Q9HSZ8 - HALSA - GREMLIN Contacts

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Q9HSZ8 - Glucose-1-phosphate thymidylyltransferase

UniProt:	Q9HSZ8	Sequences: MQAIVVAAGRGTRMGPLTETRPKPLVPVAGATLLEHVLDAAAGVVDEYVIVVGYRGDQIRERIGASYAGTPVVYAEQDTQEGTAHAVGCAEPHVEGPCLVLNGDVYVTSALVEALAGADGTAMSVMPVADPQSYGVVERGDDGRVTNVVEKPTDPPTDLANLGLYRFTPRVFEYIDTVERSERGEYELTDALARAIDREDGGVTAVSYDGPWLDVGRPWELLAANSALLAEQEREINGTVADGATLTGRVVVEDGARVRDGAYIEGPVVIQSGADVGPNAYVRGATVVGPDVRVGNAVEVKNSILMADTAVGHHAYVGDSVLGADVNFGAGTKVANLRHDDAPVQVQVNGELVDTGRRKFGVVVGDDTKTGINTSLNAGVTLGTGTRTTLGAVVTTDKGRD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	401 (328)
Sequences:	6764 (4348)
Seq/√Len:	240.1

ECOLI - GLMU GLGC RMLA2 RMLA1
BACSU - GLMU GLGC GLGD
HALSA - Q9HSZ8 Q9HSZ9 Q9HS61
SULSO - Q7LXK9 Q97ZD1 Q980D4 Q980H9 Q7LXE7 Q97XG0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
282_V	285_A	3.512	1.00
317_V	320_S	3.485	1.00
300_V	303_S	3.393	1.00
283_R	301_K	3.172	1.00
115_L	122_A	3.109	1.00
127_P	158_D	3.056	1.00
284_G	302_N	2.988	1.00
305_L	311_V	2.984	1.00
301_K	318_G	2.879	1.00
295_G	313_H	2.875	1.00
312_G	330_A	2.660	1.00
140_G	144_R	2.639	1.00
288_V	294_V	2.628	1.00
127_P	207_S	2.537	1.00
313_H	330_A	2.518	1.00
265_E	283_R	2.513	1.00
296_N	313_H	2.395	1.00
302_N	319_D	2.393	1.00
290_P	307_A	2.380	1.00
121_T	168_T	2.360	1.00
273_G	291_D	2.318	1.00
114_A	118_A	2.275	1.00
281_Y	299_E	2.272	1.00
257_R	275_D	2.232	1.00
3_A	45_V	2.198	1.00
275_D	293_R	2.180	1.00
291_D	308_D	2.157	1.00
97_P	116_A	2.134	1.00
113_E	117_G	2.112	1.00
298_V	315_A	2.103	1.00
31_A	39_D	2.103	1.00
138_E	147_N	2.083	1.00
125_V	205_A	2.077	1.00
272_S	290_P	2.067	1.00
38_L	48_Y	1.994	1.00
149_V	156_P	1.962	1.00
91_E	176_D	1.939	1.00
111_L	124_S	1.912	1.00
274_A	288_V	1.910	1.00
256_A	274_A	1.910	1.00
97_P	168_T	1.905	1.00
120_G	204_T	1.881	1.00
288_V	292_V	1.872	1.00
111_L	166_R	1.870	1.00
112_V	166_R	1.859	1.00
114_A	206_V	1.815	1.00
35_E	62_R	1.797	1.00
3_A	41_A	1.795	1.00
144_R	202_G	1.792	1.00
285_A	300_V	1.758	1.00
289_G	307_A	1.753	1.00
118_A	204_T	1.751	1.00
47_E	71_P	1.744	1.00
295_G	312_G	1.733	1.00
263_Y	281_Y	1.732	1.00
271_Q	290_P	1.731	1.00
278_P	296_N	1.724	1.00
173_E	177_T	1.720	1.00
144_R	204_T	1.714	1.00
293_R	310_A	1.705	1.00
253_E	272_S	1.704	1.00
264_I	267_P	1.679	1.00
138_E	157_T	1.667	1.00
305_L	309_T	1.664	1.00
145_V	205_A	1.658	1.00
259_R	278_P	1.654	1.00
253_E	256_A	1.611	1.00
315_A	332_T	1.609	1.00
241_A	244_A	1.607	1.00
34_L	63_I	1.581	1.00
111_L	115_L	1.579	1.00
