GREMLIN Database
Q9HSZ3 - Uncharacterized protein
UniProt: Q9HSZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 123 (114)
Sequences: 123 (95)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_F36_A3.1820.93
21_V52_A2.8630.88
5_R8_F2.6220.83
3_I8_F2.5550.81
85_Y89_E2.3970.76
22_P48_V2.2720.72
62_G97_Q2.1870.69
52_A61_K2.1560.68
7_T69_K2.0700.65
21_V56_A2.0450.64
3_I36_A1.8990.58
80_E97_Q1.8230.54
54_S69_K1.8210.54
32_N80_E1.8140.54
93_A114_E1.7910.53
2_S45_Q1.7130.50
44_S47_G1.6840.48
39_A50_E1.6430.47
49_D52_A1.6370.46
32_N83_D1.6290.46
78_D81_R1.6220.46
19_L23_D1.6140.45
41_E107_W1.5780.44
5_R36_A1.5760.44
25_V56_A1.4740.40
2_S37_F1.4700.39
32_N105_E1.4630.39
76_T82_L1.4390.38
24_Q78_D1.4340.38
6_D83_D1.4070.37
33_K79_A1.4020.37
85_Y88_Y1.3880.36
24_Q34_D1.3880.36
5_R67_E1.3880.36
21_V48_V1.3700.35
53_V56_A1.3330.34
4_D7_T1.3230.34
61_K78_D1.3120.33
48_V52_A1.2940.32
37_F111_A1.2830.32
44_S52_A1.2560.31
5_R56_A1.2350.30
38_K54_S1.2320.30
32_N35_R1.2230.30
75_I84_G1.2160.30
70_A92_T1.2150.30
11_T101_A1.1960.29
38_K82_L1.1900.29
75_I91_A1.1710.28
67_E74_A1.1510.27
79_A84_G1.1150.26
2_S20_S1.1110.26
21_V107_W1.1010.26
49_D78_D1.0860.25
12_N105_E1.0840.25
37_F91_A1.0790.25
25_V53_V1.0770.25
34_D111_A1.0350.23
58_S61_K1.0310.23
3_I13_E1.0280.23
16_L65_L1.0020.22
6_D40_H0.9960.22
42_I102_E0.9760.22
65_L74_A0.9750.22
18_D103_D0.9660.21
54_S99_L0.9580.21
15_E102_E0.9430.21
53_V92_T0.9420.21
2_S38_K0.9420.21
47_G109_E0.8920.19
37_F41_E0.8770.19
43_A81_R0.8700.19
5_R51_G0.8690.19
103_D109_E0.8680.19
16_L20_S0.8610.19
83_D108_R0.8580.18
34_D84_G0.8560.18
22_P97_Q0.8460.18
52_A56_A0.8430.18
7_T96_N0.8410.18
15_E27_G0.8370.18
56_A112_P0.8290.18
99_L102_E0.8260.18
17_A47_G0.8060.17
52_A55_T0.8030.17
88_Y91_A0.8020.17
107_W111_A0.7980.17
62_G106_S0.7890.17
13_E99_L0.7860.17
4_D74_A0.7840.17
26_L86_S0.7840.17
17_A34_D0.7820.17
20_S56_A0.7740.16
53_V74_A0.7650.16
48_V101_A0.7630.16
1_M113_E0.7610.16
35_R90_R0.7600.16
48_V98_Q0.7560.16
50_E104_K0.7560.16
64_N113_E0.7520.16
43_A103_D0.7420.16
5_R23_D0.7380.16
39_A52_A0.7370.16
99_L109_E0.7360.15
37_F85_Y0.7310.15
20_S81_R0.7300.15
75_I106_S0.7190.15
26_L53_V0.7180.15
8_F25_V0.7170.15
17_A30_A0.7160.15
65_L76_T0.7090.15
5_R9_E0.7040.15
27_G80_E0.6960.15
51_G79_A0.6950.15
39_A51_G0.6940.15
19_L95_F0.6930.15
37_F82_L0.6910.15
46_I92_T0.6910.15
33_K51_G0.6900.14
42_I68_H0.6890.14
53_V63_R0.6820.14
5_R100_G0.6790.14
26_L75_I0.6710.14
28_F68_H0.6650.14
36_A69_K0.6600.14
51_G67_E0.6520.14
23_D69_K0.6440.14
64_N101_A0.6280.13
58_S97_Q0.6270.13
34_D106_S0.6240.13
55_T112_P0.6220.13
58_S103_D0.6220.13
10_N23_D0.6210.13
22_P40_H0.6210.13
54_S61_K0.6200.13
28_F63_R0.6110.13
83_D101_A0.6100.13
14_D83_D0.6070.13
33_K52_A0.6060.13
20_S94_L0.6050.13
4_D98_Q0.6040.13
51_G87_G0.6030.13
40_H89_E0.6020.13
13_E37_F0.5950.13
19_L96_N0.5890.12
83_D99_L0.5790.12
103_D106_S0.5770.12
65_L78_D0.5750.12
47_G105_E0.5710.12
74_A78_D0.5660.12
20_S30_A0.5640.12
56_A102_E0.5560.12
60_L68_H0.5550.12
27_G99_L0.5480.12
39_A61_K0.5470.12
19_L25_V0.5430.12
31_A56_A0.5390.12
3_I46_I0.5350.11
36_A56_A0.5350.11
46_I52_A0.5320.11
14_D51_G0.5290.11
9_E46_I0.5280.11
45_Q82_L0.5230.11
45_Q92_T0.5210.11
6_D9_E0.5210.11
10_N106_S0.5180.11
44_S64_N0.5160.11
51_G107_W0.5130.11
25_V42_I0.5120.11
35_R82_L0.5020.11
61_K115_P0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lnbA 1 0.6423 98.6 0.783 Contact Map
1qgpA 1 0.5854 98.1 0.813 Contact Map
1q1hA 1 0.6341 98 0.821 Contact Map
3u1dA 2 0.9675 97.8 0.826 Contact Map
2mlgA 1 0.626 97.7 0.83 Contact Map
1xmkA 1 0.6016 97.7 0.83 Contact Map
2heoA 1 0.4715 97.7 0.832 Contact Map
3pqkA 2 0.7317 97.7 0.833 Contact Map
1qbjA 1 0.4959 97.6 0.835 Contact Map
1oyiA 1 0.4797 97.6 0.835 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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