Q9HSW3 - HALSA - GREMLIN Contacts

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Q9HSW3 - Uncharacterized protein

UniProt:	Q9HSW3	Sequences: MAISDRIMQSIQDGRIFSAIKDRFVAIPHVFATSSLSGEYLMEQAGIKADLSNTNIRPLVKYRLNTGYLEYEKTEVKFIQEYLPPELDVIDLGAGIGFTACVADRKLNQGRDVIAIEANPKLESSIKYNAGLNGSSVKVISAGYSPSVGTIEISDKDSYRSNSVYENTSDEVEVETTSLVEITNEFSIDSFSLISDIEGSEAELIQEIELIKSKCHTIIIEIHEEKNSAVKETISRLENEGFRLIDSEERVRVFQNQAL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	259 (207)
Sequences:	1241 (1151)
Seq/√Len:	80.0

HALSA - Q9HSW3 Q9HQP5
SULSO - Q97XG4 Q97XU3 Q97X54 Q7LXG2 Q7LXE9 Q7LXF6 Q7LXE1 Q97XT4 Q7LXF9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
197_I	204_L	4.750	1.00
123_E	139_V	4.097	1.00
145_S	176_T	3.863	1.00
120_P	172_V	3.783	1.00
116_I	182_I	3.147	1.00
216_H	242_F	3.062	1.00
123_E	141_S	3.036	1.00
94_A	115_A	2.933	1.00
150_T	173_E	2.931	1.00
148_V	181_E	2.923	1.00
180_V	206_Q	2.756	1.00
146_P	203_E	2.650	1.00
178_S	181_E	2.590	1.00
145_S	200_S	2.578	1.00
180_V	207_E	2.358	1.00
114_I	140_I	2.347	1.00
91_D	194_I	2.314	1.00
92_L	195_S	2.235	1.00
143_G	176_T	2.232	1.00
130_A	137_V	2.184	1.00
150_T	175_E	2.088	1.00
100_A	137_V	2.061	1.00
143_G	174_V	2.055	1.00
218_I	237_L	2.035	1.00
123_E	127_K	2.021	1.00
179_L	207_E	1.927	1.00
89_V	103_A	1.904	1.00
119_N	122_L	1.898	1.00
118_A	141_S	1.874	1.00
94_A	126_I	1.800	1.00
152_E	173_E	1.795	1.00
116_I	144_Y	1.778	1.00
92_L	144_Y	1.758	1.00
123_E	126_I	1.754	1.00
152_E	171_E	1.749	1.00
76_V	98_F	1.726	1.00
95_G	221_E	1.679	1.00
108_N	111_R	1.657	1.00
148_V	177_T	1.642	1.00
177_T	181_E	1.638	1.00
140_I	182_I	1.637	1.00
116_I	140_I	1.597	1.00
130_A	139_V	1.578	1.00
126_I	129_N	1.553	0.99
142_A	177_T	1.533	0.99
101_C	129_N	1.526	0.99
112_D	138_K	1.459	0.99
195_S	204_L	1.458	0.99
86_E	111_R	1.451	0.99
180_V	211_I	1.449	0.99
151_I	176_T	1.441	0.99
120_P	141_S	1.418	0.99
104_D	113_V	1.404	0.99
148_V	178_S	1.387	0.99
104_D	136_S	1.377	0.99
144_Y	204_L	1.361	0.99
202_A	236_R	1.338	0.98
145_S	149_G	1.335	0.98
129_N	132_L	1.316	0.98
193_L	215_C	1.312	0.98
98_F	102_V	1.303	0.98
180_V	210_L	1.263	0.98
200_S	203_E	1.253	0.98
90_I	191_F	1.252	0.98
104_D	135_S	1.240	0.97
198_E	201_E	1.239	0.97
95_G	194_I	1.232	0.97
92_L	204_L	1.226	0.97
83_L	103_A	1.223	0.97
107_L	111_R	1.223	0.97
118_A	143_G	1.221	0.97
197_I	201_E	1.196	0.97
83_L	89_V	1.177	0.97
86_E	108_N	1.176	0.97
180_V	208_I	1.157	0.96
99_T	103_A	1.152	0.96
58_P	61_K	1.147	0.96
207_E	210_L	1.146	0.96
192_S	219_I	1.113	0.95
182_I	186_F	1.110	0.95
153_I	162_N	1.106	0.95
90_I	179_L	1.103	0.95
115_A	126_I	1.102	0.95
180_V	209_E	1.096	0.95
122_L	126_I	1.094	0.95
206_Q	211_I	1.078	0.94
86_E	107_L	1.075	0.94
198_E	221_E	1.069	0.94
114_I	182_I	1.066	0.94
197_I	206_Q	1.051	0.94
89_V	108_N	1.046	0.93
