GREMLIN Database
Q9HSW3 - Uncharacterized protein
UniProt: Q9HSW3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 259 (207)
Sequences: 1241 (1151)
Seq/√Len: 80.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_I204_L4.7501.00
123_E139_V4.0971.00
145_S176_T3.8631.00
120_P172_V3.7831.00
116_I182_I3.1471.00
216_H242_F3.0621.00
123_E141_S3.0361.00
94_A115_A2.9331.00
150_T173_E2.9311.00
148_V181_E2.9231.00
180_V206_Q2.7561.00
146_P203_E2.6501.00
178_S181_E2.5901.00
145_S200_S2.5781.00
180_V207_E2.3581.00
114_I140_I2.3471.00
91_D194_I2.3141.00
92_L195_S2.2351.00
143_G176_T2.2321.00
130_A137_V2.1841.00
150_T175_E2.0881.00
100_A137_V2.0611.00
143_G174_V2.0551.00
218_I237_L2.0351.00
123_E127_K2.0211.00
179_L207_E1.9271.00
89_V103_A1.9041.00
119_N122_L1.8981.00
118_A141_S1.8741.00
94_A126_I1.8001.00
152_E173_E1.7951.00
116_I144_Y1.7781.00
92_L144_Y1.7581.00
123_E126_I1.7541.00
152_E171_E1.7491.00
76_V98_F1.7261.00
95_G221_E1.6791.00
108_N111_R1.6571.00
148_V177_T1.6421.00
177_T181_E1.6381.00
140_I182_I1.6371.00
116_I140_I1.5971.00
130_A139_V1.5781.00
126_I129_N1.5530.99
142_A177_T1.5330.99
101_C129_N1.5260.99
112_D138_K1.4590.99
195_S204_L1.4580.99
86_E111_R1.4510.99
180_V211_I1.4490.99
151_I176_T1.4410.99
120_P141_S1.4180.99
104_D113_V1.4040.99
148_V178_S1.3870.99
104_D136_S1.3770.99
144_Y204_L1.3610.99
202_A236_R1.3380.98
145_S149_G1.3350.98
129_N132_L1.3160.98
193_L215_C1.3120.98
98_F102_V1.3030.98
180_V210_L1.2630.98
200_S203_E1.2530.98
90_I191_F1.2520.98
104_D135_S1.2400.97
198_E201_E1.2390.97
95_G194_I1.2320.97
92_L204_L1.2260.97
83_L103_A1.2230.97
107_L111_R1.2230.97
118_A143_G1.2210.97
197_I201_E1.1960.97
83_L89_V1.1770.97
86_E108_N1.1760.97
180_V208_I1.1570.96
99_T103_A1.1520.96
58_P61_K1.1470.96
207_E210_L1.1460.96
192_S219_I1.1130.95
182_I186_F1.1100.95
153_I162_N1.1060.95
90_I179_L1.1030.95
115_A126_I1.1020.95
180_V209_E1.0960.95
122_L126_I1.0940.95
206_Q211_I1.0780.94
86_E107_L1.0750.94
198_E221_E1.0690.94
114_I182_I1.0660.94
197_I206_Q1.0510.94
89_V108_N1.0460.93
89_V113_V1.0420.93
193_L218_I1.0370.93
201_E220_I1.0330.93
90_I116_I1.0300.93
75_E219_I1.0160.92
128_Y131_G1.0120.92
88_D111_R0.9960.92
99_T102_V0.9810.91
207_E211_I0.9810.91
148_V175_E0.9800.91
145_S203_E0.9760.91
151_I164_V0.9620.90
117_E123_E0.9450.89
193_L216_H0.9400.89
119_N153_I0.9400.89
94_A117_E0.9280.88
197_I200_S0.9180.88
72_E99_T0.9170.88
84_P87_L0.9150.88
89_V100_A0.9060.87
71_Y76_V0.8980.87
92_L197_I0.8920.86
145_S151_I0.8890.86
153_I172_V0.8870.86
92_L116_I0.8860.86
100_A115_A0.8860.86
89_V111_R0.8850.86
92_L206_Q0.8820.86
198_E223_H0.8800.86
130_A135_S0.8720.85
116_I142_A0.8700.85
80_Q106_K0.8640.85
193_L207_E0.8610.84
215_C242_F0.8560.84
186_F191_F0.8500.84
178_S206_Q0.8440.83
100_A139_V0.8430.83
119_N155_D0.8390.83
99_T223_H0.8390.83
79_I89_V0.8360.83
206_Q209_E0.8320.82
91_D95_G0.8200.81
76_V102_V0.8100.81
107_L110_G0.8090.81
101_C104_D0.8060.80
126_I139_V0.7950.79
104_D137_V0.7870.79
185_E213_S0.7870.79
209_E213_S0.7870.79
127_K141_S0.7810.78
222_I233_T0.7740.78
49_A129_N0.7690.77
221_E224_E0.7640.77
87_L111_R0.7630.77
192_S217_T0.7580.76
229_A232_E0.7520.75
116_I178_S0.7510.75
231_K235_S0.7490.75
143_G151_I0.7470.75
92_L193_L0.7470.75
76_V79_I0.7460.75
118_A151_I0.7420.75
90_I193_L0.7380.74
196_D221_E0.7370.74
61_K64_L0.7340.74
149_G174_V0.7310.73
222_I230_V0.7300.73
95_G98_F0.7270.73
103_A194_I0.7260.73
213_S216_H0.7260.73
138_K186_F0.7250.73
