Q9HSY4 - HALSA - GREMLIN Contacts

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Q9HSY4 - Uncharacterized protein

UniProt:	Q9HSY4	Sequences: MTLFDDDTVSLSTTESRVRCDLALPDADDSYQRQYLDSVEWSVTESTLTARDGEYFLHIGFRRSKTDTERNTAEDGTVLGVDLGIENLAVTSTAYFFSGRELAHDLREFEKVRAGLQQTGTRSAHRTLEQSSGRELRYVRDVLHQASNAIVDEALRYECDIIAFEDLTHIRERTGASWGHKWAFRTLYEQVAYKAEAEGISVKQVGSAYTSQRCAECGFTADENRPTRNDFQCGKCGAEANADYNAAKNIGLRYVRRGQQSSRRTGNSQLALQSGTVTPSDGFTAHPEGFEAEFMDKPHPPRARQRE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	307 (242)
Sequences:	3986 (2437)
Seq/√Len:	156.7

ECOLI - INSQ
HALSA - Q9HSY4 Q9HSZ6 Q9HSW9 Q9HSD4 Q9HHU6 Q9HHJ9 Q9HSW7 Q9HM87 Q9HHX8 Q9HHG8
SULSO - Q97XQ8 Q97YI2 Q97XA4 Q97Y67 Q97X39 Q97WZ3 Q97V47 Q97V53 Q7LXD9 Q97V25 Q97Y44 Q97XP1 Q97YU1 Q97WY6 Q97YW4 Q7LXH2 Q97YI5 Q97U68 Q97UQ8 Q97XQ0 Q97Z61 Q97U51 Q7LXH6 Q97Y48 Q97XB6 Q97YW9 Q97YF7 Q97U09 Q7LX59 Q97YK6 Y2105 Q97YH4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
141_D	145_Q	4.723	1.00
215_A	245_N	3.725	1.00
195_A	202_V	3.279	1.00
188_Y	204_Q	2.838	1.00
163_A	254_Y	2.823	1.00
164_F	191_V	2.787	1.00
88_L	187_L	2.705	1.00
186_T	190_Q	2.650	1.00
148_N	152_D	2.387	1.00
106_L	177_S	2.352	1.00
46_S	57_L	2.304	1.00
253_R	256_R	2.285	1.00
186_T	189_E	2.235	1.00
225_R	228_R	2.174	1.00
212_Q	224_N	2.110	1.00
105_D	138_Y	2.100	1.00
213_R	220_T	2.099	1.00
144_H	193_Y	2.098	1.00
151_V	195_A	2.075	1.00
144_H	190_Q	2.059	1.00
205_V	250_I	2.030	1.00
44_T	62_R	1.991	1.00
209_Y	212_Q	1.986	1.00
192_A	204_Q	1.978	1.00
88_L	142_V	1.978	1.00
112_V	124_A	1.950	1.00
162_I	195_A	1.898	1.00
169_H	172_E	1.893	1.00
232_Q	239_E	1.886	1.00
210_T	250_I	1.851	1.00
144_H	147_S	1.818	1.00
212_Q	222_D	1.815	1.00
144_H	194_K	1.798	1.00
164_F	202_V	1.786	1.00
147_S	190_Q	1.778	1.00
187_L	191_V	1.777	1.00
90_V	96_F	1.761	1.00
124_A	128_L	1.752	1.00
169_H	173_R	1.740	1.00
81_V	89_A	1.711	1.00
160_D	200_I	1.707	1.00
216_E	238_A	1.704	1.00
140_R	186_T	1.678	1.00
18_V	57_L	1.642	1.00
173_R	176_A	1.615	1.00
143_L	186_T	1.589	1.00
87_N	90_V	1.584	1.00
221_A	224_N	1.577	1.00
143_L	190_Q	1.550	1.00
192_A	196_E	1.513	1.00
229_N	242_A	1.502	1.00
164_F	204_Q	1.491	1.00
122_R	125_H	1.490	1.00
217_C	236_C	1.481	1.00
164_F	188_Y	1.477	1.00
217_C	233_C	1.452	1.00
248_K	252_L	1.439	1.00
119_T	122_R	1.436	1.00
225_R	242_A	1.433	1.00
221_A	231_F	1.411	1.00
52_D	133_G	1.403	1.00
147_S	193_Y	1.399	1.00
231_F	240_A	1.398	1.00
78_V	251_G	1.394	1.00
179_G	184_F	1.383	1.00
