GREMLIN Database
Q9HSZ8 - Glucose-1-phosphate thymidylyltransferase
UniProt: Q9HSZ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 401 (328)
Sequences: 6764 (4348)
Seq/√Len: 240.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
282_V285_A3.5121.00
317_V320_S3.4851.00
300_V303_S3.3931.00
283_R301_K3.1721.00
115_L122_A3.1091.00
127_P158_D3.0561.00
284_G302_N2.9881.00
305_L311_V2.9841.00
301_K318_G2.8791.00
295_G313_H2.8751.00
312_G330_A2.6601.00
140_G144_R2.6391.00
288_V294_V2.6281.00
127_P207_S2.5371.00
313_H330_A2.5181.00
265_E283_R2.5131.00
296_N313_H2.3951.00
302_N319_D2.3931.00
290_P307_A2.3801.00
121_T168_T2.3601.00
273_G291_D2.3181.00
114_A118_A2.2751.00
281_Y299_E2.2721.00
257_R275_D2.2321.00
3_A45_V2.1981.00
275_D293_R2.1801.00
291_D308_D2.1571.00
97_P116_A2.1341.00
113_E117_G2.1121.00
298_V315_A2.1031.00
31_A39_D2.1031.00
138_E147_N2.0831.00
125_V205_A2.0771.00
272_S290_P2.0671.00
38_L48_Y1.9941.00
149_V156_P1.9621.00
91_E176_D1.9391.00
111_L124_S1.9121.00
274_A288_V1.9101.00
256_A274_A1.9101.00
97_P168_T1.9051.00
120_G204_T1.8811.00
288_V292_V1.8721.00
111_L166_R1.8701.00
112_V166_R1.8591.00
114_A206_V1.8151.00
35_E62_R1.7971.00
3_A41_A1.7951.00
144_R202_G1.7921.00
285_A300_V1.7581.00
289_G307_A1.7531.00
118_A204_T1.7511.00
47_E71_P1.7441.00
295_G312_G1.7331.00
263_Y281_Y1.7321.00
271_Q290_P1.7311.00
278_P296_N1.7241.00
173_E177_T1.7201.00
144_R204_T1.7141.00
293_R310_A1.7051.00
253_E272_S1.7041.00
264_I267_P1.6791.00
138_E157_T1.6671.00
305_L309_T1.6641.00
145_V205_A1.6581.00
259_R278_P1.6541.00
253_E256_A1.6111.00
315_A332_T1.6091.00
241_A244_A1.6071.00
34_L63_I1.5811.00
111_L115_L1.5791.00
322_L328_F1.5601.00
274_A292_V1.5471.00
211_P227_A1.5431.00
295_G310_A1.5431.00
99_L166_R1.5401.00
292_V309_T1.5391.00
125_V137_V1.5391.00
310_A327_N1.5271.00
309_T326_V1.5251.00
299_E316_Y1.5041.00
41_A101_L1.5041.00
297_A314_H1.4971.00
254_D272_S1.4791.00
81_E85_H1.4751.00
261_G279_N1.4751.00
121_T201_G1.4421.00
316_Y333_K1.4411.00
279_N296_N1.4201.00
270_I274_A1.4061.00
266_G284_G1.4051.00
98_C169_P1.3961.00
315_A330_A1.3861.00
56_G60_R1.3631.00
138_E149_V1.3491.00
184_G190_D1.3491.00
309_T322_L1.3491.00
322_L326_V1.3451.00
34_L59_I1.3271.00
143_G207_S1.3211.00
100_V167_F1.3211.00
256_A290_P1.3171.00
140_G146_T1.3121.00
139_R205_A1.3001.00
88_G91_E1.2901.00
121_T202_G1.2831.00
252_V256_A1.2691.00
136_V160_A1.2671.00
49_V75_A1.2671.00
253_E290_P1.2351.00
139_R159_L1.2341.00
25_L62_R1.2251.00
85_H89_C1.2231.00
255_G273_G1.2231.00
177_T194_R1.2151.00
170_R173_E1.2071.00
21_R27_P1.2001.00
48_Y70_T1.1831.00
294_V298_V1.1811.00
