GREMLIN Database
Q9HSX5 - Uncharacterized protein
UniProt: Q9HSX5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (240)
Sequences: 2449 (1705)
Seq/√Len: 110.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_V257_T3.4741.00
42_L60_L3.4691.00
54_R78_Y3.4601.00
59_Y63_M3.2521.00
143_I230_S3.1951.00
195_C200_T3.1341.00
140_T156_T3.0831.00
150_I260_C2.9491.00
152_D172_R2.9301.00
46_R56_S2.8091.00
22_P26_A2.4691.00
37_W41_A2.4201.00
26_A29_S2.4021.00
171_R198_E2.3221.00
62_E65_G2.3121.00
153_V260_C2.2271.00
57_E78_Y2.0961.00
193_E197_S2.0961.00
126_Y129_R2.0761.00
110_A142_L2.0521.00
141_I234_F2.0401.00
115_S238_K2.0011.00
144_D147_S1.9831.00
139_T256_L1.9671.00
167_M194_E1.9561.00
130_A133_S1.8771.00
154_H253_V1.8591.00
161_W164_H1.8461.00
79_S83_R1.8011.00
53_L85_E1.7961.00
166_G191_L1.7681.00
239_E243_E1.7671.00
99_A102_E1.7381.00
165_I168_Q1.7341.00
112_I142_L1.6871.00
110_A151_K1.6751.00
179_V203_L1.6631.00
140_T186_Y1.6461.00
22_P25_P1.6301.00
39_Q84_W1.6241.00
195_C204_I1.6201.00
247_S251_R1.6181.00
89_R254_P1.5501.00
174_A198_E1.5431.00
94_R98_R1.5371.00
138_K162_D1.5141.00
102_E106_W1.5061.00
156_T165_I1.5061.00
41_A70_F1.4961.00
60_L70_F1.4921.00
79_S82_C1.4791.00
57_E77_H1.4671.00
188_W191_L1.4671.00
149_A267_Q1.4541.00
141_I233_G1.4521.00
112_I166_G1.4421.00
235_S239_E1.4301.00
42_L81_F1.4291.00
245_L255_E1.4251.00
245_L252_P1.4241.00
237_L259_K1.4191.00
97_L260_C1.3961.00
114_A138_K1.3801.00
143_I233_G1.3801.00
150_I264_N1.3651.00
152_D169_V1.3581.00
160_A165_I1.3541.00
72_L75_A1.3531.00
124_Y128_D1.3371.00
179_V201_R1.3351.00
236_Q263_H1.3331.00
57_E75_A1.3271.00
182_A204_I1.3200.99
241_D263_H1.2960.99
96_L261_I1.2920.99
34_Y38_V1.2710.99
129_R132_Y1.2590.99
191_L194_E1.2550.99
114_A162_D1.2510.99
55_E59_Y1.2380.99
165_I169_V1.2360.99
126_Y132_Y1.2340.99
42_L56_S1.2190.99
124_Y127_R1.2060.99
166_G170_F1.2030.99
224_Y228_W1.2020.99
154_H165_I1.2010.99
196_R202_P1.1970.99
111_A229_M1.1960.99
155_Y253_V1.1930.99
127_R131_N1.1850.99
111_A145_V1.1850.99
97_L257_T1.1780.99
187_S207_R1.1560.99
166_G180_L1.1470.99
256_L260_C1.1450.99
38_V72_L1.1410.99
58_D62_E1.1280.98
57_E61_N1.1230.98
241_D266_T1.1110.98
228_W232_T1.1090.98
154_H168_Q1.1020.98
253_V257_T1.0890.98
237_L263_H1.0880.98
104_A149_A1.0860.98
127_R130_A1.0850.98
142_L152_D1.0830.98
181_S203_L1.0800.98
127_R132_Y1.0720.98
30_G33_G1.0610.98
120_D248_G1.0580.98
93_L257_T1.0500.97
262_I266_T1.0440.97
126_Y130_A1.0400.97
25_P29_S1.0310.97
124_Y131_N1.0280.97
235_S240_D1.0280.97
171_R194_E1.0240.97
139_T155_Y1.0230.97
38_V74_E1.0110.97
126_Y131_N1.0090.97
