_A	0.864	0.47
238_T	303_S	0.860	0.46
272_L	302_T	0.859	0.46
109_T	137_S	0.856	0.46
80_T	89_T	0.853	0.46
282_V	295_Y	0.853	0.46
164_I	202_D	0.852	0.46
334_Y	339_T	0.852	0.46
316_S	320_E	0.851	0.46
274_S	311_T	0.850	0.46
278_A	342_V	0.849	0.46
303_S	306_A	0.846	0.45
88_A	106_L	0.844	0.45
138_V	156_T	0.843	0.45
190_V	205_N	0.838	0.45
67_S	198_V	0.838	0.45
73_S	77_N	0.837	0.45
262_T	266_S	0.834	0.44
277_A	339_T	0.831	0.44
270_A	296_F	0.830	0.44
45_V	118_L	0.826	0.44
140_V	200_E	0.826	0.44
147_S	226_L	0.825	0.44
63_S	215_S	0.824	0.44
195_V	231_S	0.824	0.44
114_G	297_V	0.814	0.43
141_T	186_D	0.814	0.43
156_T	303_S	0.814	0.43
261_T	333_R	0.813	0.43
322_P	331_G	0.811	0.43
268_D	307_T	0.809	0.42
76_V	87_L	0.809	0.42
66_N	74_A	0.805	0.42
136_R	213_I	0.803	0.42
173_T	176_I	0.800	0.42
60_I	120_V	0.798	0.42
247_A	328_S	0.796	0.41
181_L	222_G	0.795	0.41
216_G	244_Q	0.794	0.41
252_T	270_A	0.793	0.41
110_F	118_L	0.793	0.41
86_L	201_S	0.789	0.41
40_V	66_N	0.788	0.41
38_V	331_G	0.787	0.41
186_D	254_V	0.786	0.41
282_V	305_F	0.785	0.41
63_S	256_A	0.782	0.40
57_Q	110_F	0.777	0.40
270_A	322_P	0.773	0.40
103_E	205_N	0.771	0.40
42_I	52_P	0.769	0.39
162_T	274_S	0.768	0.39
160_G	173_T	0.766	0.39
93_L	161_S	0.765	0.39
170_Q	198_V	0.764	0.39
322_P	337_V	0.762	0.39
126_N	132_F	0.762	0.39
347_S	352_S	0.761	0.39
179_G	230_H	0.760	0.39
56_T	59_L	0.759	0.39
207_T	329_A	0.758	0.39
54_T	158_T	0.755	0.38
269_A	338_V	0.755	0.38
36_G	40_V	0.754	0.38
156_T	312_V	0.753	0.38
48_S	95_R	0.751	0.38
201_S	275_A	0.749	0.38
96_L	301_E	0.748	0.38
185_S	241_Y	0.745	0.38
67_S	81_L	0.742	0.37
341_D	348_G	0.740	0.37
78_E	81_L	0.739	0.37
119_S	135_Q	0.739	0.37
254_V	297_V	0.738	0.37
194_P	266_S	0.735	0.37
335_S	346_S	0.733	0.37
65_N	78_E	0.732	0.37
76_V	139_Y	0.732	0.37
49_P	216_G	0.731	0.37
223_E	265_I	0.731	0.37
116_H	183_V	0.731	0.37
194_P	227_D	0.731	0.37
220_I	276_D	0.729	0.36
222_G	314_A	0.728	0.36
116_H	124_G	0.728	0.36
69_S	118_L	0.727	0.36
147_S	153_A	0.726	0.36
84_D	168_I	0.726	0.36
334_Y	351_T	0.726	0.36
159_N	260_G	0.724	0.36
191_E	264_T	0.722	0.36
169_T	203_S	0.721	0.36
185_S	226_L	0.718	0.36
114_G	298_G	0.716	0.35
148_D	265_I	0.714	0.35
295_Y	309_D	0.714	0.35
349_S	352_S	0.713	0.35
168_I	269_A	0.707	0.35
