Q9HSZ6 - HALSA - GREMLIN Contacts

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Q9HSZ6 - Uncharacterized protein

UniProt:	Q9HSZ6	Sequences: MAWGKCNAKSDVQPLAYDSVREETDLGSQHAILATHQAAQAITGCLERRSNGKKASKPTFTAPTVTYDTRTMTLFDDDTVSLSTTESRVRCPLALPDADDGYQRQYLDSEEWSVTESTLTARDGDYVLHIGFRRPKTDTERNTAEDGTVLGVDLGIENLAVTSTATFLSGRELTHDLREFEKVRAGLQQTGTRSAHRTLVQSSGRELRYVRDVLHRASNAIVAEALRYNCDVIAFEDLTHIRNRTRASWGHKWAFRTLYEQVAYKAEAIGVSVTQVGAAYTSKRCAECGFTADENRPTRNDFQCGKCGAEANADYNAAKNIGLRYVRRGQQSSRRTGDSQLALQSGTVTPSGGFTAYPDGFEAEFMDKPHPPRANPSG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	378 (301)
Sequences:	4478 (2827)
Seq/√Len:	162.9

ECOLI - INSQ
HALSA - Q9HSZ6 Q9HSW9 Q9HSY4 Q9HHJ9 Q9HSW7 Q9HSD4 Q9HM87 Q9HHU6 Q9HHG8 Q9HHX8
SULSO - Q97WZ3 Q97X39 Q97XA4 Q97XQ8 Q97Y67 Q7LXD9 Q97V53 Q97YI2 Q97XP1 Q97YI5 Q7LXH2 Q7LXH6 Q97V25 Q97YU1 Q97Y44 Q97V47 Q97YW4 Q97UQ8 Q97XQ0 Q97Z61 Q97U68 Q97Y48 Q97U51 Q97WY6 Q97XB6 Q97YW9 Q97YF7 Q97U09 Q7LX59 Y2105 Q97YK6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
212_D	216_R	5.247	1.00
286_A	316_N	4.361	1.00
266_A	273_V	3.613	1.00
259_Y	275_Q	3.074	1.00
234_A	325_Y	3.060	1.00
235_F	262_V	2.978	1.00
219_N	223_A	2.943	1.00
159_L	258_L	2.848	1.00
257_T	261_Q	2.838	1.00
117_S	128_L	2.523	1.00
242_R	251_H	2.477	1.00
280_Y	283_K	2.443	1.00
263_A	275_Q	2.380	1.00
257_T	260_E	2.366	1.00
276_V	321_I	2.364	1.00
284_R	291_T	2.336	1.00
222_V	266_A	2.333	1.00
177_L	248_S	2.278	1.00
324_R	327_R	2.255	1.00
215_H	261_Q	2.240	1.00
215_H	264_Y	2.218	1.00
281_T	321_I	2.137	1.00
258_L	262_V	2.096	1.00
303_Q	310_E	2.076	1.00
183_V	195_A	2.059	1.00
115_T	133_R	2.054	1.00
233_I	266_A	2.043	1.00
176_D	209_Y	2.029	1.00
283_K	295_N	2.015	1.00
161_V	167_F	2.003	1.00
235_F	273_V	1.955	1.00
288_C	307_C	1.915	1.00
283_K	293_D	1.905	1.00
211_R	257_T	1.886	1.00
263_A	267_E	1.854	1.00
159_L	213_V	1.853	1.00
11_D	14_P	1.849	1.00
215_H	218_S	1.843	1.00
215_H	265_K	1.840	1.00
193_R	196_H	1.823	1.00
195_A	199_L	1.822	1.00
296_R	299_R	1.803	1.00
218_S	261_Q	1.794	1.00
288_C	304_C	1.756	1.00
231_D	271_V	1.719	1.00
214_L	261_Q	1.710	1.00
37_Q	73_T	1.694	1.00
152_V	160_A	1.691	1.00
287_E	309_A	1.657	1.00
300_N	313_A	1.654	1.00
285_C	304_C	1.625	1.00
285_C	288_C	1.621	1.00
235_F	275_Q	1.582	1.00
214_L	257_T	1.569	1.00
302_F	311_A	1.569	1.00
285_C	307_C	1.546	1.00
235_F	259_Y	1.534	1.00
304_C	307_C	1.510	1.00
