GREMLIN Database
Q9HSW5 - UDP-glucose dehydrogenase
UniProt: Q9HSW5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 430 (404)
Sequences: 8482 (5134)
Seq/√Len: 255.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_Q37_D4.6111.00
355_Y395_F4.0531.00
308_L387_V3.3391.00
2_R25_D3.2691.00
318_R351_N3.1991.00
329_G393_D3.1831.00
318_R353_A3.1161.00
38_A43_K2.9921.00
309_D348_R2.9551.00
130_E206_E2.8261.00
151_A185_L2.7201.00
68_D71_D2.6051.00
203_T242_E2.5911.00
308_L385_A2.5901.00
102_E135_I2.5581.00
129_T206_E2.5331.00
320_A383_A2.5291.00
98_E131_T2.5181.00
133_A150_V2.5131.00
21_D57_T2.4841.00
321_V342_I2.4171.00
177_D181_A2.4161.00
4_S75_T2.4011.00
302_E344_G2.3941.00
234_K307_L2.3601.00
37_D41_A2.2671.00
288_A295_A2.2671.00
204_G207_E2.2611.00
40_N65_A2.2411.00
325_A359_A2.1881.00
64_A71_D2.1581.00
341_V389_C2.1481.00
164_E168_N2.1301.00
239_D242_E2.1231.00
25_D64_A2.0931.00
109_R115_H2.0681.00
24_H191_P2.0161.00
77_V188_I2.0101.00
33_Q67_T1.9781.00
319_V350_A1.9421.00
25_D62_T1.9361.00
69_Y103_T1.9361.00
8_S28_N1.9311.00
71_D74_E1.9081.00
34_D37_D1.8881.00
353_A383_A1.8871.00
70_E107_T1.8861.00
236_F283_T1.8771.00
143_Q146_A1.8691.00
215_N247_I1.8511.00
203_T211_I1.8451.00
78_T115_H1.8411.00
402_F408_R1.8331.00
102_E138_D1.8251.00
217_A225_L1.8171.00
117_V136_L1.8121.00
182_I202_E1.8041.00
149_H178_S1.8031.00
375_A378_D1.8011.00
44_A55_L1.7981.00
388_V416_I1.7881.00
87_K91_S1.7671.00
281_T291_E1.7391.00
99_A102_E1.7251.00
353_A373_T1.7121.00
70_E73_L1.6961.00
210_M233_C1.6931.00
320_A379_A1.6871.00
114_D149_H1.6771.00
182_I186_H1.6671.00
221_S293_A1.6621.00
183_D187_E1.6521.00
32_D35_I1.6371.00
98_E102_E1.6271.00
286_E291_E1.6191.00
101_A132_L1.6131.00
37_D40_N1.5871.00
3_V188_I1.5731.00
2_R74_E1.5511.00
186_H202_E1.5501.00
133_A137_A1.5381.00
218_F222_K1.5191.00
393_D396_A1.5141.00
303_R307_L1.5101.00
4_S78_T1.5041.00
344_G347_E1.4961.00
291_E295_A1.4871.00
277_I291_E1.4861.00
17_A55_L1.4831.00
30_D36_V1.4811.00
116_V184_T1.4801.00
183_D201_V1.4791.00
17_A63_L1.4751.00
17_A54_L1.4721.00
18_C21_D1.4481.00
235_E285_Y1.4431.00
38_A45_P1.4401.00
308_L411_V1.4381.00
19_F188_I1.4351.00
324_L354_A1.4201.00
328_P391_D1.4151.00
36_V67_T1.4141.00
98_E135_I1.4051.00
231_N303_R1.4041.00
39_I65_A1.4011.00
50_G53_D1.3981.00
108_L115_H1.3941.00
234_K303_R1.3881.00
384_S406_E1.3871.00
218_F256_R1.3781.00
29_V69_Y1.3781.00
232_I287_P1.3751.00
344_G348_R1.3701.00
231_N300_Q1.3541.00
345_L350_A1.3511.00
312_G317_E1.3481.00
34_D38_A1.3471.00
187_E190_K1.3321.00
176_S182_I1.3291.00
