Q9HSZ9 - HALSA - GREMLIN Contacts

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Q9HSZ9 - Glucose-1-phosphate thymidylyltransferase

UniProt:	Q9HSZ9	Sequences: MQAVVLAAGKGERLWPLTENRPKPMVPVANQPILEHIVDALVSAGVTRVMLVVGSNRERVQRHFEDGSRWGIEISYVVQDRQLGTGHALAQAESVVGESFVALNGDRVIDASLVEDVWECHRESGDSAMGVTQVETPSAYGVVDLDGGTVTDIDEQPVPELVASEYINAGVYAFGPSVFAAIRRTDSYGELALTDALDEQLADHELRAVRYDGRWLDVSEPWDLVAANSALITDRRFDPPVERRKPRGSVPGDDQQAPVGGGTVCGEGVIVHPQAVVRNGVALGDNVTVGANAVIEQSILLPDSTVNPGAVVNDSIVGANATIGPNTTVEGGQTDVVLGDTVHQGVRFGALVGDNAEVGAGVTVAPGSIVGNSAVVDSATVVTGRVDDQAHVTRG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	395 (322)
Sequences:	7460 (4882)
Seq/√Len:	272.0

ECOLI - GLMU GLGC RMLA2 RMLA1
BACSU - GLMU GLGC GLGD YNGB
HALSA - Q9HSZ9 Q9HSZ8 Q9HS61
SULSO - Q7LXK9 Q980H9 Q97ZD1 Q980D4 Q7LXE7 Q97XG0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
295_I	298_S	4.739	1.00
296_E	313_N	3.778	1.00
312_V	315_S	3.749	1.00
121_H	128_A	3.404	1.00
297_Q	314_D	3.177	1.00
133_Q	165_E	3.033	1.00
291_A	308_P	2.967	1.00
290_G	308_P	2.963	1.00
286_N	303_D	2.928	1.00
146_D	149_T	2.736	1.00
300_L	306_V	2.666	1.00
119_E	123_E	2.449	1.00
31_Q	39_D	2.435	1.00
292_N	309_G	2.427	1.00
288_T	305_T	2.415	1.00
307_N	325_P	2.319	1.00
266_G	285_D	2.216	1.00
99_S	122_R	2.201	1.00
126_D	175_G	2.190	1.00
285_D	302_P	2.174	1.00
308_P	325_P	2.156	1.00
120_C	124_S	2.096	1.00
117_V	130_G	2.044	1.00
293_A	310_A	2.043	1.00
284_G	302_P	2.037	1.00
133_Q	210_R	2.025	1.00
156_Q	162_V	2.004	1.00
131_V	208_A	1.997	1.00
283_L	289_V	1.978	1.00
277_V	281_V	1.970	1.00
272_H	291_A	1.966	1.00
150_V	208_A	1.961	1.00
117_V	173_A	1.959	1.00
3_A	46_V	1.945	1.00
144_D	152_D	1.924	1.00
99_S	175_G	1.921	1.00
278_R	296_E	1.902	1.00
298_S	312_V	1.889	1.00
317_V	323_I	1.862	1.00
267_E	285_D	1.842	1.00
72_I	75_S	1.829	1.00
124_S	207_R	1.828	1.00
270_I	288_T	1.828	1.00
304_S	321_A	1.820	1.00
283_L	287_V	1.814	1.00
269_V	287_V	1.787	1.00
144_D	164_S	1.787	1.00
38_V	49_V	1.769	1.00
35_E	63_H	1.749	1.00
146_D	151_T	1.748	1.00
294_V	311_V	1.741	1.00
317_V	321_A	1.717	1.00
3_A	41_L	1.709	1.00
93_E	183_R	1.690	1.00
303_D	320_N	1.681	1.00
274_Q	292_N	1.680	1.00
149_T	205_E	1.675	1.00
305_T	322_T	1.672	1.00
118_W	173_A	1.651	1.00
120_C	209_V	1.646	1.00
266_G	269_V	1.615	1.00
181_A	203_D	1.614	1.00
282_A	299_I	1.598	1.00
311_V	328_T	1.589	1.00
287_V	304_S	1.560	1.00
300_L	304_S	1.536	1.00
48_R	73_E	1.503	1.00
149_T	207_R	1.496	1.00
220_E	246_P	1.480	1.00
290_G	307_N	1.474	1.00
