Q9HSX5 - HALSA - GREMLIN Contacts

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Q9HSX5 - Uncharacterized protein

UniProt:	Q9HSX5	Sequences: MASLRRLAWMCRNLAKQHVDDPDVPAAPSGAGGYAEWVQIALILYRVELEKSLRESEDYLNEMPGVLAVFGLDEAPHYSSFCRWENEYRMRELRRLLRASAEQAGWSGEAAIDASGFQRDQTSYHYRDRANYSFQSMKTTILIDVNSLAIKDVHYTTQKAWDGHIGMQVFRRNAEDLRVLSADANYSWSDLREECRSESTRPLIKHREQTPLQKAHHARMNEDYNQRWMSETGFSQLKEDDGEKLRSGAGRPVPELTRKCIIHNLTQAAS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	270 (240)
Sequences:	2449 (1705)
Seq/√Len:	110.0

ECOLI - INSH6 INSH5 INSH1 INSH2 INSH3 INSH4 INSH7 INSH8 INSH9 INH10 INH11
HALSA - Q9HSX5 Q7LYM0 TH11 Q9HPK7
SULSO - Q97TV4 Q7LX34 Q97Y57

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
153_V	257_T	3.474	1.00
42_L	60_L	3.469	1.00
54_R	78_Y	3.460	1.00
59_Y	63_M	3.252	1.00
143_I	230_S	3.195	1.00
195_C	200_T	3.134	1.00
140_T	156_T	3.083	1.00
150_I	260_C	2.949	1.00
152_D	172_R	2.930	1.00
46_R	56_S	2.809	1.00
22_P	26_A	2.469	1.00
37_W	41_A	2.420	1.00
26_A	29_S	2.402	1.00
171_R	198_E	2.322	1.00
62_E	65_G	2.312	1.00
153_V	260_C	2.227	1.00
57_E	78_Y	2.096	1.00
193_E	197_S	2.096	1.00
126_Y	129_R	2.076	1.00
110_A	142_L	2.052	1.00
141_I	234_F	2.040	1.00
115_S	238_K	2.001	1.00
144_D	147_S	1.983	1.00
139_T	256_L	1.967	1.00
167_M	194_E	1.956	1.00
130_A	133_S	1.877	1.00
154_H	253_V	1.859	1.00
161_W	164_H	1.846	1.00
79_S	83_R	1.801	1.00
53_L	85_E	1.796	1.00
166_G	191_L	1.768	1.00
239_E	243_E	1.767	1.00
99_A	102_E	1.738	1.00
165_I	168_Q	1.734	1.00
112_I	142_L	1.687	1.00
110_A	151_K	1.675	1.00
179_V	203_L	1.663	1.00
140_T	186_Y	1.646	1.00
22_P	25_P	1.630	1.00
39_Q	84_W	1.624	1.00
195_C	204_I	1.620	1.00
247_S	251_R	1.618	1.00
89_R	254_P	1.550	1.00
174_A	198_E	1.543	1.00
94_R	98_R	1.537	1.00
138_K	162_D	1.514	1.00
102_E	106_W	1.506	1.00
156_T	165_I	1.506	1.00
41_A	70_F	1.496	1.00
60_L	70_F	1.492	1.00
79_S	82_C	1.479	1.00
57_E	77_H	1.467	1.00
188_W	191_L	1.467	1.00
149_A	267_Q	1.454	1.00
141_I	233_G	1.452	1.00
112_I	166_G	1.442	1.00
235_S	239_E	1.430	1.00
42_L	81_F	1.429	1.00
245_L	255_E	1.425	1.00
245_L	252_P	1.424	1.00
237_L	259_K	1.419	1.00
97_L	260_C	1.396	1.00
114_A	138_K	1.380	1.00
143_I	233_G	1.380	1.00
150_I	264_N	1.365	1.00
152_D	169_V	1.358	1.00
160_A	165_I	1.354	1.00
72_L	75_A	1.353	1.00
124_Y	128_D	1.337	1.00
179_V	201_R	1.335	1.00
236_Q	263_H	1.333	1.00
57_E	75_A	1.327	1.00
