GREMLIN Database
Q9HSW9 - Neutral proteinase
UniProt: Q9HSW9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (348)
Sequences: 4495 (2889)
Seq/√Len: 154.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_H267_T5.2121.00
290_S294_E4.1771.00
348_S378_N4.1081.00
328_A335_V3.4821.00
285_A387_V2.9581.00
286_V324_L2.9321.00
210_F320_F2.9321.00
321_T337_E2.9101.00
8_R330_M2.7811.00
270_K274_Q2.7701.00
319_R323_L2.6941.00
342_D345_K2.4271.00
171_V182_L2.3551.00
346_S353_T2.3291.00
325_E337_E2.3271.00
320_F324_L2.3061.00
273_V328_A2.2911.00
319_R322_D2.2351.00
386_N389_P2.1931.00
338_V383_I2.1361.00
358_R361_R2.1221.00
296_E313_H2.1041.00
284_I328_A2.0891.00
343_T383_I2.0431.00
169_Q187_K2.0291.00
365_V372_V2.0181.00
40_W44_R2.0161.00
43_D103_P2.0051.00
286_V335_V1.9931.00
266_H323_L1.9761.00
231_D246_D1.9651.00
234_Y238_R1.9651.00
17_Q20_V1.9611.00
266_H326_Y1.9601.00
246_D250_A1.9481.00
350_C369_C1.8871.00
345_K357_N1.8801.00
347_C350_C1.8681.00
25_D175_W1.8671.00
262_T319_R1.8661.00
55_H59_T1.8561.00
269_S323_L1.8501.00
306_K309_N1.8301.00
282_G333_I1.8141.00
25_D180_W1.8131.00
38_G80_L1.8071.00
56_T59_T1.7991.00
350_C366_C1.7871.00
39_R83_L1.7711.00
13_S179_E1.7391.00
210_F264_Y1.7291.00
349_C371_T1.7251.00
325_E329_E1.7241.00
265_F323_L1.7221.00
26_S70_D1.7061.00
305_G309_N1.7021.00
134_V182_L1.6781.00
366_C369_C1.6741.00
232_D236_S1.6721.00
286_V337_E1.6391.00
266_H327_K1.6371.00
362_G375_A1.6331.00
266_H269_S1.6261.00
347_C369_C1.6111.00
347_C366_C1.5861.00
364_Y373_A1.5571.00
239_L242_C1.5561.00
265_F319_R1.5541.00
129_T132_N1.5381.00
200_T384_R1.5351.00
212_A377_V1.5341.00
22_D26_S1.5231.00
82_E119_T1.5231.00
24_L180_W1.5081.00
288_D337_E1.5071.00
203_V211_A1.5021.00
33_K67_R1.4981.00
354_R357_N1.4821.00
55_H81_Q1.4581.00
9_T183_H1.4561.00
286_V321_T1.4551.00
89_G101_A1.4371.00
363_L372_V1.4231.00
213_L217_D1.4221.00
358_R375_A1.4151.00
21_S25_D1.4041.00
56_T60_S1.3981.00
364_Y371_T1.3951.00
84_A88_N1.3701.00
209_N212_A1.3511.00
276_C282_G1.3471.00
354_R364_Y1.3441.00
235_F247_S1.3431.00
179_E255_E1.3391.00
74_Q121_K1.3381.00
269_S326_Y1.3311.00
201_V213_L1.3271.00
255_E259_A1.3111.00
93_K101_A1.3101.00
38_G83_L1.3071.00
381_E385_Q1.3031.00
176_T255_E1.2971.00
240_A244_D1.2901.00
287_G340_E1.2811.00
357_N361_R1.2741.00
41_V61_Y1.2721.00
92_G100_R1.2581.00
126_K135_R1.2521.00
325_E335_V1.2511.00
352_R367_D1.2501.00
28_G180_W1.2391.00
345_K355_D1.2371.00
269_S320_F1.2361.00
304_W307_H1.2241.00
58_L62_L1.2221.00
269_S327_K1.2031.00
241_Q244_D1.2021.00
74_Q122_Q1.1961.00
85_E89_G1.1941.00
136_L173_S1.1911.00
43_D47_S1.1851.00
231_D253_L1.1851.00
312_L317_F1.1841.00
229_K232_D1.1821.00
377_V381_E1.1821.00
31_A79_V1.1751.00
201_V276_C1.1741.00
177_G255_E1.1741.00
