GREMLIN Database
Q9HSW2 - Uncharacterized protein
UniProt: Q9HSW2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 480 (449)
Sequences: 17270 (14934)
Seq/√Len: 704.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
280_E283_E4.8171.00
208_P212_R3.3731.00
143_R146_R3.1861.00
99_L102_A3.0811.00
355_E358_R3.0191.00
327_E331_P2.9781.00
416_L420_K2.9251.00
44_A248_T2.8851.00
357_T361_I2.7441.00
307_S331_P2.7031.00
142_R274_A2.6871.00
355_E408_I2.5821.00
246_I325_N2.4871.00
69_S140_A2.4381.00
311_V315_R2.3711.00
310_S327_E2.3141.00
366_A397_R2.2181.00
417_M420_K2.2171.00
240_G243_A2.1951.00
339_F395_G2.1741.00
332_I384_E2.1731.00
231_D247_Y2.1451.00
310_S331_P2.1241.00
275_A283_E2.0711.00
199_L202_P2.0571.00
97_Y119_I2.0561.00
235_I239_L2.0501.00
362_I400_L2.0291.00
219_P360_S2.0281.00
67_R71_S2.0221.00
274_A278_N2.0101.00
231_D374_N2.0061.00
329_I383_L2.0041.00
373_L389_A2.0011.00
332_I391_T1.9581.00
12_I145_K1.9501.00
286_R290_N1.9441.00
319_T322_I1.9411.00
309_L312_A1.9351.00
305_G309_L1.9041.00
36_G39_A1.8881.00
68_Y213_Y1.8841.00
431_V454_I1.8801.00
239_L243_A1.8131.00
428_M432_L1.8071.00
312_A315_R1.8041.00
281_F285_S1.8041.00
378_L386_A1.7891.00
299_A341_G1.7721.00
234_L378_L1.7491.00
381_I388_V1.7251.00
369_L396_F1.7051.00
171_S174_D1.6821.00
33_K319_T1.6711.00
382_G385_G1.6641.00
428_M451_G1.6611.00
142_R271_N1.6551.00
203_D206_T1.6521.00
234_L374_N1.6511.00
45_T236_I1.6431.00
311_V327_E1.6421.00
304_G429_V1.6421.00
288_Y349_P1.6261.00
328_W384_E1.6241.00
137_Y141_L1.6221.00
385_G389_A1.6211.00
231_D390_T1.6071.00
145_K149_A1.6061.00
100_S119_I1.6061.00
377_L389_A1.6061.00
239_L383_L1.5981.00
374_N378_L1.5941.00
223_S364_F1.5911.00
43_W47_L1.5861.00
283_E286_R1.5801.00
452_V456_F1.5641.00
276_W353_A1.5491.00
332_I388_V1.5301.00
303_I338_A1.5291.00
305_G448_P1.5261.00
329_I387_A1.5171.00
272_V284_L1.5121.00
77_V81_T1.5111.00
311_V331_P1.5061.00
399_V403_H1.5031.00
75_S79_S1.5011.00
309_L313_I1.5011.00
285_S289_S1.5001.00
32_T249_V1.4971.00
314_L330_V1.4931.00
432_L451_G1.4851.00
372_C376_V1.4821.00
76_Q203_D1.4801.00
306_L334_A1.4751.00
336_G391_T1.4741.00
254_S333_L1.4681.00
76_Q80_D1.4661.00
328_W331_P1.4641.00
314_L326_G1.4611.00
235_I386_A1.4611.00
300_L425_T1.4571.00
332_I387_A1.4551.00
339_F398_T1.4421.00
240_G244_A1.4371.00
305_G428_M1.4361.00
174_D178_A1.4331.00
377_L381_I1.4301.00
429_V433_I1.4281.00
283_E287_F1.4251.00
370_N374_N1.4231.00
424_A428_M1.4181.00
71_S354_E1.4161.00
275_A287_F1.3931.00
376_V379_P1.3911.00
284_L349_P1.3851.00
158_E182_T1.3801.00
96_F122_A1.3771.00
389_A393_S1.3601.00
19_V152_I1.3601.00
243_A383_L1.3551.00
403_H407_S1.3551.00
242_S246_I1.3451.00
320_P323_A1.3401.00
289_S293_R1.3311.00
250_S326_G1.3291.00
74_A77_V1.3261.00
73_D76_Q1.3261.00
25_L29_S1.3241.00
268_L291_F1.3231.00
361_I365_F1.3171.00
46_I121_A1.3151.00
377_L380_I1.3141.00
235_I244_A1.3131.00
84_V207_F1.3051.00
362_I404_L1.3051.00
28_I252_T1.3051.00
157_I185_I1.3051.00
216_P360_S1.2991.00
234_L375_L1.2981.00
18_I22_I1.2961.00
282_D286_R1.2961.00
230_A371_L1.2951.00
250_S329_I1.2941.00
164_V168_L1.2941.00
229_H232_K1.2861.00
