GREMLIN Database
Q9HSY4 - Uncharacterized protein
UniProt: Q9HSY4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 307 (242)
Sequences: 3986 (2437)
Seq/√Len: 156.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_D145_Q4.7231.00
215_A245_N3.7251.00
195_A202_V3.2791.00
188_Y204_Q2.8381.00
163_A254_Y2.8231.00
164_F191_V2.7871.00
88_L187_L2.7051.00
186_T190_Q2.6501.00
148_N152_D2.3871.00
106_L177_S2.3521.00
46_S57_L2.3041.00
253_R256_R2.2851.00
186_T189_E2.2351.00
225_R228_R2.1741.00
212_Q224_N2.1101.00
105_D138_Y2.1001.00
213_R220_T2.0991.00
144_H193_Y2.0981.00
151_V195_A2.0751.00
144_H190_Q2.0591.00
205_V250_I2.0301.00
44_T62_R1.9911.00
209_Y212_Q1.9861.00
192_A204_Q1.9781.00
88_L142_V1.9781.00
112_V124_A1.9501.00
162_I195_A1.8981.00
169_H172_E1.8931.00
232_Q239_E1.8861.00
210_T250_I1.8511.00
144_H147_S1.8181.00
212_Q222_D1.8151.00
144_H194_K1.7981.00
164_F202_V1.7861.00
147_S190_Q1.7781.00
187_L191_V1.7771.00
90_V96_F1.7611.00
124_A128_L1.7521.00
169_H173_R1.7401.00
81_V89_A1.7111.00
160_D200_I1.7071.00
216_E238_A1.7041.00
140_R186_T1.6781.00
18_V57_L1.6421.00
173_R176_A1.6151.00
143_L186_T1.5891.00
87_N90_V1.5841.00
221_A224_N1.5771.00
143_L190_Q1.5501.00
192_A196_E1.5131.00
229_N242_A1.5021.00
164_F204_Q1.4911.00
122_R125_H1.4901.00
217_C236_C1.4811.00
164_F188_Y1.4771.00
217_C233_C1.4521.00
248_K252_L1.4391.00
119_T122_R1.4361.00
225_R242_A1.4331.00
221_A231_F1.4111.00
52_D133_G1.4031.00
147_S193_Y1.3991.00
231_F240_A1.3981.00
78_V251_G1.3941.00
179_G184_F1.3831.00
54_E133_G1.3771.00
214_C217_C1.3651.00
214_C233_C1.3601.00
147_S194_K1.3591.00
112_V115_G1.3561.00
231_F238_A1.3521.00
168_T207_S1.3521.00
90_V244_Y1.3451.00
170_I173_R1.3451.00
166_D204_Q1.3371.00
116_L125_H1.3311.00
112_V131_S1.3021.00
91_T95_Y1.3021.00
165_E207_S1.2941.00
133_G137_R1.2831.00
49_T58_H1.2811.00
153_E159_C1.2701.00
230_D239_E1.2621.00
215_A248_K1.2411.00
113_R117_Q1.2371.00
233_C236_C1.2351.00
221_A234_G1.2341.00
172_E175_G1.2271.00
214_C236_C1.2171.00
149_A153_E1.2121.00
224_N228_R1.2081.00
105_D135_E1.1971.00
148_N198_E1.1871.00
81_V91_T1.1561.00
87_N96_F1.1471.00
108_E112_V1.1451.00
83_L184_F1.1381.00
151_V198_E1.1381.00
219_F234_G1.1351.00
258_G261_S1.1231.00
151_V162_I1.1151.00
147_S187_L1.0920.99
140_R190_Q1.0900.99
96_F244_Y1.0890.99
147_S191_V1.0860.99
190_Q193_Y1.0800.99
85_I182_W1.0720.99
109_F132_S1.0590.99
112_V128_L1.0530.99
50_A55_Y1.0530.99
210_T253_R1.0500.99
195_A200_I1.0490.99
207_S210_T1.0400.99
205_V253_R1.0370.99
31_Y34_Q1.0350.99
96_F241_N1.0240.99
170_I180_H1.0220.99
240_A248_K1.0110.99
215_A240_A1.0060.99
79_L91_T0.9990.99
152_D198_E0.9970.99