172_R177_L1.0090.97
226_Q229_M1.0080.97
59_Y66_V1.0070.97
245_L256_L1.0060.97
148_L236_Q0.9860.96
69_V135_Q0.9840.96
47_V255_E0.9770.96
219_R222_E0.9740.96
233_G263_H0.9730.96
45_Y66_V0.9730.96
96_L100_S0.9720.96
250_G253_V0.9700.96
218_A221_N0.9680.96
45_Y49_L0.9620.96
217_H220_M0.9600.96
29_S32_G0.9560.96
100_S104_A0.9510.95
118_Q244_K0.9480.95
139_T260_C0.9470.95
109_E149_A0.9450.95
140_T162_D0.9360.95
49_L66_V0.9330.95
247_S252_P0.9290.95
237_L260_C0.9270.95
115_S139_T0.9240.95
39_Q80_S0.9240.95
220_M223_D0.9200.95
163_G188_W0.9120.94
247_S255_E0.9050.94
77_H80_S0.9030.94
67_L75_A0.9030.94
49_L62_E0.9020.94
114_A140_T0.8970.94
236_Q266_T0.8950.94
205_K209_Q0.8940.94
41_A69_V0.8900.93
78_Y82_C0.8870.93
36_E39_Q0.8860.93
195_C202_P0.8770.93
225_N228_W0.8750.93
94_R253_V0.8740.93
34_Y76_P0.8700.93
112_I182_A0.8690.93
118_Q134_F0.8660.93
163_G185_N0.8650.93
44_L265_L0.8640.92
124_Y130_A0.8640.92
170_F204_I0.8600.92
229_M232_T0.8550.92
153_V256_L0.8540.92
168_Q171_R0.8530.92
166_G182_A0.8520.92
148_L153_V0.8490.92
128_D132_Y0.8410.91
207_R210_T0.8350.91
115_S234_F0.8280.91
151_K173_N0.8250.91
61_N67_L0.8230.91
57_E81_F0.8190.90
180_L200_T0.8130.90
64_P67_L0.8090.90
156_T250_G0.8030.89
236_Q241_D0.8030.89
219_R225_N0.8020.89
148_L229_M0.8010.89
156_T169_V0.8000.89
184_A206_H0.7990.89
161_W188_W0.7960.89
117_F245_L0.7910.89
142_L169_V0.7890.89
140_T160_A0.7850.88
184_A208_E0.7840.88
182_A185_N0.7800.88
93_L254_P0.7710.87
167_M191_L0.7680.87
124_Y129_R0.7680.87
187_S192_R0.7620.87
206_H210_T0.7610.87
94_R172_R0.7610.87
148_L233_G0.7600.87
184_A221_N0.7600.87
182_A191_L0.7570.86
205_K224_Y0.7500.86
26_A33_G0.7500.86
164_H190_D0.7420.85
140_T169_V0.7420.85
141_I230_S0.7410.85
53_L82_C0.7400.85
54_R248_G0.7320.85
56_S81_F0.7300.84
57_E60_L0.7290.84
42_L76_P0.7290.84
116_G162_D0.7270.84
211_P218_A0.7260.84
164_H191_L0.7250.84
100_S261_I0.7250.84
230_S233_G0.7250.84
44_L48_E0.7200.84
43_I85_E0.7190.84
119_R137_M0.7170.83
115_S210_T0.7170.83
25_P28_P0.7160.83
184_A207_R0.7130.83
205_K208_E0.7110.83
51_K59_Y0.7090.83
60_L75_A0.7090.83
94_R152_D0.7080.83
263_H267_Q0.7060.82
222_E225_N0.6970.82
140_T165_I0.6970.82
27_A32_G0.6940.81
42_L70_F0.6920.81
206_H209_Q0.6890.81
48_E262_I0.6840.80
202_P205_K0.6820.80
50_E71_G0.6810.80
141_I150_I0.6790.80
103_Q118_Q0.6730.79
182_A187_S0.6730.79
246_R255_E0.6720.79
28_P32_G0.6710.79
126_Y133_S0.6690.79
43_I56_S0.6660.79
97_L153_V0.6660.79
255_E259_K0.6650.79
54_R79_S0.6650.79
35_A38_V0.6630.78
236_Q240_D0.6630.78
148_L263_H0.6560.78
233_G236_Q0.6550.77
218_A222_E0.6520.77
150_I153_V0.6490.77