89_V	113_V	1.042	0.93
193_L	218_I	1.037	0.93
201_E	220_I	1.033	0.93
90_I	116_I	1.030	0.93
75_E	219_I	1.016	0.92
128_Y	131_G	1.012	0.92
88_D	111_R	0.996	0.92
99_T	102_V	0.981	0.91
207_E	211_I	0.981	0.91
148_V	175_E	0.980	0.91
145_S	203_E	0.976	0.91
151_I	164_V	0.962	0.90
117_E	123_E	0.945	0.89
193_L	216_H	0.940	0.89
119_N	153_I	0.940	0.89
94_A	117_E	0.928	0.88
197_I	200_S	0.918	0.88
72_E	99_T	0.917	0.88
84_P	87_L	0.915	0.88
89_V	100_A	0.906	0.87
71_Y	76_V	0.898	0.87
92_L	197_I	0.892	0.86
145_S	151_I	0.889	0.86
153_I	172_V	0.887	0.86
92_L	116_I	0.886	0.86
100_A	115_A	0.886	0.86
89_V	111_R	0.885	0.86
92_L	206_Q	0.882	0.86
198_E	223_H	0.880	0.86
130_A	135_S	0.872	0.85
116_I	142_A	0.870	0.85
80_Q	106_K	0.864	0.85
193_L	207_E	0.861	0.84
215_C	242_F	0.856	0.84
186_F	191_F	0.850	0.84
178_S	206_Q	0.844	0.83
100_A	139_V	0.843	0.83
119_N	155_D	0.839	0.83
99_T	223_H	0.839	0.83
79_I	89_V	0.836	0.83
206_Q	209_E	0.832	0.82
91_D	95_G	0.820	0.81
76_V	102_V	0.810	0.81
107_L	110_G	0.809	0.81
101_C	104_D	0.806	0.80
126_I	139_V	0.795	0.79
104_D	137_V	0.787	0.79
185_E	213_S	0.787	0.79
209_E	213_S	0.787	0.79
127_K	141_S	0.781	0.78
222_I	233_T	0.774	0.78
49_A	129_N	0.769	0.77
221_E	224_E	0.764	0.77
87_L	111_R	0.763	0.77
192_S	217_T	0.758	0.76
229_A	232_E	0.752	0.75
116_I	178_S	0.751	0.75
231_K	235_S	0.749	0.75
143_G	151_I	0.747	0.75
92_L	193_L	0.747	0.75
76_V	79_I	0.746	0.75
118_A	151_I	0.742	0.75
90_I	193_L	0.738	0.74
196_D	221_E	0.737	0.74
61_K	64_L	0.734	0.74
149_G	174_V	0.731	0.73
222_I	230_V	0.730	0.73
95_G	98_F	0.727	0.73
103_A	194_I	0.726	0.73
213_S	216_H	0.726	0.73
138_K	186_F	0.725	0.73
142_A	175_E	0.725	0.73
89_V	192_S	0.724	0.73
211_I	218_I	0.724	0.73
205_I	236_R	0.722	0.72
100_A	113_V	0.722	0.72
77_K	80_Q	0.721	0.72
90_I	114_I	0.715	0.72
155_D	172_V	0.715	0.72
143_G	198_E	0.711	0.71
88_D	114_I	0.710	0.71
127_K	131_G	0.709	0.71
144_Y	207_E	0.708	0.71
91_D	94_A	0.708	0.71
101_C	133_N	0.703	0.70
124_S	127_K	0.702	0.70
144_Y	179_L	0.702	0.70
183_T	188_I	0.702	0.70
128_Y	132_L	0.701	0.70
144_Y	177_T	0.701	0.70
81_E	184_N	0.700	0.70
122_L	163_S	0.699	0.70
85_P	109_Q	0.698	0.70
95_G	129_N	0.698	0.70
195_S	205_I	0.696	0.70
211_I	216_H	0.695	0.70
72_E	98_F	0.694	0.69
235_S	239_N	0.691	0.69
154_S	163_S	0.690	0.69
215_C	241_G	0.690	0.69
93_G	199_G	0.684	0.68
123_E	140_I	0.683	0.68
91_D	101_C	0.683	0.68
208_I	212_K	0.681	0.68
179_L	210_L	0.680	0.68
61_K	71_Y	0.680	0.68
118_A	123_E	0.680	0.68
218_I	221_E	0.669	0.67
95_G	122_L	0.668	0.67
208_I	240_E	0.665	0.66
90_I	219_I	0.665	0.66
92_L	178_S	0.663	0.66
72_E	201_E	0.658	0.65
118_A	122_L	0.656	0.65
144_Y	178_S	0.654	0.65
193_L	241_G	0.650	0.64
90_I	144_Y	0.649	0.64
183_T	186_F	0.649	0.64
122_L	129_N	0.648	0.64
60_V	67_G	0.647	0.64