53_V	57_R	1.472	1.00
41_L	103_L	1.465	1.00
34_L	64_F	1.463	1.00
72_I	76_Y	1.463	1.00
301_L	319_A	1.461	1.00
83_L	87_H	1.455	1.00
126_D	205_E	1.408	1.00
295_I	300_L	1.394	1.00
131_V	143_V	1.391	1.00
57_R	61_Q	1.389	1.00
35_E	39_D	1.373	1.00
264_V	282_A	1.369	1.00
214_R	230_A	1.358	1.00
281_V	295_I	1.356	1.00
304_S	317_V	1.349	1.00
115_E	119_E	1.347	1.00
21_R	27_P	1.346	1.00
199_E	203_D	1.346	1.00
180_A	184_R	1.344	1.00
152_D	161_L	1.340	1.00
290_G	305_T	1.337	1.00
263_T	277_V	1.331	1.00
307_N	322_T	1.315	1.00
50_M	77_V	1.313	1.00
144_D	154_D	1.313	1.00
313_N	330_E	1.308	1.00
112_S	116_D	1.299	1.00
100_F	176_P	1.294	1.00
102_A	174_F	1.293	1.00
265_C	269_V	1.285	1.00
262_G	280_G	1.282	1.00
145_L	208_A	1.266	1.00
112_S	115_E	1.262	1.00
142_V	167_I	1.250	1.00
302_P	319_A	1.242	1.00
188_Y	195_D	1.241	1.00
310_A	323_I	1.238	1.00
309_G	326_N	1.233	1.00
101_V	173_A	1.220	1.00
145_L	166_Y	1.217	1.00
310_A	325_P	1.217	1.00
48_R	75_S	1.214	1.00
177_S	180_A	1.208	1.00
34_L	60_V	1.205	1.00
117_V	128_A	1.205	1.00
260_G	278_R	1.194	1.00
89_L	102_A	1.192	1.00
310_A	327_T	1.187	1.00
279_N	297_Q	1.185	1.00
21_R	59_R	1.181	1.00
87_H	91_Q	1.175	1.00
136_T	139_A	1.172	1.00
259_V	263_T	1.166	1.00
74_I	77_V	1.161	1.00
73_E	76_Y	1.158	1.00
148_G	210_R	1.156	1.00
50_M	95_V	1.155	1.00
116_D	119_E	1.154	1.00
248_G	251_P	1.151	1.00
293_A	308_P	1.150	1.00
218_V	227_A	1.148	1.00
25_M	63_H	1.147	1.00
181_A	185_T	1.140	1.00
154_D	163_A	1.139	1.00
284_G	287_V	1.137	1.00
290_G	293_A	1.136	1.00
293_A	325_P	1.130	1.00
33_I	218_V	1.128	1.00
168_N	172_Y	1.128	1.00
131_V	166_Y	1.124	1.00
300_L	317_V	1.109	1.00
127_S	200_Q	1.104	1.00
150_V	206_L	1.099	1.00
220_E	223_D	1.088	1.00
301_L	318_G	1.086	1.00
297_Q	313_N	1.073	1.00
22_P	59_R	1.071	1.00
198_D	202_A	1.069	1.00
287_V	300_L	1.068	1.00
286_N	302_P	1.063	1.00
129_M	150_V	1.062	1.00
222_W	226_A	1.050	1.00
136_T	156_Q	1.050	1.00
98_E	175_G	1.047	1.00
161_L	164_S	1.047	1.00
247_R	251_P	1.045	1.00
58_E	62_R	1.044	1.00
11_G	23_K	1.044	1.00
40_A	111_A	1.042	1.00
280_G	297_Q	1.041	1.00
120_C	123_E	1.041	1.00
129_M	143_V	1.022	1.00
216_L	226_A	1.015	1.00
65_E	76_Y	1.015	1.00
35_E	64_F	1.014	1.00
99_S	173_A	1.002	1.00
120_C	207_R	1.000	1.00
127_S	174_F	0.999	1.00
49_V	72_I	0.989	1.00
34_L	51_L	0.988	1.00
87_H	90_A	0.986	1.00
216_L	230_A	0.982	1.00
125_G	175_G	0.981	1.00
271_V	275_A	0.980	1.00
181_A	199_E	0.979	1.00
75_S	79_Q	0.979	1.00
51_L	64_F	0.973	1.00
158_V	161_L	0.970	1.00