322_L	328_F	1.560	1.00
274_A	292_V	1.547	1.00
211_P	227_A	1.543	1.00
295_G	310_A	1.543	1.00
99_L	166_R	1.540	1.00
292_V	309_T	1.539	1.00
125_V	137_V	1.539	1.00
310_A	327_N	1.527	1.00
309_T	326_V	1.525	1.00
299_E	316_Y	1.504	1.00
41_A	101_L	1.504	1.00
297_A	314_H	1.497	1.00
254_D	272_S	1.479	1.00
81_E	85_H	1.475	1.00
261_G	279_N	1.475	1.00
121_T	201_G	1.442	1.00
316_Y	333_K	1.441	1.00
279_N	296_N	1.420	1.00
270_I	274_A	1.406	1.00
266_G	284_G	1.405	1.00
98_C	169_P	1.396	1.00
315_A	330_A	1.386	1.00
56_G	60_R	1.363	1.00
138_E	149_V	1.349	1.00
184_G	190_D	1.349	1.00
309_T	322_L	1.349	1.00
322_L	326_V	1.345	1.00
34_L	59_I	1.327	1.00
143_G	207_S	1.321	1.00
100_V	167_F	1.321	1.00
256_A	290_P	1.317	1.00
140_G	146_T	1.312	1.00
139_R	205_A	1.300	1.00
88_G	91_E	1.290	1.00
121_T	202_G	1.283	1.00
252_V	256_A	1.269	1.00
136_V	160_A	1.267	1.00
49_V	75_A	1.267	1.00
253_E	290_P	1.235	1.00
139_R	159_L	1.234	1.00
25_L	62_R	1.225	1.00
85_H	89_C	1.223	1.00
255_G	273_G	1.223	1.00
177_T	194_R	1.215	1.00
170_R	173_E	1.207	1.00
21_R	27_P	1.200	1.00
48_Y	70_T	1.183	1.00
294_V	298_V	1.181	1.00
145_V	203_V	1.177	1.00
303_S	317_V	1.170	1.00
35_E	39_D	1.159	1.00
295_G	298_V	1.154	1.00
298_V	312_G	1.139	1.00
33_L	215_V	1.134	1.00
49_V	93_H	1.131	1.00
85_H	88_G	1.130	1.00
130_D	133_S	1.125	1.00
280_A	296_N	1.114	1.00
219_W	223_A	1.113	1.00
52_V	56_G	1.113	1.00
273_G	290_P	1.099	1.00
258_V	264_I	1.096	1.00
11_G	23_K	1.094	1.00
314_H	331_G	1.094	1.00
279_N	297_A	1.094	1.00
174_Y	194_R	1.094	1.00
329_G	332_T	1.088	1.00
267_P	284_G	1.078	1.00
308_D	325_D	1.064	1.00
259_R	275_D	1.064	1.00
265_E	281_Y	1.062	1.00
114_A	204_T	1.057	1.00
70_T	74_Y	1.050	1.00
311_V	317_V	1.049	1.00
312_G	327_N	1.048	1.00
213_L	227_A	1.044	1.00
215_V	224_A	1.041	1.00
21_R	58_Q	1.036	1.00
300_V	305_L	1.033	1.00
247_T	265_E	1.021	1.00
317_V	322_L	1.012	1.00
96_G	168_T	1.012	1.00
64_G	74_Y	1.007	1.00
292_V	306_M	1.001	1.00
289_G	306_M	0.997	1.00
274_A	289_G	0.996	1.00
174_Y	195_A	0.994	1.00
4_I	49_V	0.994	1.00
45_V	112_V	0.993	1.00
314_H	330_A	0.992	1.00
25_L	58_Q	0.990	1.00
57_D	61_E	0.985	1.00
174_Y	178_V	0.983	1.00
111_L	122_A	0.978	1.00
47_E	73_V	0.976	1.00
267_P	285_A	0.963	1.00
88_G	176_D	0.957	1.00
50_I	63_I	0.954	1.00
69_G	75_A	0.950	1.00
114_A	117_G	0.950	1.00
125_V	159_L	0.948	1.00
306_M	321_V	0.947	1.00
56_G	76_E	0.944	1.00
123_M	137_V	0.943	1.00
217_R	220_E	0.943	1.00
34_L	50_I	0.941	1.00
318_G	335_A	0.939	1.00
108_T	211_P	0.934	1.00
29_A	228_L	0.933	1.00
102_N	105_V	0.931	1.00
161_N	165_Y	0.929	1.00
