Q9HSW4 - HALSA - GREMLIN Contacts

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Q9HSW4 - Glucose-1-phosphate thymidylyltransferase

UniProt:	Q9HSW4	Sequences: MVEVDGKPILTHCFEQLVELGADGLVVVVGYRKQDIIEHYGDEFEGVPITYAHQREQKGLAHALLNVEEHVDEDFMLMLGDNIFQANLEDVVRRQQEERADAAFLVEEVDWDDASRYGVCDTNQYGEVTDVVEKPDDPPSNLVMTGFYTFSPAIFHACHLVQPSNRGEYEISEAIDLLIQSGRTIDAIGLEGWRVDVGYPEDREEAEERLAEAEDAVA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	218 (206)
Sequences:	17692 (10652)
Seq/√Len:	742.2

ECOLI - RMLA1 GALF RMLA2 GALU GLMU GLGC
BACSU - RMLA YNGB GLMU GTAB YTDA RFBF GLGC GLGD
HALSA - Q9HSW4 Q9HQQ4 Q9HSV0 Q9HSZ8 Q9HSZ9 Q9HS61
SULSO - Q7LXG3 Q97ZD1 Q97U06 Q7LXE7 Q97XG0 Q980H9 Q97VX4 Q7LXK9 Q980D4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
68_E	159_H	3.345	1.00
108_E	141_N	2.767	1.00
7_K	15_E	2.678	1.00
24_G	48_P	2.580	1.00
58_K	62_H	2.557	1.00
106_V	187_A	2.423	1.00
157_A	181_S	2.407	1.00
157_A	177_L	2.328	1.00
108_E	189_G	2.279	1.00
100_A	186_D	2.264	1.00
74_D	151_S	2.116	1.00
95_Q	103_A	2.102	1.00
121_D	130_D	2.093	1.00
123_N	127_E	2.054	1.00
11_T	39_H	2.022	1.00
127_E	186_D	1.963	1.00
121_D	129_T	1.908	1.00
74_D	96_Q	1.881	1.00
94_R	188_I	1.857	1.00
24_G	50_T	1.855	1.00
177_L	180_Q	1.851	1.00
113_D	116_R	1.839	1.00
177_L	181_S	1.836	1.00
130_D	176_D	1.810	1.00
134_K	138_P	1.806	1.00
11_T	15_E	1.802	1.00
98_E	186_D	1.785	1.00
106_V	120_C	1.756	1.00
123_N	129_T	1.745	1.00
52_A	66_N	1.736	1.00
101_D	151_S	1.707	1.00
91_V	105_L	1.693	1.00
34_Q	38_E	1.666	1.00
100_A	184_T	1.650	1.00
65_L	68_E	1.650	1.00
122_T	142_L	1.631	1.00
26_V	70_H	1.624	1.00
176_D	180_Q	1.619	1.00
142_L	189_G	1.601	1.00
14_F	25_L	1.583	1.00
94_R	98_E	1.573	1.00
132_V	139_P	1.541	1.00
29_V	33_K	1.535	1.00
89_E	93_R	1.524	1.00
128_V	187_A	1.507	1.00
37_I	53_H	1.479	1.00
25_L	47_V	1.473	1.00
1_M	35_D	1.472	1.00
35_D	38_E	1.461	1.00
62_H	66_N	1.454	1.00
64_L	77_L	1.444	1.00
33_K	53_H	1.443	1.00
157_A	174_A	1.441	1.00
17_L	78_M	1.426	1.00
193_W	209_R	1.421	1.00
101_D	184_T	1.410	1.00
93_R	97_E	1.409	1.00
26_V	52_A	1.394	1.00
127_E	184_T	1.380	1.00
203_R	207_E	1.379	1.00
173_E	176_D	1.375	1.00
102_A	150_F	1.371	1.00
106_V	142_L	1.340	1.00
29_V	51_Y	1.335	1.00
160_L	177_L	1.323	1.00
18_V	47_V	1.312	1.00
65_L	159_H	1.296	1.00
195_V	209_R	1.275	1.00
199_Y	202_D	1.264	1.00
26_V	67_V	1.260	1.00
120_C	128_V	1.234	1.00
29_V	37_I	1.233	1.00
121_D	140_S	1.224	1.00
22_A	76_M	1.213	1.00
150_F	175_I	1.206	1.00
72_D	152_P	1.195	1.00
152_P	155_F	1.194	1.00
153_A	156_H	1.179	1.00
90_D	93_R	1.179	1.00
33_K	37_I	1.175	1.00
91_V	149_T	1.162	1.00
87_N	90_D	1.157	1.00
160_L	181_S	1.154	1.00
204_E	208_E	1.152	1.00
10_L	40_Y	1.151	1.00
29_V	53_H	1.149	1.00
115_S	134_K	1.128	1.00
