GREMLIN Database
CDC6A - ORC1-type DNA replication protein 10
UniProt: Q9HSW6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 413 (353)
Sequences: 2279 (1622)
Seq/√Len: 86.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
245_A248_D5.8291.00
271_A278_H4.1281.00
345_Q349_H2.6301.00
233_L237_V2.5981.00
269_Q278_H2.5691.00
275_S278_H2.5081.00
330_A334_K2.4061.00
276_T279_V2.3991.00
326_Y330_A2.3811.00
345_Q348_V2.2111.00
162_Y166_R2.2061.00
271_A275_S2.1861.00
95_C148_L2.1771.00
299_T302_G2.1111.00
233_L239_Q2.0991.00
342_P346_R2.0871.00
347_S350_N2.0681.00
237_V240_H2.0391.00
39_Y55_I2.0341.00
191_E196_R2.0191.00
163_E167_A1.9891.00
275_S279_V1.9771.00
241_C244_L1.9681.00
212_D215_E1.9421.00
169_S173_L1.9371.00
165_P168_R1.9131.00
160_L164_L1.9111.00
340_D345_Q1.9001.00
326_Y329_Y1.8891.00
159_D164_L1.8781.00
159_D162_Y1.8731.00
229_A232_S1.8681.00
160_L163_E1.8671.00
35_E209_P1.8651.00
162_Y165_P1.8591.00
31_E218_N1.8371.00
346_R349_H1.8271.00
98_L108_L1.8221.00
329_Y333_C1.7931.00
236_G239_Q1.7851.00
319_P323_R1.7831.00
233_L240_H1.7761.00
320_S325_I1.7671.00
331_S335_S1.7661.00
309_V361_L1.7641.00
235_E240_H1.7581.00
166_R169_S1.7531.00
160_L165_P1.7461.00
163_E166_R1.7431.00
73_L147_V1.7391.00
343_L348_V1.7331.00
344_K348_V1.7221.00
164_L168_R1.7171.00
303_R306_L1.6791.00
239_Q243_A1.6531.00
349_H352_L1.6501.00
351_H354_D1.6491.00
160_L166_R1.6361.00
353_S357_M1.6331.00
99_S108_L1.6291.00
329_Y332_L1.6281.00
327_D331_S1.6261.00
271_A279_V1.6221.00
278_H282_A1.6161.00
319_P333_C1.6141.00
163_E169_S1.6061.00
158_D162_Y1.6021.00
281_A284_S1.5991.00
302_G306_L1.5991.00
235_E239_Q1.5971.00
29_I67_A1.5961.00
220_L255_A1.5951.00
228_I263_G1.5761.00
291_V294_G1.5591.00
347_S351_H1.5401.00
164_L167_A1.5401.00
162_Y167_A1.5291.00
56_F151_V1.5261.00
328_E331_S1.5261.00
350_N353_S1.5161.00
333_C336_A1.5111.00
159_D163_E1.4930.99
301_H329_Y1.4770.99
348_V352_L1.4730.99
128_S132_K1.4530.99
233_L236_G1.4400.99
310_V314_A1.4330.99
347_S357_M1.4310.99
312_K315_K1.4220.99
340_D343_L1.4190.99
307_L311_S1.4170.99
352_L356_H1.4170.99
343_L349_H1.4150.99
291_V295_M1.4130.99
107_E110_N1.4130.99
354_D358_L1.4120.99
309_V312_K1.3920.99
274_I279_V1.3890.99
321_R324_A1.3830.99
269_Q281_A1.3820.99
350_N354_D1.3810.99
165_P169_S1.3780.99
352_L358_L1.3740.99
290_R294_G1.3740.99
323_R327_D1.3710.99
236_G240_H1.3690.99
152_D185_N1.3660.99
341_D345_Q1.3570.99
333_C337_A1.3520.99
164_L169_S1.3520.99
99_S109_V1.3510.99
341_D348_V1.3490.99
107_E111_K1.3360.99
227_A230_D1.3320.99
162_Y168_R1.3260.99
240_H244_L1.3170.99
32_R35_E1.3150.99
341_D349_H1.3040.99
345_Q351_H1.3000.99
340_D346_R1.2950.99
160_L167_A1.2910.99
273_A278_H1.2850.98
308_A312_K1.2840.98
227_A231_D1.2820.98
319_P322_T1.2810.98
151_V182_G1.2810.98
228_I231_D1.2700.98
191_E194_D1.2650.98
325_I329_Y1.2560.98
346_R350_N1.2530.98
