Q9HSW7 - HALSA - GREMLIN Contacts

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Q9HSW7 - Uncharacterized protein

UniProt:	Q9HSW7	Sequences: MTATTTKTLEATLAPPTAHKERKLCDLLETYREGLHEAFDAGCDTMTATSDVVTPYDLPYQAKAALCNYVPQLHDTYNAQELDDDHPVRLTNQAAEFDHSAARDYEFTWWAPQPGRGTNFWIPLRINPEQDGLWHDLVHGEASAGQLRLQRHRTSWTLHVTVEFPVEQPDYEPTDEDVTPVGFDIGEAHLLAGCACKQGTPTDPLLINGGRARHLRKEMFTTLKRLQERDAAQWRIDERFDHYQNALTDIIEKASRQAIEYACRFEKPVVVLEDLSYIREDLDYGEWMNRRLHAWAFARLQERIEDKAREAGIPVEYIRPEYTSQTCHECGHIGYRDGDEFRCQNDECWVSEYHADINAAVNIADRHDPWGESLPLKPAGDDISRDGSACDSAATPTEQSQPRQMTLGEVGSEPTAGS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	418 (346)
Sequences:	4566 (3009)
Seq/√Len:	161.8

ECOLI - INSQ
HALSA - Q9HSW7 Q9HHG8 Q9HM87 Q9HHJ9 Q9HHU6 Q9HSW9 Q9HSZ6 Q9HSD4 Q9HHX8 Q9HSY4
SULSO - Q97X39 Q7LXD9 Q97WZ3 Q97XQ8 Q97Y67 Q97YI2 Q97V47 Q97WY6 Q97YU1 Q97XP1 Q97Y44 Q7LXH2 Q97V25 Q97YI5 Q97UQ8 Q97YW4 Q97U51 Q97U68 Q97XQ0 Q97YW9 Q97Z61 Q97XB6 Q97Y48 Q97XA4 Q97V53 Q7LXH6 Q97YF7 Y2105 Q97U09 Q7LX59

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
249_D	253_K	5.678	1.00
328_H	358_N	4.569	1.00
276_S	281_D	4.123	1.00
308_A	315_V	3.678	1.00
190_L	300_L	3.209	1.00
271_V	367_H	3.084	1.00
301_Q	317_Y	3.074	1.00
7_K	310_E	3.035	1.00
272_L	304_I	3.034	1.00
350_V	353_Y	3.021	1.00
299_R	303_R	2.907	1.00
256_R	260_E	2.854	1.00
147_L	158_L	2.554	1.00
326_T	333_I	2.516	1.00
209_G	290_R	2.498	1.00
300_L	304_I	2.484	1.00
305_E	317_Y	2.464	1.00
299_R	302_E	2.415	1.00
259_I	308_A	2.414	1.00
270_V	308_A	2.378	1.00
322_Y	325_Q	2.330	1.00
283_D	293_H	2.320	1.00
318_I	363_I	2.314	1.00
252_E	306_D	2.302	1.00
336_R	355_A	2.165	1.00
252_E	303_R	2.163	1.00
17_T	20_K	2.153	1.00
40_D	44_D	2.151	1.00
145_G	163_E	2.141	1.00
366_R	369_P	2.138	1.00
25_C	151_R	2.084	1.00
215_L	232_A	2.082	1.00
323_T	363_I	2.070	1.00
330_C	348_C	2.052	1.00
342_R	352_E	2.034	1.00
190_L	250_I	2.025	1.00
272_L	315_V	1.969	1.00
255_S	303_R	1.963	1.00
286_E	289_N	1.955	1.00
285_G	289_N	1.941	1.00
343_C	348_C	1.923	1.00
268_P	313_I	1.914	1.00
330_C	343_C	1.912	1.00
327_C	330_C	1.874	1.00
248_T	299_R	1.859	1.00
218_E	222_T	1.853	1.00
251_I	303_R	1.850	1.00
43_C	94_A	1.847	1.00
252_E	307_K	1.845	1.00
327_C	348_C	1.792	1.00
252_E	255_S	1.790	1.00
