GREMLIN Database
Q9HSW7 - Uncharacterized protein
UniProt: Q9HSW7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 418 (346)
Sequences: 4566 (3009)
Seq/√Len: 161.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_D253_K5.6781.00
328_H358_N4.5691.00
276_S281_D4.1231.00
308_A315_V3.6781.00
190_L300_L3.2091.00
271_V367_H3.0841.00
301_Q317_Y3.0741.00
7_K310_E3.0351.00
272_L304_I3.0341.00
350_V353_Y3.0211.00
299_R303_R2.9071.00
256_R260_E2.8541.00
147_L158_L2.5541.00
326_T333_I2.5161.00
209_G290_R2.4981.00
300_L304_I2.4841.00
305_E317_Y2.4641.00
299_R302_E2.4151.00
259_I308_A2.4141.00
270_V308_A2.3781.00
322_Y325_Q2.3301.00
283_D293_H2.3201.00
318_I363_I2.3141.00
252_E306_D2.3021.00
336_R355_A2.1651.00
252_E303_R2.1631.00
17_T20_K2.1531.00
40_D44_D2.1511.00
145_G163_E2.1411.00
366_R369_P2.1381.00
25_C151_R2.0841.00
215_L232_A2.0821.00
323_T363_I2.0701.00
330_C348_C2.0521.00
342_R352_E2.0341.00
190_L250_I2.0251.00
272_L315_V1.9691.00
255_S303_R1.9631.00
286_E289_N1.9551.00
285_G289_N1.9411.00
343_C348_C1.9231.00
268_P313_I1.9141.00
330_C343_C1.9121.00
327_C330_C1.8741.00
248_T299_R1.8591.00
218_E222_T1.8531.00
251_I303_R1.8501.00
43_C94_A1.8471.00
252_E307_K1.8451.00
327_C348_C1.7921.00
252_E255_S1.7901.00
232_A236_I1.7681.00
327_C343_C1.7651.00
12_T155_S1.7451.00
305_E309_R1.7421.00
25_C156_W1.7401.00
12_T15_P1.7371.00
341_F353_Y1.7071.00
183_F191_L1.7011.00
251_I299_R1.6891.00
24_L156_W1.6811.00
59_P63_K1.6651.00
272_L317_Y1.6391.00
274_D317_Y1.6231.00
336_R339_D1.6011.00
230_D233_Q1.5981.00
227_Q230_D1.5971.00
329_E350_V1.5811.00
272_L301_Q1.5661.00
208_N246_A1.5551.00
84_D87_P1.5321.00
8_T159_H1.5311.00
16_P20_K1.5181.00
180_P364_A1.5121.00
22_R26_D1.4971.00
193_G197_K1.4811.00
60_Y63_K1.4781.00
219_M233_Q1.4751.00
59_P62_A1.4731.00
341_F350_V1.4601.00
273_E320_P1.4591.00
58_L62_A1.4511.00
255_S306_D1.4501.00
28_L156_W1.4441.00
241_D245_N1.4121.00
189_H192_A1.4091.00
255_S307_K1.4071.00
192_A357_I1.4051.00
80_Q84_D1.4001.00
60_Y64_A1.3811.00
332_H344_Q1.3741.00
155_S241_D1.3581.00
120_F158_L1.3561.00
152_H241_D1.3561.00
111_A115_G1.3561.00
361_V365_D1.3541.00
21_E25_C1.3481.00
58_L63_K1.3441.00
340_E352_E1.3221.00
111_A114_P1.3021.00
54_T57_D1.2681.00
225_R229_R1.2631.00
292_L297_F1.2571.00
222_T232_A1.2561.00
181_V193_G1.2451.00
305_E315_V1.2451.00
86_H91_T1.2381.00
328_H353_Y1.2271.00
26_D69_Y1.2271.00
215_L239_R1.2181.00
177_D268_P1.2171.00
208_N243_Y1.2071.00
357_I361_V1.2051.00
153_R241_D1.2031.00
328_H361_V1.2011.00
88_V92_N1.2011.00
122_I149_L1.1971.00
259_I311_A1.1961.00
185_I297_F1.1891.00
43_C47_T1.1741.00
223_L226_L1.1701.00
256_R311_A1.1681.00
18_A21_E1.1661.00
251_I255_S1.1661.00
255_S300_L1.1651.00
276_S320_P1.1631.00
251_I300_L1.1581.00
