GREMLIN Database
Q9HSZ7 - Uncharacterized protein
UniProt: Q9HSZ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 477 (434)
Sequences: 4334 (3523)
Seq/√Len: 169.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
306_I376_L5.8021.00
309_A367_V5.4221.00
285_R289_I5.3471.00
339_S371_L5.1041.00
313_D366_R4.5681.00
323_E331_T4.4881.00
296_L383_W4.3901.00
385_V423_L4.3351.00
323_E333_E4.1361.00
321_N333_E3.8041.00
287_F291_F3.6091.00
439_E442_R3.5271.00
306_I371_L3.4701.00
370_V374_T3.4311.00
392_V460_V3.1891.00
305_A309_A2.9781.00
144_R170_V2.7141.00
317_T342_E2.6601.00
92_V119_T2.6541.00
343_N347_A2.6181.00
293_A386_L2.5711.00
426_L430_N2.5461.00
382_L392_V2.4791.00
292_S296_L2.4281.00
295_G299_L2.4221.00
291_F392_V2.4131.00
310_I313_D2.3861.00
325_T331_T2.3691.00
321_N335_Y2.3311.00
311_K318_V2.2951.00
292_S386_L2.2161.00
307_T318_V2.2151.00
319_L335_Y2.2111.00
382_L423_L2.1701.00
341_V347_A2.1351.00
221_T249_K2.1191.00
144_R220_D2.1001.00
367_V371_L2.0931.00
458_K462_R2.0501.00
360_V369_R2.0361.00
175_V213_V2.0241.00
311_K316_G2.0161.00
446_Q450_K2.0141.00
343_N346_D2.0081.00
335_Y387_K1.9901.00
399_R402_L1.9711.00
398_E402_L1.9551.00
212_D216_A1.9511.00
299_L303_I1.9231.00
398_E406_I1.8861.00
406_I437_P1.8371.00
325_T403_D1.8311.00
136_R139_P1.8151.00
289_I292_S1.8141.00
287_F453_I1.8131.00
146_I175_V1.8081.00
393_V424_T1.8061.00
213_V217_H1.7871.00
300_S304_L1.7831.00
142_A170_V1.7771.00
304_L308_G1.7731.00
371_L374_T1.7601.00
159_V174_V1.7481.00
383_W387_K1.7471.00
145_T169_Y1.7241.00
296_L300_S1.7131.00
306_I337_F1.7111.00
373_Q470_D1.7071.00
31_G125_A1.6911.00
308_G312_L1.6891.00
303_I319_L1.6891.00
293_A297_L1.6731.00
402_L406_I1.6711.00
303_I337_F1.6101.00
371_L376_L1.6081.00
288_D391_S1.6021.00
436_D439_E1.5921.00
295_G382_L1.5891.00
147_V155_I1.5841.00
206_G209_R1.5841.00
364_V369_R1.5761.00
352_I402_L1.5601.00
24_G28_S1.5571.00
326_A421_P1.5521.00
426_L446_Q1.5421.00
289_I293_A1.5391.00
347_A350_A1.5191.00
320_Y345_E1.5181.00
301_P304_L1.5141.00
209_R212_D1.5141.00
173_T205_G1.5121.00
379_I382_L1.5011.00
295_G392_V1.4871.00
67_V72_L1.4821.00
398_E403_D1.4761.00
341_V362_P1.4591.00
398_E437_P1.4571.00
23_V129_L1.4501.00
291_F295_G1.4461.00
299_L302_V1.4421.00
103_Y112_R1.4191.00
39_P112_R1.4151.00
398_E440_K1.4091.00
147_V159_V1.3921.00
400_P404_S1.3891.00
83_V134_R1.3591.00
426_L450_K1.3511.00
264_D267_T1.3421.00
335_Y384_A1.3361.00
155_I174_V1.3241.00
462_R466_K1.3151.00
139_P168_G1.3001.00
345_E349_G1.2991.00
419_V448_V1.2901.00
399_R437_P1.2811.00
300_S303_I1.2801.00
214_L246_V1.2801.00
151_T155_I1.2771.00
39_P113_T1.2691.00
375_H433_T1.2601.00
28_S122_L1.2351.00
465_W469_V1.2331.00
407_Q414_R1.2321.00
432_V443_Y1.2271.00
285_R292_S1.2231.00
437_P440_K1.2131.00