200_T283_T1.1711.00
238_R246_D1.1681.00
87_F103_P1.1671.00
88_N92_G1.1631.00
59_T81_Q1.1631.00
44_R48_E1.1601.00
55_H80_L1.1581.00
238_R241_Q1.1561.00
55_H58_L1.1381.00
359_V362_G1.1321.00
18_Q21_S1.1301.00
270_K331_E1.1291.00
348_S381_E1.1251.00
271_H275_R1.1231.00
45_V49_I1.1221.00
205_L317_F1.1211.00
273_V331_E1.1191.00
354_R367_D1.1151.00
348_S373_A1.1131.00
54_S57_E1.1080.99
265_F320_F1.1080.99
228_L232_D1.1060.99
203_V213_L1.1020.99
354_R358_R1.0970.99
228_L236_S1.0860.99
72_H75_S1.0820.99
197_G282_G1.0790.99
238_R242_C1.0780.99
16_N24_L1.0720.99
290_S340_E1.0700.99
262_T323_L1.0680.99
232_D242_C1.0650.99
227_C231_D1.0580.99
89_G100_R1.0550.99
62_L80_L1.0520.99
174_V183_H1.0520.99
16_N20_V1.0510.99
240_A243_D1.0490.99
373_A381_E1.0460.99
323_L326_Y1.0450.99
214_A380_A1.0440.99
207_I315_W1.0420.99
78_R81_Q1.0350.99
338_V386_N1.0330.99
90_W103_P1.0310.99
59_T80_L1.0310.99
258_S262_T1.0250.99
59_T62_L1.0250.99
35_W79_V1.0240.99
345_K353_T1.0230.99
78_R121_K1.0200.99
235_F246_D1.0140.99
202_G384_R1.0090.99
273_V284_I1.0050.99
265_F269_S1.0050.99
327_K330_M1.0020.99
120_F136_L0.9960.99
119_T172_R0.9890.99
346_S386_N0.9840.99
235_F238_R0.9830.99
239_L244_D0.9810.99
274_Q331_E0.9800.99
89_G93_K0.9760.99
239_L243_D0.9690.99
231_D234_Y0.9680.99
176_T179_E0.9660.99
273_V333_I0.9640.99
343_T386_N0.9630.99
205_L321_T0.9610.99
288_D340_E0.9600.99
373_A377_V0.9600.99
269_S324_L0.9550.98
200_T388_S0.9500.98
124_G137_S0.9480.98
205_L211_A0.9470.98
39_R87_F0.9460.98
128_D135_R0.9460.98
236_S240_A0.9440.98
218_G374_N0.9360.98
285_A383_I0.9360.98
10_Y186_C0.9330.98
296_E305_G0.9260.98
338_V387_V0.9200.98
212_A218_G0.9180.98
322_D325_E0.9140.98
33_K37_V0.9120.98
93_K100_R0.9110.98
253_L257_K0.9090.98
62_L77_Q0.9030.98
11_T176_T0.9030.98
256_K260_R0.9020.98
68_Y76_S0.8950.98
265_F316_A0.8940.98
12_A182_L0.8940.98
249_Q252_R0.8910.98
43_D87_F0.8910.98
93_K102_N0.8880.98
35_W83_L0.8850.98
348_S371_T0.8840.97
29_F32_S0.8830.97
283_T334_S0.8830.97
389_P392_V0.8830.97
235_F243_D0.8770.97
77_Q81_Q0.8730.97
221_E224_P0.8720.97
200_T285_A0.8710.97
211_A268_L0.8700.97
82_E172_R0.8680.97
235_F250_A0.8680.97
234_Y237_K0.8620.97
328_A333_I0.8610.97
352_R368_S0.8600.97
362_G374_N0.8590.97
377_V380_A0.8590.97
156_I159_D0.8560.97
35_W86_A0.8510.97
207_I311_D0.8510.97
7_T185_V0.8510.97
231_D250_A0.8450.97
238_R244_D0.8430.97
217_D271_H0.8420.97
363_L373_A0.8410.97
231_D235_F0.8400.97
361_R364_Y0.8390.97
74_Q78_R0.8360.96
345_K356_A0.8350.96
201_V214_A0.8320.96
236_S239_L0.8310.96
233_Y236_S0.8260.96
57_E60_S0.8240.96
292_V318_D0.8230.96
30_A68_Y0.8200.96
209_N220_S0.8190.96
379_G382_N0.8170.96
224_P260_R0.8150.96
349_C381_E0.8140.96
283_T336_E0.8120.96
89_G92_G0.8120.96
30_A67_R0.8100.96