232_A	236_I	1.768	1.00
327_C	343_C	1.765	1.00
12_T	155_S	1.745	1.00
305_E	309_R	1.742	1.00
25_C	156_W	1.740	1.00
12_T	15_P	1.737	1.00
341_F	353_Y	1.707	1.00
183_F	191_L	1.701	1.00
251_I	299_R	1.689	1.00
24_L	156_W	1.681	1.00
59_P	63_K	1.665	1.00
272_L	317_Y	1.639	1.00
274_D	317_Y	1.623	1.00
336_R	339_D	1.601	1.00
230_D	233_Q	1.598	1.00
227_Q	230_D	1.597	1.00
329_E	350_V	1.581	1.00
272_L	301_Q	1.566	1.00
208_N	246_A	1.555	1.00
84_D	87_P	1.532	1.00
8_T	159_H	1.531	1.00
16_P	20_K	1.518	1.00
180_P	364_A	1.512	1.00
22_R	26_D	1.497	1.00
193_G	197_K	1.481	1.00
60_Y	63_K	1.478	1.00
219_M	233_Q	1.475	1.00
59_P	62_A	1.473	1.00
341_F	350_V	1.460	1.00
273_E	320_P	1.459	1.00
58_L	62_A	1.451	1.00
255_S	306_D	1.450	1.00
28_L	156_W	1.444	1.00
241_D	245_N	1.412	1.00
189_H	192_A	1.409	1.00
255_S	307_K	1.407	1.00
192_A	357_I	1.405	1.00
80_Q	84_D	1.400	1.00
60_Y	64_A	1.381	1.00
332_H	344_Q	1.374	1.00
155_S	241_D	1.358	1.00
120_F	158_L	1.356	1.00
152_H	241_D	1.356	1.00
111_A	115_G	1.356	1.00
361_V	365_D	1.354	1.00
21_E	25_C	1.348	1.00
58_L	63_K	1.344	1.00
340_E	352_E	1.322	1.00
111_A	114_P	1.302	1.00
54_T	57_D	1.268	1.00
225_R	229_R	1.263	1.00
292_L	297_F	1.257	1.00
222_T	232_A	1.256	1.00
181_V	193_G	1.245	1.00
305_E	315_V	1.245	1.00
86_H	91_T	1.238	1.00
328_H	353_Y	1.227	1.00
26_D	69_Y	1.227	1.00
215_L	239_R	1.218	1.00
177_D	268_P	1.217	1.00
208_N	243_Y	1.207	1.00
357_I	361_V	1.205	1.00
153_R	241_D	1.203	1.00
328_H	361_V	1.201	1.00
88_V	92_N	1.201	1.00
122_I	149_L	1.197	1.00
259_I	311_A	1.196	1.00
185_I	297_F	1.189	1.00
43_C	47_T	1.174	1.00
223_L	226_L	1.170	1.00
256_R	311_A	1.168	1.00
18_A	21_E	1.166	1.00
251_I	255_S	1.166	1.00
255_S	300_L	1.165	1.00
276_S	320_P	1.163	1.00
251_I	300_L	1.158	1.00
277_Y	298_A	1.155	1.00
339_D	355_A	1.153	1.00
183_F	193_G	1.148	1.00
74_H	77_Y	1.142	1.00
303_R	306_D	1.137	1.00
150_Q	159_H	1.131	1.00
248_T	303_R	1.119	1.00
53_V	56_Y	1.114	1.00
44_D	48_A	1.106	1.00
180_P	269_V	1.099	1.00
81_E	85_D	1.096	1.00
10_E	152_H	1.094	1.00
318_I	366_R	1.094	1.00
187_E	295_W	1.086	0.99
194_C	360_A	1.084	0.99
326_T	366_R	1.078	0.99
51_D	54_T	1.076	0.99
116_R	119_N	1.071	0.99
33_E	66_L	1.062	0.99
219_M	232_A	1.060	0.99
328_H	350_V	1.059	0.99
58_L	61_Q	1.057	0.99
