GREMLIN Database
Q9HSW8 - Uncharacterized protein
UniProt: Q9HSW8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 130 (123)
Sequences: 1729 (1152)
Seq/√Len: 103.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_R93_E4.6221.00
37_R94_F2.8301.00
42_A82_L2.4131.00
17_Y69_T2.2991.00
41_I86_T2.2761.00
55_N128_D2.1031.00
42_A86_T2.0831.00
19_F79_I1.9231.00
51_A78_F1.8841.00
69_T75_L1.8561.00
19_F67_F1.8091.00
17_Y114_T1.7821.00
125_D129_D1.7461.00
37_R40_E1.7231.00
89_R92_S1.7191.00
49_F81_S1.7191.00
88_R92_S1.7141.00
13_Y112_L1.7071.00
66_L127_V1.6921.00
22_V107_Q1.6631.00
91_R103_D1.5491.00
125_D128_D1.5421.00
37_R41_I1.5391.00
120_I124_M1.5271.00
77_K80_N1.5101.00
39_A43_H1.4661.00
67_F78_F1.4591.00
15_L69_T1.4501.00
87_S91_R1.4461.00
30_L105_F1.4211.00
46_A53_I1.3981.00
38_V90_I1.3781.00
45_I85_V1.3661.00
50_E72_T1.3651.00
45_I49_F1.3610.99
8_G11_T1.3410.99
35_L39_A1.3280.99
27_A101_L1.3070.99
70_K73_T1.3040.99
66_L120_I1.2890.99
52_D68_Q1.2800.99
15_L112_L1.2750.99
22_V26_R1.2710.99
121_D124_M1.2560.99
124_M128_D1.2460.99
30_L38_V1.2260.99
69_T78_F1.2180.99
17_Y112_L1.2150.99
115_T120_I1.2060.99
41_I85_V1.1630.98
17_Y75_L1.1520.98
15_L75_L1.1130.98
97_V103_D1.1130.98
41_I89_R1.1120.98
119_S122_T1.0920.98
46_A82_L1.0880.98
76_T110_Y1.0870.98
43_H47_D1.0750.97
8_G13_Y1.0660.97
19_F75_L1.0650.97
39_A57_D1.0620.97
34_R96_E1.0560.97
71_P76_T1.0530.97
46_A51_A1.0460.97
75_L112_L1.0460.97
42_A56_V1.0290.97
46_A65_I1.0280.97
87_S103_D1.0150.96
74_D77_K1.0080.96
42_A63_V0.9890.96
44_D48_D0.9880.96
39_A58_G0.9770.95
75_L79_I0.9710.95
55_N124_M0.9640.95
19_F112_L0.9600.95
16_Q115_T0.9500.95
81_S85_V0.9490.95
44_D47_D0.9390.94
46_A78_F0.9330.94
41_I45_I0.9330.94
13_Y68_Q0.9300.94
38_V42_A0.9230.94
18_H115_T0.9230.94
73_T78_F0.9210.94
34_R90_I0.8990.93
51_A73_T0.8890.92
66_L115_T0.8860.92
16_Q68_Q0.8850.92
106_W110_Y0.8810.92
14_A113_A0.8770.92
39_A56_V0.8700.92
116_G119_S0.8570.91
122_T125_D0.8500.91
80_N108_P0.8470.90
58_G63_V0.8310.90
37_R90_I0.8270.89
35_L59_G0.8200.89
91_R98_T0.8170.89
16_Q54_K0.8160.89
30_L90_I0.8150.89
40_E47_D0.8090.88
33_E37_R0.8050.88
67_F75_L0.8040.88
40_E90_I0.7980.88
45_I81_S0.7940.87
41_I44_D0.7830.87
98_T101_L0.7740.86
28_D61_D0.7710.86
30_L35_L0.7710.86
15_L114_T0.7640.85
81_S84_G0.7630.85
67_F112_L0.7620.85
46_A84_G0.7560.85
87_S104_A0.7530.85
21_T67_F0.7520.84
35_L57_D0.7500.84
11_T15_L0.7440.84
74_D79_I0.7430.84
42_A65_I0.7400.83
90_I93_E0.7370.83
91_R104_A0.7180.82
77_K81_S0.7160.81
13_Y17_Y0.7150.81
14_A111_F0.7150.81
119_S127_V0.7050.80
35_L58_G0.6990.80
43_H53_I0.6920.79
14_A68_Q0.6880.79
95_P98_T0.6810.78
118_V123_L0.6750.77
97_V101_L0.6740.77
32_Y36_E0.6680.77
39_A59_G0.6590.76
30_L34_R0.6560.75
70_K76_T0.6550.75
80_N84_G0.6530.75
103_D107_Q0.6400.74
9_S109_G0.6400.74
40_E44_D0.6390.74
13_Y71_P0.6390.74
35_L56_V0.6310.73
42_A53_I0.6220.72
55_N63_V0.6100.70
41_I78_F0.6080.70
113_A119_S0.6070.70
101_L104_A0.6070.70
70_K74_D0.6050.69
121_D125_D0.6040.69
50_E70_K0.6010.69
53_I67_F0.5990.69
84_G91_R0.5970.68
30_L58_G0.5930.68
113_A118_V0.5930.68
54_K68_Q0.5920.68
44_D89_R0.5920.68
36_E40_E0.5870.67
8_G70_K0.5720.65
51_A79_I0.5650.64
10_H109_G0.5640.64
18_H62_H0.5630.64
84_G104_A0.5620.64
16_Q120_I0.5570.63
18_H64_H0.5560.63
74_D114_T0.5550.63
49_F85_V0.5490.62
84_G88_R0.5480.62
84_G87_S0.5450.61
104_A108_P0.5440.61
48_D85_V0.5360.60
25_Y105_F0.5310.59
47_D53_I0.5310.59
66_L118_V0.5310.59
85_V89_R0.5240.58
31_T35_L0.5200.58
118_V122_T0.5190.58
16_Q66_L0.5190.58
45_I48_D0.5180.58
91_R95_P0.5130.57
33_E36_E0.5120.57
99_Q102_E0.5120.57
127_V130_Q0.5110.57
117_Q120_I0.5100.56
15_L80_N0.5020.55
85_V88_R0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vjvA 2 0.9538 100 0.33 Contact Map
2f5gA 2 0.9538 100 0.354 Contact Map
2fyxA 2 0.9615 100 0.361 Contact Map
4er8A 1 0.9 99.9 0.494 Contact Map
4re1A 1 0.6 20.3 0.937 Contact Map
4nrdA 3 0.5769 19.7 0.937 Contact Map
1jnpA 2 0.2385 17.8 0.938 Contact Map
3l15A 1 0.5692 12 0.943 Contact Map
3knyA 2 0.6923 10.2 0.945 Contact Map
2ii1A 2 0.7154 8.4 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0062 seconds.