GREMLIN Database
Q9HSY2 - Uncharacterized protein
UniProt: Q9HSY2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 184 (149)
Sequences: 1076 (808)
Seq/√Len: 66.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_G72_A4.9291.00
121_A124_Y3.6791.00
92_V115_E3.4641.00
38_L47_A3.3331.00
120_Y124_Y2.9361.00
124_Y128_K2.6891.00
112_L125_L2.6061.00
47_A58_G2.5901.00
42_D46_E2.5021.00
83_A90_V2.4901.00
105_T126_P2.3761.00
56_S59_Y2.3421.00
54_S57_T2.3311.00
37_N42_D2.3241.00
85_L89_E2.1421.00
146_R151_E2.1231.00
42_D50_R2.1051.00
53_R61_W2.0371.00
113_Q119_E1.9571.00
79_G82_P1.9561.00
44_I59_Y1.9381.00
90_V131_E1.9111.00
37_N50_R1.8641.00
45_S55_E1.7671.00
124_Y127_R1.7211.00
151_E154_D1.7201.00
89_E112_L1.6930.99
38_L62_V1.6850.99
152_A156_D1.6220.99
46_E49_S1.5750.99
12_S15_E1.5480.99
75_P78_G1.5350.99
57_T61_W1.5280.99
103_V108_V1.5070.99
120_Y128_K1.4900.99
45_S49_S1.4620.98
44_I62_V1.4230.98
13_D17_D1.4000.98
47_A51_E1.3800.98
137_R143_T1.3750.98
90_V132_V1.3690.98
86_S89_E1.3570.97
140_A143_T1.3440.97
69_G73_L1.2960.97
33_G37_N1.2740.96
23_A26_G1.2460.96
89_E118_V1.2360.95
37_N51_E1.2290.95
111_I115_E1.2050.95
55_E59_Y1.1930.94
30_R53_R1.1920.94
48_I58_G1.1880.94
30_R51_E1.1810.94
33_G51_E1.1360.93
112_L121_A1.1240.92
91_D95_E1.1130.92
47_A55_E1.0880.91
13_D40_L1.0690.90
46_E50_R1.0690.90
19_L32_L1.0520.90
152_A155_W1.0360.89
134_L151_E1.0220.88
65_W69_G1.0210.88
12_S69_G1.0170.88
127_R149_V1.0090.88
71_D74_L0.9950.87
137_R145_D0.9850.86
94_L134_L0.9840.86
35_V39_Y0.9830.86
90_V94_L0.9800.86
33_G40_L0.9780.86
17_D25_S0.9660.85
34_F51_E0.9610.85
109_E122_A0.9560.85
92_V96_C0.9510.84
35_V38_L0.9500.84
96_C111_I0.9470.84
153_V157_E0.9420.84
84_K120_Y0.9260.83
138_P143_T0.9230.83
100_R104_S0.9230.83
19_L25_S0.9170.82
83_A87_E0.9040.81
19_L23_A0.9010.81
27_E30_R0.8950.81
108_V128_K0.8900.80
126_P144_V0.8840.80
25_S29_A0.8690.79
97_I137_R0.8660.78
123_E126_P0.8640.78
157_E160_P0.8590.78
149_V152_A0.8550.78
89_E92_V0.8550.78
34_F53_R0.8550.78
58_G119_E0.8540.77
102_P139_A0.8490.77
148_V159_T0.8470.77
130_E135_V0.8440.77
110_S114_T0.8400.76
89_E108_V0.8380.76
37_N40_L0.8370.76
110_S119_E0.8370.76
124_Y131_E0.8350.76
78_G82_P0.8260.75
43_S46_E0.8250.75
121_A127_R0.8230.75
109_E125_L0.8180.74
94_L132_V0.8110.74
113_Q117_G0.8110.74
15_E19_L0.8070.73
56_S60_R0.8020.73
127_R131_E0.8020.73
53_R57_T0.8000.73
17_D56_S0.7980.73
65_W108_V0.7950.72
136_Y139_A0.7930.72
20_L36_K0.7850.71
18_Q46_E0.7610.69
128_K132_V0.7580.69
105_T136_Y0.7560.68