104_A108_G0.6480.77
95_R102_E0.6440.76
161_W185_N0.6420.76
167_M198_E0.6390.76
113_D183_D0.6380.76
148_L232_T0.6340.75
195_C198_E0.6330.75
194_E198_E0.6280.74
178_R223_D0.6270.74
42_L266_T0.6260.74
117_F121_Q0.6230.74
117_F139_T0.6220.74
192_R205_K0.6210.74
227_R231_E0.6190.73
121_Q248_G0.6150.73
36_E54_R0.6150.73
155_Y252_P0.6140.73
106_W209_Q0.6130.73
119_R122_T0.6100.72
110_A177_L0.6100.72
251_R254_P0.6070.72
148_L267_Q0.6060.72
254_P258_R0.6050.72
53_L84_W0.6030.71
105_G219_R0.6010.71
63_M66_V0.6010.71
54_R205_K0.6010.71
57_E79_S0.6010.71
198_E218_A0.6000.71
129_R133_S0.5990.71
197_S221_N0.5970.71
171_R175_E0.5970.71
42_L57_E0.5960.71
247_S256_L0.5950.70
185_N234_F0.5940.70
51_K56_S0.5930.70
97_L266_T0.5920.70
187_S206_H0.5900.70
33_G39_Q0.5880.70
137_M248_G0.5880.70
188_W199_S0.5850.69
185_N188_W0.5840.69
97_L101_A0.5840.69
51_K80_S0.5830.69
23_D26_A0.5820.69
138_K158_Q0.5810.69
62_E185_N0.5760.68
235_S263_H0.5740.68
189_S193_E0.5720.67
86_N251_R0.5720.67
53_L69_V0.5710.67
37_W40_I0.5700.67
219_R223_D0.5690.67
144_D234_F0.5670.67
232_T235_S0.5650.67
196_R211_P0.5650.67
142_L182_A0.5640.66
90_M99_A0.5630.66
23_D27_A0.5610.66
121_Q135_Q0.5590.66
116_G158_Q0.5580.66
154_H169_V0.5580.66
33_G36_E0.5550.65
44_L92_E0.5540.65
133_S218_A0.5510.65
86_N112_I0.5500.64
77_H247_S0.5490.64
170_F194_E0.5470.64
192_R202_P0.5460.64
239_E244_K0.5450.64
137_M252_P0.5450.64
252_P261_I0.5440.64
38_V75_A0.5430.63
46_R53_L0.5430.63
129_R134_F0.5430.63
242_G255_E0.5420.63
175_E194_E0.5420.63
184_A187_S0.5390.63
180_L191_L0.5390.63
46_R85_E0.5330.62
46_R258_R0.5320.62
96_L210_T0.5300.62
117_F242_G0.5300.62
48_E266_T0.5290.61
67_L132_Y0.5270.61
253_V256_L0.5260.61
36_E84_W0.5230.61
99_A242_G0.5220.60
34_Y42_L0.5210.60
176_D199_S0.5210.60
57_E82_C0.5200.60
190_D197_S0.5160.60
171_R190_D0.5160.60
128_D133_S0.5160.60
227_R238_K0.5150.59
39_Q81_F0.5140.59
34_Y84_W0.5100.59
82_C85_E0.5100.59
169_V181_S0.5100.59
81_F255_E0.5090.59
195_C248_G0.5070.58
221_N224_Y0.5030.58
173_N177_L0.5020.58
124_Y133_S0.5020.58
44_L262_I0.5010.57
243_E259_K0.5000.57
23_D28_P0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9074 98.5 0.843 Contact Map
4u7bA 2 0.8815 95 0.906 Contact Map
4fcyA 4 0.8667 92.7 0.915 Contact Map
4mq3A 1 0.4667 92.5 0.915 Contact Map
4fw1A 2 0.5296 90.8 0.919 Contact Map
3kksA 2 0.4778 88.9 0.922 Contact Map
4pa1A 2 0.4852 88.2 0.923 Contact Map
1cxqA 2 0.4926 84.6 0.927 Contact Map
3l3uA 2 0.4852 83.8 0.928 Contact Map
1c6vA 4 0.4556 83.5 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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