GREMLIN Database
Q9HSZ9 - Glucose-1-phosphate thymidylyltransferase
UniProt: Q9HSZ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 395 (322)
Sequences: 7460 (4882)
Seq/√Len: 272.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
295_I298_S4.7391.00
296_E313_N3.7781.00
312_V315_S3.7491.00
121_H128_A3.4041.00
297_Q314_D3.1771.00
133_Q165_E3.0331.00
291_A308_P2.9671.00
290_G308_P2.9631.00
286_N303_D2.9281.00
146_D149_T2.7361.00
300_L306_V2.6661.00
119_E123_E2.4491.00
31_Q39_D2.4351.00
292_N309_G2.4271.00
288_T305_T2.4151.00
307_N325_P2.3191.00
266_G285_D2.2161.00
99_S122_R2.2011.00
126_D175_G2.1901.00
285_D302_P2.1741.00
308_P325_P2.1561.00
120_C124_S2.0961.00
117_V130_G2.0441.00
293_A310_A2.0431.00
284_G302_P2.0371.00
133_Q210_R2.0251.00
156_Q162_V2.0041.00
131_V208_A1.9971.00
283_L289_V1.9781.00
277_V281_V1.9701.00
272_H291_A1.9661.00
150_V208_A1.9611.00
117_V173_A1.9591.00
3_A46_V1.9451.00
144_D152_D1.9241.00
99_S175_G1.9211.00
278_R296_E1.9021.00
298_S312_V1.8891.00
317_V323_I1.8621.00
267_E285_D1.8421.00
72_I75_S1.8291.00
124_S207_R1.8281.00
270_I288_T1.8281.00
304_S321_A1.8201.00
283_L287_V1.8141.00
269_V287_V1.7871.00
144_D164_S1.7871.00
38_V49_V1.7691.00
35_E63_H1.7491.00
146_D151_T1.7481.00
294_V311_V1.7411.00
317_V321_A1.7171.00
3_A41_L1.7091.00
93_E183_R1.6901.00
303_D320_N1.6811.00
274_Q292_N1.6801.00
149_T205_E1.6751.00
305_T322_T1.6721.00
118_W173_A1.6511.00
120_C209_V1.6461.00
266_G269_V1.6151.00
181_A203_D1.6141.00
282_A299_I1.5981.00
311_V328_T1.5891.00
287_V304_S1.5601.00
300_L304_S1.5361.00
48_R73_E1.5031.00
149_T207_R1.4961.00
220_E246_P1.4801.00
290_G307_N1.4741.00
53_V57_R1.4721.00
41_L103_L1.4651.00
34_L64_F1.4631.00
72_I76_Y1.4631.00
301_L319_A1.4611.00
83_L87_H1.4551.00
126_D205_E1.4081.00
295_I300_L1.3941.00
131_V143_V1.3911.00
57_R61_Q1.3891.00
35_E39_D1.3731.00
264_V282_A1.3691.00
214_R230_A1.3581.00
281_V295_I1.3561.00
304_S317_V1.3491.00
115_E119_E1.3471.00
21_R27_P1.3461.00
199_E203_D1.3461.00
180_A184_R1.3441.00
152_D161_L1.3401.00
290_G305_T1.3371.00
263_T277_V1.3311.00
307_N322_T1.3151.00
50_M77_V1.3131.00
144_D154_D1.3131.00
313_N330_E1.3081.00
112_S116_D1.2991.00
100_F176_P1.2941.00
102_A174_F1.2931.00
265_C269_V1.2851.00
262_G280_G1.2821.00
145_L208_A1.2661.00
112_S115_E1.2621.00
142_V167_I1.2501.00
302_P319_A1.2421.00
188_Y195_D1.2411.00
310_A323_I1.2381.00
309_G326_N1.2331.00
101_V173_A1.2201.00
145_L166_Y1.2171.00
310_A325_P1.2171.00
48_R75_S1.2141.00
177_S180_A1.2081.00
34_L60_V1.2051.00
117_V128_A1.2051.00
260_G278_R1.1941.00
89_L102_A1.1921.00