122_V	166_A	0.706	0.35
120_V	149_V	0.706	0.35
164_I	298_G	0.706	0.35
87_L	284_A	0.704	0.35
36_G	48_S	0.704	0.35
112_E	200_E	0.703	0.35
342_V	348_G	0.703	0.35
66_N	298_G	0.702	0.34
96_L	272_L	0.701	0.34
95_R	207_T	0.700	0.34
318_V	349_S	0.700	0.34
96_L	151_V	0.700	0.34
218_L	222_G	0.698	0.34
197_N	250_A	0.694	0.34
66_N	139_Y	0.692	0.34
73_S	76_V	0.690	0.34
226_L	297_V	0.685	0.33
289_L	313_Q	0.685	0.33
192_R	234_T	0.684	0.33
68_G	102_I	0.684	0.33
61_T	211_A	0.683	0.33
77_N	144_D	0.683	0.33
224_Y	314_A	0.682	0.33
132_F	148_D	0.679	0.33
116_H	336_D	0.679	0.33
297_V	349_S	0.677	0.33
253_G	284_A	0.676	0.33
51_N	56_T	0.672	0.32
277_A	280_V	0.672	0.32
52_P	120_V	0.671	0.32
56_T	255_E	0.671	0.32
103_E	112_E	0.671	0.32
204_A	340_V	0.670	0.32
251_L	291_A	0.669	0.32
267_G	282_V	0.665	0.32
186_D	221_R	0.664	0.32
219_V	302_T	0.663	0.32
315_D	320_E	0.663	0.32
288_G	304_E	0.662	0.32
284_A	294_G	0.661	0.32
114_G	281_R	0.661	0.32
120_V	165_Q	0.655	0.31
64_I	168_I	0.654	0.31
265_I	295_Y	0.652	0.31
40_V	45_V	0.652	0.31
60_I	113_P	0.650	0.31
34_G	38_V	0.649	0.31
64_I	140_V	0.648	0.31
52_P	306_A	0.648	0.31
118_L	164_I	0.647	0.31
343_S	350_A	0.646	0.31
156_T	240_T	0.644	0.30
104_V	195_V	0.642	0.30
187_G	197_N	0.641	0.30
166_A	209_D	0.639	0.30
145_R	222_G	0.639	0.30
41_T	45_V	0.639	0.30
38_V	199_S	0.638	0.30
138_V	262_T	0.635	0.30
60_I	155_T	0.635	0.30
338_V	346_S	0.635	0.30
195_V	206_V	0.634	0.30
196_A	237_T	0.633	0.30
120_V	216_G	0.630	0.30
116_H	298_G	0.626	0.29
148_D	250_A	0.625	0.29
279_S	296_F	0.623	0.29
96_L	350_A	0.622	0.29
97_G	307_T	0.621	0.29
58_V	220_I	0.620	0.29
245_R	277_A	0.620	0.29
62_P	138_V	0.619	0.29
247_A	327_Y	0.619	0.29
148_D	308_F	0.618	0.29
268_D	309_D	0.615	0.29
76_V	282_V	0.614	0.29
67_S	210_G	0.614	0.29
215_S	218_L	0.612	0.28
172_G	270_A	0.612	0.28
102_I	341_D	0.612	0.28
247_A	294_G	0.611	0.28
42_I	129_G	0.610	0.28
186_D	267_G	0.610	0.28
141_T	255_E	0.607	0.28
178_S	227_D	0.606	0.28
171_Y	249_V	0.603	0.28
120_V	211_A	0.600	0.28
35_S	69_S	0.597	0.27
112_E	143_D	0.597	0.27
66_N	300_I	0.596	0.27
281_R	296_F	0.596	0.27
169_T	252_T	0.592	0.27
35_S	39_S	0.591	0.27
252_T	318_V	0.591	0.27
176_I	179_G	0.588	0.27
169_T	238_T	0.588	0.27
198_V	216_G	0.586	0.27
186_D	269_A	0.586	0.27