52_D56_A1.3281.00
77_V116_V1.3211.00
262_L413_G1.3151.00
131_T135_I1.3051.00
36_V65_A1.3021.00
339_I343_N1.2901.00
18_C167_Q1.2871.00
73_L109_R1.2871.00
53_D57_T1.2841.00
305_L341_V1.2791.00
221_S225_L1.2461.00
131_T134_P1.2461.00
149_H181_A1.2441.00
242_E245_D1.2341.00
231_N235_E1.2201.00
226_I244_A1.2061.00
289_M292_A1.2021.00
318_R382_D1.2001.00
2_R27_V1.1991.00
161_T164_E1.1961.00
320_A386_C1.1951.00
358_V394_E1.1911.00
179_E183_D1.1871.00
54_L163_V1.1821.00
305_L344_G1.1821.00
184_T187_E1.1761.00
410_V417_I1.1751.00
307_L411_V1.1751.00
204_G242_E1.1681.00
380_L386_C1.1681.00
114_D147_D1.1641.00
340_P343_N1.1621.00
95_S99_A1.1601.00
251_D256_R1.1581.00
289_M296_V1.1571.00
21_D167_Q1.1561.00
40_N64_A1.1521.00
211_I246_A1.1491.00
233_C240_A1.1431.00
221_S289_M1.1401.00
38_A41_A1.1401.00
77_V184_T1.1391.00
27_V75_T1.1331.00
176_S181_A1.1321.00
69_Y107_T1.1291.00
27_V64_A1.1281.00
319_V385_A1.1271.00
110_E114_D1.1251.00
27_V74_E1.1161.00
153_N189_F1.1091.00
393_D397_V1.1061.00
6_V100_A1.0971.00
264_W294_V1.0961.00
214_A229_I1.0921.00
102_E106_D1.0891.00
27_V66_T1.0871.00
39_I63_L1.0851.00
56_A59_G1.0851.00
311_H315_E1.0751.00
229_I240_A1.0751.00
101_A135_I1.0701.00
101_A105_G1.0671.00
241_Y259_R1.0651.00
288_A299_R1.0631.00
241_Y245_D1.0581.00
105_G136_L1.0571.00
320_A353_A1.0501.00
381_A404_A1.0481.00
302_E306_S1.0471.00
133_A177_D1.0411.00
322_L398_L1.0391.00
6_V78_T1.0381.00
402_F405_M1.0371.00
36_V40_N1.0341.00
207_E238_V1.0321.00
35_I45_P1.0311.00
174_F185_L1.0301.00
324_L364_R1.0291.00
343_N346_Q1.0281.00
149_H177_D1.0251.00
8_S16_A1.0201.00
342_I346_Q1.0201.00
190_K199_T1.0161.00
74_E109_R1.0141.00
99_A103_T1.0111.00
165_D168_N1.0081.00
181_A185_L1.0061.00
186_H190_K1.0051.00
85_P93_D1.0021.00
126_R129_T1.0021.00
116_V151_A1.0021.00
388_V417_I1.0001.00
351_N371_E0.9891.00
245_D255_E0.9871.00
388_V410_V0.9851.00
309_D350_A0.9851.00
238_V243_V0.9841.00
76_D115_H0.9841.00
119_T132_L0.9821.00
363_M367_F0.9691.00
3_V19_F0.9651.00
54_L57_T0.9631.00
343_N347_E0.9621.00
178_S181_A0.9621.00
103_T106_D0.9601.00
317_E384_S0.9601.00
127_T131_T0.9571.00
168_N195_A0.9571.00
340_P344_G0.9561.00
21_D53_D0.9561.00
207_E243_V0.9551.00
262_L389_C0.9551.00
365_T371_E0.9531.00
80_L104_L0.9521.00
231_N299_R0.9521.00
306_S310_D0.9511.00
319_V387_V0.9401.00
308_L413_G0.9401.00
16_A28_N0.9391.00
23_G191_P0.9371.00
299_R302_E0.9361.00
110_E115_H0.9351.00
51_L55_L0.9311.00
314_V350_A0.9291.00
385_A409_V0.9281.00
373_T378_D0.9241.00
16_A63_L0.9221.00
186_H201_V0.9201.00