172_S	176_D	1.122	1.00
121_D	132_V	1.122	1.00
108_E	142_L	1.120	1.00
1_M	39_H	1.117	1.00
22_A	92_V	1.110	1.00
195_V	205_E	1.107	1.00
9_I	197_V	1.102	1.00
204_E	207_E	1.097	1.00
75_F	152_P	1.095	1.00
50_T	70_H	1.087	1.00
102_A	185_I	1.084	1.00
201_E	205_E	1.075	1.00
79_L	146_G	1.073	1.00
74_D	152_P	1.071	1.00
62_H	65_L	1.069	1.00
202_D	205_E	1.069	1.00
8_P	11_T	1.067	1.00
32_R	35_D	1.065	1.00
197_V	206_A	1.064	1.00
175_I	185_I	1.062	1.00
73_E	152_P	1.062	1.00
101_D	153_A	1.061	1.00
94_R	186_D	1.060	1.00
10_L	27_V	1.053	1.00
144_M	148_Y	1.045	1.00
122_T	187_A	1.038	1.00
71_V	75_F	1.026	1.00
30_G	33_K	1.020	1.00
14_F	49_I	1.014	1.00
107_E	145_T	0.996	1.00
130_D	137_D	0.992	1.00
102_A	178_L	0.989	1.00
90_D	94_R	0.987	1.00
68_E	155_F	0.987	1.00
156_H	160_L	0.983	1.00
27_V	49_I	0.978	1.00
103_A	186_D	0.968	1.00
20_L	89_E	0.962	1.00
7_K	11_T	0.956	1.00
205_E	208_E	0.952	1.00
128_V	185_I	0.951	1.00
76_M	149_T	0.950	1.00
104_F	120_C	0.947	1.00
34_Q	37_I	0.945	1.00
76_M	92_V	0.943	1.00
41_G	51_Y	0.940	1.00
10_L	36_I	0.935	1.00
157_A	160_L	0.931	1.00
153_A	157_A	0.916	1.00
77_L	150_F	0.909	1.00
94_R	103_A	0.887	1.00
153_A	184_T	0.886	1.00
26_V	50_T	0.876	1.00
29_V	36_I	0.875	1.00
118_G	133_E	0.873	1.00
116_R	134_K	0.870	1.00
154_I	178_L	0.869	1.00
208_E	211_A	0.867	1.00
116_R	202_D	0.865	1.00
78_M	88_L	0.859	1.00
109_V	114_A	0.851	1.00
7_K	12_H	0.842	1.00
205_E	209_R	0.842	1.00
82_N	194_R	0.842	1.00
116_R	199_Y	0.842	1.00
18_V	46_G	0.841	1.00
91_V	103_A	0.835	1.00
74_D	149_T	0.833	1.00
5_D	207_E	0.829	1.00
17_L	22_A	0.826	1.00
93_R	96_Q	0.825	1.00
200_P	204_E	0.825	1.00
95_Q	151_S	0.821	1.00
52_A	67_V	0.820	1.00
150_F	171_I	0.820	1.00
121_D	139_P	0.818	1.00
64_L	154_I	0.815	1.00
153_A	181_S	0.810	1.00
207_E	211_A	0.808	1.00
163_P	169_Y	0.806	1.00
126_G	189_G	0.806	1.00
195_V	206_A	0.803	1.00
11_T	40_Y	0.802	1.00
14_F	47_V	0.797	1.00
161_V	169_Y	0.796	1.00
16_Q	20_L	0.792	1.00
65_L	169_Y	0.791	1.00
71_V	155_F	0.785	1.00
23_D	48_P	0.784	1.00
9_I	13_C	0.774	1.00
98_E	103_A	0.770	1.00
62_H	169_Y	0.767	1.00
156_H	159_H	0.761	1.00
106_V	189_G	0.759	1.00
30_G	57_Q	0.758	1.00
4_V	207_E	0.757	1.00
65_L	158_C	0.754	1.00
12_H	210_L	0.753	1.00
132_V	135_P	0.750	1.00
122_T	125_Y	0.749	1.00
161_V	177_L	0.747	1.00
29_V	34_Q	0.746	1.00
92_V	96_Q	0.744	1.00
119_V	143_V	0.743	1.00
157_A	178_L	0.742	1.00
14_F	40_Y	0.741	1.00
59_G	170_E	0.741	1.00
103_A	188_I	0.738	1.00
131_V	144_M	0.734	1.00
161_V	173_E	0.733	1.00
18_V	23_D	0.732	1.00
37_I	51_Y	0.722	1.00
40_Y	49_I	0.718	1.00
5_D	210_L	0.716	1.00
11_T	43_E	0.713	1.00
28_V	63_A	0.709	1.00
4_V	83_I	0.707	1.00
57_Q	62_H	0.705	1.00
105_L	190_L	0.702	1.00
79_L	82_N	0.702	1.00
3_E	8_P	0.701	1.00
18_V	25_L	0.697	1.00
16_Q	19_E	0.696	1.00