35_L	76_T	1.054	0.99
255_S	304_I	1.052	0.99
260_E	311_A	1.048	0.99
82_L	86_H	1.043	0.99
55_P	59_P	1.043	0.99
235_R	238_E	1.042	0.99
257_Q	266_E	1.042	0.99
109_W	112_P	1.042	0.99
259_I	313_I	1.040	0.99
126_I	130_Q	1.028	0.99
323_T	366_R	1.027	0.99
259_I	270_V	1.027	0.99
325_Q	335_Y	1.027	0.99
33_E	37_E	1.024	0.99
182_G	364_A	1.018	0.99
45_T	49_T	1.017	0.99
353_Y	357_I	1.014	0.99
9_L	162_V	1.013	0.99
84_D	94_A	1.010	0.99
332_H	347_E	1.009	0.99
50_S	53_V	1.008	0.99
61_Q	64_A	1.006	0.99
83_D	87_P	1.003	0.99
211_R	215_L	0.999	0.99
59_P	64_A	0.995	0.99
112_P	115_G	0.990	0.99
353_Y	361_V	0.984	0.99
283_D	289_N	0.980	0.99
185_I	301_Q	0.979	0.99
51_D	57_D	0.974	0.99
318_I	367_H	0.973	0.99
244_Q	248_T	0.971	0.99
307_K	310_E	0.966	0.99
205_L	208_N	0.965	0.99
192_A	198_Q	0.963	0.99
302_E	305_E	0.954	0.99
213_R	216_R	0.950	0.99
180_P	271_V	0.949	0.99
369_P	372_E	0.949	0.99
180_P	368_D	0.948	0.99
269_V	314_P	0.942	0.99
181_V	267_K	0.942	0.99
125_R	128_P	0.941	0.99
320_P	323_T	0.939	0.99
215_L	236_I	0.932	0.98
86_H	92_N	0.924	0.98
328_H	359_A	0.922	0.98
251_I	296_A	0.919	0.98
65_A	68_N	0.918	0.98
258_A	270_V	0.915	0.98
204_P	246_A	0.914	0.98
308_A	313_I	0.911	0.98
338_G	341_F	0.908	0.98
16_P	24_L	0.908	0.98
50_S	54_T	0.903	0.98
358_N	362_N	0.901	0.98
107_F	110_W	0.900	0.98
271_V	363_I	0.898	0.98
108_T	112_P	0.897	0.98
357_I	360_A	0.896	0.98
119_N	127_N	0.895	0.98
88_V	91_T	0.892	0.98
107_F	111_A	0.891	0.98
215_L	218_E	0.891	0.98
216_R	220_F	0.890	0.98
152_H	155_S	0.888	0.98
195_A	267_K	0.888	0.98
222_T	225_R	0.887	0.98
216_R	236_I	0.881	0.98
334_G	341_F	0.879	0.98
72_Q	76_T	0.878	0.98
274_D	320_P	0.874	0.98
108_T	111_A	0.872	0.98
277_Y	297_F	0.869	0.98
229_R	233_Q	0.869	0.98
239_R	243_Y	0.868	0.98
41_A	45_T	0.866	0.98
71_P	74_H	0.866	0.98
359_A	362_N	0.866	0.98
29_E	32_R	0.864	0.97
285_G	288_M	0.860	0.97
37_E	41_A	0.860	0.97
27_L	31_Y	0.859	0.97
6_T	161_T	0.859	0.97
325_Q	333_I	0.853	0.97
13_L	158_L	0.849	0.97
80_Q	83_D	0.848	0.97
361_V	364_A	0.841	0.97
63_K	66_L	0.841	0.97
189_H	198_Q	0.840	0.97
120_F	147_L	0.838	0.97
187_E	291_R	0.837	0.97
151_R	156_W	0.837	0.97
256_R	307_K	0.831	0.97
89_R	92_N	0.830	0.97
74_H	84_D	0.827	0.97
126_I	129_E	0.825	0.97
367_H	371_G	0.823	0.97
