GREMLIN Database
Q9HSW4 - Glucose-1-phosphate thymidylyltransferase
UniProt: Q9HSW4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (206)
Sequences: 17692 (10652)
Seq/√Len: 742.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_E159_H3.3451.00
108_E141_N2.7671.00
7_K15_E2.6781.00
24_G48_P2.5801.00
58_K62_H2.5571.00
106_V187_A2.4231.00
157_A181_S2.4071.00
157_A177_L2.3281.00
108_E189_G2.2791.00
100_A186_D2.2641.00
74_D151_S2.1161.00
95_Q103_A2.1021.00
121_D130_D2.0931.00
123_N127_E2.0541.00
11_T39_H2.0221.00
127_E186_D1.9631.00
121_D129_T1.9081.00
74_D96_Q1.8811.00
94_R188_I1.8571.00
24_G50_T1.8551.00
177_L180_Q1.8511.00
113_D116_R1.8391.00
177_L181_S1.8361.00
130_D176_D1.8101.00
134_K138_P1.8061.00
11_T15_E1.8021.00
98_E186_D1.7851.00
106_V120_C1.7561.00
123_N129_T1.7451.00
52_A66_N1.7361.00
101_D151_S1.7071.00
91_V105_L1.6931.00
34_Q38_E1.6661.00
100_A184_T1.6501.00
65_L68_E1.6501.00
122_T142_L1.6311.00
26_V70_H1.6241.00
176_D180_Q1.6191.00
142_L189_G1.6011.00
14_F25_L1.5831.00
94_R98_E1.5731.00
132_V139_P1.5411.00
29_V33_K1.5351.00
89_E93_R1.5241.00
128_V187_A1.5071.00
37_I53_H1.4791.00
25_L47_V1.4731.00
1_M35_D1.4721.00
35_D38_E1.4611.00
62_H66_N1.4541.00
64_L77_L1.4441.00
33_K53_H1.4431.00
157_A174_A1.4411.00
17_L78_M1.4261.00
193_W209_R1.4211.00
101_D184_T1.4101.00
93_R97_E1.4091.00
26_V52_A1.3941.00
127_E184_T1.3801.00
203_R207_E1.3791.00
173_E176_D1.3751.00
102_A150_F1.3711.00
106_V142_L1.3401.00
29_V51_Y1.3351.00
160_L177_L1.3231.00
18_V47_V1.3121.00
65_L159_H1.2961.00
195_V209_R1.2751.00
199_Y202_D1.2641.00
26_V67_V1.2601.00
120_C128_V1.2341.00
29_V37_I1.2331.00
121_D140_S1.2241.00
22_A76_M1.2131.00
150_F175_I1.2061.00
72_D152_P1.1951.00
152_P155_F1.1941.00
153_A156_H1.1791.00
90_D93_R1.1791.00
33_K37_I1.1751.00
91_V149_T1.1621.00
87_N90_D1.1571.00
160_L181_S1.1541.00
204_E208_E1.1521.00
10_L40_Y1.1511.00
29_V53_H1.1491.00
115_S134_K1.1281.00
172_S176_D1.1221.00
121_D132_V1.1221.00
108_E142_L1.1201.00
1_M39_H1.1171.00
22_A92_V1.1101.00
195_V205_E1.1071.00
9_I197_V1.1021.00
204_E207_E1.0971.00
75_F152_P1.0951.00
50_T70_H1.0871.00
102_A185_I1.0841.00
201_E205_E1.0751.00
79_L146_G1.0731.00
74_D152_P1.0711.00
62_H65_L1.0691.00
202_D205_E1.0691.00
8_P11_T1.0671.00
32_R35_D1.0651.00
197_V206_A1.0641.00
175_I185_I1.0621.00
73_E152_P1.0621.00
101_D153_A1.0611.00
94_R186_D1.0601.00
10_L27_V1.0531.00
144_M148_Y1.0451.00
122_T187_A1.0381.00
71_V75_F1.0261.00
30_G33_K1.0201.00
14_F49_I1.0141.00
107_E145_T0.9961.00
130_D137_D0.9921.00
102_A178_L0.9891.00
90_D94_R0.9871.00
68_E155_F0.9871.00
156_H160_L0.9831.00
27_V49_I0.9781.00
103_A186_D0.9681.00
20_L89_E0.9621.00
7_K11_T0.9561.00
205_E208_E0.9521.00
128_V185_I0.9511.00
76_M149_T0.9501.00
104_F120_C0.9471.00
34_Q37_I0.9451.00
76_M92_V0.9431.00
41_G51_Y0.9401.00
10_L36_I0.9351.00
157_A160_L0.9311.00
153_A157_A0.9161.00
77_L150_F0.9091.00
94_R103_A0.8871.00
153_A184_T0.8861.00
26_V50_T0.8761.00
29_V36_I0.8751.00
118_G133_E0.8731.00
116_R134_K0.8701.00
154_I178_L0.8691.00
208_E211_A0.8671.00
116_R202_D0.8651.00
78_M88_L0.8591.00
109_V114_A0.8511.00
7_K12_H0.8421.00
205_E209_R0.8421.00
82_N194_R0.8421.00
116_R199_Y0.8421.00
18_V46_G0.8411.00
91_V103_A0.8351.00
74_D149_T0.8331.00
5_D207_E0.8291.00
17_L22_A0.8261.00
93_R96_Q0.8251.00
200_P204_E0.8251.00
95_Q151_S0.8211.00
52_A67_V0.8201.00