306_I309_A1.2081.00
427_A434_G1.2051.00
432_V439_E1.2051.00
88_Q123_L1.2001.00
269_A273_V1.1981.00
413_W427_A1.1851.00
320_Y399_R1.1801.00
27_N129_L1.1751.00
399_R406_I1.1751.00
215_V244_H1.1691.00
102_G105_D1.1691.00
402_L437_P1.1601.00
27_N125_A1.1591.00
309_A312_L1.1561.00
21_L24_G1.1531.00
382_L460_V1.1521.00
467_V470_D1.1491.00
453_I457_M1.1451.00
393_V460_V1.1441.00
287_F457_M1.1431.00
27_N31_G1.1381.00
147_V174_V1.1371.00
146_I173_T1.1351.00
31_G35_T1.1281.00
341_V344_A1.1261.00
313_D365_T1.1241.00
150_D176_P1.1231.00
399_R403_D1.1221.00
436_D440_K1.1221.00
344_A351_T1.1201.00
319_L383_W1.1191.00
303_I379_I1.1131.00
427_A433_T1.1131.00
211_E240_A1.1101.00
398_E413_W1.1051.00
457_M461_I1.0971.00
427_A432_V1.0961.00
63_C67_V1.0931.00
433_T440_K1.0911.00
150_D155_I1.0881.00
302_V306_I1.0871.00
370_V376_L1.0841.00
105_D112_R1.0821.00
434_G471_A1.0811.00
136_R141_A1.0781.00
329_G417_W1.0711.00
352_I399_R1.0681.00
287_F460_V1.0681.00
305_A308_G1.0570.99
213_V219_I1.0550.99
413_W440_K1.0540.99
401_E405_D1.0510.99
398_E441_L1.0500.99
159_V171_C1.0470.99
214_L241_C1.0430.99
147_V225_A1.0430.99
392_V423_L1.0400.99
289_I382_L1.0390.99
413_W417_W1.0390.99
415_K449_K1.0330.99
351_T355_E1.0320.99
172_P219_I1.0310.99
283_L287_F1.0300.99
352_I398_E1.0290.99
398_E427_A1.0230.99
375_H451_Q1.0190.99
351_T354_D1.0180.99
398_E416_R1.0150.99
383_W389_D1.0070.99
113_T117_A1.0070.99
284_K288_D1.0070.99
352_I435_A1.0030.99
465_W471_A1.0020.99
416_R440_K0.9990.99
24_G31_G0.9980.99
286_G289_I0.9950.99
282_V286_G0.9920.99
84_V127_P0.9910.99
117_A121_V0.9900.99
102_G112_R0.9890.99
467_V472_V0.9880.99
302_V379_I0.9870.99
306_I310_I0.9810.99
122_L126_V0.9810.99
460_V467_V0.9790.99
438_V442_R0.9760.99
303_I383_W0.9730.99
311_K314_D0.9680.99
24_G35_T0.9680.99
28_S31_G0.9670.99
398_E433_T0.9650.99
348_T351_T0.9650.99
350_A402_L0.9650.99
146_I219_I0.9640.99
222_V241_C0.9620.99
24_G27_N0.9610.99
351_T362_P0.9610.99
310_I367_V0.9540.99
322_Q399_R0.9530.99
66_A70_L0.9520.99
313_D367_V0.9510.99
375_H431_D0.9470.99
375_H440_K0.9430.99
159_V201_H0.9430.99
323_E401_E0.9430.99
95_L119_T0.9430.99
402_L435_A0.9410.99
398_E401_E0.9370.99
461_I465_W0.9350.99
297_L300_S0.9340.99
91_V123_L0.9310.99
366_R369_R0.9220.99
348_T401_E0.9190.99
332_F390_M0.9160.99
66_A90_R0.9140.98
136_R168_G0.9110.98
291_F460_V0.9090.98
417_W434_G0.9090.98
426_L455_F0.9040.98
413_W437_P0.9030.98
432_V435_A0.9010.98
433_T437_P0.9010.98
427_A440_K0.8970.98
401_E406_I0.8890.98
353_S402_L0.8890.98
375_H432_V0.8880.98
350_A354_D0.8870.98
31_G121_V0.8840.98
304_L307_T0.8770.98
70_L90_R0.8760.98
29_P60_T0.8760.98
431_D451_Q0.8750.98
146_I213_V0.8730.98
414_R417_W0.8730.98
348_T427_A0.8720.98
123_L127_P0.8720.98
205_G209_R0.8720.98
