GREMLIN Database
Q9HSX1 - Uncharacterized protein
UniProt: Q9HSX1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (115)
Sequences: 343 (253)
Seq/√Len: 23.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_L123_P3.8461.00
68_N100_N3.7611.00
67_K70_E3.2611.00
71_L86_A3.1341.00
35_R39_A2.6170.99
82_S123_P2.4390.98
78_H89_L2.1910.96
75_I110_I2.0750.95
37_K40_Q1.9770.94
38_A43_E1.9030.92
90_V97_V1.7230.88
84_S93_D1.7110.87
20_V86_A1.6590.86
16_P50_P1.6440.85
84_S88_E1.6250.85
96_Q99_Q1.5940.83
21_T51_V1.5640.82
21_T53_N1.5630.82
83_I123_P1.5580.82
67_K95_K1.5520.82
85_E89_L1.5300.81
65_S68_N1.5280.81
20_V109_V1.5210.80
97_V104_L1.5000.79
58_T66_P1.4800.78
94_Y98_H1.4670.78
84_S94_Y1.4210.75
84_S118_G1.4040.75
61_S65_S1.3600.72
95_K99_Q1.3440.71
84_S106_D1.3250.70
93_D118_G1.3150.69
18_L67_K1.3070.69
40_Q109_V1.2980.68
124_K132_I1.2240.64
86_A109_V1.2090.63
44_D128_D1.2030.62
113_E117_T1.1890.62
85_E90_V1.1540.59
33_R56_S1.1270.57
101_L110_I1.1140.56
45_L49_Q1.0870.55
26_D42_G1.0800.54
31_R39_A1.0710.53
78_H119_Q1.0640.53
74_T90_V1.0610.53
87_A97_V1.0530.52
71_L127_Y1.0450.52
109_V124_K1.0300.51
24_K114_H1.0280.50
23_G34_S1.0270.50
90_V100_N1.0240.50
107_I125_L1.0220.50
112_F123_P1.0200.50
77_E125_L1.0130.49
54_F64_L1.0120.49
87_A118_G1.0100.49
125_L134_I1.0080.49
27_R47_D1.0020.49
24_K27_R0.9960.48
17_T118_G0.9830.47
88_E118_G0.9710.46
73_E78_H0.9680.46
56_S73_E0.9670.46
106_D111_T0.9550.45
31_R72_L0.9540.45
69_L87_A0.9540.45
100_N103_E0.9450.45
75_I82_S0.9450.45
71_L82_S0.9350.44
94_Y127_Y0.9250.43
65_S100_N0.9180.43
82_S101_L0.9150.42
48_A53_N0.8950.41
52_L129_G0.8910.41
61_S132_I0.8890.41
56_S59_E0.8890.41
75_I123_P0.8880.41
24_K70_E0.8840.40
43_E113_E0.8820.40
96_Q100_N0.8800.40
83_I101_L0.8800.40
90_V93_D0.8770.40
66_P128_D0.8750.40
79_D126_A0.8680.39
77_E89_L0.8650.39
101_L105_E0.8640.39
88_E94_Y0.8610.39
58_T73_E0.8580.39
20_V130_L0.8570.39
43_E58_T0.8540.38
56_S117_T0.8520.38
131_E134_I0.8490.38
111_T130_L0.8450.38
114_H126_A0.8310.37
69_L104_L0.8280.37
126_A130_L0.8270.37
57_Y61_S0.8260.36
105_E123_P0.8240.36
87_A123_P0.8100.35
101_L112_F0.8060.35
36_I56_S0.8010.35
36_I40_Q0.7950.34
68_N126_A0.7820.34
56_S64_L0.7550.32
84_S90_V0.7540.32
75_I80_P0.7520.32
26_D62_R0.7370.31
32_T36_I0.7340.31
94_Y109_V0.7320.31
83_I102_S0.7230.30
18_L85_E0.7200.30
35_R97_V0.7180.30
65_S103_E0.7130.29
49_Q69_L0.7100.29
32_T51_V0.7040.29
54_F65_S0.7030.29
55_E111_T0.7020.29
98_H102_S0.6950.28
70_E134_I0.6930.28
50_P55_E0.6870.28
96_Q103_E0.6870.28
57_Y118_G0.6810.28
47_D94_Y0.6810.28
80_P123_P0.6800.28
80_P135_P0.6790.28
22_V53_N0.6790.28
68_N90_V0.6750.27
75_I124_K0.6700.27
32_T43_E0.6680.27
84_S132_I0.6530.26
107_I130_L0.6460.26
19_K131_E0.6370.25
70_E106_D0.6360.25
16_P82_S0.6220.24
16_P137_A0.6160.24
26_D35_R0.6140.24
68_N101_L0.6090.24
80_P137_A0.6080.24
75_I102_S0.6060.24
73_E118_G0.6050.24
37_K41_E0.5990.23
82_S119_Q0.5970.23
18_L132_I0.5870.23
81_E87_A0.5810.22
55_E127_Y0.5790.22
57_Y132_I0.5780.22
18_L52_L0.5710.22
113_E119_Q0.5710.22
16_P24_K0.5700.22
127_Y130_L0.5690.22
82_S99_Q0.5650.22
33_R43_E0.5630.22
77_E113_E0.5610.21
44_D114_H0.5570.21
127_Y133_D0.5560.21
70_E102_S0.5540.21
25_R70_E0.5530.21
32_T57_Y0.5400.20
60_L93_D0.5370.20
77_E137_A0.5350.20
48_A110_I0.5350.20
68_N86_A0.5330.20
51_V64_L0.5270.20
75_I105_E0.5220.20
34_S38_A0.5190.19
104_L118_G0.5070.19
18_L72_L0.5060.19
105_E134_I0.5040.19
62_R70_E0.5020.19
67_K134_I0.5020.19
52_L136_F0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lb6B 2 0.4257 97.5 0.835 Contact Map
1u2wA 2 0.7297 97.4 0.838 Contact Map
2p4wA 2 0.6419 97.3 0.839 Contact Map
1r1uA 2 0.6554 97.3 0.84 Contact Map
2oqgA 4 0.6622 97.2 0.842 Contact Map
2fu4A 2 0.473 97.1 0.844 Contact Map
2lkpA 2 0.7432 97.1 0.845 Contact Map
3pqkA 2 0.6689 97.1 0.845 Contact Map
4k2eA 2 0.6351 97 0.846 Contact Map
1i1gA 5 0.527 96.9 0.848 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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