GREMLIN Database
Q9HSZ6 - Uncharacterized protein
UniProt: Q9HSZ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 378 (301)
Sequences: 4478 (2827)
Seq/√Len: 162.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
212_D216_R5.2471.00
286_A316_N4.3611.00
266_A273_V3.6131.00
259_Y275_Q3.0741.00
234_A325_Y3.0601.00
235_F262_V2.9781.00
219_N223_A2.9431.00
159_L258_L2.8481.00
257_T261_Q2.8381.00
117_S128_L2.5231.00
242_R251_H2.4771.00
280_Y283_K2.4431.00
263_A275_Q2.3801.00
257_T260_E2.3661.00
276_V321_I2.3641.00
284_R291_T2.3361.00
222_V266_A2.3331.00
177_L248_S2.2781.00
324_R327_R2.2551.00
215_H261_Q2.2401.00
215_H264_Y2.2181.00
281_T321_I2.1371.00
258_L262_V2.0961.00
303_Q310_E2.0761.00
183_V195_A2.0591.00
115_T133_R2.0541.00
233_I266_A2.0431.00
176_D209_Y2.0291.00
283_K295_N2.0151.00
161_V167_F2.0031.00
235_F273_V1.9551.00
288_C307_C1.9151.00
283_K293_D1.9051.00
211_R257_T1.8861.00
263_A267_E1.8541.00
159_L213_V1.8531.00
11_D14_P1.8491.00
215_H218_S1.8431.00
215_H265_K1.8401.00
193_R196_H1.8231.00
195_A199_L1.8221.00
296_R299_R1.8031.00
218_S261_Q1.7941.00
288_C304_C1.7561.00
231_D271_V1.7191.00
214_L261_Q1.7101.00
37_Q73_T1.6941.00
152_V160_A1.6911.00
287_E309_A1.6571.00
300_N313_A1.6541.00
285_C304_C1.6251.00
285_C288_C1.6211.00
235_F275_Q1.5821.00
214_L257_T1.5691.00
302_F311_A1.5691.00
285_C307_C1.5461.00
235_F259_Y1.5341.00
304_C307_C1.5101.00
42_I57_K1.5001.00
292_A302_F1.4971.00
190_T193_R1.4951.00
39_A43_T1.4631.00
292_A295_N1.4621.00
296_R313_A1.4551.00
301_D310_E1.4501.00
183_V186_G1.4481.00
218_S265_K1.4471.00
236_E278_A1.4351.00
319_K323_L1.4291.00
295_N299_R1.4221.00
218_S264_Y1.4211.00
302_F309_A1.4161.00
290_F305_G1.4081.00
187_L196_H1.4011.00
125_D204_G1.3891.00
43_T47_E1.3871.00
158_N161_V1.3711.00
184_R188_Q1.3641.00
162_T166_T1.3421.00
13_Q17_Y1.3331.00
167_F312_N1.3301.00
244_R247_A1.3251.00
13_Q16_A1.3231.00
250_G255_F1.3191.00
161_V315_Y1.3141.00
204_G208_R1.3131.00
49_R55_A1.3081.00
48_R55_A1.3081.00
149_V322_G1.3031.00
237_D275_Q1.2991.00
150_L162_T1.2981.00
33_L36_H1.2931.00
123_D204_G1.2711.00
286_A311_A1.2631.00
44_G49_R1.2611.00
292_A296_R1.2561.00
154_L255_F1.2551.00
40_Q44_G1.2451.00
67_Y71_T1.2421.00
286_A319_K1.2401.00
183_V202_S1.2351.00
27_G30_H1.2321.00
263_A273_V1.2311.00
14_P17_Y1.2271.00
146_D231_D1.2231.00
44_G48_R1.2171.00
222_V269_I1.2161.00
89_V128_L1.2151.00
45_C57_K1.2151.00
176_D206_E1.2141.00