110_D	214_R	0.970	1.00
138_S	156_Q	0.969	1.00
304_S	318_G	0.968	1.00
299_I	316_I	0.965	1.00
28_V	33_I	0.962	1.00
90_A	93_E	0.962	1.00
252_G	270_I	0.959	1.00
20_N	286_N	0.959	1.00
25_M	59_R	0.958	1.00
229_S	232_I	0.958	1.00
174_F	196_A	0.955	1.00
181_A	184_R	0.954	1.00
275_A	293_A	0.947	1.00
36_H	231_L	0.946	1.00
272_H	290_G	0.946	1.00
277_V	283_L	0.945	1.00
5_V	41_L	0.942	1.00
141_G	155_E	0.942	1.00
278_R	281_V	0.933	1.00
38_V	74_I	0.931	1.00
32_P	35_E	0.930	1.00
307_N	324_G	0.928	1.00
75_S	78_V	0.922	1.00
276_V	294_V	0.922	1.00
262_G	279_N	0.914	1.00
57_R	78_V	0.913	1.00
184_R	199_E	0.906	1.00
275_A	291_A	0.905	1.00
104_N	107_R	0.902	1.00
74_I	78_V	0.899	1.00
74_I	79_Q	0.898	1.00
72_I	77_V	0.896	1.00
324_G	327_T	0.890	1.00
242_E	246_P	0.887	1.00
269_V	285_D	0.887	1.00
59_R	62_R	0.886	1.00
201_L	206_L	0.884	1.00
27_P	32_P	0.881	1.00
29_A	231_L	0.875	1.00
312_V	317_V	0.875	1.00
23_K	106_D	0.874	1.00
134_V	167_I	0.874	1.00
37_I	103_L	0.874	1.00
28_V	228_N	0.859	1.00
272_H	275_A	0.859	1.00
35_E	67_G	0.858	1.00
113_L	214_R	0.856	1.00
61_Q	78_V	0.853	1.00
4_V	50_M	0.850	1.00
36_H	39_D	0.846	1.00
301_L	304_S	0.844	1.00
50_M	96_V	0.844	1.00
268_G	285_D	0.843	1.00
76_Y	79_Q	0.841	1.00
260_G	263_T	0.837	1.00
90_A	183_R	0.837	1.00
73_E	77_V	0.836	1.00
244_R	247_R	0.834	1.00
222_W	246_P	0.833	0.99
287_V	302_P	0.832	0.99
103_L	113_L	0.829	0.99
254_D	257_A	0.826	0.99
199_E	202_A	0.826	0.99
292_N	308_P	0.825	0.99
13_R	23_K	0.823	0.99
53_V	61_Q	0.822	0.99
82_Q	87_H	0.822	0.99
5_V	38_V	0.819	0.99
184_R	203_D	0.817	0.99
46_V	118_W	0.815	0.99
30_N	264_V	0.814	0.99
244_R	265_C	0.813	0.99
272_H	293_A	0.811	0.99
116_D	120_C	0.811	0.99
121_H	175_G	0.808	0.99
32_P	36_H	0.806	0.99
301_L	316_I	0.805	0.99
132_T	215_W	0.803	0.99
39_D	43_S	0.798	0.99
67_G	70_W	0.798	0.99
72_I	78_V	0.792	0.99
328_T	331_G	0.792	0.99
180_A	183_R	0.788	0.99
310_A	324_G	0.788	0.99
224_L	301_L	0.788	0.99
42_V	73_E	0.781	0.99
53_V	76_Y	0.777	0.99
309_G	325_P	0.770	0.99
18_T	26_V	0.770	0.99
119_E	122_R	0.769	0.99
24_P	105_G	0.767	0.99
287_V	301_L	0.766	0.99
178_V	200_Q	0.765	0.99
258_P	276_V	0.764	0.99
293_A	306_V	0.758	0.99
54_G	82_Q	0.755	0.99
58_E	61_Q	0.755	0.99
329_V	332_G	0.751	0.99
276_V	281_V	0.751	0.99
190_E	194_T	0.749	0.99
269_V	283_L	0.749	0.99
185_T	196_A	0.740	0.99
266_G	302_P	0.739	0.99
268_G	286_N	0.738	0.99
272_H	288_T	0.737	0.99
225_V	254_D	0.737	0.99
106_D	217_D	0.735	0.99
54_G	87_H	0.732	0.99
127_S	197_L	0.731	0.99