310_A327_T1.1871.00
279_N297_Q1.1851.00
21_R59_R1.1811.00
87_H91_Q1.1751.00
136_T139_A1.1721.00
259_V263_T1.1661.00
74_I77_V1.1611.00
73_E76_Y1.1581.00
148_G210_R1.1561.00
50_M95_V1.1551.00
116_D119_E1.1541.00
248_G251_P1.1511.00
293_A308_P1.1501.00
218_V227_A1.1481.00
25_M63_H1.1471.00
181_A185_T1.1401.00
154_D163_A1.1391.00
284_G287_V1.1371.00
290_G293_A1.1361.00
293_A325_P1.1301.00
33_I218_V1.1281.00
168_N172_Y1.1281.00
131_V166_Y1.1241.00
300_L317_V1.1091.00
127_S200_Q1.1041.00
150_V206_L1.0991.00
220_E223_D1.0881.00
301_L318_G1.0861.00
297_Q313_N1.0731.00
22_P59_R1.0711.00
198_D202_A1.0691.00
287_V300_L1.0681.00
286_N302_P1.0631.00
129_M150_V1.0621.00
222_W226_A1.0501.00
136_T156_Q1.0501.00
98_E175_G1.0471.00
161_L164_S1.0471.00
247_R251_P1.0451.00
58_E62_R1.0441.00
11_G23_K1.0441.00
40_A111_A1.0421.00
280_G297_Q1.0411.00
120_C123_E1.0411.00
129_M143_V1.0221.00
216_L226_A1.0151.00
65_E76_Y1.0151.00
35_E64_F1.0141.00
99_S173_A1.0021.00
120_C207_R1.0001.00
127_S174_F0.9991.00
49_V72_I0.9891.00
34_L51_L0.9881.00
87_H90_A0.9861.00
216_L230_A0.9821.00
125_G175_G0.9811.00
271_V275_A0.9801.00
181_A199_E0.9791.00
75_S79_Q0.9791.00
51_L64_F0.9731.00
158_V161_L0.9701.00
110_D214_R0.9701.00
138_S156_Q0.9691.00
304_S318_G0.9681.00
299_I316_I0.9651.00
28_V33_I0.9621.00
90_A93_E0.9621.00
252_G270_I0.9591.00
20_N286_N0.9591.00
25_M59_R0.9581.00
229_S232_I0.9581.00
174_F196_A0.9551.00
181_A184_R0.9541.00
275_A293_A0.9471.00
36_H231_L0.9461.00
272_H290_G0.9461.00
277_V283_L0.9451.00
5_V41_L0.9421.00
141_G155_E0.9421.00
278_R281_V0.9331.00
38_V74_I0.9311.00
32_P35_E0.9301.00
307_N324_G0.9281.00
75_S78_V0.9221.00
276_V294_V0.9221.00
262_G279_N0.9141.00
57_R78_V0.9131.00
184_R199_E0.9061.00
275_A291_A0.9051.00
104_N107_R0.9021.00
74_I78_V0.8991.00
74_I79_Q0.8981.00
72_I77_V0.8961.00
324_G327_T0.8901.00
242_E246_P0.8871.00
269_V285_D0.8871.00
59_R62_R0.8861.00
201_L206_L0.8841.00
27_P32_P0.8811.00
29_A231_L0.8751.00
312_V317_V0.8751.00
23_K106_D0.8741.00
134_V167_I0.8741.00
37_I103_L0.8741.00
28_V228_N0.8591.00
272_H275_A0.8591.00
35_E67_G0.8581.00
113_L214_R0.8561.00
61_Q78_V0.8531.00
4_V50_M0.8501.00
36_H39_D0.8461.00
301_L304_S0.8441.00
50_M96_V0.8441.00
268_G285_D0.8431.00
76_Y79_Q0.8411.00
260_G263_T0.8371.00
90_A183_R0.8371.00
73_E77_V0.8361.00
244_R247_R0.8341.00
222_W246_P0.8330.99
287_V302_P0.8320.99
103_L113_L0.8290.99
254_D257_A0.8260.99
199_E202_A0.8260.99
292_N308_P0.8250.99
13_R23_K0.8230.99
53_V61_Q0.8220.99
82_Q87_H0.8220.99
5_V38_V0.8190.99
184_R203_D0.8170.99
46_V118_W0.8150.99