42_I	57_K	1.500	1.00
292_A	302_F	1.497	1.00
190_T	193_R	1.495	1.00
39_A	43_T	1.463	1.00
292_A	295_N	1.462	1.00
296_R	313_A	1.455	1.00
301_D	310_E	1.450	1.00
183_V	186_G	1.448	1.00
218_S	265_K	1.447	1.00
236_E	278_A	1.435	1.00
319_K	323_L	1.429	1.00
295_N	299_R	1.422	1.00
218_S	264_Y	1.421	1.00
302_F	309_A	1.416	1.00
290_F	305_G	1.408	1.00
187_L	196_H	1.401	1.00
125_D	204_G	1.389	1.00
43_T	47_E	1.387	1.00
158_N	161_V	1.371	1.00
184_R	188_Q	1.364	1.00
162_T	166_T	1.342	1.00
13_Q	17_Y	1.333	1.00
167_F	312_N	1.330	1.00
244_R	247_A	1.325	1.00
13_Q	16_A	1.323	1.00
250_G	255_F	1.319	1.00
161_V	315_Y	1.314	1.00
204_G	208_R	1.313	1.00
49_R	55_A	1.308	1.00
48_R	55_A	1.308	1.00
149_V	322_G	1.303	1.00
237_D	275_Q	1.299	1.00
150_L	162_T	1.298	1.00
33_L	36_H	1.293	1.00
123_D	204_G	1.271	1.00
286_A	311_A	1.263	1.00
44_G	49_R	1.261	1.00
292_A	296_R	1.256	1.00
154_L	255_F	1.255	1.00
40_Q	44_G	1.245	1.00
67_Y	71_T	1.242	1.00
286_A	319_K	1.240	1.00
183_V	202_S	1.235	1.00
27_G	30_H	1.232	1.00
263_A	273_V	1.231	1.00
14_P	17_Y	1.227	1.00
146_D	231_D	1.223	1.00
44_G	48_R	1.217	1.00
222_V	269_I	1.216	1.00
89_V	128_L	1.215	1.00
45_C	57_K	1.215	1.00
176_D	206_E	1.214	1.00
44_G	55_A	1.195	1.00
239_T	278_A	1.189	1.00
152_V	162_T	1.185	1.00
60_F	63_P	1.182	1.00
218_S	258_L	1.176	1.00
120_T	129_H	1.176	1.00
149_V	232_V	1.175	1.00
218_S	262_V	1.169	1.00
219_N	269_I	1.164	1.00
261_Q	264_Y	1.160	1.00
121_A	126_Y	1.159	1.00
292_A	305_G	1.155	1.00
180_F	203_S	1.151	1.00
214_L	258_L	1.143	1.00
192_T	196_H	1.140	1.00
78_D	81_S	1.138	1.00
276_V	325_Y	1.132	1.00
151_G	322_G	1.124	1.00
79_T	82_L	1.120	1.00
311_A	319_K	1.118	1.00
281_T	324_R	1.111	1.00
276_V	324_R	1.105	1.00
296_R	302_F	1.101	1.00
315_Y	319_K	1.099	1.00
154_L	259_Y	1.095	1.00
283_K	291_T	1.094	1.00
222_V	271_V	1.085	1.00
156_I	253_W	1.078	0.99
184_R	199_L	1.076	0.99
284_R	324_R	1.075	0.99
223_A	269_I	1.069	0.99
211_R	261_Q	1.067	0.99
179_E	183_V	1.062	0.99
234_A	321_I	1.059	0.99
149_V	326_V	1.051	0.99
183_V	199_L	1.048	0.99
180_F	199_L	1.043	0.99
187_L	199_L	1.033	0.99
90_R	97_D	1.033	0.99
207_L	211_R	1.018	0.99
23_E	31_A	1.016	0.99
158_N	167_F	1.014	0.99
107_L	112_W	1.012	0.99
265_K	268_A	0.999	0.99
77_D	81_S	0.998	0.99
29_Q	33_L	0.996	0.99
180_F	206_E	0.993	0.99
237_D	278_A	0.987	0.99
37_Q	118_T	0.982	0.99
222_V	233_I	0.978	0.99
29_Q	78_D	0.974	0.99
300_N	312_N	0.973	0.99