44_G55_A1.1951.00
239_T278_A1.1891.00
152_V162_T1.1851.00
60_F63_P1.1821.00
218_S258_L1.1761.00
120_T129_H1.1761.00
149_V232_V1.1751.00
218_S262_V1.1691.00
219_N269_I1.1641.00
261_Q264_Y1.1601.00
121_A126_Y1.1591.00
292_A305_G1.1551.00
180_F203_S1.1511.00
214_L258_L1.1431.00
192_T196_H1.1401.00
78_D81_S1.1381.00
276_V325_Y1.1321.00
151_G322_G1.1241.00
79_T82_L1.1201.00
311_A319_K1.1181.00
281_T324_R1.1111.00
276_V324_R1.1051.00
296_R302_F1.1011.00
315_Y319_K1.0991.00
154_L259_Y1.0951.00
283_K291_T1.0941.00
222_V271_V1.0851.00
156_I253_W1.0780.99
184_R199_L1.0760.99
284_R324_R1.0750.99
223_A269_I1.0690.99
211_R261_Q1.0670.99
179_E183_V1.0620.99
234_A321_I1.0590.99
149_V326_V1.0510.99
183_V199_L1.0480.99
180_F199_L1.0430.99
187_L199_L1.0330.99
90_R97_D1.0330.99
207_L211_R1.0180.99
23_E31_A1.0160.99
158_N167_F1.0140.99
107_L112_W1.0120.99
265_K268_A0.9990.99
77_D81_S0.9980.99
29_Q33_L0.9960.99
180_F206_E0.9930.99
237_D278_A0.9870.99
37_Q118_T0.9820.99
222_V233_I0.9780.99
29_Q78_D0.9740.99
300_N312_N0.9730.99
150_L233_I0.9690.99
242_R247_A0.9670.99
18_D21_R0.9670.99
42_I45_C0.9650.99
290_F306_K0.9650.99
266_A271_V0.9630.99
10_S14_P0.9570.99
44_G47_E0.9570.99
167_F315_Y0.9540.99
88_R97_D0.9520.99
181_E185_A0.9470.99
32_I36_H0.9440.99
64_T67_Y0.9370.99
286_A309_A0.9320.98
311_A315_Y0.9320.98
260_E263_A0.9300.98
149_V234_A0.9200.98
278_A281_T0.9180.98
198_T201_Q0.9170.98
118_T129_H0.9140.98
26_L31_A0.9100.98
91_C119_L0.9090.98
10_S13_Q0.9070.98
85_T88_R0.9050.98
35_T39_A0.9050.98
232_V272_S0.9030.98
182_K186_G0.9010.98
214_L254_A0.8990.98
220_A229_N0.8990.98
191_G194_S0.8970.98
112_W132_F0.8960.98
256_R260_E0.8940.98
184_R203_S0.8930.98
26_L29_Q0.8870.98
12_V16_A0.8830.98
316_N320_N0.8790.98
38_A42_I0.8780.98
170_G253_W0.8750.98
214_L218_S0.8730.98
299_R313_A0.8700.98
286_A323_L0.8700.98
166_T220_A0.8670.98
116_E131_G0.8660.98
181_E184_R0.8550.97
160_A168_L0.8470.97
295_N313_A0.8430.97
160_A217_A0.8390.97
119_L128_L0.8370.97
286_A317_A0.8370.97
77_D80_V0.8350.97
33_L37_Q0.8330.97
183_V198_T0.8330.97
301_D311_A0.8330.97
205_R209_Y0.8320.97
234_A274_T0.8310.97
102_Y105_Q0.8270.97
280_Y324_R0.8270.97
187_L195_A0.8270.97
283_K292_A0.8240.97
29_Q32_I0.8170.97
150_L230_C0.8160.97
294_E299_R0.8090.96
158_N169_S0.8060.96
327_R330_Q0.8040.96
202_S206_E0.8020.96
42_I46_L0.8010.96
148_T231_D0.8000.96
284_R320_N0.7980.96
324_R328_R0.7970.96
297_P300_N0.7920.96