62_P	87_L	0.586	0.27
245_R	328_S	0.583	0.27
90_E	283_N	0.583	0.27
83_G	153_A	0.579	0.26
38_V	42_I	0.577	0.26
260_G	268_D	0.577	0.26
83_G	148_D	0.576	0.26
35_S	44_D	0.575	0.26
54_T	308_F	0.574	0.26
241_Y	284_A	0.570	0.26
52_P	96_L	0.568	0.26
298_G	308_F	0.567	0.26
147_S	211_A	0.566	0.26
81_L	115_D	0.564	0.25
56_T	141_T	0.564	0.25
124_G	147_S	0.563	0.25
162_T	344_G	0.562	0.25
156_T	243_P	0.561	0.25
247_A	337_V	0.558	0.25
148_D	153_A	0.557	0.25
111_T	173_T	0.556	0.25
179_G	205_N	0.554	0.25
97_G	140_V	0.553	0.25
266_S	314_A	0.553	0.25
77_N	80_T	0.551	0.25
204_A	207_T	0.549	0.25
245_R	272_L	0.549	0.25
155_T	191_E	0.548	0.24
147_S	294_G	0.548	0.24
171_Y	267_G	0.548	0.24
65_N	217_E	0.548	0.24
207_T	335_S	0.547	0.24
45_V	183_V	0.545	0.24
167_T	239_L	0.545	0.24
71_S	166_A	0.544	0.24
129_G	146_T	0.540	0.24
111_T	200_E	0.540	0.24
300_I	304_E	0.536	0.24
73_S	78_E	0.535	0.24
164_I	186_D	0.535	0.24
196_A	206_V	0.530	0.23
267_G	281_R	0.530	0.23
305_F	308_F	0.528	0.23
60_I	321_I	0.528	0.23
282_V	287_D	0.528	0.23
323_I	327_Y	0.527	0.23
163_D	167_T	0.527	0.23
88_A	230_H	0.526	0.23
295_Y	305_F	0.525	0.23
61_T	69_S	0.525	0.23
81_L	171_Y	0.525	0.23
45_V	53_T	0.524	0.23
221_R	275_A	0.523	0.23
55_G	58_V	0.521	0.23
60_I	185_S	0.521	0.23
111_T	251_L	0.521	0.23
159_N	303_S	0.520	0.23
34_G	37_A	0.517	0.23
189_I	244_Q	0.517	0.23
65_N	101_S	0.517	0.23
266_S	317_A	0.514	0.23
84_D	93_L	0.514	0.23
107_S	250_A	0.514	0.23
217_E	240_T	0.513	0.22
64_I	155_T	0.512	0.22
270_A	307_T	0.509	0.22
150_G	342_V	0.508	0.22
78_E	195_V	0.505	0.22
136_R	141_T	0.505	0.22
96_L	307_T	0.504	0.22
164_I	182_Q	0.503	0.22
170_Q	200_E	0.502	0.22
65_N	152_S	0.501	0.22
152_S	316_S	0.500	0.22
162_T	297_V	0.500	0.22
47_V	60_I	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3iduA	1	0.2818	98.5	0.852	Contact Map
3j8f7	1	0.6983	98.5	0.853	Contact Map
2l0dA	1	0.2668	98.3	0.86	Contact Map
2qsvA	1	0.4938	98.3	0.86	Contact Map
2kutA	1	0.2618	98.2	0.862	Contact Map
2q3zA	2	0.5062	98.1	0.868	Contact Map
4e9lA	1	0.7456	97.9	0.873	Contact Map
4ktyA	1	0.5112	97.9	0.873	Contact Map
1l9mA	2	0.5436	97.9	0.874	Contact Map
4liqE	1	0.8229	97.7	0.879	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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