54_E	133_G	1.377	1.00
214_C	217_C	1.365	1.00
214_C	233_C	1.360	1.00
147_S	194_K	1.359	1.00
112_V	115_G	1.356	1.00
231_F	238_A	1.352	1.00
168_T	207_S	1.352	1.00
90_V	244_Y	1.345	1.00
170_I	173_R	1.345	1.00
166_D	204_Q	1.337	1.00
116_L	125_H	1.331	1.00
112_V	131_S	1.302	1.00
91_T	95_Y	1.302	1.00
165_E	207_S	1.294	1.00
133_G	137_R	1.283	1.00
49_T	58_H	1.281	1.00
153_E	159_C	1.270	1.00
230_D	239_E	1.262	1.00
215_A	248_K	1.241	1.00
113_R	117_Q	1.237	1.00
233_C	236_C	1.235	1.00
221_A	234_G	1.234	1.00
172_E	175_G	1.227	1.00
214_C	236_C	1.217	1.00
149_A	153_E	1.212	1.00
224_N	228_R	1.208	1.00
105_D	135_E	1.197	1.00
148_N	198_E	1.187	1.00
81_V	91_T	1.156	1.00
87_N	96_F	1.147	1.00
108_E	112_V	1.145	1.00
83_L	184_F	1.138	1.00
151_V	198_E	1.138	1.00
219_F	234_G	1.135	1.00
258_G	261_S	1.123	1.00
151_V	162_I	1.115	1.00
147_S	187_L	1.092	0.99
140_R	190_Q	1.090	0.99
96_F	244_Y	1.089	0.99
147_S	191_V	1.086	0.99
190_Q	193_Y	1.080	0.99
85_I	182_W	1.072	0.99
109_F	132_S	1.059	0.99
112_V	128_L	1.053	0.99
50_A	55_Y	1.053	0.99
210_T	253_R	1.050	0.99
195_A	200_I	1.049	0.99
207_S	210_T	1.040	0.99
205_V	253_R	1.037	0.99
31_Y	34_Q	1.035	0.99
96_F	241_N	1.024	0.99
170_I	180_H	1.022	0.99
240_A	248_K	1.011	0.99
215_A	240_A	1.006	0.99
79_L	91_T	0.999	0.99
152_D	198_E	0.997	0.99
143_L	187_L	0.996	0.99
219_F	235_K	0.996	0.99
121_T	125_H	0.993	0.99
8_T	21_D	0.992	0.99
113_R	128_L	0.988	0.99
116_L	124_A	0.986	0.99
169_H	175_G	0.980	0.99
113_R	132_S	0.977	0.99
192_A	202_V	0.972	0.99
163_A	250_I	0.971	0.99
83_L	188_Y	0.965	0.99
12_S	15_E	0.961	0.99
170_I	174_T	0.959	0.99
95_Y	149_A	0.956	0.99
75_D	160_D	0.954	0.99
80_G	251_G	0.954	0.99
226_P	229_N	0.954	0.99
47_T	58_H	0.952	0.99
134_R	138_Y	0.946	0.98
244_Y	248_K	0.946	0.98
212_Q	220_T	0.942	0.98
213_R	253_R	0.938	0.98
14_T	17_R	0.938	0.98
78_V	255_V	0.934	0.98
109_F	128_L	0.932	0.98
209_Y	253_R	0.930	0.98
29_D	32_Q	0.918	0.98
166_D	188_Y	0.918	0.98
240_A	244_Y	0.916	0.98
109_F	135_E	0.915	0.98
166_D	207_S	0.913	0.98
112_V	127_T	0.905	0.98
169_H	174_T	0.898	0.98
9_V	21_D	0.889	0.98
116_L	128_L	0.887	0.98
18_V	46_S	0.885	0.98
12_S	19_R	0.878	0.97
225_R	229_N	0.876	0.97
120_G	123_S	0.875	0.97
221_A	225_R	0.866	0.97
194_K	197_A	0.863	0.97
20_C	48_L	0.860	0.97
125_H	129_E	0.847	0.97
78_V	161_I	0.844	0.97
136_L	140_R	0.843	0.97
54_E	137_R	0.828	0.96
72_T	75_D	0.828	0.96
168_T	172_E	0.827	0.96
115_G	118_Q	0.824	0.96
19_R	26_D	0.819	0.96
36_L	41_W	0.817	0.96