150_L	233_I	0.969	0.99
242_R	247_A	0.967	0.99
18_D	21_R	0.967	0.99
42_I	45_C	0.965	0.99
290_F	306_K	0.965	0.99
266_A	271_V	0.963	0.99
10_S	14_P	0.957	0.99
44_G	47_E	0.957	0.99
167_F	315_Y	0.954	0.99
88_R	97_D	0.952	0.99
181_E	185_A	0.947	0.99
32_I	36_H	0.944	0.99
64_T	67_Y	0.937	0.99
286_A	309_A	0.932	0.98
311_A	315_Y	0.932	0.98
260_E	263_A	0.930	0.98
149_V	234_A	0.920	0.98
278_A	281_T	0.918	0.98
198_T	201_Q	0.917	0.98
118_T	129_H	0.914	0.98
26_L	31_A	0.910	0.98
91_C	119_L	0.909	0.98
10_S	13_Q	0.907	0.98
85_T	88_R	0.905	0.98
35_T	39_A	0.905	0.98
232_V	272_S	0.903	0.98
182_K	186_G	0.901	0.98
214_L	254_A	0.899	0.98
220_A	229_N	0.899	0.98
191_G	194_S	0.897	0.98
112_W	132_F	0.896	0.98
256_R	260_E	0.894	0.98
184_R	203_S	0.893	0.98
26_L	29_Q	0.887	0.98
12_V	16_A	0.883	0.98
316_N	320_N	0.879	0.98
38_A	42_I	0.878	0.98
170_G	253_W	0.875	0.98
214_L	218_S	0.873	0.98
299_R	313_A	0.870	0.98
286_A	323_L	0.870	0.98
166_T	220_A	0.867	0.98
116_E	131_G	0.866	0.98
181_E	184_R	0.855	0.97
160_A	168_L	0.847	0.97
295_N	313_A	0.843	0.97
160_A	217_A	0.839	0.97
119_L	128_L	0.837	0.97
286_A	317_A	0.837	0.97
77_D	80_V	0.835	0.97
33_L	37_Q	0.833	0.97
183_V	198_T	0.833	0.97
301_D	311_A	0.833	0.97
205_R	209_Y	0.832	0.97
234_A	274_T	0.831	0.97
102_Y	105_Q	0.827	0.97
280_Y	324_R	0.827	0.97
187_L	195_A	0.827	0.97
283_K	292_A	0.824	0.97
29_Q	32_I	0.817	0.97
150_L	230_C	0.816	0.97
294_E	299_R	0.809	0.96
158_N	169_S	0.806	0.96
327_R	330_Q	0.804	0.96
202_S	206_E	0.802	0.96
42_I	46_L	0.801	0.96
148_T	231_D	0.800	0.96
284_R	320_N	0.798	0.96
324_R	328_R	0.797	0.96
297_P	300_N	0.792	0.96
186_G	189_Q	0.787	0.96
296_R	300_N	0.786	0.96
156_I	249_W	0.786	0.96
221_I	233_I	0.785	0.96
81_S	90_R	0.784	0.96
100_D	105_Q	0.781	0.96
213_V	217_A	0.780	0.96
67_Y	70_R	0.779	0.95
274_T	325_Y	0.778	0.95
287_E	319_K	0.776	0.95
125_D	208_R	0.769	0.95
217_A	220_A	0.769	0.95
219_N	265_K	0.769	0.95
317_A	320_N	0.767	0.95
76_D	80_V	0.766	0.95
154_L	160_A	0.766	0.95
232_V	274_T	0.764	0.95
35_T	38_A	0.764	0.95
157_E	161_V	0.762	0.95
57_K	60_F	0.760	0.95
259_Y	263_A	0.760	0.95
242_R	245_T	0.756	0.95
168_L	217_A	0.755	0.95
193_R	197_R	0.755	0.95
80_V	84_T	0.753	0.95
143_T	146_D	0.753	0.95
326_V	330_Q	0.751	0.94
196_H	200_V	0.751	0.94
150_L	163_S	0.749	0.94
246_R	250_G	0.749	0.94
291_T	295_N	0.748	0.94
145_E	148_T	0.747	0.94
315_Y	318_A	0.741	0.94
94_A	97_D	0.740	0.94