212_A	236_I	0.819	0.97
181_V	194_C	0.818	0.96
148_R	159_H	0.815	0.96
340_E	353_Y	0.814	0.96
74_H	78_N	0.814	0.96
326_T	362_N	0.810	0.96
219_M	236_I	0.808	0.96
81_E	84_D	0.805	0.96
250_I	254_A	0.804	0.96
21_E	156_W	0.801	0.96
149_L	158_L	0.798	0.96
189_H	200_T	0.794	0.96
194_C	357_I	0.794	0.96
212_A	240_F	0.793	0.96
341_F	355_A	0.793	0.96
112_P	121_W	0.788	0.96
281_D	292_L	0.784	0.96
198_Q	354_H	0.778	0.95
275_L	320_P	0.777	0.95
197_K	257_Q	0.775	0.95
30_T	33_E	0.775	0.95
23_K	27_L	0.772	0.95
199_G	202_T	0.767	0.95
185_I	191_L	0.767	0.95
219_M	222_T	0.764	0.95
67_C	70_V	0.762	0.95
45_T	53_V	0.762	0.95
142_A	162_V	0.761	0.95
103_R	106_E	0.761	0.95
122_I	147_L	0.760	0.95
366_R	370_W	0.757	0.95
274_D	301_Q	0.757	0.95
58_L	64_A	0.756	0.95
222_T	226_L	0.755	0.95
316_E	367_H	0.755	0.95
188_A	339_D	0.755	0.95
109_W	113_Q	0.755	0.95
339_D	354_H	0.750	0.94
288_M	292_L	0.749	0.94
206_L	291_R	0.748	0.94
254_A	257_Q	0.747	0.94
242_H	246_A	0.747	0.94
284_Y	288_M	0.747	0.94
188_A	192_A	0.745	0.94
337_D	355_A	0.744	0.94
201_P	204_P	0.743	0.94
74_H	80_Q	0.743	0.94
40_D	97_F	0.742	0.94
52_V	55_P	0.741	0.94
122_I	125_R	0.740	0.94
127_N	130_Q	0.739	0.94
322_Y	326_T	0.738	0.94
11_A	158_L	0.737	0.94
29_E	33_E	0.736	0.94
269_V	316_E	0.732	0.94
41_A	44_D	0.731	0.94
322_Y	366_R	0.729	0.93
198_Q	357_I	0.729	0.93
179_T	268_P	0.728	0.93
178_V	268_P	0.728	0.93
336_R	341_F	0.727	0.93
181_V	270_V	0.727	0.93
192_A	206_L	0.725	0.93
66_L	70_V	0.723	0.93
56_Y	59_P	0.723	0.93
184_D	356_D	0.722	0.93
191_L	254_A	0.721	0.93
334_G	338_G	0.720	0.93
363_I	366_R	0.718	0.93
6_T	163_E	0.718	0.93
285_G	293_H	0.718	0.93
298_A	302_E	0.717	0.93
219_M	229_R	0.716	0.93
212_A	220_F	0.716	0.93
328_H	365_D	0.716	0.93
66_L	71_P	0.712	0.93
226_L	229_R	0.709	0.92
271_V	316_E	0.705	0.92
286_E	293_H	0.702	0.92
214_H	218_E	0.701	0.92
10_E	159_H	0.701	0.92
87_P	94_A	0.701	0.92
247_L	294_A	0.699	0.92
243_Y	294_A	0.696	0.92
222_T	235_R	0.695	0.92
65_A	70_V	0.694	0.92
83_D	88_V	0.694	0.92
121_W	127_N	0.694	0.92
10_E	150_Q	0.692	0.92
101_A	104_D	0.690	0.91
146_Q	161_T	0.688	0.91
368_D	372_E	0.686	0.91
110_W	113_Q	0.683	0.91
11_A	136_D	0.683	0.91
80_Q	86_H	0.682	0.91
198_Q	201_P	0.682	0.91
75_D	79_A	0.682	0.91