318_R383_A0.9181.00
254_S258_L0.9161.00
287_P290_L0.9131.00
309_D314_V0.9131.00
110_E147_D0.9131.00
233_C243_V0.9121.00
333_V363_M0.9121.00
108_L148_L0.9111.00
232_I285_Y0.9111.00
4_S29_V0.9041.00
137_A148_L0.9031.00
167_Q194_E0.9021.00
301_P340_P0.9011.00
278_H282_E0.9001.00
118_V185_L0.8921.00
183_D202_E0.8901.00
144_L176_S0.8881.00
133_A205_V0.8871.00
29_V66_T0.8871.00
322_L386_C0.8861.00
114_D148_L0.8861.00
18_C166_F0.8821.00
130_E134_P0.8771.00
220_A294_V0.8761.00
135_I138_D0.8741.00
8_S63_L0.8741.00
373_T379_A0.8691.00
116_V181_A0.8641.00
104_L117_V0.8611.00
346_Q369_D0.8611.00
307_L310_D0.8580.99
279_A282_E0.8570.99
338_A389_C0.8560.99
4_S27_V0.8560.99
359_A372_Y0.8560.99
324_L336_S0.8540.99
391_D414_R0.8520.99
186_H199_T0.8450.99
128_T132_L0.8450.99
80_L97_I0.8410.99
15_V166_F0.8400.99
3_V24_H0.8390.99
129_T205_V0.8360.99
77_V118_V0.8340.99
183_D186_H0.8330.99
136_L150_V0.8310.99
101_A119_T0.8310.99
308_L319_V0.8290.99
378_D381_A0.8280.99
31_I103_T0.8230.99
69_Y106_D0.8230.99
404_A407_T0.8230.99
316_S351_N0.8220.99
298_D340_P0.8220.99
55_L63_L0.8220.99
76_D184_T0.8210.99
346_Q370_I0.8190.99
274_N294_V0.8160.99
320_A380_L0.8140.99
322_L395_F0.8100.99
304_L413_G0.8030.99
362_N365_T0.8020.99
182_I201_V0.7990.99
308_L345_L0.7980.99
222_K258_L0.7960.99
264_W273_T0.7940.99
278_H281_T0.7940.99
304_L411_V0.7920.99
277_I294_V0.7850.99
328_P393_D0.7840.99
43_K51_L0.7840.99
376_P394_E0.7800.99
92_I275_A0.7790.99
376_P380_L0.7780.99
4_S72_V0.7780.99
324_L333_V0.7770.99
248_G257_F0.7760.99
277_I290_L0.7750.99
311_H317_E0.7720.99
305_L348_R0.7710.99
353_A371_E0.7700.99
201_V249_L0.7680.99
322_L380_L0.7680.99
232_I276_I0.7670.99
353_A382_D0.7640.99
333_V339_I0.7610.99
157_L166_F0.7600.99
119_T129_T0.7590.99
400_D417_I0.7590.99
170_D251_D0.7580.99
333_V364_R0.7580.99
80_L117_V0.7580.99
333_V359_A0.7570.99
324_L342_I0.7570.99
137_A144_L0.7560.99
66_T71_D0.7550.99
402_F406_E0.7550.99
374_D378_D0.7530.99
402_F407_T0.7510.99
110_E146_A0.7500.99
336_S339_I0.7490.99
299_R306_S0.7460.99
405_M408_R0.7430.99
77_V185_L0.7420.99
342_I354_A0.7410.99
194_E199_T0.7380.98
360_A372_Y0.7370.98
118_V188_I0.7360.98
5_I16_A0.7340.98
78_T104_L0.7330.98
76_D110_E0.7320.98
105_G148_L0.7290.98
120_K189_F0.7270.98
130_E205_V0.7180.98
168_N194_E0.7180.98
346_Q352_V0.7170.98
391_D396_A0.7170.98
218_F258_L0.7150.98
377_Q404_A0.7150.98
15_V19_F0.7130.98
240_A244_A0.7130.98
29_V67_T0.7130.98
361_E374_D0.7110.98
158_R161_T0.7110.98
134_P138_D0.7080.98
222_K226_I0.7080.98
217_A290_L0.7060.98
79_F188_I0.7060.98