28_V	67_V	0.695	1.00
181_S	184_T	0.695	1.00
90_D	188_I	0.689	1.00
56_E	62_H	0.689	1.00
8_P	12_H	0.680	1.00
102_A	175_I	0.679	1.00
109_V	143_V	0.677	1.00
60_L	79_L	0.673	1.00
179_I	185_I	0.671	1.00
77_L	171_I	0.670	1.00
91_V	188_I	0.670	1.00
204_E	211_A	0.668	1.00
156_H	181_S	0.663	1.00
5_D	12_H	0.661	1.00
95_Q	149_T	0.660	1.00
27_V	40_Y	0.656	1.00
15_E	19_E	0.651	1.00
94_R	97_E	0.648	1.00
55_R	66_N	0.647	1.00
92_V	149_T	0.646	1.00
8_P	39_H	0.641	1.00
161_V	174_A	0.639	1.00
64_L	171_I	0.638	1.00
28_V	52_A	0.633	1.00
2_V	207_E	0.632	1.00
174_A	177_L	0.629	1.00
162_Q	169_Y	0.626	1.00
43_E	46_G	0.625	1.00
83_I	206_A	0.622	1.00
112_D	141_N	0.619	1.00
135_P	165_N	0.617	1.00
3_E	6_G	0.616	1.00
18_V	43_E	0.613	1.00
58_K	169_Y	0.608	1.00
122_T	126_G	0.607	1.00
14_F	27_V	0.606	1.00
55_R	58_K	0.605	1.00
76_M	88_L	0.602	1.00
145_T	194_R	0.601	1.00
25_L	49_I	0.600	1.00
79_L	148_Y	0.596	1.00
107_E	143_V	0.596	1.00
42_D	45_E	0.594	1.00
107_E	194_R	0.591	1.00
15_E	18_V	0.591	1.00
67_V	70_H	0.591	1.00
33_K	36_I	0.589	1.00
166_R	170_E	0.585	1.00
55_R	62_H	0.584	1.00
1_M	8_P	0.583	1.00
195_V	202_D	0.582	1.00
91_V	95_Q	0.580	1.00
161_V	167_G	0.578	1.00
50_T	53_H	0.576	1.00
81_D	198_G	0.572	1.00
186_D	189_G	0.571	1.00
16_Q	147_F	0.567	1.00
117_Y	196_D	0.566	1.00
73_E	151_S	0.563	1.00
43_E	48_P	0.563	1.00
129_T	132_V	0.559	1.00
68_E	156_H	0.552	1.00
113_D	134_K	0.552	1.00
99_R	151_S	0.551	1.00
23_D	46_G	0.550	1.00
13_C	78_M	0.548	1.00
75_F	155_F	0.548	1.00
145_T	190_L	0.548	1.00
104_F	144_M	0.548	1.00
106_V	128_V	0.548	1.00
17_L	76_M	0.548	1.00
98_E	184_T	0.548	1.00
138_P	141_N	0.547	1.00
47_V	51_Y	0.542	1.00
64_L	75_F	0.540	1.00
13_C	80_G	0.537	1.00
16_Q	88_L	0.537	1.00
114_A	119_V	0.535	1.00
18_V	48_P	0.533	1.00
158_C	169_Y	0.527	1.00
168_E	173_E	0.525	1.00
127_E	179_I	0.524	1.00
115_S	136_D	0.523	1.00
102_A	106_V	0.523	1.00
84_F	145_T	0.521	1.00
4_V	206_A	0.521	1.00
114_A	117_Y	0.520	1.00
38_E	41_G	0.520	1.00
19_E	89_E	0.518	1.00
41_G	45_E	0.514	1.00
137_D	140_S	0.513	1.00
12_H	16_Q	0.512	1.00
150_F	174_A	0.509	1.00
173_E	177_L	0.509	1.00
120_C	187_A	0.508	1.00
196_D	202_D	0.503	1.00
105_L	147_F	0.503	1.00
119_V	135_P	0.502	1.00
58_K	163_P	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3jukA	3	0.9771	100	0.311	Contact Map
2e3dA	3	0.9817	100	0.316	Contact Map
2ux8A	4	0.9908	100	0.32	Contact Map
2pa4A	3	0.9954	100	0.333	Contact Map
1iimA	3	0.9862	100	0.346	Contact Map
1lvwA	3	0.9908	100	0.346	Contact Map
4ho4A	3	0.9862	100	0.355	Contact Map
1mc3A	3	0.9862	100	0.355	Contact Map
3brkX	2	0.9404	100	0.363	Contact Map
4ecmA	3	0.9817	100	0.38	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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