74_H	83_D	0.680	0.91
12_T	157_T	0.678	0.91
108_T	113_Q	0.667	0.90
122_I	128_P	0.667	0.90
39_F	80_Q	0.666	0.90
85_D	89_R	0.662	0.90
88_V	95_A	0.660	0.90
77_Y	81_E	0.658	0.89
165_P	170_D	0.658	0.89
78_N	81_E	0.656	0.89
284_Y	293_H	0.655	0.89
260_E	269_V	0.647	0.89
62_A	74_H	0.645	0.88
45_T	48_A	0.644	0.88
233_Q	237_D	0.643	0.88
285_G	292_L	0.643	0.88
190_L	251_I	0.641	0.88
66_L	74_H	0.639	0.88
99_H	102_A	0.639	0.88
40_D	43_C	0.638	0.88
67_C	71_P	0.635	0.88
78_N	82_L	0.635	0.88
8_T	161_T	0.634	0.88
18_A	22_R	0.634	0.88
59_P	77_Y	0.634	0.88
9_L	136_D	0.631	0.87
69_Y	73_L	0.628	0.87
270_V	304_I	0.625	0.87
83_D	86_H	0.624	0.87
65_A	69_Y	0.624	0.87
281_D	320_P	0.622	0.87
104_D	107_F	0.622	0.87
81_E	87_P	0.621	0.87
38_A	77_Y	0.621	0.87
52_V	56_Y	0.620	0.86
190_L	295_W	0.620	0.86
186_G	192_A	0.618	0.86
303_R	307_K	0.616	0.86
218_E	221_T	0.615	0.86
95_A	98_D	0.614	0.86
26_D	30_T	0.614	0.86
329_E	361_V	0.614	0.86
319_R	322_Y	0.611	0.86
80_Q	87_P	0.610	0.86
179_T	267_K	0.610	0.86
267_K	313_I	0.609	0.85
112_P	123_P	0.608	0.85
230_D	234_W	0.607	0.85
86_H	90_L	0.606	0.85
26_D	29_E	0.605	0.85
306_D	310_E	0.603	0.85
240_F	247_L	0.597	0.84
24_L	28_L	0.597	0.84
66_L	69_Y	0.596	0.84
23_K	26_D	0.595	0.84
95_A	99_H	0.593	0.84
199_G	250_I	0.593	0.84
245_N	249_D	0.592	0.84
49_T	52_V	0.589	0.84
321_E	325_Q	0.589	0.84
30_T	70_V	0.589	0.84
113_Q	123_P	0.589	0.84
271_V	364_A	0.588	0.83
101_A	105_Y	0.587	0.83
245_N	248_T	0.587	0.83
176_E	179_T	0.585	0.83
271_V	366_R	0.582	0.83
90_L	98_D	0.580	0.83
73_L	77_Y	0.579	0.83
253_K	256_R	0.576	0.82
368_D	371_G	0.576	0.82
70_V	73_L	0.574	0.82
72_Q	75_D	0.571	0.82
155_S	245_N	0.571	0.82
308_A	311_A	0.570	0.82
166_V	309_R	0.568	0.81
71_P	78_N	0.567	0.81
46_M	49_T	0.566	0.81
187_E	282_L	0.564	0.81
53_V	57_D	0.562	0.81
108_T	122_I	0.562	0.81
37_E	40_D	0.562	0.81
338_G	355_A	0.562	0.81
326_T	331_G	0.561	0.81
325_Q	334_G	0.561	0.81
182_G	360_A	0.560	0.80
336_R	354_H	0.560	0.80
332_H	341_F	0.558	0.80
215_L	222_T	0.558	0.80
99_H	105_Y	0.557	0.80
248_T	252_E	0.557	0.80
42_G	46_M	0.556	0.80
39_F	43_C	0.556	0.80
341_F	344_Q	0.556	0.80
353_Y	358_N	0.556	0.80
365_D	368_D	0.554	0.80
79_A	84_D	0.553	0.80
143_S	163_E	0.551	0.79
200_T	203_D	0.551	0.79
342_R	350_V	0.551	0.79