121_A133_G0.7480.68
21_K68_G0.7440.67
17_D52_G0.7340.66
109_E121_A0.7340.66
84_K118_V0.7320.66
53_R58_G0.7300.66
108_V111_I0.7230.65
62_V66_N0.7160.64
95_E98_E0.7060.63
16_L36_K0.6980.62
38_L44_I0.6980.62
17_D20_L0.6950.62
35_V65_W0.6850.61
123_E127_R0.6840.61
135_V147_Q0.6830.61
138_P144_V0.6740.60
35_V72_A0.6720.59
72_A87_E0.6720.59
136_Y140_A0.6710.59
24_D119_E0.6710.59
20_L32_L0.6640.58
85_L116_F0.6620.58
54_S60_R0.6590.58
137_R141_R0.6580.58
109_E112_L0.6570.58
18_Q23_A0.6510.57
28_R74_L0.6500.57
93_F132_V0.6410.56
71_D152_A0.6400.56
109_E116_F0.6380.55
63_H66_N0.6330.55
97_I107_T0.6320.55
64_R148_V0.6300.54
154_D159_T0.6270.54
34_F47_A0.6270.54
21_K113_Q0.6210.53
22_T25_S0.6190.53
49_S95_E0.6160.53
56_S63_H0.6140.53
96_C103_V0.6120.52
97_I134_L0.6110.52
98_E134_L0.6070.52
83_A115_E0.6060.52
85_L120_Y0.6020.51
74_L114_T0.6010.51
103_V107_T0.6010.51
103_V126_P0.5980.51
71_D92_V0.5970.51
47_A62_V0.5940.50
101_Q138_P0.5940.50
39_Y47_A0.5930.50
67_D71_D0.5900.50
93_F112_L0.5870.49
101_Q116_F0.5870.49
31_R74_L0.5840.49
32_L73_L0.5800.49
28_R72_A0.5790.48
109_E119_E0.5750.48
42_D92_V0.5700.47
139_A144_V0.5660.47
110_S117_G0.5650.47
32_L93_F0.5640.47
22_T69_G0.5570.46
15_E72_A0.5560.46
110_S113_Q0.5540.46
91_D113_Q0.5530.45
128_K131_E0.5520.45
38_L65_W0.5490.45
87_E117_G0.5470.45
33_G104_S0.5440.44
33_G102_P0.5440.44
38_L78_G0.5420.44
15_E131_E0.5410.44
147_Q151_E0.5400.44
135_V139_A0.5390.44
147_Q150_L0.5390.44
102_P136_Y0.5380.44
17_D21_K0.5370.44
42_D48_I0.5340.43
29_A47_A0.5330.43
15_E18_Q0.5310.43
45_S150_L0.5280.43
15_E104_S0.5280.43
32_L74_L0.5250.42
12_S16_L0.5230.42
107_T138_P0.5220.42
111_I154_D0.5220.42
87_E91_D0.5210.42
59_Y76_S0.5210.42
156_D159_T0.5200.42
64_R68_G0.5200.42
112_L116_F0.5190.41
35_V73_L0.5180.41
13_D39_Y0.5150.41
59_Y158_K0.5130.41
143_T154_D0.5130.41
94_L98_E0.5120.41
52_G85_L0.5100.40
49_S94_L0.5090.40
155_W158_K0.5080.40
71_D133_G0.5060.40
109_E113_Q0.5040.40
26_G30_R0.5030.40
34_F58_G0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k27A 1 0.8261 99.7 0.624 Contact Map
4u7bA 2 0.7826 99.7 0.627 Contact Map
1k78A 1 0.6467 99.7 0.645 Contact Map
1u78A 1 0.5598 99.6 0.658 Contact Map
1pdnC 1 0.6359 99.6 0.665 Contact Map
4fcyA 4 0.7717 99.4 0.705 Contact Map
1hlvA 1 0.625 98.4 0.795 Contact Map
2lvsA 1 0.5707 98.3 0.805 Contact Map
2jn6A 1 0.5163 98.2 0.811 Contact Map
2elhA 1 0.413 98 0.818 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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