142_A175_E0.7250.73
89_V192_S0.7240.73
211_I218_I0.7240.73
205_I236_R0.7220.72
100_A113_V0.7220.72
77_K80_Q0.7210.72
90_I114_I0.7150.72
155_D172_V0.7150.72
143_G198_E0.7110.71
88_D114_I0.7100.71
127_K131_G0.7090.71
144_Y207_E0.7080.71
91_D94_A0.7080.71
101_C133_N0.7030.70
124_S127_K0.7020.70
144_Y179_L0.7020.70
183_T188_I0.7020.70
128_Y132_L0.7010.70
144_Y177_T0.7010.70
81_E184_N0.7000.70
122_L163_S0.6990.70
85_P109_Q0.6980.70
95_G129_N0.6980.70
195_S205_I0.6960.70
211_I216_H0.6950.70
72_E98_F0.6940.69
235_S239_N0.6910.69
154_S163_S0.6900.69
215_C241_G0.6900.69
93_G199_G0.6840.68
123_E140_I0.6830.68
91_D101_C0.6830.68
208_I212_K0.6810.68
179_L210_L0.6800.68
61_K71_Y0.6800.68
118_A123_E0.6800.68
218_I221_E0.6690.67
95_G122_L0.6680.67
208_I240_E0.6650.66
90_I219_I0.6650.66
92_L178_S0.6630.66
72_E201_E0.6580.65
118_A122_L0.6560.65
144_Y178_S0.6540.65
193_L241_G0.6500.64
90_I144_Y0.6490.64
183_T186_F0.6490.64
122_L129_N0.6480.64
60_V67_G0.6470.64
118_A153_I0.6430.64
127_K139_V0.6420.63
99_T194_I0.6410.63
221_E231_K0.6400.63
71_Y98_F0.6380.63
87_L217_T0.6370.63
100_A126_I0.6360.63
101_C126_I0.6350.63
113_V137_V0.6340.63
139_V164_V0.6310.62
99_T192_S0.6280.62
179_L183_T0.6250.61
51_L227_N0.6230.61
99_T219_I0.6210.61
200_S223_H0.6180.61
51_L179_L0.6180.61
94_A125_S0.6170.60
202_A232_E0.6160.60
107_L113_V0.6140.60
39_E43_E0.6140.60
114_I138_K0.6130.60
197_I223_H0.6120.60
43_E46_G0.6070.59
178_S207_E0.6030.59
195_S201_E0.5890.57
181_E184_N0.5880.57
147_S178_S0.5850.56
223_H234_I0.5840.56
197_I222_I0.5830.56
72_E75_E0.5820.56
78_F82_Y0.5810.56
98_F223_H0.5790.56
57_R61_K0.5790.56
236_R240_E0.5780.56
39_E42_M0.5750.55
177_T182_I0.5750.55
208_I211_I0.5730.55
150_T239_N0.5710.55
93_G97_G0.5700.54
78_F237_L0.5700.54
95_G115_A0.5680.54
49_A101_C0.5640.54
141_S175_E0.5620.53
123_E129_N0.5550.53
71_Y197_I0.5500.52
47_I182_I0.5490.52
75_E192_S0.5490.52
146_P202_A0.5470.52
231_K243_R0.5450.51
115_A137_V0.5410.51
80_Q177_T0.5410.51
114_I131_G0.5400.51
114_I183_T0.5380.50
221_E234_I0.5370.50
82_Y220_I0.5360.50
50_D128_Y0.5350.50
83_L108_N0.5340.50
100_A130_A0.5340.50
79_I106_K0.5340.50
78_F242_F0.5330.50
65_N144_Y0.5320.50
211_I215_C0.5320.50
110_G113_V0.5320.50
71_Y191_F0.5320.50
211_I236_R0.5320.50
83_L107_L0.5320.50
99_T200_S0.5270.49
120_P175_E0.5250.49
113_V132_L0.5250.49
179_L204_L0.5250.49
131_G185_E0.5240.49
163_S224_E0.5230.48
77_K189_D0.5230.48
163_S198_E0.5210.48
91_D115_A0.5200.48
241_G244_L0.5170.48
73_K76_V0.5170.48
134_G187_S0.5160.47
162_N198_E0.5150.47
83_L227_N0.5150.47
71_Y198_E0.5120.47
78_F219_I0.5120.47
89_V99_T0.5120.47
83_L88_D0.5110.47
101_C194_I0.5110.47
100_A106_K0.5110.47
108_N113_V0.5100.47
88_D103_A0.5100.47
64_L98_F0.5100.47
88_D190_S0.5080.46
63_R248_E0.5080.46
125_S129_N0.5040.46
130_A142_A0.5040.46
166_E177_T0.5020.46
206_Q210_L0.5020.46
145_S245_I0.5020.46
153_I241_G0.5010.46
226_K229_A0.5000.45
95_G99_T0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2py6A 4 0.8803 100 0.481 Contact Map
3a27A 1 0.7529 97.9 0.843 Contact Map
3sm3A 2 0.668 97.7 0.848 Contact Map
2jjqA 1 0.7876 97.7 0.848 Contact Map
1o54A 4 0.8263 97.7 0.848 Contact Map
3k6rA 1 0.7915 97.7 0.848 Contact Map
3dxyA 1 0.7452 97.7 0.85 Contact Map
2nxcA 1 0.7799 97.6 0.851 Contact Map
1uwvA 1 0.8069 97.5 0.854 Contact Map
2fcaA 2 0.722 97.5 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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