16_P	21_E	0.550	0.79
10_E	248_T	0.550	0.79
19_H	22_R	0.549	0.79
222_T	229_R	0.549	0.79
63_K	77_Y	0.549	0.79
202_T	205_L	0.545	0.79
204_P	208_N	0.545	0.79
289_N	293_H	0.544	0.78
216_R	240_F	0.544	0.78
190_L	255_S	0.543	0.78
213_R	217_K	0.542	0.78
243_Y	247_L	0.542	0.78
79_A	83_D	0.542	0.78
184_D	324_S	0.541	0.78
322_Y	333_I	0.540	0.78
282_L	286_E	0.540	0.78
251_I	254_A	0.539	0.78
75_D	83_D	0.539	0.78
284_Y	287_W	0.539	0.78
217_K	220_F	0.538	0.78
51_D	56_Y	0.536	0.77
55_P	63_K	0.536	0.77
110_W	115_G	0.536	0.77
110_W	114_P	0.535	0.77
283_D	286_E	0.534	0.77
108_T	115_G	0.534	0.77
6_T	145_G	0.534	0.77
151_R	157_T	0.533	0.77
304_I	315_V	0.532	0.77
182_G	271_V	0.532	0.77
208_N	242_H	0.532	0.77
124_L	128_P	0.531	0.77
320_P	366_R	0.531	0.77
363_I	367_H	0.529	0.77
42_G	49_T	0.527	0.76
350_V	358_N	0.527	0.76
27_L	70_V	0.527	0.76
108_T	123_P	0.526	0.76
102_A	106_E	0.526	0.76
354_H	359_A	0.526	0.76
68_N	72_Q	0.525	0.76
42_G	45_T	0.525	0.76
326_T	341_F	0.525	0.76
109_W	115_G	0.524	0.76
66_L	83_D	0.524	0.76
205_L	290_R	0.523	0.76
24_L	106_E	0.523	0.76
364_A	368_D	0.523	0.76
213_R	221_T	0.523	0.76
119_N	122_I	0.522	0.76
208_N	239_R	0.521	0.75
198_Q	202_T	0.520	0.75
287_W	291_R	0.520	0.75
69_Y	148_R	0.520	0.75
42_G	81_E	0.520	0.75
13_L	130_Q	0.519	0.75
220_F	236_I	0.519	0.75
191_L	199_G	0.518	0.75
55_P	77_Y	0.518	0.75
365_D	370_W	0.518	0.75
68_N	71_P	0.516	0.75
201_P	205_L	0.515	0.75
184_D	273_E	0.515	0.75
225_R	230_D	0.514	0.75
191_L	300_L	0.513	0.74
38_A	80_Q	0.513	0.74
39_F	42_G	0.511	0.74
56_Y	60_Y	0.510	0.74
334_G	344_Q	0.509	0.74
107_F	112_P	0.505	0.73
224_K	227_Q	0.504	0.73
102_A	105_Y	0.503	0.73
43_C	84_D	0.502	0.73
228_E	231_A	0.501	0.73
124_L	130_Q	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nu0A	1	0.3134	95.6	0.929	Contact Map
1iv0A	1	0.2344	95.3	0.93	Contact Map
1vhxA	2	0.3301	95.1	0.931	Contact Map
4ep4A	2	0.3923	80.8	0.949	Contact Map
1hjrA	2	0.378	80.5	0.949	Contact Map
1qypA	1	0.1029	71.6	0.953	Contact Map
2k4xA	1	0.1268	69.8	0.954	Contact Map
3j20Y	1	0.1148	68.6	0.954	Contact Map
4aybP	1	0.0957	65.6	0.955	Contact Map
2kdxA	1	0.2679	51.5	0.959	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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