182_A	204_I	1.320	0.99
241_D	263_H	1.296	0.99
96_L	261_I	1.292	0.99
34_Y	38_V	1.271	0.99
129_R	132_Y	1.259	0.99
191_L	194_E	1.255	0.99
114_A	162_D	1.251	0.99
55_E	59_Y	1.238	0.99
165_I	169_V	1.236	0.99
126_Y	132_Y	1.234	0.99
42_L	56_S	1.219	0.99
124_Y	127_R	1.206	0.99
166_G	170_F	1.203	0.99
224_Y	228_W	1.202	0.99
154_H	165_I	1.201	0.99
196_R	202_P	1.197	0.99
111_A	229_M	1.196	0.99
155_Y	253_V	1.193	0.99
127_R	131_N	1.185	0.99
111_A	145_V	1.185	0.99
97_L	257_T	1.178	0.99
187_S	207_R	1.156	0.99
166_G	180_L	1.147	0.99
256_L	260_C	1.145	0.99
38_V	72_L	1.141	0.99
58_D	62_E	1.128	0.98
57_E	61_N	1.123	0.98
241_D	266_T	1.111	0.98
228_W	232_T	1.109	0.98
154_H	168_Q	1.102	0.98
253_V	257_T	1.089	0.98
237_L	263_H	1.088	0.98
104_A	149_A	1.086	0.98
127_R	130_A	1.085	0.98
142_L	152_D	1.083	0.98
181_S	203_L	1.080	0.98
127_R	132_Y	1.072	0.98
30_G	33_G	1.061	0.98
120_D	248_G	1.058	0.98
93_L	257_T	1.050	0.97
262_I	266_T	1.044	0.97
126_Y	130_A	1.040	0.97
25_P	29_S	1.031	0.97
124_Y	131_N	1.028	0.97
235_S	240_D	1.028	0.97
171_R	194_E	1.024	0.97
139_T	155_Y	1.023	0.97
38_V	74_E	1.011	0.97
126_Y	131_N	1.009	0.97
172_R	177_L	1.009	0.97
226_Q	229_M	1.008	0.97
59_Y	66_V	1.007	0.97
245_L	256_L	1.006	0.97
148_L	236_Q	0.986	0.96
69_V	135_Q	0.984	0.96
47_V	255_E	0.977	0.96
219_R	222_E	0.974	0.96
233_G	263_H	0.973	0.96
45_Y	66_V	0.973	0.96
96_L	100_S	0.972	0.96
250_G	253_V	0.970	0.96
218_A	221_N	0.968	0.96
45_Y	49_L	0.962	0.96
217_H	220_M	0.960	0.96
29_S	32_G	0.956	0.96
100_S	104_A	0.951	0.95
118_Q	244_K	0.948	0.95
139_T	260_C	0.947	0.95
109_E	149_A	0.945	0.95
140_T	162_D	0.936	0.95
49_L	66_V	0.933	0.95
247_S	252_P	0.929	0.95
237_L	260_C	0.927	0.95
115_S	139_T	0.924	0.95
39_Q	80_S	0.924	0.95
220_M	223_D	0.920	0.95
163_G	188_W	0.912	0.94
247_S	255_E	0.905	0.94
77_H	80_S	0.903	0.94
67_L	75_A	0.903	0.94
49_L	62_E	0.902	0.94
114_A	140_T	0.897	0.94
236_Q	266_T	0.895	0.94
205_K	209_Q	0.894	0.94
41_A	69_V	0.890	0.93
78_Y	82_C	0.887	0.93
36_E	39_Q	0.886	0.93
195_C	202_P	0.877	0.93
225_N	228_W	0.875	0.93
94_R	253_V	0.874	0.93
34_Y	76_P	0.870	0.93
112_I	182_A	0.869	0.93
118_Q	134_F	0.866	0.93
163_G	185_N	0.865	0.93
44_L	265_L	0.864	0.92
124_Y	130_A	0.864	0.92
170_F	204_I	0.860	0.92
229_M	232_T	0.855	0.92
153_V	256_L	0.854	0.92
168_Q	171_R	0.853	0.92
166_G	182_A	0.852	0.92
148_L	153_V	0.849	0.92
128_D	132_Y	0.841	0.91