30_N264_V0.8140.99
244_R265_C0.8130.99
272_H293_A0.8110.99
116_D120_C0.8110.99
121_H175_G0.8080.99
32_P36_H0.8060.99
301_L316_I0.8050.99
132_T215_W0.8030.99
39_D43_S0.7980.99
67_G70_W0.7980.99
72_I78_V0.7920.99
328_T331_G0.7920.99
180_A183_R0.7880.99
310_A324_G0.7880.99
224_L301_L0.7880.99
42_V73_E0.7810.99
53_V76_Y0.7770.99
309_G325_P0.7700.99
18_T26_V0.7700.99
119_E122_R0.7690.99
24_P105_G0.7670.99
287_V301_L0.7660.99
178_V200_Q0.7650.99
258_P276_V0.7640.99
293_A306_V0.7580.99
54_G82_Q0.7550.99
58_E61_Q0.7550.99
329_V332_G0.7510.99
276_V281_V0.7510.99
190_E194_T0.7490.99
269_V283_L0.7490.99
185_T196_A0.7400.99
266_G302_P0.7390.99
268_G286_N0.7380.99
272_H288_T0.7370.99
225_V254_D0.7370.99
106_D217_D0.7350.99
54_G87_H0.7320.99
127_S197_L0.7310.99
296_E311_V0.7300.99
22_P56_N0.7270.99
9_G23_K0.7240.99
40_A44_A0.7230.99
52_V88_A0.7230.99
38_V64_F0.7210.99
144_D151_T0.7190.99
4_V89_L0.7150.98
255_Q258_P0.7140.98
93_E97_G0.7130.98
304_S319_A0.7090.98
97_G183_R0.7080.98
127_S206_L0.7050.98
166_Y210_R0.7040.98
41_L46_V0.7040.98
196_A199_E0.7010.98
260_G276_V0.7000.98
269_V272_H0.6990.98
260_G279_N0.6980.98
98_E177_S0.6950.98
29_A36_H0.6930.98
38_V72_I0.6920.98
178_V181_A0.6880.98
130_G171_V0.6860.98
269_V302_P0.6840.98
266_G287_V0.6790.98
50_M92_A0.6710.98
8_A52_V0.6690.98
263_T281_V0.6690.98
134_V165_E0.6680.98
278_R294_V0.6670.98
188_Y194_T0.6660.98
315_S329_V0.6590.97
295_I312_V0.6590.97
79_Q87_H0.6540.97
303_D319_A0.6530.97
5_V37_I0.6520.97
304_S323_I0.6510.97
247_R253_D0.6510.97
293_A307_N0.6500.97
318_G321_A0.6480.97
182_I185_T0.6470.97
15_W19_E0.6470.97
233_T280_G0.6460.97
314_D331_G0.6460.97
4_V100_F0.6450.97
21_R318_G0.6420.97
101_V118_W0.6420.97
86_G182_I0.6400.97
243_R247_R0.6400.97
235_R243_R0.6380.97
42_V72_I0.6370.97
306_V310_A0.6360.97
162_V165_E0.6350.97
154_D161_L0.6350.97
47_T73_E0.6350.97
138_S158_V0.6350.97
128_A173_A0.6340.97
7_A51_L0.6300.97
42_V49_V0.6280.97
233_T236_R0.6270.97
121_H173_A0.6270.97
137_P162_V0.6270.97
226_A230_A0.6270.97
256_Q274_Q0.6250.96
242_E245_K0.6230.96
259_V265_C0.6220.96
132_T167_I0.6220.96
251_P257_A0.6220.96
181_A200_Q0.6200.96
109_I171_V0.6190.96
116_D209_V0.6170.96
245_K248_G0.6170.96
253_D257_A0.6150.96
327_T332_G0.6150.96
13_R24_P0.6130.96
137_P140_Y0.6120.96
294_V308_P0.6100.96
257_A277_V0.6090.96
50_M75_S0.6060.96
6_L88_A0.6050.96
143_V150_V0.6010.96
293_A309_G0.6000.96
118_W122_R0.5980.95
295_I306_V0.5980.95
29_A228_N0.5970.95
275_A289_V0.5960.95
263_T279_N0.5950.95
104_N170_G0.5950.95
33_I37_I0.5950.95
323_I329_V0.5940.95