277_Y298_A1.1551.00
339_D355_A1.1531.00
183_F193_G1.1481.00
74_H77_Y1.1421.00
303_R306_D1.1371.00
150_Q159_H1.1311.00
248_T303_R1.1191.00
53_V56_Y1.1141.00
44_D48_A1.1061.00
180_P269_V1.0991.00
81_E85_D1.0961.00
10_E152_H1.0941.00
318_I366_R1.0941.00
187_E295_W1.0860.99
194_C360_A1.0840.99
326_T366_R1.0780.99
51_D54_T1.0760.99
116_R119_N1.0710.99
33_E66_L1.0620.99
219_M232_A1.0600.99
328_H350_V1.0590.99
58_L61_Q1.0570.99
35_L76_T1.0540.99
255_S304_I1.0520.99
260_E311_A1.0480.99
82_L86_H1.0430.99
55_P59_P1.0430.99
235_R238_E1.0420.99
257_Q266_E1.0420.99
109_W112_P1.0420.99
259_I313_I1.0400.99
126_I130_Q1.0280.99
323_T366_R1.0270.99
259_I270_V1.0270.99
325_Q335_Y1.0270.99
33_E37_E1.0240.99
182_G364_A1.0180.99
45_T49_T1.0170.99
353_Y357_I1.0140.99
9_L162_V1.0130.99
84_D94_A1.0100.99
332_H347_E1.0090.99
50_S53_V1.0080.99
61_Q64_A1.0060.99
83_D87_P1.0030.99
211_R215_L0.9990.99
59_P64_A0.9950.99
112_P115_G0.9900.99
353_Y361_V0.9840.99
283_D289_N0.9800.99
185_I301_Q0.9790.99
51_D57_D0.9740.99
318_I367_H0.9730.99
244_Q248_T0.9710.99
307_K310_E0.9660.99
205_L208_N0.9650.99
192_A198_Q0.9630.99
302_E305_E0.9540.99
213_R216_R0.9500.99
180_P271_V0.9490.99
369_P372_E0.9490.99
180_P368_D0.9480.99
269_V314_P0.9420.99
181_V267_K0.9420.99
125_R128_P0.9410.99
320_P323_T0.9390.99
215_L236_I0.9320.98
86_H92_N0.9240.98
328_H359_A0.9220.98
251_I296_A0.9190.98
65_A68_N0.9180.98
258_A270_V0.9150.98
204_P246_A0.9140.98
308_A313_I0.9110.98
338_G341_F0.9080.98
16_P24_L0.9080.98
50_S54_T0.9030.98
358_N362_N0.9010.98
107_F110_W0.9000.98
271_V363_I0.8980.98
108_T112_P0.8970.98
357_I360_A0.8960.98
119_N127_N0.8950.98
88_V91_T0.8920.98
107_F111_A0.8910.98
215_L218_E0.8910.98
216_R220_F0.8900.98
152_H155_S0.8880.98
195_A267_K0.8880.98
222_T225_R0.8870.98
216_R236_I0.8810.98
334_G341_F0.8790.98
72_Q76_T0.8780.98
274_D320_P0.8740.98
108_T111_A0.8720.98
277_Y297_F0.8690.98
229_R233_Q0.8690.98
239_R243_Y0.8680.98
41_A45_T0.8660.98
71_P74_H0.8660.98
359_A362_N0.8660.98
29_E32_R0.8640.97
285_G288_M0.8600.97
37_E41_A0.8600.97
27_L31_Y0.8590.97
6_T161_T0.8590.97
325_Q333_I0.8530.97
13_L158_L0.8490.97
80_Q83_D0.8480.97
361_V364_A0.8410.97
63_K66_L0.8410.97
189_H198_Q0.8400.97
120_F147_L0.8380.97
187_E291_R0.8370.97
151_R156_W0.8370.97
256_R307_K0.8310.97
89_R92_N0.8300.97
74_H84_D0.8270.97
126_I129_E0.8250.97
367_H371_G0.8230.97
212_A236_I0.8190.97
181_V194_C0.8180.96
148_R159_H0.8150.96
340_E353_Y0.8140.96
74_H78_N0.8140.96
326_T362_N0.8100.96
219_M236_I0.8080.96
81_E84_D0.8050.96
250_I254_A0.8040.96
21_E156_W0.8010.96
149_L158_L0.7980.96
189_H200_T0.7940.96
194_C357_I0.7940.96
212_A240_F0.7930.96
341_F355_A0.7930.96
112_P121_W0.7880.96
281_D292_L0.7840.96
198_Q354_H0.7780.95