361_R375_A0.8100.96
42_C58_L0.8100.96
126_K129_T0.8080.96
120_F123_K0.8080.96
209_N218_G0.8060.96
37_V41_V0.8010.96
80_L84_A0.8000.95
74_Q123_K0.7990.95
340_E343_T0.7980.95
21_S180_W0.7970.95
45_V53_P0.7960.95
232_D235_F0.7950.95
353_T357_N0.7930.95
207_I296_E0.7910.95
14_I182_L0.7900.95
40_W106_Y0.7840.95
218_G377_V0.7830.95
229_K236_S0.7810.95
41_V45_V0.7780.95
34_L79_V0.7770.95
231_D236_S0.7770.95
173_S182_L0.7770.95
348_S385_Q0.7750.95
232_D240_A0.7740.95
78_R119_T0.7740.95
357_N375_A0.7730.95
71_L74_Q0.7730.95
42_C87_F0.7720.95
318_D322_D0.7710.94
46_W87_F0.7710.94
119_T170_Q0.7710.94
378_N382_N0.7660.94
13_S181_E0.7660.94
172_R183_H0.7660.94
381_E384_R0.7630.94
238_R249_Q0.7620.94
272_I284_I0.7620.94
342_D386_N0.7610.94
348_S379_G0.7600.94
215_Y276_C0.7590.94
296_E309_N0.7540.94
336_E387_V0.7540.94
358_R362_G0.7530.94
222_L225_L0.7510.94
387_V391_P0.7500.94
170_Q185_V0.7480.94
264_Y268_L0.7480.94
7_T187_K0.7450.93
74_Q124_G0.7450.93
270_K327_K0.7440.93
199_K282_G0.7430.93
15_R155_Q0.7330.93
231_D238_R0.7320.93
81_Q121_K0.7300.93
204_D376_D0.7260.93
78_R82_E0.7260.93
214_A377_V0.7250.92
306_K313_H0.7250.92
90_W104_P0.7240.92
42_C84_A0.7210.92
386_N390_S0.7160.92
208_N212_A0.7160.92
134_V171_V0.7140.92
74_Q77_Q0.7140.92
198_E282_G0.7130.92
232_D241_Q0.7130.92
30_A71_L0.7110.92
247_S251_T0.7110.92
18_Q22_D0.7000.91
276_C284_I0.6990.91
125_F137_S0.6980.91
201_V284_I0.6930.91
257_K314_S0.6920.91
292_V317_F0.6890.90
254_N261_R0.6880.90
346_S382_N0.6870.90
23_D27_L0.6860.90
124_G127_L0.6860.90
53_P62_L0.6850.90
38_G62_L0.6850.90
29_F33_K0.6840.90
364_Y375_A0.6800.90
236_S250_A0.6790.90
166_E186_C0.6780.90
308_G312_L0.6760.90
210_F315_W0.6750.90
27_L31_A0.6740.90
261_R314_S0.6730.89
167_N187_K0.6720.89
136_L139_G0.6710.89
24_L118_V0.6700.89
274_Q283_T0.6700.89
175_W180_W0.6700.89
214_A218_G0.6690.89
304_W313_H0.6670.89
73_S122_Q0.6650.89
12_A158_P0.6640.89
26_S30_A0.6630.89
156_I160_V0.6630.89
83_L87_F0.6630.89
344_S357_N0.6610.89
190_V329_E0.6600.89
285_A336_E0.6590.88
262_T266_H0.6580.88
268_L271_H0.6570.88
11_T174_V0.6570.88
284_I324_L0.6570.88
328_A331_E0.6560.88
228_L235_F0.6550.88
342_D353_T0.6520.88
305_G308_G0.6490.88
229_K233_Y0.6490.88
289_L340_E0.6490.88
30_A33_K0.6490.88
342_D346_S0.6450.87
46_W50_G0.6440.87
388_S392_V0.6440.87
9_T185_V0.6400.87
58_L61_Y0.6400.87
346_S355_D0.6390.87
359_V375_A0.6390.87
38_G58_L0.6290.86
356_A361_R0.6280.86
87_F91_Y0.6280.86
285_A384_R0.6270.86
115_R174_V0.6260.86
324_L335_V0.6260.86
24_L28_G0.6250.86
288_D321_T0.6250.86
228_L242_C0.6240.86
358_R364_Y0.6230.86
27_L71_L0.6220.85
66_E69_D0.6210.85
235_F239_L0.6200.85
211_A320_F0.6190.85
41_V44_R0.6170.85
228_L250_A0.6160.85
285_A386_N0.6140.85
326_Y330_M0.6120.84