237_V241_C1.2520.98
353_S356_H1.2450.98
150_E185_N1.2380.98
344_K352_L1.2280.98
95_C154_I1.2230.98
217_A221_D1.2070.98
160_L168_R1.1980.98
26_P29_I1.1920.97
193_L202_C1.1910.97
306_L310_V1.1910.97
234_A239_Q1.1700.97
272_D278_H1.1670.97
36_I68_V1.1560.97
163_E168_R1.1560.97
277_D281_A1.1540.97
343_L351_H1.1530.97
323_R326_Y1.1430.97
303_R307_L1.1380.97
350_N355_L1.1380.97
311_S314_A1.1360.97
349_H358_L1.1350.97
320_S323_R1.1330.97
196_R199_D1.1310.97
341_D344_K1.1190.96
306_L312_K1.1160.96
309_V314_A1.1150.96
213_A243_A1.1120.96
274_I277_D1.1080.96
265_L268_N1.1040.96
277_D280_E1.0930.96
344_K349_H1.0920.96
340_D349_H1.0920.96
332_L335_S1.0890.96
318_T326_Y1.0890.96
273_A279_V1.0820.96
332_L336_A1.0800.95
272_D275_S1.0780.95
326_Y333_C1.0770.95
127_Q134_Y1.0760.95
299_T303_R1.0730.95
321_R326_Y1.0710.95
135_Q139_A1.0690.95
159_D166_R1.0680.95
42_A55_I1.0630.95
318_T329_Y1.0620.95
244_L247_R1.0620.95
292_E296_R1.0570.95
342_P349_H1.0560.95
349_H353_S1.0550.95
319_P326_Y1.0540.95
305_T312_K1.0540.95
345_Q353_S1.0520.95
354_D357_M1.0430.95
166_R200_T1.0390.94
130_F134_Y1.0380.94
273_A277_D1.0330.94
303_R312_K1.0310.94
126_Q130_F1.0290.94
340_D352_L1.0240.94
352_L361_L1.0200.94
95_C99_S1.0200.94
134_Y137_L1.0190.94
250_G253_R1.0180.94
251_S254_Q1.0180.94
233_L274_I1.0170.94
42_A264_E1.0130.94
279_V284_S1.0120.94
159_D168_R1.0100.94
345_Q352_L1.0030.93
301_H311_S1.0030.93
352_L355_L1.0010.93
227_A232_S0.9870.93
377_Y380_D0.9860.93
326_Y334_K0.9810.93
98_L109_V0.9800.92
348_V357_M0.9780.92
320_S330_A0.9740.92
70_D92_Y0.9690.92
343_L352_L0.9680.92
322_T326_Y0.9670.92
231_D235_E0.9630.92
343_L346_R0.9610.92
325_I333_C0.9560.92
307_L310_V0.9560.92
241_C245_A0.9520.91
309_V313_A0.9460.91
199_D202_C0.9450.91
341_D352_L0.9440.91
325_I332_L0.9430.91
284_S288_R0.9430.91
347_S358_L0.9380.91
159_D165_P0.9340.91
279_V282_A0.9260.90
240_H280_E0.9250.90
133_L137_L0.9230.90
250_G254_Q0.9210.90
237_V244_L0.9200.90
302_G309_V0.9140.90
193_L196_R0.9120.90
313_A317_D0.9100.89
274_I278_H0.9090.89
320_S324_A0.9070.89
319_P337_A0.9060.89
211_Y219_I0.9020.89
360_I363_K0.9010.89
308_A332_L0.9000.89
353_S358_L0.9000.89
344_K350_N0.8990.89
306_L309_V0.8970.89
234_A240_H0.8940.89
224_T259_L0.8930.89
217_A239_Q0.8920.88
185_N250_G0.8880.88
305_T309_V0.8820.88
374_Y377_Y0.8820.88
344_K353_S0.8800.88
160_L169_S0.8760.88
300_T304_L0.8750.87
323_R334_K0.8730.87
356_H361_L0.8720.87
351_H358_L0.8710.87
282_A286_L0.8670.87
342_P348_V0.8660.87
99_S103_Q0.8620.87
346_R352_L0.8620.87
20_L227_A0.8620.87
341_D346_R0.8610.87
317_D325_I0.8610.87
301_H305_T0.8600.87
260_R264_E0.8580.86
345_Q350_N0.8560.86
94_N162_Y0.8550.86
359_G362_S0.8490.86
32_R211_Y0.8490.86
357_M361_L0.8460.86
342_P345_Q0.8450.86
162_Y169_S0.8420.85
310_V313_A0.8410.85
270_D274_I0.8390.85
317_D329_Y0.8370.85
312_K316_A0.8370.85