275_L320_P0.7770.95
197_K257_Q0.7750.95
30_T33_E0.7750.95
23_K27_L0.7720.95
199_G202_T0.7670.95
185_I191_L0.7670.95
219_M222_T0.7640.95
67_C70_V0.7620.95
45_T53_V0.7620.95
142_A162_V0.7610.95
103_R106_E0.7610.95
122_I147_L0.7600.95
366_R370_W0.7570.95
274_D301_Q0.7570.95
58_L64_A0.7560.95
222_T226_L0.7550.95
316_E367_H0.7550.95
188_A339_D0.7550.95
109_W113_Q0.7550.95
339_D354_H0.7500.94
288_M292_L0.7490.94
206_L291_R0.7480.94
254_A257_Q0.7470.94
242_H246_A0.7470.94
284_Y288_M0.7470.94
188_A192_A0.7450.94
337_D355_A0.7440.94
201_P204_P0.7430.94
74_H80_Q0.7430.94
40_D97_F0.7420.94
52_V55_P0.7410.94
122_I125_R0.7400.94
127_N130_Q0.7390.94
322_Y326_T0.7380.94
11_A158_L0.7370.94
29_E33_E0.7360.94
269_V316_E0.7320.94
41_A44_D0.7310.94
322_Y366_R0.7290.93
198_Q357_I0.7290.93
179_T268_P0.7280.93
178_V268_P0.7280.93
336_R341_F0.7270.93
181_V270_V0.7270.93
192_A206_L0.7250.93
66_L70_V0.7230.93
56_Y59_P0.7230.93
184_D356_D0.7220.93
191_L254_A0.7210.93
334_G338_G0.7200.93
363_I366_R0.7180.93
6_T163_E0.7180.93
285_G293_H0.7180.93
298_A302_E0.7170.93
219_M229_R0.7160.93
212_A220_F0.7160.93
328_H365_D0.7160.93
66_L71_P0.7120.93
226_L229_R0.7090.92
271_V316_E0.7050.92
286_E293_H0.7020.92
214_H218_E0.7010.92
10_E159_H0.7010.92
87_P94_A0.7010.92
247_L294_A0.6990.92
243_Y294_A0.6960.92
222_T235_R0.6950.92
65_A70_V0.6940.92
83_D88_V0.6940.92
121_W127_N0.6940.92
10_E150_Q0.6920.92
101_A104_D0.6900.91
146_Q161_T0.6880.91
368_D372_E0.6860.91
110_W113_Q0.6830.91
11_A136_D0.6830.91
80_Q86_H0.6820.91
198_Q201_P0.6820.91
75_D79_A0.6820.91
74_H83_D0.6800.91
12_T157_T0.6780.91
108_T113_Q0.6670.90
122_I128_P0.6670.90
39_F80_Q0.6660.90
85_D89_R0.6620.90
88_V95_A0.6600.90
77_Y81_E0.6580.89
165_P170_D0.6580.89
78_N81_E0.6560.89
284_Y293_H0.6550.89
260_E269_V0.6470.89
62_A74_H0.6450.88
45_T48_A0.6440.88
233_Q237_D0.6430.88
285_G292_L0.6430.88
190_L251_I0.6410.88
66_L74_H0.6390.88
99_H102_A0.6390.88
40_D43_C0.6380.88
67_C71_P0.6350.88
78_N82_L0.6350.88
8_T161_T0.6340.88
18_A22_R0.6340.88
59_P77_Y0.6340.88
9_L136_D0.6310.87
69_Y73_L0.6280.87
270_V304_I0.6250.87
83_D86_H0.6240.87
65_A69_Y0.6240.87
281_D320_P0.6220.87
104_D107_F0.6220.87
81_E87_P0.6210.87
38_A77_Y0.6210.87
52_V56_Y0.6200.86
190_L295_W0.6200.86
186_G192_A0.6180.86
303_R307_K0.6160.86
218_E221_T0.6150.86
95_A98_D0.6140.86
26_D30_T0.6140.86
329_E361_V0.6140.86
319_R322_Y0.6110.86
80_Q87_P0.6100.86
179_T267_K0.6100.86
267_K313_I0.6090.85
112_P123_P0.6080.85
230_D234_W0.6070.85
86_H90_L0.6060.85
26_D29_E0.6050.85
306_D310_E0.6030.85
240_F247_L0.5970.84
24_L28_L0.5970.84
66_L69_Y0.5960.84
23_K26_D0.5950.84
95_A99_H0.5930.84
199_G250_I0.5930.84
245_N249_D0.5920.84
49_T52_V0.5890.84
321_E325_Q0.5890.84
30_T70_V0.5890.84
113_Q123_P0.5890.84
