Q9HSY2 - HALSA - GREMLIN Contacts

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Q9HSY2 - Uncharacterized protein

UniProt:	Q9HSY2	Sequences: MGGSISVERRLSDAELDQLLKTADSGERARRLGFVKNLYLGDSISEAISREGRSESTGYRWVHRWNDGGLDALLPSYGGGRPAKLSESEVDVFLECIERRQPVSTATVESILQTEFGVEYAAEYLPRKLEEVGLVYRPAARETVDRQVVLEAVDWDEKTPVEHTRGLPYDGRASRATAGWIVQE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	184 (149)
Sequences:	1076 (808)
Seq/√Len:	66.2

HALSA - Q9HSY2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
68_G	72_A	4.929	1.00
121_A	124_Y	3.679	1.00
92_V	115_E	3.464	1.00
38_L	47_A	3.333	1.00
120_Y	124_Y	2.936	1.00
124_Y	128_K	2.689	1.00
112_L	125_L	2.606	1.00
47_A	58_G	2.590	1.00
42_D	46_E	2.502	1.00
83_A	90_V	2.490	1.00
105_T	126_P	2.376	1.00
56_S	59_Y	2.342	1.00
54_S	57_T	2.331	1.00
37_N	42_D	2.324	1.00
85_L	89_E	2.142	1.00
146_R	151_E	2.123	1.00
42_D	50_R	2.105	1.00
53_R	61_W	2.037	1.00
113_Q	119_E	1.957	1.00
79_G	82_P	1.956	1.00
44_I	59_Y	1.938	1.00
90_V	131_E	1.911	1.00
37_N	50_R	1.864	1.00
45_S	55_E	1.767	1.00
124_Y	127_R	1.721	1.00
151_E	154_D	1.720	1.00
89_E	112_L	1.693	0.99
38_L	62_V	1.685	0.99
152_A	156_D	1.622	0.99
46_E	49_S	1.575	0.99
12_S	15_E	1.548	0.99
75_P	78_G	1.535	0.99
57_T	61_W	1.528	0.99
103_V	108_V	1.507	0.99
120_Y	128_K	1.490	0.99
45_S	49_S	1.462	0.98
44_I	62_V	1.423	0.98
13_D	17_D	1.400	0.98
47_A	51_E	1.380	0.98
137_R	143_T	1.375	0.98
90_V	132_V	1.369	0.98
86_S	89_E	1.357	0.97
140_A	143_T	1.344	0.97
69_G	73_L	1.296	0.97
33_G	37_N	1.274	0.96
23_A	26_G	1.246	0.96
89_E	118_V	1.236	0.95
37_N	51_E	1.229	0.95
111_I	115_E	1.205	0.95
55_E	59_Y	1.193	0.94
30_R	53_R	1.192	0.94
48_I	58_G	1.188	0.94
30_R	51_E	1.181	0.94
33_G	51_E	1.136	0.93
112_L	121_A	1.124	0.92
91_D	95_E	1.113	0.92
47_A	55_E	1.088	0.91
13_D	40_L	1.069	0.90
46_E	50_R	1.069	0.90
19_L	32_L	1.052	0.90
152_A	155_W	1.036	0.89
134_L	151_E	1.022	0.88
65_W	69_G	1.021	0.88
12_S	69_G	1.017	0.88
127_R	149_V	1.009	0.88
71_D	74_L	0.995	0.87
137_R	145_D	0.985	0.86
94_L	134_L	0.984	0.86
35_V	39_Y	0.983	0.86
90_V	94_L	0.980	0.86
33_G	40_L	0.978	0.86
17_D	25_S	0.966	0.85
34_F	51_E	0.961	0.85
109_E	122_A	0.956	0.85
92_V	96_C	0.951	0.84
35_V	38_L	0.950	0.84
96_C	111_I	0.947	0.84
153_V	157_E	0.942	0.84
84_K	120_Y	0.926	0.83
138_P	143_T	0.923	0.83
100_R	104_S	0.923	0.83
19_L	25_S	0.917	0.82
83_A	87_E	0.904	0.81
19_L	23_A	0.901	0.81
27_E	30_R	0.895	0.81
108_V	128_K	0.890	0.80
126_P	144_V	0.884	0.80
25_S	29_A	0.869	0.79
97_I	137_R	0.866	0.78
123_E	126_P	0.864	0.78
157_E	160_P	0.859	0.78
149_V	152_A	0.855	0.78
89_E	92_V	0.855	0.78
34_F	53_R	0.855	0.78
58_G	119_E	0.854	0.77
102_P	139_A	0.849	0.77
148_V	159_T	0.847	0.77
130_E	135_V	0.844	0.77
110_S	114_T	0.840	0.76
89_E	108_V	0.838	0.76
37_N	40_L	0.837	0.76
110_S	119_E	0.837	0.76
124_Y	131_E	0.835	0.76
78_G	82_P	0.826	0.75
43_S	46_E	0.825	0.75
121_A	127_R	0.823	0.75
109_E	125_L	0.818	0.74
94_L	132_V	0.811	0.74
113_Q	117_G	0.811	0.74
15_E	19_L	0.807	0.73
56_S	60_R	0.802	0.73
127_R	131_E	0.802	0.73