289_G	292_V	0.925	1.00
36_H	228_L	0.923	1.00
138_E	146_T	0.918	1.00
240_V	244_A	0.916	1.00
23_K	104_D	0.916	1.00
149_V	154_D	0.916	1.00
294_V	300_V	0.904	1.00
22_P	58_Q	0.904	1.00
298_V	311_V	0.903	1.00
253_E	271_Q	0.902	1.00
35_E	63_I	0.901	1.00
38_L	72_V	0.899	1.00
87_V	100_V	0.899	1.00
256_A	272_S	0.898	1.00
53_G	80_Q	0.895	1.00
178_V	191_A	0.894	1.00
175_I	178_V	0.894	1.00
280_A	298_V	0.892	1.00
300_V	317_V	0.887	0.99
237_N	243_G	0.886	0.99
123_M	145_V	0.885	0.99
255_G	272_S	0.885	0.99
28_V	225_N	0.882	0.99
258_V	262_A	0.879	0.99
24_P	103_G	0.877	0.99
298_V	330_A	0.876	0.99
276_V	280_A	0.876	0.99
312_G	329_G	0.873	0.99
5_V	38_L	0.873	0.99
280_A	294_V	0.870	0.99
13_R	23_K	0.870	0.99
195_A	201_G	0.865	0.99
137_V	145_V	0.862	0.99
237_N	244_A	0.859	0.99
147_N	156_P	0.857	0.99
91_E	172_F	0.855	0.99
113_E	116_A	0.850	0.99
135_G	150_E	0.848	0.99
37_V	101_L	0.848	0.99
256_A	271_Q	0.839	0.99
131_P	155_P	0.834	0.99
249_R	267_P	0.834	0.99
178_V	183_R	0.831	0.99
32_T	36_H	0.830	0.99
213_L	223_A	0.830	0.99
32_T	35_E	0.829	0.99
194_R	197_D	0.827	0.99
18_T	26_V	0.826	0.99
259_R	262_A	0.824	0.99
36_H	39_D	0.824	0.99
264_I	270_I	0.824	0.99
274_A	290_P	0.823	0.99
88_G	179_E	0.823	0.99
256_A	270_I	0.821	0.99
65_A	68_A	0.819	0.99
159_L	207_S	0.814	0.99
292_V	307_A	0.813	0.99
302_N	318_G	0.812	0.99
138_E	156_P	0.812	0.99
49_V	94_V	0.807	0.99
95_E	169_P	0.805	0.99
97_P	166_R	0.804	0.99
119_D	168_T	0.802	0.99
262_A	282_V	0.797	0.99
188_L	193_A	0.796	0.99
262_A	267_P	0.796	0.99
278_P	295_G	0.790	0.99
264_I	268_V	0.788	0.99
292_V	305_L	0.785	0.99
124_S	164_L	0.783	0.99
193_A	197_D	0.781	0.99
5_V	41_A	0.780	0.99
96_G	169_P	0.775	0.99
80_Q	85_H	0.774	0.99
196_I	203_V	0.769	0.99
276_V	288_V	0.766	0.99
249_R	252_V	0.765	0.99
4_I	98_C	0.764	0.98
112_V	116_A	0.764	0.98
57_D	60_R	0.763	0.98
167_F	171_V	0.762	0.98
28_V	33_L	0.762	0.98
30_G	271_Q	0.761	0.98
139_R	143_G	0.760	0.98
58_Q	61_E	0.757	0.98
96_G	170_R	0.753	0.98
252_V	258_V	0.752	0.98
90_A	93_H	0.752	0.98
237_N	242_D	0.751	0.98
132_Q	151_K	0.750	0.98
128_V	160_A	0.748	0.98
88_G	175_I	0.746	0.98
297_A	313_H	0.746	0.98
173_E	176_D	0.746	0.98
301_K	316_Y	0.745	0.98
159_L	205_A	0.743	0.98
262_A	265_E	0.741	0.98
33_L	37_V	0.740	0.98
270_I	276_V	0.738	0.98
119_D	202_G	0.736	0.98
9_G	23_K	0.736	0.98
213_L	224_A	0.735	0.98
39_D	42_A	0.732	0.98
99_L	112_V	0.730	0.98
307_A	324_A	0.728	0.98
289_G	304_I	0.726	0.98
218_P	222_L	0.726	0.98
292_V	311_V	0.723	0.98
309_T	324_A	0.722	0.98
41_A	45_V	0.720	0.98
21_R	323_G	0.717	0.98