150_F171_I0.8201.00
121_D139_P0.8181.00
64_L154_I0.8151.00
153_A181_S0.8101.00
207_E211_A0.8081.00
163_P169_Y0.8061.00
126_G189_G0.8061.00
195_V206_A0.8031.00
11_T40_Y0.8021.00
14_F47_V0.7971.00
161_V169_Y0.7961.00
16_Q20_L0.7921.00
65_L169_Y0.7911.00
71_V155_F0.7851.00
23_D48_P0.7841.00
9_I13_C0.7741.00
98_E103_A0.7701.00
62_H169_Y0.7671.00
156_H159_H0.7611.00
106_V189_G0.7591.00
30_G57_Q0.7581.00
4_V207_E0.7571.00
65_L158_C0.7541.00
12_H210_L0.7531.00
132_V135_P0.7501.00
122_T125_Y0.7491.00
161_V177_L0.7471.00
29_V34_Q0.7461.00
92_V96_Q0.7441.00
119_V143_V0.7431.00
157_A178_L0.7421.00
14_F40_Y0.7411.00
59_G170_E0.7411.00
103_A188_I0.7381.00
131_V144_M0.7341.00
161_V173_E0.7331.00
18_V23_D0.7321.00
37_I51_Y0.7221.00
40_Y49_I0.7181.00
5_D210_L0.7161.00
11_T43_E0.7131.00
28_V63_A0.7091.00
4_V83_I0.7071.00
57_Q62_H0.7051.00
105_L190_L0.7021.00
79_L82_N0.7021.00
3_E8_P0.7011.00
18_V25_L0.6971.00
16_Q19_E0.6961.00
28_V67_V0.6951.00
181_S184_T0.6951.00
90_D188_I0.6891.00
56_E62_H0.6891.00
8_P12_H0.6801.00
102_A175_I0.6791.00
109_V143_V0.6771.00
60_L79_L0.6731.00
179_I185_I0.6711.00
77_L171_I0.6701.00
91_V188_I0.6701.00
204_E211_A0.6681.00
156_H181_S0.6631.00
5_D12_H0.6611.00
95_Q149_T0.6601.00
27_V40_Y0.6561.00
15_E19_E0.6511.00
94_R97_E0.6481.00
55_R66_N0.6471.00
92_V149_T0.6461.00
8_P39_H0.6411.00
161_V174_A0.6391.00
64_L171_I0.6381.00
28_V52_A0.6331.00
2_V207_E0.6321.00
174_A177_L0.6291.00
162_Q169_Y0.6261.00
43_E46_G0.6251.00
83_I206_A0.6221.00
112_D141_N0.6191.00
135_P165_N0.6171.00
3_E6_G0.6161.00
18_V43_E0.6131.00
58_K169_Y0.6081.00
122_T126_G0.6071.00
14_F27_V0.6061.00
55_R58_K0.6051.00
76_M88_L0.6021.00
145_T194_R0.6011.00
25_L49_I0.6001.00
79_L148_Y0.5961.00
107_E143_V0.5961.00
42_D45_E0.5941.00
107_E194_R0.5911.00
15_E18_V0.5911.00
67_V70_H0.5911.00
33_K36_I0.5891.00
166_R170_E0.5851.00
55_R62_H0.5841.00
1_M8_P0.5831.00
195_V202_D0.5821.00
91_V95_Q0.5801.00
161_V167_G0.5781.00
50_T53_H0.5761.00
81_D198_G0.5721.00
186_D189_G0.5711.00
16_Q147_F0.5671.00
117_Y196_D0.5661.00
73_E151_S0.5631.00
43_E48_P0.5631.00
129_T132_V0.5591.00
68_E156_H0.5521.00
113_D134_K0.5521.00
99_R151_S0.5511.00
23_D46_G0.5501.00
13_C78_M0.5481.00
75_F155_F0.5481.00
145_T190_L0.5481.00
104_F144_M0.5481.00
106_V128_V0.5481.00
17_L76_M0.5481.00
98_E184_T0.5481.00
138_P141_N0.5471.00
47_V51_Y0.5421.00
64_L75_F0.5401.00
13_C80_G0.5371.00
16_Q88_L0.5371.00
114_A119_V0.5351.00
18_V48_P0.5331.00
158_C169_Y0.5271.00
168_E173_E0.5251.00
127_E179_I0.5241.00
115_S136_D0.5231.00
102_A106_V0.5231.00
84_F145_T0.5211.00
4_V206_A0.5211.00
114_A117_Y0.5201.00
38_E41_G0.5201.00
19_E89_E0.5181.00
41_G45_E0.5141.00
137_D140_S0.5131.00
12_H16_Q0.5121.00
150_F174_A0.5091.00
173_E177_L0.5091.00
120_C187_A0.5081.00
196_D202_D0.5031.00
105_L147_F0.5031.00
119_V135_P0.5021.00
58_K163_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jukA 3 0.9771 100 0.311 Contact Map
2e3dA 3 0.9817 100 0.316 Contact Map
2ux8A 4 0.9908 100 0.32 Contact Map
2pa4A 3 0.9954 100 0.333 Contact Map
1iimA 3 0.9862 100 0.346 Contact Map
1lvwA 3 0.9908 100 0.346 Contact Map
4ho4A 3 0.9862 100 0.355 Contact Map
1mc3A 3 0.9862 100 0.355 Contact Map
3brkX 2 0.9404 100 0.363 Contact Map
4ecmA 3 0.9817 100 0.38 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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