310_I314_D0.8720.98
403_D417_W0.8700.98
309_A313_D0.8680.98
399_R440_K0.8660.98
413_W441_L0.8660.98
384_A389_D0.8620.98
235_F239_D0.8600.98
113_T116_L0.8600.98
402_L417_W0.8590.98
426_L443_Y0.8580.98
299_L382_L0.8580.98
204_L213_V0.8570.98
325_T399_R0.8570.98
434_G440_K0.8550.98
290_A294_A0.8480.98
156_E160_A0.8470.98
348_T402_L0.8440.97
434_G437_P0.8430.97
289_I386_L0.8420.97
311_K315_G0.8400.97
350_A353_S0.8380.97
402_L443_Y0.8360.97
60_T64_V0.8350.97
105_D111_P0.8350.97
52_A56_L0.8320.97
425_G440_K0.8310.97
352_I437_P0.8310.97
83_V130_F0.8300.97
144_R172_P0.8270.97
402_L427_A0.8260.97
402_L433_T0.8240.97
284_K391_S0.8220.97
36_G39_P0.8220.97
325_T400_P0.8210.97
430_N443_Y0.8190.97
86_L89_K0.8180.97
400_P403_D0.8150.97
34_L125_A0.8120.97
287_F392_V0.8060.97
276_W281_Y0.8060.97
345_E399_R0.8040.97
319_L333_E0.8030.97
63_C94_A0.8030.97
416_R437_P0.8030.97
129_L133_I0.8020.97
153_D302_V0.7990.96
301_P305_A0.7970.96
308_G311_K0.7970.96
178_T182_A0.7950.96
398_E435_A0.7940.96
432_V437_P0.7940.96
406_I416_R0.7910.96
126_V129_L0.7910.96
214_L222_V0.7900.96
280_D451_Q0.7880.96
144_R218_D0.7860.96
355_E398_E0.7860.96
141_A168_G0.7850.96
322_Q416_R0.7840.96
33_A37_A0.7840.96
76_R136_R0.7800.96
348_T352_I0.7800.96
199_N202_D0.7800.96
331_T400_P0.7780.96
91_V122_L0.7780.96
96_F100_A0.7780.96
145_T223_V0.7730.96
130_F134_R0.7720.96
211_E215_V0.7690.96
349_G352_I0.7690.96
367_V370_V0.7680.96
158_L223_V0.7650.95
287_F290_A0.7640.95
82_D85_V0.7640.95
71_P74_K0.7640.95
143_S221_T0.7640.95
35_T39_P0.7630.95
165_P168_G0.7620.95
437_P441_L0.7610.95
85_V89_K0.7590.95
430_N433_T0.7580.95
157_R161_D0.7580.95
52_A110_L0.7560.95
283_L286_G0.7560.95
126_V130_F0.7550.95
149_G225_A0.7550.95
146_I204_L0.7500.95
322_Q334_V0.7490.95
341_V364_V0.7480.95
427_A437_P0.7480.95
430_N462_R0.7480.95
27_N126_V0.7480.95
177_R233_E0.7460.95
334_V339_S0.7450.95
403_D406_I0.7450.95
241_C248_A0.7440.95
431_D435_A0.7430.95
177_R205_G0.7390.95
399_R435_A0.7380.95
80_V131_V0.7370.94
197_A200_D0.7330.94
173_T204_L0.7320.94
435_A440_K0.7290.94
352_I355_E0.7240.94
325_T402_L0.7240.94
427_A472_V0.7210.94
263_D272_D0.7210.94
398_E417_W0.7190.94
230_D233_E0.7180.94
125_A129_L0.7170.94
348_T399_R0.7160.94
155_I176_P0.7130.93
350_A399_R0.7120.93
415_K418_F0.7110.93
435_A443_Y0.7100.93
352_I406_I0.7090.93
310_I318_V0.7080.93
350_A401_E0.7070.93
470_D473_E0.7060.93
314_D367_V0.7040.93
348_T398_E0.7040.93
150_D177_R0.7020.93
76_R80_V0.7000.93
398_E434_G0.6990.93
155_I225_A0.6980.93
406_I435_A0.6960.93
425_G441_L0.6940.93
398_E411_V0.6930.92
399_R433_T0.6910.92
347_A427_A0.6880.92
92_V123_L0.6870.92
105_D108_Y0.6860.92
212_D215_V0.6850.92
303_I382_L0.6850.92
311_K317_T0.6850.92
80_V84_V0.6850.92
345_E348_T0.6810.92
425_G428_Q0.6800.92