322_T325_I0.8350.85
326_Y336_A0.8340.85
347_S354_D0.8330.85
317_D321_R0.8310.85
350_N356_H0.8300.85
272_D279_V0.8290.85
345_Q358_L0.8240.84
162_Y196_R0.8240.84
329_Y336_A0.8190.84
320_S332_L0.8170.84
59_G64_G0.8150.84
306_L314_A0.8130.83
343_L353_S0.8120.83
211_Y253_R0.8090.83
126_Q134_Y0.8080.83
194_D197_V0.8070.83
348_V353_S0.8060.83
301_H342_P0.8030.83
234_A238_T0.8000.82
345_Q355_L0.7990.82
228_I232_S0.7890.81
384_E388_D0.7860.81
349_H357_M0.7830.81
230_D274_I0.7830.81
323_R374_Y0.7830.81
191_E195_P0.7810.81
301_H308_A0.7810.81
300_T303_R0.7800.81
351_H357_M0.7800.81
55_I181_I0.7790.81
276_T280_E0.7780.81
129_V137_L0.7760.80
191_E202_C0.7750.80
342_P352_L0.7690.80
194_D199_D0.7670.80
108_L111_K0.7660.80
349_H355_L0.7590.79
282_A288_R0.7580.79
195_P198_Q0.7580.79
347_S352_L0.7560.79
316_A337_A0.7540.78
353_S360_I0.7530.78
348_V354_D0.7530.78
352_L363_K0.7520.78
259_L279_V0.7520.78
283_R286_L0.7440.78
234_A273_A0.7440.78
347_S353_S0.7420.77
43_L72_L0.7420.77
129_V132_K0.7410.77
188_K192_Q0.7410.77
319_P330_A0.7400.77
317_D331_S0.7390.77
68_V208_F0.7380.77
298_L302_G0.7370.77
344_K347_S0.7350.77
38_K41_D0.7340.77
127_Q131_K0.7310.76
194_D202_C0.7300.76
270_D277_D0.7260.76
238_T242_A0.7250.76
293_E297_E0.7220.75
72_L76_L0.7220.75
30_E222_S0.7180.75
351_H355_L0.7180.75
282_A285_E0.7160.75
193_L200_T0.7130.75
302_G305_T0.7120.74
349_H363_K0.7080.74
382_P385_S0.7070.74
307_L314_A0.7060.74
59_G65_K0.7060.74
162_Y199_D0.7040.74
302_G312_K0.6990.73
220_L238_T0.6990.73
84_D90_V0.6970.73
154_I160_L0.6960.73
221_D235_E0.6960.73
196_R202_C0.6940.73
340_D353_S0.6940.73
345_Q357_M0.6940.73
299_T304_L0.6930.72
218_N221_D0.6930.72
295_M301_H0.6930.72
348_V351_H0.6900.72
265_L269_Q0.6880.72
54_N203_E0.6870.72
216_L220_L0.6860.72
340_D344_K0.6840.71
211_Y223_R0.6840.71
319_P329_Y0.6830.71
348_V356_H0.6830.71
376_S379_L0.6820.71
43_L181_I0.6800.71
259_L274_I0.6800.71
275_S288_R0.6790.71
103_Q106_V0.6790.71
306_L315_K0.6740.70
197_V200_T0.6730.70
234_A237_V0.6710.70
265_L278_H0.6710.70
318_T325_I0.6700.70
342_P347_S0.6680.70
303_R315_K0.6670.70
41_D265_L0.6660.69
104_V108_L0.6660.69
90_V147_V0.6610.69
352_L360_I0.6590.69
308_A311_S0.6570.68
323_R337_A0.6560.68
236_G244_L0.6550.68
354_D360_I0.6520.68
319_P334_K0.6490.67
323_R332_L0.6480.67
346_R354_D0.6450.67
244_L280_E0.6430.67
213_A246_A0.6420.67
273_A276_T0.6410.66
217_A242_A0.6400.66
321_R325_I0.6400.66
314_A387_V0.6390.66
151_V189_F0.6390.66
320_S326_Y0.6380.66
340_D360_I0.6370.66
347_S361_L0.6370.66
367_R371_R0.6350.66
196_R200_T0.6330.66
304_L329_Y0.6330.66
320_S334_K0.6330.66
193_L197_V0.6330.66
36_I71_H0.6320.65
288_R291_V0.6310.65
151_V154_I0.6310.65
208_F211_Y0.6310.65
355_L358_L0.6290.65
232_S235_E0.6280.65
101_S105_A0.6280.65
348_V358_L0.6270.65
348_V355_L0.6270.65
151_V352_L0.6260.65
343_L347_S0.6190.64
87_T143_T0.6180.64