53_R	57_T	0.800	0.73
17_D	56_S	0.798	0.73
65_W	108_V	0.795	0.72
136_Y	139_A	0.793	0.72
20_L	36_K	0.785	0.71
18_Q	46_E	0.761	0.69
128_K	132_V	0.758	0.69
105_T	136_Y	0.756	0.68
121_A	133_G	0.748	0.68
21_K	68_G	0.744	0.67
17_D	52_G	0.734	0.66
109_E	121_A	0.734	0.66
84_K	118_V	0.732	0.66
53_R	58_G	0.730	0.66
108_V	111_I	0.723	0.65
62_V	66_N	0.716	0.64
95_E	98_E	0.706	0.63
16_L	36_K	0.698	0.62
38_L	44_I	0.698	0.62
17_D	20_L	0.695	0.62
35_V	65_W	0.685	0.61
123_E	127_R	0.684	0.61
135_V	147_Q	0.683	0.61
138_P	144_V	0.674	0.60
35_V	72_A	0.672	0.59
72_A	87_E	0.672	0.59
136_Y	140_A	0.671	0.59
24_D	119_E	0.671	0.59
20_L	32_L	0.664	0.58
85_L	116_F	0.662	0.58
54_S	60_R	0.659	0.58
137_R	141_R	0.658	0.58
109_E	112_L	0.657	0.58
18_Q	23_A	0.651	0.57
28_R	74_L	0.650	0.57
93_F	132_V	0.641	0.56
71_D	152_A	0.640	0.56
109_E	116_F	0.638	0.55
63_H	66_N	0.633	0.55
97_I	107_T	0.632	0.55
64_R	148_V	0.630	0.54
154_D	159_T	0.627	0.54
34_F	47_A	0.627	0.54
21_K	113_Q	0.621	0.53
22_T	25_S	0.619	0.53
49_S	95_E	0.616	0.53
56_S	63_H	0.614	0.53
96_C	103_V	0.612	0.52
97_I	134_L	0.611	0.52
98_E	134_L	0.607	0.52
83_A	115_E	0.606	0.52
85_L	120_Y	0.602	0.51
74_L	114_T	0.601	0.51
103_V	107_T	0.601	0.51
103_V	126_P	0.598	0.51
71_D	92_V	0.597	0.51
47_A	62_V	0.594	0.50
101_Q	138_P	0.594	0.50
39_Y	47_A	0.593	0.50
67_D	71_D	0.590	0.50
93_F	112_L	0.587	0.49
101_Q	116_F	0.587	0.49
31_R	74_L	0.584	0.49
32_L	73_L	0.580	0.49
28_R	72_A	0.579	0.48
109_E	119_E	0.575	0.48
42_D	92_V	0.570	0.47
139_A	144_V	0.566	0.47
110_S	117_G	0.565	0.47
32_L	93_F	0.564	0.47
22_T	69_G	0.557	0.46
15_E	72_A	0.556	0.46
110_S	113_Q	0.554	0.46
91_D	113_Q	0.553	0.45
128_K	131_E	0.552	0.45
38_L	65_W	0.549	0.45
87_E	117_G	0.547	0.45
33_G	104_S	0.544	0.44
33_G	102_P	0.544	0.44
38_L	78_G	0.542	0.44
15_E	131_E	0.541	0.44
147_Q	151_E	0.540	0.44
135_V	139_A	0.539	0.44
147_Q	150_L	0.539	0.44
102_P	136_Y	0.538	0.44
17_D	21_K	0.537	0.44
42_D	48_I	0.534	0.43
29_A	47_A	0.533	0.43
15_E	18_Q	0.531	0.43
45_S	150_L	0.528	0.43
15_E	104_S	0.528	0.43
32_L	74_L	0.525	0.42
12_S	16_L	0.523	0.42
107_T	138_P	0.522	0.42
111_I	154_D	0.522	0.42
87_E	91_D	0.521	0.42
59_Y	76_S	0.521	0.42
156_D	159_T	0.520	0.42
64_R	68_G	0.520	0.42
112_L	116_F	0.519	0.41
35_V	73_L	0.518	0.41
13_D	39_Y	0.515	0.41
59_Y	158_K	0.513	0.41
143_T	154_D	0.513	0.41
94_L	98_E	0.512	0.41
52_G	85_L	0.510	0.40
49_S	94_L	0.509	0.40
155_W	158_K	0.508	0.40
71_D	133_G	0.506	0.40
109_E	113_Q	0.504	0.40
26_G	30_R	0.503	0.40
34_F	58_G	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2k27A	1	0.8261	99.7	0.624	Contact Map
4u7bA	2	0.7826	99.7	0.627	Contact Map
1k78A	1	0.6467	99.7	0.645	Contact Map
1u78A	1	0.5598	99.6	0.658	Contact Map
1pdnC	1	0.6359	99.6	0.665	Contact Map
4fcyA	4	0.7717	99.4	0.705	Contact Map
1hlvA	1	0.625	98.4	0.795	Contact Map
2lvsA	1	0.5707	98.3	0.805	Contact Map
2jn6A	1	0.5163	98.2	0.811	Contact Map
2elhA	1	0.413	98	0.818	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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