151_V	200_I	0.816	0.96
48_L	57_L	0.816	0.96
121_T	124_A	0.814	0.96
143_L	183_A	0.810	0.96
169_H	176_A	0.810	0.96
148_N	194_K	0.804	0.96
10_S	19_R	0.797	0.96
77_T	93_T	0.794	0.95
230_D	240_A	0.793	0.95
27_A	32_Q	0.792	0.95
78_V	163_A	0.789	0.95
97_F	149_A	0.788	0.95
83_L	89_A	0.787	0.95
142_V	146_A	0.783	0.95
205_V	254_Y	0.781	0.95
45_E	60_G	0.780	0.95
224_N	242_A	0.779	0.95
102_L	106_L	0.778	0.95
20_C	23_A	0.776	0.95
122_R	126_R	0.776	0.95
152_D	161_I	0.776	0.95
143_L	147_S	0.775	0.95
215_A	252_L	0.774	0.95
255_V	259_Q	0.772	0.95
84_G	90_V	0.769	0.95
228_R	242_A	0.768	0.95
85_I	178_W	0.767	0.95
215_A	246_A	0.764	0.94
163_A	203_K	0.763	0.94
89_A	146_A	0.756	0.94
189_E	192_A	0.752	0.94
99_G	182_W	0.751	0.94
80_G	247_A	0.751	0.94
229_N	241_N	0.749	0.94
163_A	251_G	0.749	0.94
8_T	11_L	0.746	0.94
103_A	178_W	0.745	0.94
211_S	225_R	0.741	0.93
188_Y	192_A	0.736	0.93
212_Q	221_A	0.734	0.93
253_R	257_R	0.733	0.93
117_Q	128_L	0.733	0.93
89_A	97_F	0.731	0.93
256_R	259_Q	0.730	0.93
185_R	189_E	0.729	0.93
79_L	92_S	0.725	0.93
77_T	160_D	0.724	0.93
248_K	251_G	0.722	0.93
87_N	98_S	0.721	0.93
79_L	159_C	0.718	0.92
150_I	162_I	0.715	0.92
135_E	181_K	0.715	0.92
216_E	248_K	0.714	0.92
203_K	254_Y	0.712	0.92
111_K	115_G	0.711	0.92
215_A	238_A	0.710	0.92
245_N	249_N	0.709	0.92
16_S	19_R	0.707	0.92
32_Q	35_Y	0.706	0.92
41_W	61_F	0.704	0.92
86_E	90_V	0.703	0.92
109_F	113_R	0.700	0.91
31_Y	35_Y	0.700	0.91
102_L	105_D	0.699	0.91
257_R	261_S	0.697	0.91
193_Y	197_A	0.696	0.91
174_T	180_H	0.693	0.91
114_A	117_Q	0.689	0.91
56_F	133_G	0.689	0.91
176_A	180_H	0.682	0.90
223_E	231_F	0.681	0.90
29_D	34_Q	0.680	0.90
162_I	191_V	0.680	0.90
29_D	36_L	0.678	0.90
96_F	99_G	0.678	0.90
105_D	109_F	0.676	0.90
146_A	149_A	0.673	0.90
110_E	113_R	0.670	0.89
81_V	150_I	0.670	0.89
29_D	33_R	0.669	0.89
20_C	46_S	0.663	0.89
209_Y	220_T	0.663	0.89
79_L	162_I	0.662	0.89
147_S	150_I	0.660	0.89
213_R	249_N	0.660	0.89
50_A	56_F	0.658	0.89
221_A	228_R	0.657	0.89
132_S	139_V	0.655	0.88
226_P	242_A	0.653	0.88
88_L	182_W	0.651	0.88
244_Y	247_A	0.650	0.88
105_D	108_E	0.648	0.88
254_Y	258_G	0.648	0.88
28_D	31_Y	0.647	0.88
161_I	201_S	0.645	0.88
115_G	127_T	0.643	0.88
190_Q	194_K	0.643	0.88
97_F	142_V	0.640	0.87
31_Y	59_I	0.638	0.87
103_A	106_L	0.635	0.87
137_R	140_R	0.633	0.87
223_E	228_R	0.632	0.87
116_L	121_T	0.629	0.86
110_E	117_Q	0.628	0.86
32_Q	36_L	0.626	0.86
110_E	114_A	0.625	0.86
220_T	224_N	0.615	0.85