145_V203_V1.1771.00
303_S317_V1.1701.00
35_E39_D1.1591.00
295_G298_V1.1541.00
298_V312_G1.1391.00
33_L215_V1.1341.00
49_V93_H1.1311.00
85_H88_G1.1301.00
130_D133_S1.1251.00
280_A296_N1.1141.00
219_W223_A1.1131.00
52_V56_G1.1131.00
273_G290_P1.0991.00
258_V264_I1.0961.00
11_G23_K1.0941.00
314_H331_G1.0941.00
279_N297_A1.0941.00
174_Y194_R1.0941.00
329_G332_T1.0881.00
267_P284_G1.0781.00
308_D325_D1.0641.00
259_R275_D1.0641.00
265_E281_Y1.0621.00
114_A204_T1.0571.00
70_T74_Y1.0501.00
311_V317_V1.0491.00
312_G327_N1.0481.00
213_L227_A1.0441.00
215_V224_A1.0411.00
21_R58_Q1.0361.00
300_V305_L1.0331.00
247_T265_E1.0211.00
317_V322_L1.0121.00
96_G168_T1.0121.00
64_G74_Y1.0071.00
292_V306_M1.0011.00
289_G306_M0.9971.00
274_A289_G0.9961.00
174_Y195_A0.9941.00
4_I49_V0.9941.00
45_V112_V0.9931.00
314_H330_A0.9921.00
25_L58_Q0.9901.00
57_D61_E0.9851.00
174_Y178_V0.9831.00
111_L122_A0.9781.00
47_E73_V0.9761.00
267_P285_A0.9631.00
88_G176_D0.9571.00
50_I63_I0.9541.00
69_G75_A0.9501.00
114_A117_G0.9501.00
125_V159_L0.9481.00
306_M321_V0.9471.00
56_G76_E0.9441.00
123_M137_V0.9431.00
217_R220_E0.9431.00
34_L50_I0.9411.00
318_G335_A0.9391.00
108_T211_P0.9341.00
29_A228_L0.9331.00
102_N105_V0.9311.00
161_N165_Y0.9291.00
289_G292_V0.9251.00
36_H228_L0.9231.00
138_E146_T0.9181.00
240_V244_A0.9161.00
23_K104_D0.9161.00
149_V154_D0.9161.00
294_V300_V0.9041.00
22_P58_Q0.9041.00
298_V311_V0.9031.00
253_E271_Q0.9021.00
35_E63_I0.9011.00
38_L72_V0.8991.00
87_V100_V0.8991.00
256_A272_S0.8981.00
53_G80_Q0.8951.00
178_V191_A0.8941.00
175_I178_V0.8941.00
280_A298_V0.8921.00
300_V317_V0.8870.99
237_N243_G0.8860.99
123_M145_V0.8850.99
255_G272_S0.8850.99
28_V225_N0.8820.99
258_V262_A0.8790.99
24_P103_G0.8770.99
298_V330_A0.8760.99
276_V280_A0.8760.99
312_G329_G0.8730.99
5_V38_L0.8730.99
280_A294_V0.8700.99
13_R23_K0.8700.99
195_A201_G0.8650.99
137_V145_V0.8620.99
237_N244_A0.8590.99
147_N156_P0.8570.99
91_E172_F0.8550.99
113_E116_A0.8500.99
135_G150_E0.8480.99
37_V101_L0.8480.99
256_A271_Q0.8390.99
131_P155_P0.8340.99
249_R267_P0.8340.99
178_V183_R0.8310.99
32_T36_H0.8300.99
213_L223_A0.8300.99
32_T35_E0.8290.99
194_R197_D0.8270.99
18_T26_V0.8260.99
259_R262_A0.8240.99
36_H39_D0.8240.99
264_I270_I0.8240.99
274_A290_P0.8230.99
88_G179_E0.8230.99
256_A270_I0.8210.99
65_A68_A0.8190.99
159_L207_S0.8140.99
292_V307_A0.8130.99
302_N318_G0.8120.99
138_E156_P0.8120.99
49_V94_V0.8070.99
95_E169_P0.8050.99
97_P166_R0.8040.99
119_D168_T0.8020.99
262_A282_V0.7970.99
188_L193_A0.7960.99
262_A267_P0.7960.99
278_P295_G0.7900.99
264_I268_V0.7880.99
292_V305_L0.7850.99