31_A	34_A	0.739	0.94
12_V	15_L	0.733	0.94
45_C	58_P	0.731	0.94
168_L	213_V	0.728	0.94
13_Q	36_H	0.726	0.93
136_K	267_E	0.725	0.93
34_A	38_A	0.723	0.93
76_D	79_T	0.722	0.93
17_Y	31_A	0.722	0.93
185_A	188_Q	0.720	0.93
29_Q	76_D	0.720	0.93
80_V	83_S	0.717	0.93
102_Y	106_Y	0.715	0.93
70_R	73_T	0.711	0.93
174_T	177_L	0.709	0.93
237_D	259_Y	0.708	0.93
294_E	302_F	0.707	0.93
302_F	313_A	0.706	0.92
100_D	103_Q	0.705	0.92
153_D	314_D	0.704	0.92
180_F	184_R	0.704	0.92
264_Y	268_A	0.702	0.92
240_H	244_R	0.702	0.92
174_T	248_S	0.701	0.92
168_L	220_A	0.697	0.92
14_P	35_T	0.697	0.92
48_R	56_S	0.696	0.92
159_L	253_W	0.693	0.92
238_L	278_A	0.693	0.92
13_Q	32_I	0.693	0.92
176_D	180_F	0.692	0.92
319_K	322_G	0.691	0.92
177_L	181_E	0.686	0.91
192_T	199_L	0.686	0.91
234_A	322_G	0.685	0.91
282_S	295_N	0.684	0.91
262_V	273_V	0.681	0.91
208_R	212_D	0.680	0.91
155_G	161_V	0.680	0.91
181_E	188_Q	0.673	0.91
68_D	72_M	0.672	0.91
234_A	324_R	0.672	0.91
326_V	329_G	0.671	0.90
45_C	48_R	0.669	0.90
247_A	251_H	0.668	0.90
160_A	258_L	0.668	0.90
148_T	164_T	0.666	0.90
240_H	278_A	0.665	0.90
240_H	243_N	0.664	0.90
173_L	177_L	0.664	0.90
325_Y	329_G	0.663	0.90
280_Y	284_R	0.662	0.90
241_I	250_G	0.662	0.90
187_L	192_T	0.662	0.90
238_L	241_I	0.661	0.90
230_C	271_V	0.660	0.90
299_R	302_F	0.657	0.90
211_R	215_H	0.656	0.89
143_T	271_V	0.655	0.89
245_T	251_H	0.653	0.89
76_D	81_S	0.653	0.89
174_T	249_W	0.649	0.89
206_E	252_K	0.648	0.89
67_Y	74_L	0.646	0.89
292_A	299_R	0.646	0.89
148_T	230_C	0.645	0.89
57_K	61_T	0.643	0.89
223_A	232_V	0.643	0.89
284_R	289_G	0.640	0.88
83_S	90_R	0.635	0.88
147_G	231_D	0.634	0.88
277_G	280_Y	0.632	0.88
185_A	189_Q	0.625	0.87
299_R	312_N	0.624	0.87
196_H	199_L	0.622	0.87
186_G	195_A	0.621	0.87
157_E	300_N	0.620	0.87
84_T	87_S	0.619	0.87
208_R	211_R	0.618	0.86
31_A	35_T	0.614	0.86
100_D	104_R	0.612	0.86
151_G	318_A	0.611	0.86
103_Q	106_Y	0.611	0.86
280_Y	291_T	0.611	0.86
34_A	37_Q	0.610	0.86
180_F	188_Q	0.605	0.85
176_D	205_R	0.603	0.85
17_Y	21_R	0.602	0.85
192_T	195_A	0.600	0.85
103_Q	107_L	0.600	0.85
261_Q	265_K	0.600	0.85
188_Q	203_S	0.597	0.85
311_A	316_N	0.596	0.84
233_I	262_V	0.595	0.84
89_V	117_S	0.595	0.84
206_E	210_V	0.593	0.84
16_A	35_T	0.591	0.84
203_S	210_V	0.590	0.84
189_Q	195_A	0.589	0.84
79_T	92_P	0.587	0.84
10_S	15_L	0.582	0.83
57_K	63_P	0.580	0.83
10_S	35_T	0.580	0.83
321_I	324_R	0.579	0.83