63_I	72_V	0.717	0.98
38_L	63_I	0.714	0.98
239_T	242_D	0.711	0.98
38_L	70_T	0.711	0.98
15_G	19_E	0.707	0.98
120_G	202_G	0.707	0.98
51_V	86_A	0.705	0.97
69_G	73_V	0.705	0.97
13_R	24_P	0.703	0.97
70_T	73_V	0.697	0.97
133_S	151_K	0.696	0.97
111_L	114_A	0.696	0.97
5_V	37_V	0.694	0.97
8_A	51_V	0.694	0.97
197_D	200_D	0.691	0.97
261_G	265_E	0.691	0.97
150_E	161_N	0.688	0.97
298_V	314_H	0.688	0.97
128_V	158_D	0.687	0.97
115_L	168_T	0.687	0.97
271_Q	274_A	0.686	0.97
121_T	171_V	0.686	0.97
248_G	255_G	0.683	0.97
323_G	326_V	0.681	0.97
174_Y	177_T	0.680	0.97
68_A	73_V	0.680	0.97
46_D	71_P	0.679	0.97
27_P	32_T	0.678	0.97
320_S	334_V	0.677	0.97
282_V	294_V	0.674	0.97
282_V	288_V	0.672	0.97
177_T	180_R	0.671	0.97
128_V	131_P	0.669	0.97
327_N	330_A	0.669	0.97
104_D	214_D	0.668	0.96
233_E	236_I	0.668	0.96
24_P	59_I	0.667	0.96
145_V	148_V	0.665	0.96
111_L	116_A	0.664	0.96
7_A	50_I	0.664	0.96
249_R	266_G	0.664	0.96
40_A	109_S	0.662	0.96
49_V	90_A	0.660	0.96
135_G	151_K	0.660	0.96
287_V	304_I	0.659	0.96
185_E	190_D	0.657	0.96
239_T	257_R	0.653	0.96
241_A	260_D	0.650	0.96
283_R	299_E	0.649	0.96
305_L	322_L	0.643	0.96
275_D	279_N	0.643	0.96
25_L	32_T	0.642	0.96
251_V	272_S	0.641	0.96
221_L	306_M	0.641	0.96
69_G	72_V	0.641	0.96
101_L	164_L	0.640	0.96
137_V	192_L	0.640	0.96
42_A	110_A	0.639	0.96
53_G	85_H	0.635	0.95
226_S	229_L	0.634	0.95
213_L	220_E	0.631	0.95
40_A	43_G	0.631	0.95
333_K	336_N	0.631	0.95
318_G	336_N	0.631	0.95
167_F	191_A	0.630	0.95
11_G	24_P	0.630	0.95
317_V	334_V	0.629	0.95
83_T	87_V	0.626	0.95
176_D	180_R	0.623	0.95
97_P	112_V	0.623	0.95
281_Y	301_K	0.623	0.95
25_L	56_G	0.622	0.95
250_V	264_I	0.621	0.95
77_Q	85_H	0.619	0.95
188_L	191_A	0.616	0.95
267_P	282_V	0.616	0.95
256_A	276_V	0.614	0.94
241_A	259_R	0.614	0.94
87_V	187_E	0.612	0.94
238_G	241_A	0.612	0.94
261_G	266_G	0.612	0.94
295_G	299_E	0.612	0.94
83_T	104_D	0.611	0.94
246_L	252_V	0.610	0.94
6_V	86_A	0.610	0.94
262_A	276_V	0.608	0.94
67_Y	71_P	0.607	0.94
45_V	99_L	0.607	0.94
122_A	125_V	0.606	0.94
14_M	26_V	0.604	0.94
250_V	267_P	0.603	0.94
105_V	162_L	0.603	0.94
237_N	255_G	0.603	0.94
126_M	162_L	0.602	0.94
32_T	62_R	0.602	0.94
259_R	266_G	0.600	0.94
306_M	324_A	0.600	0.94
252_V	270_I	0.599	0.94
292_V	324_A	0.599	0.94
183_R	187_E	0.599	0.94
184_G	189_T	0.592	0.93
136_V	152_P	0.591	0.93
237_N	241_A	0.591	0.93
9_G	13_R	0.590	0.93
3_A	43_G	0.590	0.93
11_G	214_D	0.589	0.93
74_Y	77_Q	0.589	0.93
263_Y	266_G	0.587	0.93
51_V	77_Q	0.585	0.93
265_E	268_V	0.585	0.93
52_V	74_Y	0.584	0.93