135_R141_N0.6120.84
232_D250_A0.6110.84
272_I276_C0.6110.84
37_V67_R0.6090.84
304_W308_G0.6060.84
118_V121_K0.6050.84
208_N362_G0.6050.84
345_K354_R0.6040.84
57_E61_Y0.6040.84
294_E340_E0.6030.84
230_Q234_Y0.6020.84
55_H60_S0.5990.83
19_Q22_D0.5980.83
232_D254_N0.5970.83
47_S50_G0.5960.83
212_A222_L0.5960.83
11_T183_H0.5950.83
236_S242_C0.5950.83
361_R367_D0.5940.83
10_Y158_P0.5910.82
388_S391_P0.5910.82
128_D133_R0.5910.82
27_L72_H0.5910.82
275_R282_G0.5900.82
46_W91_Y0.5890.82
86_A104_P0.5880.82
234_Y246_D0.5870.82
34_L76_S0.5850.82
359_V374_N0.5850.82
90_W93_K0.5840.82
41_V58_L0.5830.82
309_N313_H0.5820.81
28_G118_V0.5820.81
154_Y157_R0.5810.81
210_F269_S0.5810.81
219_H268_L0.5790.81
110_G116_S0.5790.81
27_L118_V0.5770.81
23_D26_S0.5770.81
16_N21_S0.5770.81
116_S175_W0.5760.81
196_P199_K0.5690.80
268_L320_F0.5670.80
228_L244_D0.5660.80
354_R361_R0.5660.80
53_P58_L0.5640.79
323_L327_K0.5630.79
71_L76_S0.5610.79
349_C373_A0.5610.79
356_A364_Y0.5570.79
215_Y218_G0.5530.78
125_F129_T0.5530.78
305_G313_H0.5530.78
79_V83_L0.5520.78
40_W43_D0.5510.78
254_N258_S0.5510.78
365_V371_T0.5510.78
92_G101_A0.5500.78
235_F242_C0.5490.78
87_F90_W0.5490.78
11_T262_T0.5490.78
229_K239_L0.5490.78
210_F265_F0.5470.77
229_K235_F0.5450.77
229_K240_A0.5450.77
54_S62_L0.5450.77
204_D344_S0.5450.77
321_T325_E0.5450.77
295_D312_L0.5440.77
46_W49_I0.5420.77
229_K234_Y0.5410.77
179_E259_A0.5410.77
80_L83_L0.5400.76
339_S342_D0.5400.76
221_E315_W0.5380.76
110_G114_P0.5370.76
285_A388_S0.5360.76
355_D364_Y0.5360.76
259_A263_H0.5340.76
117_T121_K0.5330.75
11_T181_E0.5320.75
45_V51_H0.5310.75
26_S29_F0.5290.75
226_N231_D0.5280.75
213_L218_G0.5270.75
228_L239_L0.5270.75
152_C155_Q0.5270.75
206_G212_A0.5260.75
267_T270_K0.5260.75
293_R318_D0.5260.75
259_A262_T0.5250.74
202_G214_A0.5250.74
292_V312_L0.5240.74
385_Q388_S0.5240.74
32_S110_G0.5240.74
76_S79_V0.5240.74
294_E308_G0.5230.74
244_D249_Q0.5230.74
14_I154_Y0.5210.74
125_F171_V0.5190.74
72_H118_V0.5170.73
53_P57_E0.5150.73
175_W181_E0.5140.73
140_S151_L0.5120.73
383_I386_N0.5090.72
296_E304_W0.5060.72
194_E333_I0.5060.72
373_A378_N0.5060.72
52_I58_L0.5050.72
202_G380_A0.5050.72
316_A319_R0.5040.71
232_D239_L0.5020.71
42_C45_V0.5020.71
44_R47_S0.5020.71
357_N367_D0.5000.71
376_D379_G0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3052 96.2 0.926 Contact Map
1vhxA 2 0.3216 96.1 0.927 Contact Map
1iv0A 1 0.2277 94.9 0.932 Contact Map
4aybP 1 0.1009 88.4 0.944 Contact Map
1qypA 1 0.108 83.2 0.948 Contact Map
1vd4A 1 0.1315 83.2 0.948 Contact Map
1ffkW 1 0.169 82.3 0.949 Contact Map
1vq8Z 1 0.1714 81.2 0.949 Contact Map
3j20Y 1 0.1174 79.4 0.95 Contact Map
2k4xA 1 0.1244 74.8 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0105 seconds.