343_N362_P0.6790.92
236_G240_A0.6790.92
433_T451_Q0.6770.92
352_I416_R0.6770.92
432_V440_K0.6770.92
432_V472_V0.6740.91
454_W457_M0.6710.91
56_L60_T0.6710.91
227_E230_D0.6700.91
321_N334_V0.6700.91
407_Q411_V0.6670.91
38_L54_G0.6670.91
223_V270_T0.6660.91
111_P115_L0.6650.91
34_L121_V0.6620.91
124_V127_P0.6610.91
352_I403_D0.6590.91
417_W440_K0.6580.90
446_Q455_F0.6560.90
210_I214_L0.6550.90
316_G342_E0.6550.90
413_W434_G0.6550.90
306_I367_V0.6550.90
399_R413_W0.6550.90
198_L201_H0.6520.90
174_V203_R0.6520.90
30_T33_A0.6510.90
33_A36_G0.6510.90
344_A362_P0.6510.90
361_D364_V0.6500.90
299_L306_I0.6490.90
332_F403_D0.6480.90
439_E443_Y0.6480.90
322_Q345_E0.6480.90
417_W427_A0.6470.90
406_I441_L0.6460.90
351_T427_A0.6450.90
291_F382_L0.6440.89
210_I271_V0.6430.89
402_L413_W0.6430.89
92_V96_F0.6400.89
355_E427_A0.6400.89
452_S455_F0.6390.89
399_R427_A0.6390.89
150_D203_R0.6390.89
25_V60_T0.6370.89
327_A420_R0.6370.89
427_A435_A0.6360.89
335_Y389_D0.6350.89
433_T441_L0.6340.89
402_L432_V0.6330.89
340_M364_V0.6330.89
309_A370_V0.6330.89
305_A313_D0.6330.89
403_D416_R0.6320.89
416_R427_A0.6320.89
211_E214_L0.6300.88
241_C245_G0.6290.88
146_I217_H0.6290.88
90_R94_A0.6290.88
89_K93_V0.6290.88
345_E350_A0.6280.88
325_T332_F0.6260.88
349_G402_L0.6260.88
285_R288_D0.6260.88
102_G107_T0.6250.88
171_C201_H0.6250.88
286_G290_A0.6240.88
81_L458_K0.6230.88
322_Q398_E0.6220.88
466_K470_D0.6220.88
67_V90_R0.6220.88
325_T398_E0.6200.88
393_V429_V0.6190.88
161_D267_T0.6190.88
310_I376_L0.6180.88
323_E400_P0.6160.87
426_L459_V0.6160.87
20_A24_G0.6150.87
466_K469_V0.6150.87
445_L449_K0.6140.87
301_P382_L0.6140.87
399_R441_L0.6130.87
32_Q37_A0.6110.87
395_P440_K0.6100.87
413_W433_T0.6090.87
385_V460_V0.6090.87
417_W433_T0.6070.87
145_T221_T0.6060.86
343_N349_G0.6040.86
29_P33_A0.6040.86
302_V305_A0.6040.86
32_Q36_G0.6030.86
403_D436_D0.6020.86
334_V403_D0.6010.86
403_D437_P0.5990.86
285_R293_A0.5990.86
21_L68_A0.5990.86
402_L434_G0.5960.86
151_T178_T0.5920.85
106_Y111_P0.5920.85
24_G39_P0.5920.85
353_S437_P0.5920.85
258_V261_A0.5910.85
312_L315_G0.5910.85
226_F229_T0.5900.85
415_K445_L0.5890.85
332_F335_Y0.5880.85
245_G418_F0.5880.85
62_V101_I0.5870.85
252_R257_R0.5860.85
120_P124_V0.5860.85
54_G57_E0.5860.85
116_L120_P0.5840.84
223_V311_K0.5830.84
303_I306_I0.5820.84
295_G460_V0.5820.84
403_D411_V0.5810.84
402_L416_R0.5810.84
294_A298_L0.5810.84
335_Y383_W0.5790.84
178_T233_E0.5780.84
299_L337_F0.5780.84
322_Q437_P0.5780.84
427_A430_N0.5770.84
290_A293_A0.5770.84
403_D435_A0.5770.84
431_D440_K0.5760.84
320_Y402_L0.5750.84
80_V83_V0.5750.84
205_G213_V0.5740.83
200_D203_R0.5740.83
66_A72_L0.5730.83
398_E421_P0.5730.83
69_C72_L0.5710.83
233_E236_G0.5710.83
201_H217_H0.5700.83
62_V94_A0.5700.83