143_L187_L0.9960.99
219_F235_K0.9960.99
121_T125_H0.9930.99
8_T21_D0.9920.99
113_R128_L0.9880.99
116_L124_A0.9860.99
169_H175_G0.9800.99
113_R132_S0.9770.99
192_A202_V0.9720.99
163_A250_I0.9710.99
83_L188_Y0.9650.99
12_S15_E0.9610.99
170_I174_T0.9590.99
95_Y149_A0.9560.99
75_D160_D0.9540.99
80_G251_G0.9540.99
226_P229_N0.9540.99
47_T58_H0.9520.99
134_R138_Y0.9460.98
244_Y248_K0.9460.98
212_Q220_T0.9420.98
213_R253_R0.9380.98
14_T17_R0.9380.98
78_V255_V0.9340.98
109_F128_L0.9320.98
209_Y253_R0.9300.98
29_D32_Q0.9180.98
166_D188_Y0.9180.98
240_A244_Y0.9160.98
109_F135_E0.9150.98
166_D207_S0.9130.98
112_V127_T0.9050.98
169_H174_T0.8980.98
9_V21_D0.8890.98
116_L128_L0.8870.98
18_V46_S0.8850.98
12_S19_R0.8780.97
225_R229_N0.8760.97
120_G123_S0.8750.97
221_A225_R0.8660.97
194_K197_A0.8630.97
20_C48_L0.8600.97
125_H129_E0.8470.97
78_V161_I0.8440.97
136_L140_R0.8430.97
54_E137_R0.8280.96
72_T75_D0.8280.96
168_T172_E0.8270.96
115_G118_Q0.8240.96
19_R26_D0.8190.96
36_L41_W0.8170.96
151_V200_I0.8160.96
48_L57_L0.8160.96
121_T124_A0.8140.96
143_L183_A0.8100.96
169_H176_A0.8100.96
148_N194_K0.8040.96
10_S19_R0.7970.96
77_T93_T0.7940.95
230_D240_A0.7930.95
27_A32_Q0.7920.95
78_V163_A0.7890.95
97_F149_A0.7880.95
83_L89_A0.7870.95
142_V146_A0.7830.95
205_V254_Y0.7810.95
45_E60_G0.7800.95
224_N242_A0.7790.95
102_L106_L0.7780.95
20_C23_A0.7760.95
122_R126_R0.7760.95
152_D161_I0.7760.95
143_L147_S0.7750.95
215_A252_L0.7740.95
255_V259_Q0.7720.95
84_G90_V0.7690.95
228_R242_A0.7680.95
85_I178_W0.7670.95
215_A246_A0.7640.94
163_A203_K0.7630.94
89_A146_A0.7560.94
189_E192_A0.7520.94
99_G182_W0.7510.94
80_G247_A0.7510.94
229_N241_N0.7490.94
163_A251_G0.7490.94
8_T11_L0.7460.94
103_A178_W0.7450.94
211_S225_R0.7410.93
188_Y192_A0.7360.93
212_Q221_A0.7340.93
253_R257_R0.7330.93
117_Q128_L0.7330.93
89_A97_F0.7310.93
256_R259_Q0.7300.93
185_R189_E0.7290.93
79_L92_S0.7250.93
77_T160_D0.7240.93
248_K251_G0.7220.93
87_N98_S0.7210.93
79_L159_C0.7180.92
150_I162_I0.7150.92
135_E181_K0.7150.92
216_E248_K0.7140.92
203_K254_Y0.7120.92
111_K115_G0.7110.92
215_A238_A0.7100.92
245_N249_N0.7090.92
16_S19_R0.7070.92
32_Q35_Y0.7060.92
41_W61_F0.7040.92
86_E90_V0.7030.92
109_F113_R0.7000.91
31_Y35_Y0.7000.91
102_L105_D0.6990.91
257_R261_S0.6970.91
193_Y197_A0.6960.91
174_T180_H0.6930.91
114_A117_Q0.6890.91
56_F133_G0.6890.91
176_A180_H0.6820.90
223_E231_F0.6810.90
29_D34_Q0.6800.90
162_I191_V0.6800.90
29_D36_L0.6780.90
96_F99_G0.6780.90
105_D109_F0.6760.90
146_A149_A0.6730.90
110_E113_R0.6700.89
81_V150_I0.6700.89
29_D33_R0.6690.89
20_C46_S0.6630.89
209_Y220_T0.6630.89
79_L162_I0.6620.89