325_N328_W1.2851.00
117_L176_F1.2831.00
198_D201_I1.2741.00
163_A167_Y1.2471.00
161_V178_A1.2461.00
64_A213_Y1.2431.00
376_V380_I1.2421.00
29_S33_K1.2411.00
425_T429_V1.2401.00
37_S246_I1.2381.00
234_L238_F1.2341.00
102_A106_V1.2141.00
335_V391_T1.2131.00
126_G129_L1.2061.00
281_F353_A1.2011.00
215_V219_P1.1991.00
143_R197_D1.1911.00
246_I326_G1.1901.00
40_Q44_A1.1821.00
160_I164_V1.1821.00
22_I26_L1.1811.00
272_V352_A1.1791.00
68_Y71_S1.1781.00
276_W284_L1.1781.00
70_P140_A1.1761.00
170_E174_D1.1721.00
384_E387_A1.1711.00
79_S83_T1.1691.00
173_L176_F1.1651.00
80_D207_F1.1641.00
27_I159_V1.1631.00
370_N390_T1.1621.00
101_G105_S1.1611.00
362_I401_L1.1611.00
249_V318_S1.1571.00
269_Y273_T1.1531.00
346_L402_F1.1421.00
288_Y346_L1.1381.00
198_D202_P1.1371.00
42_I241_P1.1341.00
306_L330_V1.1341.00
127_A187_D1.1311.00
314_L327_E1.1301.00
20_L155_N1.1271.00
192_F196_R1.1261.00
329_I384_E1.1191.00
381_I385_G1.1181.00
150_L190_F1.1161.00
296_V300_L1.1151.00
78_F137_Y1.1151.00
369_L373_L1.1131.00
323_A327_E1.1091.00
44_A245_G1.1091.00
32_T318_S1.1061.00
39_A42_I1.1031.00
346_L401_L1.1021.00
374_N390_T1.1011.00
144_V267_T1.1001.00
275_A280_E1.1001.00
303_I307_S1.0981.00
93_G96_F1.0951.00
349_P405_S1.0951.00
216_P357_T1.0941.00
16_R148_E1.0901.00
97_Y101_G1.0901.00
101_G119_I1.0841.00
177_W181_L1.0841.00
282_D285_S1.0831.00
226_L367_V1.0831.00
223_S360_S1.0831.00
58_G62_H1.0821.00
66_I136_N1.0761.00
209_L354_E1.0761.00
87_M91_L1.0711.00
83_T87_M1.0671.00
370_N393_S1.0671.00
364_F368_I1.0651.00
223_S367_V1.0611.00
127_A184_I1.0611.00
336_G387_A1.0521.00
10_A267_T1.0491.00
43_W175_G1.0471.00
150_L189_V1.0441.00
373_L377_L1.0431.00
45_T244_A1.0411.00
161_V165_T1.0361.00
93_G97_Y1.0351.00
188_F192_F1.0341.00
271_N274_A1.0301.00
227_L370_N1.0281.00
368_I372_C1.0241.00
211_L214_A1.0221.00
388_V392_V1.0211.00
13_S267_T1.0211.00
342_A398_T1.0211.00
23_R159_V1.0211.00
361_I364_F1.0171.00
213_Y356_T1.0151.00
231_D370_N1.0121.00
108_N111_G1.0101.00
115_T119_I1.0081.00
336_G339_F1.0021.00
358_R404_L1.0011.00
445_V449_V0.9971.00
10_A264_F0.9951.00
235_I247_Y0.9951.00
238_F378_L0.9951.00
28_I318_S0.9941.00
313_I317_I0.9921.00
29_S318_S0.9901.00
37_S245_G0.9891.00
64_A214_A0.9861.00
67_R354_E0.9841.00
374_N377_L0.9831.00
250_S333_L0.9791.00
220_K359_L0.9781.00
316_F444_L0.9781.00
403_H406_K0.9751.00
34_L167_Y0.9711.00
310_S330_V0.9701.00
5_R8_S0.9661.00
204_I208_P0.9641.00
307_S310_S0.9631.00
380_I384_E0.9621.00
245_G248_T0.9581.00
179_L183_H0.9581.00
235_I383_L0.9571.00
123_V126_G0.9571.00
30_I34_L0.9561.00
46_I117_L0.9531.00
69_S141_L0.9521.00
191_L195_S0.9501.00
51_G55_S0.9481.00
17_V21_S0.9431.00
350_L404_L0.9411.00
64_A210_Y0.9351.00
443_L447_A0.9351.00
102_A105_S0.9341.00
123_V180_A0.9331.00
333_L387_A0.9321.00
309_L447_A0.9271.00
40_Q245_G0.9241.00
100_S104_L0.9241.00
112_D115_T0.9231.00
119_I123_V0.9231.00
247_Y333_L0.9231.00
87_M90_I0.9201.00
180_A183_H0.9201.00
430_I434_M0.9191.00
14_A263_I0.9181.00
312_A447_A0.9171.00
35_I39_A0.9151.00
290_N293_R0.9111.00
34_L166_L0.9101.00
391_T394_F0.9101.00
98_I101_G0.9071.00
182_T186_F0.9071.00
178_A182_T0.9061.00