326_Y332_L0.6180.64
164_L173_L0.6170.64
327_D330_A0.6170.64
355_L359_G0.6150.63
332_L337_A0.6150.63
320_S333_C0.6140.63
323_R336_A0.6140.63
105_A167_A0.6130.63
320_S329_Y0.6120.63
98_L107_E0.6110.63
69_T190_Q0.6100.63
32_R256_L0.6080.62
344_K355_L0.6070.62
258_L283_R0.6060.62
304_L307_L0.6040.62
158_D166_R0.6030.62
318_T321_R0.6020.62
262_A282_A0.6010.62
328_E335_S0.6010.62
302_G311_S0.6010.62
59_G62_G0.6000.61
344_K356_H0.5980.61
347_S356_H0.5940.61
159_D167_A0.5930.60
130_F163_E0.5930.60
344_K354_D0.5920.60
330_A333_C0.5920.60
380_D385_S0.5900.60
104_V160_L0.5880.60
69_T183_I0.5860.60
350_N359_G0.5850.59
40_M75_Q0.5840.59
320_S337_A0.5820.59
328_E333_C0.5820.59
32_R223_R0.5810.59
195_P202_C0.5810.59
318_T336_A0.5800.59
261_L264_E0.5790.59
301_H312_K0.5780.59
41_D268_N0.5770.58
279_V286_L0.5750.58
62_G149_D0.5730.58
257_D260_R0.5730.58
98_L105_A0.5710.58
195_P200_T0.5710.58
331_S334_K0.5700.57
28_K222_S0.5690.57
278_H284_S0.5690.57
343_L367_R0.5670.57
343_L350_N0.5630.57
247_R255_A0.5610.56
193_L199_D0.5610.56
362_S365_E0.5580.56
151_V205_E0.5580.56
255_A260_R0.5560.56
158_D167_A0.5540.55
369_G372_G0.5540.55
318_T322_T0.5540.55
309_V379_L0.5530.55
241_C248_D0.5520.55
273_A302_G0.5510.55
303_R311_S0.5500.55
74_D78_T0.5490.55
77_Q90_V0.5480.55
210_P282_A0.5470.54
306_L360_I0.5440.54
240_H243_A0.5430.54
162_Y200_T0.5430.54
310_V317_D0.5390.53
296_R302_G0.5380.53
298_L355_L0.5370.53
346_R360_I0.5350.53
302_G315_K0.5330.53
333_C342_P0.5330.53
340_D347_S0.5330.53
20_L26_P0.5310.52
306_L311_S0.5290.52
381_V385_S0.5290.52
298_L311_S0.5280.52
65_K150_E0.5280.52
95_C137_L0.5260.52
325_I337_A0.5260.52
281_A286_L0.5250.51
306_L317_D0.5250.51
315_K337_A0.5230.51
316_A329_Y0.5230.51
158_D161_L0.5230.51
271_A276_T0.5220.51
67_A257_D0.5210.51
303_R310_V0.5200.51
327_D347_S0.5190.51
194_D198_Q0.5180.51
56_F184_S0.5170.50
57_V69_T0.5170.50
133_L136_E0.5170.50
108_L133_L0.5140.50
20_L223_R0.5140.50
242_A245_A0.5140.50
309_V320_S0.5130.50
206_L327_D0.5120.50
151_V315_K0.5120.50
298_L358_L0.5110.50
130_F137_L0.5100.49
39_Y206_L0.5100.49
262_A266_A0.5080.49
316_A319_P0.5080.49
359_G363_K0.5070.49
250_G262_A0.5060.49
185_N208_F0.5050.49
379_L383_F0.5040.49
362_S366_N0.5030.49
304_L312_K0.5030.49
239_Q244_L0.5030.49
278_H288_R0.5020.48
291_V298_L0.5000.48
197_V203_E0.5000.48
94_N97_T0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qbyA 1 0.8789 100 0.384 Contact Map
2v1uA 1 0.9177 100 0.391 Contact Map
4xgcA 1 0.7433 100 0.398 Contact Map
1w5sA 1 0.9056 100 0.438 Contact Map
2qbyB 1 0.8741 100 0.46 Contact Map
4xgcD 1 0.9177 100 0.465 Contact Map
1fnnA 1 0.8862 100 0.477 Contact Map
3te6A 1 0.6513 100 0.6 Contact Map
4xgcE 1 0.8208 100 0.636 Contact Map
4ko8A 3 0.6174 100 0.696 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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