108_D	112_W	0.578	0.83
30_H	72_M	0.576	0.82
183_V	187_L	0.573	0.82
173_L	176_D	0.570	0.82
29_Q	35_T	0.570	0.82
153_D	282_S	0.569	0.82
121_A	127_V	0.569	0.82
11_D	15_L	0.568	0.82
30_H	33_L	0.565	0.81
46_L	49_R	0.565	0.81
151_G	321_I	0.564	0.81
27_G	74_L	0.563	0.81
297_P	313_A	0.563	0.81
162_T	221_I	0.563	0.81
47_E	55_A	0.562	0.81
92_P	98_A	0.562	0.81
242_R	250_G	0.561	0.81
69_T	73_T	0.560	0.81
188_Q	199_L	0.559	0.81
216_R	219_N	0.558	0.80
254_A	257_T	0.558	0.80
32_I	35_T	0.558	0.80
136_K	268_A	0.557	0.80
173_L	248_S	0.557	0.80
139_T	143_T	0.556	0.80
282_S	296_R	0.556	0.80
246_R	249_W	0.553	0.80
241_I	244_R	0.552	0.80
64_T	70_R	0.552	0.80
323_L	326_V	0.550	0.79
159_L	218_S	0.546	0.79
83_S	86_E	0.545	0.79
210_V	252_K	0.544	0.79
240_H	250_G	0.543	0.79
279_A	283_K	0.541	0.78
182_K	185_A	0.540	0.78
122_R	207_L	0.540	0.78
176_D	202_S	0.538	0.78
27_G	95_L	0.537	0.78
13_Q	35_T	0.536	0.78
282_S	292_A	0.535	0.78
303_Q	306_K	0.535	0.78
284_R	293_D	0.534	0.77
73_T	118_T	0.533	0.77
312_N	317_A	0.530	0.77
127_V	204_G	0.526	0.76
155_G	158_N	0.525	0.76
115_T	131_G	0.525	0.76
82_L	92_P	0.524	0.76
295_N	302_F	0.524	0.76
266_A	269_I	0.523	0.76
46_L	58_P	0.522	0.76
309_A	316_N	0.521	0.76
101_G	106_Y	0.520	0.76
323_L	328_R	0.519	0.75
177_L	252_K	0.519	0.75
74_L	78_D	0.518	0.75
156_I	242_R	0.518	0.75
256_R	259_Y	0.516	0.75
70_R	121_A	0.515	0.75
217_A	258_L	0.515	0.75
275_Q	278_A	0.514	0.75
10_S	16_A	0.512	0.75
89_V	92_P	0.511	0.74
179_E	202_S	0.511	0.74
72_M	82_L	0.511	0.74
179_E	182_K	0.510	0.74
120_T	131_G	0.510	0.74
157_E	312_N	0.509	0.74
27_G	36_H	0.509	0.74
287_E	311_A	0.508	0.74
95_L	98_A	0.508	0.74
67_Y	73_T	0.507	0.74
244_R	251_H	0.506	0.74
164_T	230_C	0.506	0.74
41_A	58_P	0.506	0.74
91_C	117_S	0.505	0.74
203_S	207_L	0.504	0.73
68_D	71_T	0.501	0.73
276_V	279_A	0.501	0.73
36_H	40_Q	0.500	0.73
12_V	19_S	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nu0A	1	0.3386	96.5	0.916	Contact Map
1vhxA	2	0.3624	96.4	0.917	Contact Map
1iv0A	1	0.2513	95.7	0.921	Contact Map
4aybP	1	0.1138	86.8	0.94	Contact Map
1ffkW	1	0.1772	82.7	0.943	Contact Map
3j20Y	1	0.1323	80.6	0.944	Contact Map
2kdxA	1	0.2963	80.5	0.944	Contact Map
2k4xA	1	0.1455	80.4	0.944	Contact Map
1vq8Z	1	0.1852	80	0.945	Contact Map
1qypA	1	0.119	78.9	0.945	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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