207_R	210_T	0.835	0.91
115_S	234_F	0.828	0.91
151_K	173_N	0.825	0.91
61_N	67_L	0.823	0.91
57_E	81_F	0.819	0.90
180_L	200_T	0.813	0.90
64_P	67_L	0.809	0.90
156_T	250_G	0.803	0.89
236_Q	241_D	0.803	0.89
219_R	225_N	0.802	0.89
148_L	229_M	0.801	0.89
156_T	169_V	0.800	0.89
184_A	206_H	0.799	0.89
161_W	188_W	0.796	0.89
117_F	245_L	0.791	0.89
142_L	169_V	0.789	0.89
140_T	160_A	0.785	0.88
184_A	208_E	0.784	0.88
182_A	185_N	0.780	0.88
93_L	254_P	0.771	0.87
167_M	191_L	0.768	0.87
124_Y	129_R	0.768	0.87
187_S	192_R	0.762	0.87
206_H	210_T	0.761	0.87
94_R	172_R	0.761	0.87
148_L	233_G	0.760	0.87
184_A	221_N	0.760	0.87
182_A	191_L	0.757	0.86
205_K	224_Y	0.750	0.86
26_A	33_G	0.750	0.86
164_H	190_D	0.742	0.85
140_T	169_V	0.742	0.85
141_I	230_S	0.741	0.85
53_L	82_C	0.740	0.85
54_R	248_G	0.732	0.85
56_S	81_F	0.730	0.84
57_E	60_L	0.729	0.84
42_L	76_P	0.729	0.84
116_G	162_D	0.727	0.84
211_P	218_A	0.726	0.84
164_H	191_L	0.725	0.84
100_S	261_I	0.725	0.84
230_S	233_G	0.725	0.84
44_L	48_E	0.720	0.84
43_I	85_E	0.719	0.84
119_R	137_M	0.717	0.83
115_S	210_T	0.717	0.83
25_P	28_P	0.716	0.83
184_A	207_R	0.713	0.83
205_K	208_E	0.711	0.83
51_K	59_Y	0.709	0.83
60_L	75_A	0.709	0.83
94_R	152_D	0.708	0.83
263_H	267_Q	0.706	0.82
222_E	225_N	0.697	0.82
140_T	165_I	0.697	0.82
27_A	32_G	0.694	0.81
42_L	70_F	0.692	0.81
206_H	209_Q	0.689	0.81
48_E	262_I	0.684	0.80
202_P	205_K	0.682	0.80
50_E	71_G	0.681	0.80
141_I	150_I	0.679	0.80
103_Q	118_Q	0.673	0.79
182_A	187_S	0.673	0.79
246_R	255_E	0.672	0.79
28_P	32_G	0.671	0.79
126_Y	133_S	0.669	0.79
43_I	56_S	0.666	0.79
97_L	153_V	0.666	0.79
255_E	259_K	0.665	0.79
54_R	79_S	0.665	0.79
35_A	38_V	0.663	0.78
236_Q	240_D	0.663	0.78
148_L	263_H	0.656	0.78
233_G	236_Q	0.655	0.77
218_A	222_E	0.652	0.77
150_I	153_V	0.649	0.77
104_A	108_G	0.648	0.77
95_R	102_E	0.644	0.76
161_W	185_N	0.642	0.76
167_M	198_E	0.639	0.76
113_D	183_D	0.638	0.76
148_L	232_T	0.634	0.75
195_C	198_E	0.633	0.75
194_E	198_E	0.628	0.74
178_R	223_D	0.627	0.74
42_L	266_T	0.626	0.74
117_F	121_Q	0.623	0.74
117_F	139_T	0.622	0.74
192_R	205_K	0.621	0.74
227_R	231_E	0.619	0.73
121_Q	248_G	0.615	0.73
36_E	54_R	0.615	0.73
155_Y	252_P	0.614	0.73
106_W	209_Q	0.613	0.73
119_R	122_T	0.610	0.72
110_A	177_L	0.610	0.72
251_R	254_P	0.607	0.72
148_L	267_Q	0.606	0.72
254_P	258_R	0.605	0.72
53_L	84_W	0.603	0.71
105_G	219_R	0.601	0.71