271_V364_A0.5880.83
101_A105_Y0.5870.83
245_N248_T0.5870.83
176_E179_T0.5850.83
271_V366_R0.5820.83
90_L98_D0.5800.83
73_L77_Y0.5790.83
253_K256_R0.5760.82
368_D371_G0.5760.82
70_V73_L0.5740.82
72_Q75_D0.5710.82
155_S245_N0.5710.82
308_A311_A0.5700.82
166_V309_R0.5680.81
71_P78_N0.5670.81
46_M49_T0.5660.81
187_E282_L0.5640.81
53_V57_D0.5620.81
108_T122_I0.5620.81
37_E40_D0.5620.81
338_G355_A0.5620.81
326_T331_G0.5610.81
325_Q334_G0.5610.81
182_G360_A0.5600.80
336_R354_H0.5600.80
332_H341_F0.5580.80
215_L222_T0.5580.80
99_H105_Y0.5570.80
248_T252_E0.5570.80
42_G46_M0.5560.80
39_F43_C0.5560.80
341_F344_Q0.5560.80
353_Y358_N0.5560.80
365_D368_D0.5540.80
79_A84_D0.5530.80
143_S163_E0.5510.79
200_T203_D0.5510.79
342_R350_V0.5510.79
16_P21_E0.5500.79
10_E248_T0.5500.79
19_H22_R0.5490.79
222_T229_R0.5490.79
63_K77_Y0.5490.79
202_T205_L0.5450.79
204_P208_N0.5450.79
289_N293_H0.5440.78
216_R240_F0.5440.78
190_L255_S0.5430.78
213_R217_K0.5420.78
243_Y247_L0.5420.78
79_A83_D0.5420.78
184_D324_S0.5410.78
322_Y333_I0.5400.78
282_L286_E0.5400.78
251_I254_A0.5390.78
75_D83_D0.5390.78
284_Y287_W0.5390.78
217_K220_F0.5380.78
51_D56_Y0.5360.77
55_P63_K0.5360.77
110_W115_G0.5360.77
110_W114_P0.5350.77
283_D286_E0.5340.77
108_T115_G0.5340.77
6_T145_G0.5340.77
151_R157_T0.5330.77
304_I315_V0.5320.77
182_G271_V0.5320.77
208_N242_H0.5320.77
124_L128_P0.5310.77
320_P366_R0.5310.77
363_I367_H0.5290.77
42_G49_T0.5270.76
350_V358_N0.5270.76
27_L70_V0.5270.76
108_T123_P0.5260.76
102_A106_E0.5260.76
354_H359_A0.5260.76
68_N72_Q0.5250.76
42_G45_T0.5250.76
326_T341_F0.5250.76
109_W115_G0.5240.76
66_L83_D0.5240.76
205_L290_R0.5230.76
24_L106_E0.5230.76
364_A368_D0.5230.76
213_R221_T0.5230.76
119_N122_I0.5220.76
208_N239_R0.5210.75
198_Q202_T0.5200.75
287_W291_R0.5200.75
69_Y148_R0.5200.75
42_G81_E0.5200.75
13_L130_Q0.5190.75
220_F236_I0.5190.75
191_L199_G0.5180.75
55_P77_Y0.5180.75
365_D370_W0.5180.75
68_N71_P0.5160.75
201_P205_L0.5150.75
184_D273_E0.5150.75
225_R230_D0.5140.75
191_L300_L0.5130.74
38_A80_Q0.5130.74
39_F42_G0.5110.74
56_Y60_Y0.5100.74
334_G344_Q0.5090.74
107_F112_P0.5050.73
224_K227_Q0.5040.73
102_A105_Y0.5030.73
43_C84_D0.5020.73
228_E231_A0.5010.73
124_L130_Q0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3134 95.6 0.929 Contact Map
1iv0A 1 0.2344 95.3 0.93 Contact Map
1vhxA 2 0.3301 95.1 0.931 Contact Map
4ep4A 2 0.3923 80.8 0.949 Contact Map
1hjrA 2 0.378 80.5 0.949 Contact Map
1qypA 1 0.1029 71.6 0.953 Contact Map
2k4xA 1 0.1268 69.8 0.954 Contact Map
3j20Y 1 0.1148 68.6 0.954 Contact Map
4aybP 1 0.0957 65.6 0.955 Contact Map
2kdxA 1 0.2679 51.5 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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