296_E	311_V	0.730	0.99
22_P	56_N	0.727	0.99
9_G	23_K	0.724	0.99
40_A	44_A	0.723	0.99
52_V	88_A	0.723	0.99
38_V	64_F	0.721	0.99
144_D	151_T	0.719	0.99
4_V	89_L	0.715	0.98
255_Q	258_P	0.714	0.98
93_E	97_G	0.713	0.98
304_S	319_A	0.709	0.98
97_G	183_R	0.708	0.98
127_S	206_L	0.705	0.98
166_Y	210_R	0.704	0.98
41_L	46_V	0.704	0.98
196_A	199_E	0.701	0.98
260_G	276_V	0.700	0.98
269_V	272_H	0.699	0.98
260_G	279_N	0.698	0.98
98_E	177_S	0.695	0.98
29_A	36_H	0.693	0.98
38_V	72_I	0.692	0.98
178_V	181_A	0.688	0.98
130_G	171_V	0.686	0.98
269_V	302_P	0.684	0.98
266_G	287_V	0.679	0.98
50_M	92_A	0.671	0.98
8_A	52_V	0.669	0.98
263_T	281_V	0.669	0.98
134_V	165_E	0.668	0.98
278_R	294_V	0.667	0.98
188_Y	194_T	0.666	0.98
315_S	329_V	0.659	0.97
295_I	312_V	0.659	0.97
79_Q	87_H	0.654	0.97
303_D	319_A	0.653	0.97
5_V	37_I	0.652	0.97
304_S	323_I	0.651	0.97
247_R	253_D	0.651	0.97
293_A	307_N	0.650	0.97
318_G	321_A	0.648	0.97
182_I	185_T	0.647	0.97
15_W	19_E	0.647	0.97
233_T	280_G	0.646	0.97
314_D	331_G	0.646	0.97
4_V	100_F	0.645	0.97
21_R	318_G	0.642	0.97
101_V	118_W	0.642	0.97
86_G	182_I	0.640	0.97
243_R	247_R	0.640	0.97
235_R	243_R	0.638	0.97
42_V	72_I	0.637	0.97
306_V	310_A	0.636	0.97
162_V	165_E	0.635	0.97
154_D	161_L	0.635	0.97
47_T	73_E	0.635	0.97
138_S	158_V	0.635	0.97
128_A	173_A	0.634	0.97
7_A	51_L	0.630	0.97
42_V	49_V	0.628	0.97
233_T	236_R	0.627	0.97
121_H	173_A	0.627	0.97
137_P	162_V	0.627	0.97
226_A	230_A	0.627	0.97
256_Q	274_Q	0.625	0.96
242_E	245_K	0.623	0.96
259_V	265_C	0.622	0.96
132_T	167_I	0.622	0.96
251_P	257_A	0.622	0.96
181_A	200_Q	0.620	0.96
109_I	171_V	0.619	0.96
116_D	209_V	0.617	0.96
245_K	248_G	0.617	0.96
253_D	257_A	0.615	0.96
327_T	332_G	0.615	0.96
13_R	24_P	0.613	0.96
137_P	140_Y	0.612	0.96
294_V	308_P	0.610	0.96
257_A	277_V	0.609	0.96
50_M	75_S	0.606	0.96
6_L	88_A	0.605	0.96
143_V	150_V	0.601	0.96
293_A	309_G	0.600	0.96
118_W	122_R	0.598	0.95
295_I	306_V	0.598	0.95
29_A	228_N	0.597	0.95
275_A	289_V	0.596	0.95
263_T	279_N	0.595	0.95
104_N	170_G	0.595	0.95
33_I	37_I	0.595	0.95
323_I	329_V	0.594	0.95
305_T	308_P	0.593	0.95
125_G	205_E	0.592	0.95
256_Q	259_V	0.592	0.95
25_M	64_F	0.592	0.95
221_P	225_V	0.591	0.95
262_G	265_C	0.588	0.95
14_L	26_V	0.586	0.95
11_G	24_P	0.583	0.95
143_V	197_L	0.583	0.95
169_A	215_W	0.582	0.95
42_V	67_G	0.579	0.95
6_L	52_V	0.578	0.95
274_Q	279_N	0.578	0.95
289_V	293_A	0.578	0.95
131_V	210_R	0.577	0.94
143_V	166_Y	0.576	0.94
229_S	297_Q	0.576	0.94
311_V	326_N	0.575	0.94