305_T308_P0.5930.95
125_G205_E0.5920.95
256_Q259_V0.5920.95
25_M64_F0.5920.95
221_P225_V0.5910.95
262_G265_C0.5880.95
14_L26_V0.5860.95
11_G24_P0.5830.95
143_V197_L0.5830.95
169_A215_W0.5820.95
42_V67_G0.5790.95
6_L52_V0.5780.95
274_Q279_N0.5780.95
289_V293_A0.5780.95
131_V210_R0.5770.94
143_V166_Y0.5760.94
229_S297_Q0.5760.94
311_V326_N0.5750.94
250_V253_D0.5730.94
139_A156_Q0.5730.94
126_D178_V0.5720.94
7_A60_V0.5710.94
21_R319_A0.5710.94
9_G13_R0.5700.94
216_L227_A0.5690.94
249_S253_D0.5680.94
271_V277_V0.5680.94
221_P250_V0.5670.94
99_S118_W0.5670.94
3_A44_A0.5670.94
235_R244_R0.5660.94
85_T106_D0.5640.94
189_G195_D0.5630.94
108_V227_A0.5620.94
278_R291_A0.5590.94
314_D333_Q0.5580.93
251_P271_V0.5570.93
265_C271_V0.5550.93
31_Q36_H0.5550.93
247_R250_V0.5540.93
64_F74_I0.5530.93
311_V314_D0.5530.93
20_N267_E0.5520.93
187_S195_D0.5520.93
264_V279_N0.5500.93
249_S252_G0.5500.93
226_A229_S0.5480.93
6_L104_N0.5470.93
59_R63_H0.5460.93
254_D273_P0.5450.93
186_D189_G0.5440.93
56_N59_R0.5430.93
23_K219_S0.5430.93
43_S111_A0.5400.92
306_V312_V0.5380.92
322_T325_P0.5370.92
260_G281_V0.5360.92
24_P60_V0.5360.92
328_T332_G0.5350.92
129_M206_L0.5340.92
116_D212_D0.5330.92
315_S318_G0.5330.92
73_E78_V0.5330.92
72_I79_Q0.5300.92
132_T169_A0.5290.92
103_L171_V0.5280.91
96_V100_F0.5260.91
256_Q273_P0.5250.91
263_T275_A0.5240.91
155_E168_N0.5220.91
25_M34_L0.5220.91
3_A45_G0.5220.91
28_V227_A0.5210.91
134_V137_P0.5210.91
32_P63_H0.5180.91
31_Q35_E0.5170.91
277_V298_S0.5160.91
110_D234_D0.5160.91
84_G88_A0.5140.90
233_T242_E0.5140.90
87_H189_G0.5130.90
174_F178_V0.5120.90
9_G85_T0.5120.90
311_V331_G0.5110.90
304_S320_N0.5110.90
150_V153_I0.5100.90
139_A220_E0.5090.90
81_R87_H0.5090.90
11_G217_D0.5090.90
225_V229_S0.5080.90
236_R251_P0.5070.90
261_G278_R0.5070.90
188_Y192_A0.5060.90
53_V60_V0.5060.90
40_A43_S0.5060.90
166_Y208_A0.5060.90
75_S95_V0.5060.90
85_T89_L0.5040.90
263_T266_G0.5030.89
67_G71_G0.5030.89
132_T171_V0.5020.89
156_Q219_S0.5010.89
222_W242_E0.5010.89
185_T189_G0.5010.89
53_V78_V0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ggoA 3 0.962 100 0.355 Contact Map
4g3qA 3 0.9848 100 0.385 Contact Map
1hm9A 3 0.9696 100 0.388 Contact Map
1yp2A 4 0.9089 100 0.398 Contact Map
2v0hA 3 0.9722 100 0.398 Contact Map
4fceA 3 0.9468 100 0.405 Contact Map
3brkX 2 0.8709 100 0.413 Contact Map
2icyA 1 0.7671 100 0.546 Contact Map
2i5kA 5 0.7772 100 0.571 Contact Map
3jukA 3 0.5949 100 0.578 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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