186_G189_Q0.7870.96
296_R300_N0.7860.96
156_I249_W0.7860.96
221_I233_I0.7850.96
81_S90_R0.7840.96
100_D105_Q0.7810.96
213_V217_A0.7800.96
67_Y70_R0.7790.95
274_T325_Y0.7780.95
287_E319_K0.7760.95
125_D208_R0.7690.95
217_A220_A0.7690.95
219_N265_K0.7690.95
317_A320_N0.7670.95
76_D80_V0.7660.95
154_L160_A0.7660.95
232_V274_T0.7640.95
35_T38_A0.7640.95
157_E161_V0.7620.95
57_K60_F0.7600.95
259_Y263_A0.7600.95
242_R245_T0.7560.95
168_L217_A0.7550.95
193_R197_R0.7550.95
80_V84_T0.7530.95
143_T146_D0.7530.95
326_V330_Q0.7510.94
196_H200_V0.7510.94
150_L163_S0.7490.94
246_R250_G0.7490.94
291_T295_N0.7480.94
145_E148_T0.7470.94
315_Y318_A0.7410.94
94_A97_D0.7400.94
31_A34_A0.7390.94
12_V15_L0.7330.94
45_C58_P0.7310.94
168_L213_V0.7280.94
13_Q36_H0.7260.93
136_K267_E0.7250.93
34_A38_A0.7230.93
76_D79_T0.7220.93
17_Y31_A0.7220.93
185_A188_Q0.7200.93
29_Q76_D0.7200.93
80_V83_S0.7170.93
102_Y106_Y0.7150.93
70_R73_T0.7110.93
174_T177_L0.7090.93
237_D259_Y0.7080.93
294_E302_F0.7070.93
302_F313_A0.7060.92
100_D103_Q0.7050.92
153_D314_D0.7040.92
180_F184_R0.7040.92
264_Y268_A0.7020.92
240_H244_R0.7020.92
174_T248_S0.7010.92
168_L220_A0.6970.92
14_P35_T0.6970.92
48_R56_S0.6960.92
159_L253_W0.6930.92
238_L278_A0.6930.92
13_Q32_I0.6930.92
176_D180_F0.6920.92
319_K322_G0.6910.92
177_L181_E0.6860.91
192_T199_L0.6860.91
234_A322_G0.6850.91
282_S295_N0.6840.91
262_V273_V0.6810.91
208_R212_D0.6800.91
155_G161_V0.6800.91
181_E188_Q0.6730.91
68_D72_M0.6720.91
234_A324_R0.6720.91
326_V329_G0.6710.90
45_C48_R0.6690.90
247_A251_H0.6680.90
160_A258_L0.6680.90
148_T164_T0.6660.90
240_H278_A0.6650.90
240_H243_N0.6640.90
173_L177_L0.6640.90
325_Y329_G0.6630.90
280_Y284_R0.6620.90
241_I250_G0.6620.90
187_L192_T0.6620.90
238_L241_I0.6610.90
230_C271_V0.6600.90
299_R302_F0.6570.90
211_R215_H0.6560.89
143_T271_V0.6550.89
245_T251_H0.6530.89
76_D81_S0.6530.89
174_T249_W0.6490.89
206_E252_K0.6480.89
67_Y74_L0.6460.89
292_A299_R0.6460.89
148_T230_C0.6450.89
57_K61_T0.6430.89
223_A232_V0.6430.89
284_R289_G0.6400.88
83_S90_R0.6350.88
147_G231_D0.6340.88
277_G280_Y0.6320.88
185_A189_Q0.6250.87
299_R312_N0.6240.87
196_H199_L0.6220.87
186_G195_A0.6210.87
157_E300_N0.6200.87
84_T87_S0.6190.87
208_R211_R0.6180.86
31_A35_T0.6140.86
100_D104_R0.6120.86
151_G318_A0.6110.86
103_Q106_Y0.6110.86
280_Y291_T0.6110.86
34_A37_Q0.6100.86
180_F188_Q0.6050.85
176_D205_R0.6030.85
17_Y21_R0.6020.85