425_G431_D0.5680.83
158_L162_I0.5670.83
142_A168_G0.5640.82
344_A399_R0.5640.82
440_K451_Q0.5640.82
278_V281_Y0.5640.82
253_D256_D0.5630.82
155_I177_R0.5620.82
102_G113_T0.5620.82
401_E441_L0.5610.82
343_N348_T0.5590.82
432_V451_Q0.5580.82
28_S126_V0.5570.82
105_D110_L0.5560.81
322_Q388_G0.5550.81
406_I417_W0.5550.81
334_V398_E0.5520.81
395_P398_E0.5520.81
371_L375_H0.5520.81
76_R139_P0.5520.81
66_A94_A0.5510.81
97_A101_I0.5510.81
418_F449_K0.5510.81
296_L386_L0.5500.81
406_I451_Q0.5500.81
349_G399_R0.5490.81
366_R370_V0.5490.81
292_S392_V0.5480.81
291_F294_A0.5480.81
52_A112_R0.5460.80
395_P399_R0.5460.80
159_V198_L0.5440.80
464_V468_V0.5430.80
399_R434_G0.5430.80
269_A449_K0.5420.80
70_L73_Y0.5410.80
35_T38_L0.5400.80
350_A375_H0.5400.80
91_V126_V0.5390.79
400_P437_P0.5390.79
118_V122_L0.5390.79
416_R425_G0.5390.79
214_L219_I0.5390.79
313_D371_L0.5390.79
178_T181_A0.5380.79
76_R79_R0.5370.79
347_A351_T0.5370.79
102_G115_L0.5370.79
417_W435_A0.5370.79
460_V464_V0.5360.79
403_D440_K0.5360.79
318_V337_F0.5360.79
344_A427_A0.5360.79
111_P114_T0.5340.79
316_G365_T0.5330.79
34_L37_A0.5330.79
399_R405_D0.5330.79
353_S427_A0.5320.79
36_G41_F0.5320.79
401_E437_P0.5320.79
328_F418_F0.5320.79
360_V364_V0.5300.78
292_S297_L0.5290.78
224_L234_F0.5290.78
365_T369_R0.5290.78
399_R416_R0.5270.78
406_I421_P0.5270.78
298_L301_P0.5260.78
437_P443_Y0.5250.78
382_L466_K0.5250.78
87_A123_L0.5240.78
402_L421_P0.5240.78
95_L298_L0.5210.77
300_S305_A0.5210.77
375_H441_L0.5180.77
232_A236_G0.5180.77
427_A443_Y0.5170.77
307_T310_I0.5170.77
348_T413_W0.5170.77
52_A111_P0.5170.77
398_E436_D0.5170.77
355_E360_V0.5160.76
285_R420_R0.5160.76
407_Q412_D0.5160.76
59_S118_V0.5150.76
303_I307_T0.5140.76
346_D349_G0.5140.76
433_T473_E0.5130.76
26_A30_T0.5120.76
311_K342_E0.5120.76
355_E437_P0.5120.76
400_P416_R0.5110.76
128_A212_D0.5110.76
375_H466_K0.5110.76
247_A272_D0.5100.76
174_V201_H0.5100.76
38_L121_V0.5080.75
300_S306_I0.5080.75
139_P142_A0.5070.75
23_V27_N0.5060.75
21_L64_V0.5060.75
157_R160_A0.5060.75
131_V135_R0.5050.75
375_H472_V0.5050.75
301_P395_P0.5040.75
398_E405_D0.5040.75
221_T247_A0.5030.75
319_L389_D0.5010.74
406_I433_T0.5010.74
355_E362_P0.5010.74
245_G325_T0.5010.74
34_L38_L0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nklA 2 0.2537 99.2 0.906 Contact Map
3keoA 2 0.4088 98.4 0.929 Contact Map
2dt5A 3 0.4277 98.1 0.934 Contact Map
3wg9A 2 0.4256 98.1 0.934 Contact Map
2vt3A 2 0.4151 97.9 0.938 Contact Map
2py6A 4 0.6059 97.9 0.939 Contact Map
4m98A 3 0.4298 97.1 0.946 Contact Map
4rv9A 1 0.5136 95.6 0.954 Contact Map
4ea9A 3 0.4004 94.8 0.956 Contact Map
3ff4A 1 0.2453 78.8 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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