118_A	153_I	0.643	0.64
127_K	139_V	0.642	0.63
99_T	194_I	0.641	0.63
221_E	231_K	0.640	0.63
71_Y	98_F	0.638	0.63
87_L	217_T	0.637	0.63
100_A	126_I	0.636	0.63
101_C	126_I	0.635	0.63
113_V	137_V	0.634	0.63
139_V	164_V	0.631	0.62
99_T	192_S	0.628	0.62
179_L	183_T	0.625	0.61
51_L	227_N	0.623	0.61
99_T	219_I	0.621	0.61
200_S	223_H	0.618	0.61
51_L	179_L	0.618	0.61
94_A	125_S	0.617	0.60
202_A	232_E	0.616	0.60
107_L	113_V	0.614	0.60
39_E	43_E	0.614	0.60
114_I	138_K	0.613	0.60
197_I	223_H	0.612	0.60
43_E	46_G	0.607	0.59
178_S	207_E	0.603	0.59
195_S	201_E	0.589	0.57
181_E	184_N	0.588	0.57
147_S	178_S	0.585	0.56
223_H	234_I	0.584	0.56
197_I	222_I	0.583	0.56
72_E	75_E	0.582	0.56
78_F	82_Y	0.581	0.56
98_F	223_H	0.579	0.56
57_R	61_K	0.579	0.56
236_R	240_E	0.578	0.56
39_E	42_M	0.575	0.55
177_T	182_I	0.575	0.55
208_I	211_I	0.573	0.55
150_T	239_N	0.571	0.55
93_G	97_G	0.570	0.54
78_F	237_L	0.570	0.54
95_G	115_A	0.568	0.54
49_A	101_C	0.564	0.54
141_S	175_E	0.562	0.53
123_E	129_N	0.555	0.53
71_Y	197_I	0.550	0.52
47_I	182_I	0.549	0.52
75_E	192_S	0.549	0.52
146_P	202_A	0.547	0.52
231_K	243_R	0.545	0.51
115_A	137_V	0.541	0.51
80_Q	177_T	0.541	0.51
114_I	131_G	0.540	0.51
114_I	183_T	0.538	0.50
221_E	234_I	0.537	0.50
82_Y	220_I	0.536	0.50
50_D	128_Y	0.535	0.50
83_L	108_N	0.534	0.50
100_A	130_A	0.534	0.50
79_I	106_K	0.534	0.50
78_F	242_F	0.533	0.50
65_N	144_Y	0.532	0.50
211_I	215_C	0.532	0.50
110_G	113_V	0.532	0.50
71_Y	191_F	0.532	0.50
211_I	236_R	0.532	0.50
83_L	107_L	0.532	0.50
99_T	200_S	0.527	0.49
120_P	175_E	0.525	0.49
113_V	132_L	0.525	0.49
179_L	204_L	0.525	0.49
131_G	185_E	0.524	0.49
163_S	224_E	0.523	0.48
77_K	189_D	0.523	0.48
163_S	198_E	0.521	0.48
91_D	115_A	0.520	0.48
241_G	244_L	0.517	0.48
73_K	76_V	0.517	0.48
134_G	187_S	0.516	0.47
162_N	198_E	0.515	0.47
83_L	227_N	0.515	0.47
71_Y	198_E	0.512	0.47
78_F	219_I	0.512	0.47
89_V	99_T	0.512	0.47
83_L	88_D	0.511	0.47
101_C	194_I	0.511	0.47
100_A	106_K	0.511	0.47
108_N	113_V	0.510	0.47
88_D	103_A	0.510	0.47
64_L	98_F	0.510	0.47
88_D	190_S	0.508	0.46
63_R	248_E	0.508	0.46
125_S	129_N	0.504	0.46
130_A	142_A	0.504	0.46
166_E	177_T	0.502	0.46
206_Q	210_L	0.502	0.46
145_S	245_I	0.502	0.46
153_I	241_G	0.501	0.46
226_K	229_A	0.500	0.45
95_G	99_T	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2py6A	4	0.8803	100	0.481	Contact Map
3a27A	1	0.7529	97.9	0.843	Contact Map
3sm3A	2	0.668	97.7	0.848	Contact Map
2jjqA	1	0.7876	97.7	0.848	Contact Map
1o54A	4	0.8263	97.7	0.848	Contact Map
3k6rA	1	0.7915	97.7	0.848	Contact Map
3dxyA	1	0.7452	97.7	0.85	Contact Map
2nxcA	1	0.7799	97.6	0.851	Contact Map
1uwvA	1	0.8069	97.5	0.854	Contact Map
2fcaA	2	0.722	97.5	0.855	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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