377_Q380_L0.7040.98
47_H358_V0.7040.98
103_T107_T0.7030.98
27_V71_D0.7000.98
382_D406_E0.6990.98
302_E340_P0.6990.98
18_C163_V0.6980.98
151_A176_S0.6980.98
386_C395_F0.6970.98
241_Y415_R0.6970.98
380_L404_A0.6950.98
403_D406_E0.6950.98
53_D56_A0.6950.98
280_A287_P0.6900.98
25_D74_E0.6880.98
279_A283_T0.6870.98
322_L376_P0.6860.98
199_T249_L0.6860.98
386_C405_M0.6850.98
35_I39_I0.6850.98
235_E286_E0.6840.97
72_V78_T0.6820.97
6_V69_Y0.6820.97
361_E364_R0.6810.97
24_H77_V0.6810.97
207_E242_E0.6800.97
35_I38_A0.6800.97
20_T57_T0.6790.97
104_L108_L0.6780.97
108_L136_L0.6780.97
404_A408_R0.6720.97
175_G182_I0.6710.97
105_G117_V0.6670.97
15_V171_K0.6650.97
321_V387_V0.6650.97
262_L304_L0.6640.97
73_L107_T0.6630.97
43_K52_D0.6620.97
29_V100_A0.6620.97
29_V103_T0.6610.97
8_S30_D0.6580.97
298_D301_P0.6560.97
149_H184_T0.6510.97
176_S202_E0.6490.97
24_H188_I0.6480.97
5_I15_V0.6470.96
228_D296_V0.6460.96
229_I276_I0.6460.96
292_A295_A0.6450.96
225_L229_I0.6440.96
31_I96_I0.6430.96
403_D407_T0.6420.96
10_Y334_R0.6400.96
70_E106_D0.6390.96
274_N298_D0.6380.96
104_L107_T0.6370.96
173_V211_I0.6370.96
173_V186_H0.6350.96
86_S274_N0.6350.96
342_I370_I0.6350.96
273_T294_V0.6340.96
232_I280_A0.6320.96
173_V199_T0.6310.96
244_A248_G0.6310.96
322_L388_V0.6300.96
20_T62_T0.6290.96
87_K90_G0.6290.96
203_T207_E0.6270.96
245_D248_G0.6260.96
120_K153_N0.6240.96
178_S183_D0.6240.96
177_D205_V0.6230.96
281_T286_E0.6220.96
357_P395_F0.6210.96
72_V115_H0.6210.96
231_N285_Y0.6200.96
70_E103_T0.6190.96
306_S348_R0.6180.95
97_I119_T0.6160.95
80_L119_T0.6150.95
244_A259_R0.6120.95
142_K146_A0.6110.95
277_I281_T0.6100.95
80_L132_L0.6080.95
97_I101_A0.6060.95
6_V72_V0.6050.95
400_D410_V0.6040.95
301_P341_V0.6020.95
193_I200_V0.6020.95
220_A264_W0.6020.95
300_Q303_R0.6020.95
244_A260_S0.6020.95
78_T107_T0.6000.95
87_K98_E0.6000.95
144_L148_L0.6000.95
385_A411_V0.5990.95
288_A292_A0.5980.95
157_L162_A0.5980.95
21_D54_L0.5930.94
273_T290_L0.5930.94
142_K145_G0.5930.94
30_D67_T0.5930.94
346_Q351_N0.5920.94
366_H369_D0.5920.94
133_A176_S0.5920.94
159_E326_F0.5890.94
339_I367_F0.5880.94
151_A174_F0.5870.94
172_I211_I0.5860.94
122_T268_C0.5850.94
359_A363_M0.5840.94
354_A360_A0.5840.94
119_T136_L0.5830.94
155_E268_C0.5830.94
61_D64_A0.5830.94
315_E349_G0.5820.94
94_T98_E0.5820.94
287_P291_E0.5810.94
267_S271_K0.5800.94
122_T272_D0.5800.94
250_D253_I0.5800.94
343_N366_H0.5790.94
23_G62_T0.5790.94
216_N272_D0.5790.94
376_P398_L0.5780.94
171_K215_N0.5780.94
305_L309_D0.5760.93
44_A52_D0.5760.93
354_A370_I0.5730.93