105_D	131_S	0.615	0.85
115_G	124_A	0.615	0.85
89_A	187_L	0.614	0.85
27_A	31_Y	0.609	0.85
82_D	243_D	0.609	0.85
97_F	146_A	0.605	0.84
167_L	207_S	0.602	0.84
77_T	159_C	0.602	0.84
172_E	179_G	0.601	0.84
44_T	60_G	0.601	0.84
250_I	253_R	0.599	0.84
125_H	128_L	0.599	0.84
108_E	131_S	0.596	0.83
72_T	200_I	0.595	0.83
139_V	181_K	0.594	0.83
42_S	62_R	0.593	0.83
255_V	258_G	0.593	0.83
114_A	118_Q	0.592	0.83
148_N	190_Q	0.590	0.83
37_D	41_W	0.588	0.82
65_K	197_A	0.588	0.82
232_Q	240_A	0.584	0.82
24_L	27_A	0.583	0.82
252_L	257_R	0.582	0.82
104_H	107_R	0.582	0.82
171_R	180_H	0.581	0.82
49_T	60_G	0.581	0.82
92_S	244_Y	0.581	0.82
127_T	130_Q	0.579	0.81
91_T	150_I	0.578	0.81
88_L	143_L	0.578	0.81
207_S	253_R	0.571	0.81
231_F	242_A	0.571	0.81
211_S	224_N	0.570	0.80
109_F	117_Q	0.570	0.80
238_A	244_Y	0.568	0.80
172_E	176_A	0.566	0.80
105_D	134_R	0.564	0.80
21_D	27_A	0.564	0.80
218_G	249_N	0.564	0.80
88_L	147_S	0.563	0.80
9_V	12_S	0.562	0.80
31_Y	36_L	0.561	0.79
225_R	231_F	0.561	0.79
103_A	177_S	0.559	0.79
216_E	240_A	0.557	0.79
137_R	141_D	0.556	0.79
246_A	249_N	0.555	0.79
232_Q	235_K	0.555	0.79
86_E	241_N	0.554	0.79
212_Q	225_R	0.553	0.78
89_A	164_F	0.552	0.78
213_R	252_L	0.550	0.78
166_D	210_T	0.547	0.78
102_L	177_S	0.547	0.78
76_G	160_D	0.546	0.78
117_Q	124_A	0.543	0.77
137_R	145_Q	0.542	0.77
210_T	213_R	0.540	0.77
153_E	160_D	0.534	0.76
195_A	198_E	0.531	0.76
213_R	224_N	0.530	0.76
161_I	203_K	0.526	0.75
140_R	144_H	0.526	0.75
50_A	53_G	0.526	0.75
206_G	209_Y	0.526	0.75
238_A	248_K	0.523	0.75
80_G	163_A	0.523	0.75
135_E	139_V	0.522	0.74
84_G	99_G	0.521	0.74
88_L	191_V	0.520	0.74
183_A	186_T	0.519	0.74
93_T	159_C	0.518	0.74
74_E	77_T	0.514	0.73
32_Q	44_T	0.512	0.73
17_R	26_D	0.508	0.72
112_V	116_L	0.506	0.72
240_A	245_N	0.505	0.72
9_V	46_S	0.504	0.72
219_F	222_D	0.504	0.72
68_T	72_T	0.502	0.72
171_R	174_T	0.501	0.71
121_T	128_L	0.500	0.71
238_A	245_N	0.500	0.71

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vhxA	2	0.4397	95.9	0.908	Contact Map
1nu0A	1	0.4169	95.7	0.91	Contact Map
1iv0A	1	0.3094	94.3	0.917	Contact Map
1ffkW	1	0.2215	87.6	0.93	Contact Map
4aybP	1	0.1401	86.4	0.931	Contact Map
1vq8Z	1	0.2378	83.3	0.934	Contact Map
3j20Y	1	0.1629	82.7	0.934	Contact Map
1vd4A	1	0.1824	80.8	0.936	Contact Map
1qypA	1	0.1466	80.1	0.936	Contact Map
2k4xA	1	0.1792	78.4	0.937	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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