124_S164_L0.7830.99
193_A197_D0.7810.99
5_V41_A0.7800.99
96_G169_P0.7750.99
80_Q85_H0.7740.99
196_I203_V0.7690.99
276_V288_V0.7660.99
249_R252_V0.7650.99
4_I98_C0.7640.98
112_V116_A0.7640.98
57_D60_R0.7630.98
167_F171_V0.7620.98
28_V33_L0.7620.98
30_G271_Q0.7610.98
139_R143_G0.7600.98
58_Q61_E0.7570.98
96_G170_R0.7530.98
252_V258_V0.7520.98
90_A93_H0.7520.98
237_N242_D0.7510.98
132_Q151_K0.7500.98
128_V160_A0.7480.98
88_G175_I0.7460.98
297_A313_H0.7460.98
173_E176_D0.7460.98
301_K316_Y0.7450.98
159_L205_A0.7430.98
262_A265_E0.7410.98
33_L37_V0.7400.98
270_I276_V0.7380.98
119_D202_G0.7360.98
9_G23_K0.7360.98
213_L224_A0.7350.98
39_D42_A0.7320.98
99_L112_V0.7300.98
307_A324_A0.7280.98
289_G304_I0.7260.98
218_P222_L0.7260.98
292_V311_V0.7230.98
309_T324_A0.7220.98
41_A45_V0.7200.98
21_R323_G0.7170.98
63_I72_V0.7170.98
38_L63_I0.7140.98
239_T242_D0.7110.98
38_L70_T0.7110.98
15_G19_E0.7070.98
120_G202_G0.7070.98
51_V86_A0.7050.97
69_G73_V0.7050.97
13_R24_P0.7030.97
70_T73_V0.6970.97
133_S151_K0.6960.97
111_L114_A0.6960.97
5_V37_V0.6940.97
8_A51_V0.6940.97
197_D200_D0.6910.97
261_G265_E0.6910.97
150_E161_N0.6880.97
298_V314_H0.6880.97
128_V158_D0.6870.97
115_L168_T0.6870.97
271_Q274_A0.6860.97
121_T171_V0.6860.97
248_G255_G0.6830.97
323_G326_V0.6810.97
174_Y177_T0.6800.97
68_A73_V0.6800.97
46_D71_P0.6790.97
27_P32_T0.6780.97
320_S334_V0.6770.97
282_V294_V0.6740.97
282_V288_V0.6720.97
177_T180_R0.6710.97
128_V131_P0.6690.97
327_N330_A0.6690.97
104_D214_D0.6680.96
233_E236_I0.6680.96
24_P59_I0.6670.96
145_V148_V0.6650.96
111_L116_A0.6640.96
7_A50_I0.6640.96
249_R266_G0.6640.96
40_A109_S0.6620.96
49_V90_A0.6600.96
135_G151_K0.6600.96
287_V304_I0.6590.96
185_E190_D0.6570.96
239_T257_R0.6530.96
241_A260_D0.6500.96
283_R299_E0.6490.96
305_L322_L0.6430.96
275_D279_N0.6430.96
25_L32_T0.6420.96
251_V272_S0.6410.96
221_L306_M0.6410.96
69_G72_V0.6410.96
101_L164_L0.6400.96
137_V192_L0.6400.96
42_A110_A0.6390.96
53_G85_H0.6350.95
226_S229_L0.6340.95
213_L220_E0.6310.95
40_A43_G0.6310.95
333_K336_N0.6310.95
318_G336_N0.6310.95
167_F191_A0.6300.95
11_G24_P0.6300.95
317_V334_V0.6290.95
83_T87_V0.6260.95
176_D180_R0.6230.95
97_P112_V0.6230.95
281_Y301_K0.6230.95
25_L56_G0.6220.95
250_V264_I0.6210.95
77_Q85_H0.6190.95
188_L191_A0.6160.95
267_P282_V0.6160.95
256_A276_V0.6140.94
241_A259_R0.6140.94
87_V187_E0.6120.94
238_G241_A0.6120.94
261_G266_G0.6120.94
295_G299_E0.6120.94
83_T104_D0.6110.94
246_L252_V0.6100.94
6_V86_A0.6100.94
262_A276_V0.6080.94
67_Y71_P0.6070.94
45_V99_L0.6070.94
122_A125_V0.6060.94
14_M26_V0.6040.94
250_V267_P0.6030.94
105_V162_L0.6030.94