192_T195_A0.6000.85
103_Q107_L0.6000.85
261_Q265_K0.6000.85
188_Q203_S0.5970.85
311_A316_N0.5960.84
233_I262_V0.5950.84
89_V117_S0.5950.84
206_E210_V0.5930.84
16_A35_T0.5910.84
203_S210_V0.5900.84
189_Q195_A0.5890.84
79_T92_P0.5870.84
10_S15_L0.5820.83
57_K63_P0.5800.83
10_S35_T0.5800.83
321_I324_R0.5790.83
108_D112_W0.5780.83
30_H72_M0.5760.82
183_V187_L0.5730.82
173_L176_D0.5700.82
29_Q35_T0.5700.82
153_D282_S0.5690.82
121_A127_V0.5690.82
11_D15_L0.5680.82
30_H33_L0.5650.81
46_L49_R0.5650.81
151_G321_I0.5640.81
27_G74_L0.5630.81
297_P313_A0.5630.81
162_T221_I0.5630.81
47_E55_A0.5620.81
92_P98_A0.5620.81
242_R250_G0.5610.81
69_T73_T0.5600.81
188_Q199_L0.5590.81
216_R219_N0.5580.80
254_A257_T0.5580.80
32_I35_T0.5580.80
136_K268_A0.5570.80
173_L248_S0.5570.80
139_T143_T0.5560.80
282_S296_R0.5560.80
246_R249_W0.5530.80
241_I244_R0.5520.80
64_T70_R0.5520.80
323_L326_V0.5500.79
159_L218_S0.5460.79
83_S86_E0.5450.79
210_V252_K0.5440.79
240_H250_G0.5430.79
279_A283_K0.5410.78
182_K185_A0.5400.78
122_R207_L0.5400.78
176_D202_S0.5380.78
27_G95_L0.5370.78
13_Q35_T0.5360.78
282_S292_A0.5350.78
303_Q306_K0.5350.78
284_R293_D0.5340.77
73_T118_T0.5330.77
312_N317_A0.5300.77
127_V204_G0.5260.76
155_G158_N0.5250.76
115_T131_G0.5250.76
82_L92_P0.5240.76
295_N302_F0.5240.76
266_A269_I0.5230.76
46_L58_P0.5220.76
309_A316_N0.5210.76
101_G106_Y0.5200.76
323_L328_R0.5190.75
177_L252_K0.5190.75
74_L78_D0.5180.75
156_I242_R0.5180.75
256_R259_Y0.5160.75
70_R121_A0.5150.75
217_A258_L0.5150.75
275_Q278_A0.5140.75
10_S16_A0.5120.75
89_V92_P0.5110.74
179_E202_S0.5110.74
72_M82_L0.5110.74
179_E182_K0.5100.74
120_T131_G0.5100.74
157_E312_N0.5090.74
27_G36_H0.5090.74
287_E311_A0.5080.74
95_L98_A0.5080.74
67_Y73_T0.5070.74
244_R251_H0.5060.74
164_T230_C0.5060.74
41_A58_P0.5060.74
91_C117_S0.5050.74
203_S207_L0.5040.73
68_D71_T0.5010.73
276_V279_A0.5010.73
36_H40_Q0.5000.73
12_V19_S0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3386 96.5 0.916 Contact Map
1vhxA 2 0.3624 96.4 0.917 Contact Map
1iv0A 1 0.2513 95.7 0.921 Contact Map
4aybP 1 0.1138 86.8 0.94 Contact Map
1ffkW 1 0.1772 82.7 0.943 Contact Map
3j20Y 1 0.1323 80.6 0.944 Contact Map
2kdxA 1 0.2963 80.5 0.944 Contact Map
2k4xA 1 0.1455 80.4 0.944 Contact Map
1vq8Z 1 0.1852 80 0.945 Contact Map
1qypA 1 0.119 78.9 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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