63_M	66_V	0.601	0.71
54_R	205_K	0.601	0.71
57_E	79_S	0.601	0.71
198_E	218_A	0.600	0.71
129_R	133_S	0.599	0.71
197_S	221_N	0.597	0.71
171_R	175_E	0.597	0.71
42_L	57_E	0.596	0.71
247_S	256_L	0.595	0.70
185_N	234_F	0.594	0.70
51_K	56_S	0.593	0.70
97_L	266_T	0.592	0.70
187_S	206_H	0.590	0.70
33_G	39_Q	0.588	0.70
137_M	248_G	0.588	0.70
188_W	199_S	0.585	0.69
185_N	188_W	0.584	0.69
97_L	101_A	0.584	0.69
51_K	80_S	0.583	0.69
23_D	26_A	0.582	0.69
138_K	158_Q	0.581	0.69
62_E	185_N	0.576	0.68
235_S	263_H	0.574	0.68
189_S	193_E	0.572	0.67
86_N	251_R	0.572	0.67
53_L	69_V	0.571	0.67
37_W	40_I	0.570	0.67
219_R	223_D	0.569	0.67
144_D	234_F	0.567	0.67
232_T	235_S	0.565	0.67
196_R	211_P	0.565	0.67
142_L	182_A	0.564	0.66
90_M	99_A	0.563	0.66
23_D	27_A	0.561	0.66
121_Q	135_Q	0.559	0.66
116_G	158_Q	0.558	0.66
154_H	169_V	0.558	0.66
33_G	36_E	0.555	0.65
44_L	92_E	0.554	0.65
133_S	218_A	0.551	0.65
86_N	112_I	0.550	0.64
77_H	247_S	0.549	0.64
170_F	194_E	0.547	0.64
192_R	202_P	0.546	0.64
239_E	244_K	0.545	0.64
137_M	252_P	0.545	0.64
252_P	261_I	0.544	0.64
38_V	75_A	0.543	0.63
46_R	53_L	0.543	0.63
129_R	134_F	0.543	0.63
242_G	255_E	0.542	0.63
175_E	194_E	0.542	0.63
184_A	187_S	0.539	0.63
180_L	191_L	0.539	0.63
46_R	85_E	0.533	0.62
46_R	258_R	0.532	0.62
96_L	210_T	0.530	0.62
117_F	242_G	0.530	0.62
48_E	266_T	0.529	0.61
67_L	132_Y	0.527	0.61
253_V	256_L	0.526	0.61
36_E	84_W	0.523	0.61
99_A	242_G	0.522	0.60
34_Y	42_L	0.521	0.60
176_D	199_S	0.521	0.60
57_E	82_C	0.520	0.60
190_D	197_S	0.516	0.60
171_R	190_D	0.516	0.60
128_D	133_S	0.516	0.60
227_R	238_K	0.515	0.59
39_Q	81_F	0.514	0.59
34_Y	84_W	0.510	0.59
82_C	85_E	0.510	0.59
169_V	181_S	0.510	0.59
81_F	255_E	0.509	0.59
195_C	248_G	0.507	0.58
221_N	224_Y	0.503	0.58
173_N	177_L	0.502	0.58
124_Y	133_S	0.502	0.58
44_L	262_I	0.501	0.57
243_E	259_K	0.500	0.57
23_D	28_P	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.9074	98.5	0.843	Contact Map
4u7bA	2	0.8815	95	0.906	Contact Map
4fcyA	4	0.8667	92.7	0.915	Contact Map
4mq3A	1	0.4667	92.5	0.915	Contact Map
4fw1A	2	0.5296	90.8	0.919	Contact Map
3kksA	2	0.4778	88.9	0.922	Contact Map
4pa1A	2	0.4852	88.2	0.923	Contact Map
1cxqA	2	0.4926	84.6	0.927	Contact Map
3l3uA	2	0.4852	83.8	0.928	Contact Map
1c6vA	4	0.4556	83.5	0.928	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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