237_N255_G0.6030.94
126_M162_L0.6020.94
32_T62_R0.6020.94
259_R266_G0.6000.94
306_M324_A0.6000.94
252_V270_I0.5990.94
292_V324_A0.5990.94
183_R187_E0.5990.94
184_G189_T0.5920.93
136_V152_P0.5910.93
237_N241_A0.5910.93
9_G13_R0.5900.93
3_A43_G0.5900.93
11_G214_D0.5890.93
74_Y77_Q0.5890.93
263_Y266_G0.5870.93
51_V77_Q0.5850.93
265_E268_V0.5850.93
52_V74_Y0.5840.93
274_A291_D0.5830.93
107_V208_Y0.5820.93
303_S320_S0.5810.93
72_V75_A0.5810.93
63_I70_T0.5770.92
259_R267_P0.5770.92
315_A328_F0.5750.92
64_G69_G0.5730.92
7_A59_I0.5720.92
255_G258_V0.5710.92
242_D245_T0.5700.92
222_L226_S0.5700.92
68_A72_V0.5690.92
313_H316_Y0.5690.92
135_G148_V0.5670.92
133_S217_R0.5660.92
73_V93_H0.5640.92
60_R74_Y0.5630.91
49_V73_V0.5630.91
174_Y201_G0.5630.91
250_V266_G0.5620.91
259_R279_N0.5610.91
257_R260_D0.5590.91
190_D194_R0.5590.91
69_G76_E0.5570.91
84_A178_V0.5520.91
178_V185_E0.5500.91
69_G74_Y0.5490.90
306_M309_T0.5480.90
122_A206_V0.5470.90
132_Q153_T0.5420.90
83_T90_A0.5410.90
127_P209_D0.5410.90
25_L63_I0.5410.90
151_K216_G0.5360.89
256_A273_G0.5360.89
171_V174_Y0.5350.89
127_P159_L0.5340.89
221_L225_N0.5330.89
17_L221_L0.5330.89
52_V60_R0.5310.89
142_D202_G0.5310.89
230_A233_E0.5310.89
240_V245_T0.5290.89
227_A231_E0.5280.89
262_A278_P0.5270.89
291_D307_A0.5270.89
33_L106_Y0.5270.89
174_Y191_A0.5260.88
248_G266_G0.5260.88
29_A36_H0.5250.88
282_V300_V0.5240.88
115_L121_T0.5240.88
11_G14_M0.5220.88
125_V139_R0.5210.88
60_R64_G0.5210.88
315_A329_G0.5200.88
285_A288_V0.5200.88
223_A227_A0.5200.88
58_Q324_A0.5200.88
91_E169_P0.5200.88
256_A259_R0.5190.88
78_D81_E0.5190.88
115_L166_R0.5190.88
253_E291_D0.5190.88
283_R318_G0.5170.88
65_A69_G0.5160.88
330_A336_N0.5150.87
141_D144_R0.5150.87
126_M212_W0.5150.87
73_V76_E0.5140.87
245_T263_Y0.5130.87
106_Y224_A0.5120.87
298_V313_H0.5120.87
126_M160_A0.5110.87
261_G296_N0.5100.87
294_V305_L0.5100.87
316_Y331_G0.5090.87
5_V101_L0.5090.87
71_P75_A0.5070.87
68_A75_A0.5050.86
163_G214_D0.5030.86
71_P74_Y0.5030.86
27_P324_A0.5020.86
247_T266_G0.5020.86
162_L208_Y0.5000.86
178_V194_R0.5000.86
148_V161_N0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ggoA 3 0.9776 100 0.324 Contact Map
4g3qA 3 0.985 100 0.389 Contact Map
1hm9A 3 0.9726 100 0.399 Contact Map
1yp2A 4 0.8978 100 0.405 Contact Map
4fceA 3 0.9601 100 0.42 Contact Map
2v0hA 3 0.9726 100 0.421 Contact Map
3brkX 2 0.8603 100 0.443 Contact Map
2icyA 1 0.7731 100 0.567 Contact Map
2i5kA 5 0.7332 100 0.589 Contact Map
3jukA 3 0.5761 100 0.6 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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