147_S150_I0.6600.89
213_R249_N0.6600.89
50_A56_F0.6580.89
221_A228_R0.6570.89
132_S139_V0.6550.88
226_P242_A0.6530.88
88_L182_W0.6510.88
244_Y247_A0.6500.88
105_D108_E0.6480.88
254_Y258_G0.6480.88
28_D31_Y0.6470.88
161_I201_S0.6450.88
115_G127_T0.6430.88
190_Q194_K0.6430.88
97_F142_V0.6400.87
31_Y59_I0.6380.87
103_A106_L0.6350.87
137_R140_R0.6330.87
223_E228_R0.6320.87
116_L121_T0.6290.86
110_E117_Q0.6280.86
32_Q36_L0.6260.86
110_E114_A0.6250.86
220_T224_N0.6150.85
105_D131_S0.6150.85
115_G124_A0.6150.85
89_A187_L0.6140.85
27_A31_Y0.6090.85
82_D243_D0.6090.85
97_F146_A0.6050.84
167_L207_S0.6020.84
77_T159_C0.6020.84
172_E179_G0.6010.84
44_T60_G0.6010.84
250_I253_R0.5990.84
125_H128_L0.5990.84
108_E131_S0.5960.83
72_T200_I0.5950.83
139_V181_K0.5940.83
42_S62_R0.5930.83
255_V258_G0.5930.83
114_A118_Q0.5920.83
148_N190_Q0.5900.83
37_D41_W0.5880.82
65_K197_A0.5880.82
232_Q240_A0.5840.82
24_L27_A0.5830.82
252_L257_R0.5820.82
104_H107_R0.5820.82
171_R180_H0.5810.82
49_T60_G0.5810.82
92_S244_Y0.5810.82
127_T130_Q0.5790.81
91_T150_I0.5780.81
88_L143_L0.5780.81
207_S253_R0.5710.81
231_F242_A0.5710.81
211_S224_N0.5700.80
109_F117_Q0.5700.80
238_A244_Y0.5680.80
172_E176_A0.5660.80
105_D134_R0.5640.80
21_D27_A0.5640.80
218_G249_N0.5640.80
88_L147_S0.5630.80
9_V12_S0.5620.80
31_Y36_L0.5610.79
225_R231_F0.5610.79
103_A177_S0.5590.79
216_E240_A0.5570.79
137_R141_D0.5560.79
246_A249_N0.5550.79
232_Q235_K0.5550.79
86_E241_N0.5540.79
212_Q225_R0.5530.78
89_A164_F0.5520.78
213_R252_L0.5500.78
166_D210_T0.5470.78
102_L177_S0.5470.78
76_G160_D0.5460.78
117_Q124_A0.5430.77
137_R145_Q0.5420.77
210_T213_R0.5400.77
153_E160_D0.5340.76
195_A198_E0.5310.76
213_R224_N0.5300.76
161_I203_K0.5260.75
140_R144_H0.5260.75
50_A53_G0.5260.75
206_G209_Y0.5260.75
238_A248_K0.5230.75
80_G163_A0.5230.75
135_E139_V0.5220.74
84_G99_G0.5210.74
88_L191_V0.5200.74
183_A186_T0.5190.74
93_T159_C0.5180.74
74_E77_T0.5140.73
32_Q44_T0.5120.73
17_R26_D0.5080.72
112_V116_L0.5060.72
240_A245_N0.5050.72
9_V46_S0.5040.72
219_F222_D0.5040.72
68_T72_T0.5020.72
171_R174_T0.5010.71
121_T128_L0.5000.71
238_A245_N0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 0.4397 95.9 0.908 Contact Map
1nu0A 1 0.4169 95.7 0.91 Contact Map
1iv0A 1 0.3094 94.3 0.917 Contact Map
1ffkW 1 0.2215 87.6 0.93 Contact Map
4aybP 1 0.1401 86.4 0.931 Contact Map
1vq8Z 1 0.2378 83.3 0.934 Contact Map
3j20Y 1 0.1629 82.7 0.934 Contact Map
1vd4A 1 0.1824 80.8 0.936 Contact Map
1qypA 1 0.1466 80.1 0.936 Contact Map
2k4xA 1 0.1792 78.4 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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