250_V	253_D	0.573	0.94
139_A	156_Q	0.573	0.94
126_D	178_V	0.572	0.94
7_A	60_V	0.571	0.94
21_R	319_A	0.571	0.94
9_G	13_R	0.570	0.94
216_L	227_A	0.569	0.94
249_S	253_D	0.568	0.94
271_V	277_V	0.568	0.94
221_P	250_V	0.567	0.94
99_S	118_W	0.567	0.94
3_A	44_A	0.567	0.94
235_R	244_R	0.566	0.94
85_T	106_D	0.564	0.94
189_G	195_D	0.563	0.94
108_V	227_A	0.562	0.94
278_R	291_A	0.559	0.94
314_D	333_Q	0.558	0.93
251_P	271_V	0.557	0.93
265_C	271_V	0.555	0.93
31_Q	36_H	0.555	0.93
247_R	250_V	0.554	0.93
64_F	74_I	0.553	0.93
311_V	314_D	0.553	0.93
20_N	267_E	0.552	0.93
187_S	195_D	0.552	0.93
264_V	279_N	0.550	0.93
249_S	252_G	0.550	0.93
226_A	229_S	0.548	0.93
6_L	104_N	0.547	0.93
59_R	63_H	0.546	0.93
254_D	273_P	0.545	0.93
186_D	189_G	0.544	0.93
56_N	59_R	0.543	0.93
23_K	219_S	0.543	0.93
43_S	111_A	0.540	0.92
306_V	312_V	0.538	0.92
322_T	325_P	0.537	0.92
260_G	281_V	0.536	0.92
24_P	60_V	0.536	0.92
328_T	332_G	0.535	0.92
129_M	206_L	0.534	0.92
116_D	212_D	0.533	0.92
315_S	318_G	0.533	0.92
73_E	78_V	0.533	0.92
72_I	79_Q	0.530	0.92
132_T	169_A	0.529	0.92
103_L	171_V	0.528	0.91
96_V	100_F	0.526	0.91
256_Q	273_P	0.525	0.91
263_T	275_A	0.524	0.91
155_E	168_N	0.522	0.91
25_M	34_L	0.522	0.91
3_A	45_G	0.522	0.91
28_V	227_A	0.521	0.91
134_V	137_P	0.521	0.91
32_P	63_H	0.518	0.91
31_Q	35_E	0.517	0.91
277_V	298_S	0.516	0.91
110_D	234_D	0.516	0.91
84_G	88_A	0.514	0.90
233_T	242_E	0.514	0.90
87_H	189_G	0.513	0.90
174_F	178_V	0.512	0.90
9_G	85_T	0.512	0.90
311_V	331_G	0.511	0.90
304_S	320_N	0.511	0.90
150_V	153_I	0.510	0.90
139_A	220_E	0.509	0.90
81_R	87_H	0.509	0.90
11_G	217_D	0.509	0.90
225_V	229_S	0.508	0.90
236_R	251_P	0.507	0.90
261_G	278_R	0.507	0.90
188_Y	192_A	0.506	0.90
53_V	60_V	0.506	0.90
40_A	43_S	0.506	0.90
166_Y	208_A	0.506	0.90
75_S	95_V	0.506	0.90
85_T	89_L	0.504	0.90
263_T	266_G	0.503	0.89
67_G	71_G	0.503	0.89
132_T	171_V	0.502	0.89
156_Q	219_S	0.501	0.89
222_W	242_E	0.501	0.89
185_T	189_G	0.501	0.89
53_V	78_V	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ggoA	3	0.962	100	0.355	Contact Map
4g3qA	3	0.9848	100	0.385	Contact Map
1hm9A	3	0.9696	100	0.388	Contact Map
1yp2A	4	0.9089	100	0.398	Contact Map
2v0hA	3	0.9722	100	0.398	Contact Map
4fceA	3	0.9468	100	0.405	Contact Map
3brkX	2	0.8709	100	0.413	Contact Map
2icyA	1	0.7671	100	0.546	Contact Map
2i5kA	5	0.7772	100	0.571	Contact Map
3jukA	3	0.5949	100	0.578	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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