274_A	291_D	0.583	0.93
107_V	208_Y	0.582	0.93
303_S	320_S	0.581	0.93
72_V	75_A	0.581	0.93
63_I	70_T	0.577	0.92
259_R	267_P	0.577	0.92
315_A	328_F	0.575	0.92
64_G	69_G	0.573	0.92
7_A	59_I	0.572	0.92
255_G	258_V	0.571	0.92
242_D	245_T	0.570	0.92
222_L	226_S	0.570	0.92
68_A	72_V	0.569	0.92
313_H	316_Y	0.569	0.92
135_G	148_V	0.567	0.92
133_S	217_R	0.566	0.92
73_V	93_H	0.564	0.92
60_R	74_Y	0.563	0.91
49_V	73_V	0.563	0.91
174_Y	201_G	0.563	0.91
250_V	266_G	0.562	0.91
259_R	279_N	0.561	0.91
257_R	260_D	0.559	0.91
190_D	194_R	0.559	0.91
69_G	76_E	0.557	0.91
84_A	178_V	0.552	0.91
178_V	185_E	0.550	0.91
69_G	74_Y	0.549	0.90
306_M	309_T	0.548	0.90
122_A	206_V	0.547	0.90
132_Q	153_T	0.542	0.90
83_T	90_A	0.541	0.90
127_P	209_D	0.541	0.90
25_L	63_I	0.541	0.90
151_K	216_G	0.536	0.89
256_A	273_G	0.536	0.89
171_V	174_Y	0.535	0.89
127_P	159_L	0.534	0.89
221_L	225_N	0.533	0.89
17_L	221_L	0.533	0.89
52_V	60_R	0.531	0.89
142_D	202_G	0.531	0.89
230_A	233_E	0.531	0.89
240_V	245_T	0.529	0.89
227_A	231_E	0.528	0.89
262_A	278_P	0.527	0.89
291_D	307_A	0.527	0.89
33_L	106_Y	0.527	0.89
174_Y	191_A	0.526	0.88
248_G	266_G	0.526	0.88
29_A	36_H	0.525	0.88
282_V	300_V	0.524	0.88
115_L	121_T	0.524	0.88
11_G	14_M	0.522	0.88
125_V	139_R	0.521	0.88
60_R	64_G	0.521	0.88
315_A	329_G	0.520	0.88
285_A	288_V	0.520	0.88
223_A	227_A	0.520	0.88
58_Q	324_A	0.520	0.88
91_E	169_P	0.520	0.88
256_A	259_R	0.519	0.88
78_D	81_E	0.519	0.88
115_L	166_R	0.519	0.88
253_E	291_D	0.519	0.88
283_R	318_G	0.517	0.88
65_A	69_G	0.516	0.88
330_A	336_N	0.515	0.87
141_D	144_R	0.515	0.87
126_M	212_W	0.515	0.87
73_V	76_E	0.514	0.87
245_T	263_Y	0.513	0.87
106_Y	224_A	0.512	0.87
298_V	313_H	0.512	0.87
126_M	160_A	0.511	0.87
261_G	296_N	0.510	0.87
294_V	305_L	0.510	0.87
316_Y	331_G	0.509	0.87
5_V	101_L	0.509	0.87
71_P	75_A	0.507	0.87
68_A	75_A	0.505	0.86
163_G	214_D	0.503	0.86
71_P	74_Y	0.503	0.86
27_P	324_A	0.502	0.86
247_T	266_G	0.502	0.86
162_L	208_Y	0.500	0.86
178_V	194_R	0.500	0.86
148_V	161_N	0.500	0.86

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ggoA	3	0.9776	100	0.324	Contact Map
4g3qA	3	0.985	100	0.389	Contact Map
1hm9A	3	0.9726	100	0.399	Contact Map
1yp2A	4	0.8978	100	0.405	Contact Map
4fceA	3	0.9601	100	0.42	Contact Map
2v0hA	3	0.9726	100	0.421	Contact Map
3brkX	2	0.8603	100	0.443	Contact Map
2icyA	1	0.7731	100	0.567	Contact Map
2i5kA	5	0.7332	100	0.589	Contact Map
3jukA	3	0.5761	100	0.6	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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