82_L96_I0.5690.93
354_A372_Y0.5680.93
333_V338_A0.5680.93
226_I229_I0.5680.93
301_P337_R0.5680.93
8_S39_I0.5670.93
210_M229_I0.5660.93
186_H200_V0.5650.93
176_S205_V0.5640.93
173_V182_I0.5630.93
75_T78_T0.5630.93
171_K189_F0.5620.93
231_N234_K0.5620.93
262_L341_V0.5610.93
224_S289_M0.5610.93
96_I100_A0.5610.93
255_E259_R0.5590.92
262_L328_P0.5550.92
378_D382_D0.5540.92
207_E211_I0.5540.92
285_Y296_V0.5510.92
248_G253_I0.5510.92
268_C271_K0.5510.92
179_E182_I0.5510.92
118_V151_A0.5500.92
36_V39_I0.5490.92
43_K56_A0.5490.92
308_L314_V0.5470.92
277_I287_P0.5470.92
380_L383_A0.5460.92
324_L338_A0.5460.92
372_Y375_A0.5430.91
345_L352_V0.5420.91
342_I389_C0.5410.91
79_F189_F0.5400.91
181_A184_T0.5390.91
84_T121_S0.5390.91
214_A217_A0.5390.91
120_K271_K0.5380.91
218_F226_I0.5370.91
216_N268_C0.5350.91
106_D110_E0.5310.90
229_I233_C0.5310.90
232_I236_F0.5300.90
64_A74_E0.5290.90
134_P137_A0.5280.90
137_A147_D0.5280.90
216_N327_K0.5280.90
185_L189_F0.5270.90
174_F182_I0.5270.90
117_V148_L0.5270.90
294_V298_D0.5250.90
230_G300_Q0.5250.90
288_A291_E0.5250.90
37_D67_T0.5250.90
342_I352_V0.5240.90
114_D142_K0.5230.90
290_L293_A0.5220.90
40_N71_D0.5210.90
241_Y260_S0.5210.90
159_E271_K0.5210.90
49_P54_L0.5200.89
120_K171_K0.5200.89
264_W293_A0.5200.89
50_G163_V0.5200.89
156_F215_N0.5200.89
95_S98_E0.5190.89
17_A21_D0.5180.89
50_G54_L0.5170.89
314_V317_E0.5170.89
69_Y72_V0.5160.89
137_A143_Q0.5160.89
174_F200_V0.5160.89
324_L339_I0.5160.89
119_T150_V0.5160.89
120_K159_E0.5150.89
108_L142_K0.5150.89
319_V352_V0.5140.89
281_T288_A0.5140.89
47_H331_D0.5140.89
364_R367_F0.5130.89
85_P335_D0.5120.89
364_R372_Y0.5110.89
91_S282_E0.5090.88
305_L314_V0.5090.88
10_Y331_D0.5070.88
130_E279_A0.5060.88
91_S278_H0.5050.88
310_D348_R0.5050.88
289_M293_A0.5050.88
274_N335_D0.5040.88
272_D334_R0.5040.88
19_F192_L0.5030.88
202_E246_A0.5030.88
235_E283_T0.5030.88
5_I19_F0.5030.88
396_A416_I0.5020.88
166_F192_L0.5020.88
224_S296_V0.5010.88
217_A221_S0.5010.88
234_K300_Q0.5000.88
146_A149_H0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y0cA 4 0.9907 100 0.248 Contact Map
2o3jA 4 0.9767 100 0.261 Contact Map
2q3eA 5 0.9814 100 0.266 Contact Map
3gg2A 3 0.9767 100 0.267 Contact Map
3g79A 2 0.9721 100 0.273 Contact Map
3ojoA 2 0.9372 100 0.28 Contact Map
4a7pA 2 0.9698 100 0.29 Contact Map
3vtfA 2 0.9628 100 0.301 Contact Map
4xr9A 2 0.9837 100 0.303 Contact Map
1mv8A 2 0.9698 100 0.309 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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