177_W180_A0.9051.00
31_I175_G0.9041.00
13_S148_E0.9031.00
245_G249_V0.8991.00
440_Q443_L0.8971.00
122_A126_G0.8941.00
307_S311_V0.8911.00
331_P335_V0.8911.00
301_P455_Y0.8891.00
284_L353_A0.8881.00
37_S242_S0.8851.00
232_K244_A0.8831.00
388_V391_T0.8811.00
164_V167_Y0.8801.00
65_L69_S0.8791.00
448_P451_G0.8781.00
400_L403_H0.8781.00
43_W172_L0.8771.00
271_N275_A0.8761.00
86_L90_I0.8761.00
71_S209_L0.8741.00
38_G241_P0.8741.00
379_P386_A0.8731.00
287_F291_F0.8661.00
225_T229_H0.8651.00
158_E162_L0.8601.00
326_G329_I0.8601.00
36_G322_I0.8591.00
374_N386_A0.8561.00
84_V88_M0.8551.00
29_S32_T0.8541.00
447_A451_G0.8541.00
301_P428_M0.8521.00
82_L134_L0.8511.00
351_Q359_L0.8511.00
250_S330_V0.8491.00
441_P448_P0.8451.00
211_L215_V0.8401.00
90_I94_A0.8391.00
82_L85_T0.8381.00
9_D142_R0.8371.00
269_Y348_Y0.8371.00
37_S322_I0.8371.00
189_V193_V0.8361.00
68_Y209_L0.8361.00
435_M450_T0.8341.00
95_I99_L0.8341.00
12_I16_R0.8341.00
64_A68_Y0.8321.00
375_L379_P0.8321.00
79_S82_L0.8301.00
297_L301_P0.8291.00
10_A14_A0.8281.00
421_A425_T0.8261.00
373_L392_V0.8251.00
81_T210_Y0.8231.00
162_L178_A0.8231.00
6_L10_A0.8221.00
254_S337_F0.8221.00
175_G179_L0.8221.00
91_L95_I0.8201.00
400_L404_L0.8191.00
396_F400_L0.8171.00
11_G15_L0.8141.00
448_P452_V0.8131.00
295_Y341_G0.8121.00
186_F190_F0.8111.00
41_G242_S0.8101.00
216_P356_T0.8071.00
308_F429_V0.8041.00
100_S103_I0.8021.00
358_R361_I0.8001.00
89_S93_G0.7991.00
8_S145_K0.7971.00
212_R215_V0.7971.00
350_L359_L0.7911.00
261_A265_N0.7911.00
371_L375_L0.7901.00
233_I237_R0.7891.00
80_D84_V0.7891.00
373_L376_V0.7861.00
251_Y255_S0.7861.00
7_F11_G0.7861.00
304_G308_F0.7821.00
307_S335_V0.7791.00
419_G423_A0.7781.00
9_D267_T0.7771.00
146_R193_V0.7761.00
360_S364_F0.7751.00
384_E388_V0.7751.00
425_T428_M0.7751.00
37_S321_E0.7741.00
66_I140_A0.7741.00
293_R297_L0.7741.00
275_A278_N0.7731.00
48_A232_K0.7731.00
179_L182_T0.7731.00
404_L407_S0.7721.00
362_I366_A0.7721.00
415_I419_G0.7721.00
273_T277_E0.7721.00
67_R356_T0.7701.00
165_T170_E0.7701.00
249_V252_T0.7671.00
315_R323_A0.7671.00
222_L226_L0.7671.00
422_I425_T0.7661.00
229_H233_I0.7661.00
307_S334_A0.7651.00
335_V338_A0.7631.00
321_E325_N0.7631.00
236_I244_A0.7631.00
31_I162_L0.7611.00
65_L81_T0.7601.00
248_T252_T0.7591.00
23_R27_I0.7591.00
301_P304_G0.7591.00
314_L318_S0.7571.00
417_M421_A0.7561.00
28_I32_T0.7561.00
98_I102_A0.7551.00
146_R149_A0.7531.00
336_G390_T0.7521.00
213_Y217_M0.7521.00
253_I318_S0.7501.00
61_M81_T0.7491.00
359_L363_T0.7471.00
83_T86_L0.7451.00
161_V181_L0.7431.00
47_L51_G0.7431.00
304_G425_T0.7421.00
51_G54_A0.7421.00
231_D251_Y0.7411.00
428_M431_V0.7391.00
154_L158_E0.7381.00
134_L191_L0.7301.00
161_V164_V0.7281.00
36_G321_E0.7271.00
406_K409_I0.7261.00
124_Y183_H0.7261.00
212_R216_P0.7251.00
316_F441_P0.7231.00
85_T89_S0.7231.00
217_M356_T0.7221.00
72_S76_Q0.7181.00
127_A180_A0.7171.00
395_G399_V0.7161.00
159_V163_A0.7141.00
207_F211_L0.7141.00
156_G160_I0.7131.00
97_Y100_S0.7111.00
365_F400_L0.7101.00
310_S334_A0.7081.00
94_A98_I0.7071.00
244_A248_T0.7071.00
247_Y251_Y0.7061.00
348_Y352_A0.7051.00
267_T270_P0.7051.00
229_H255_S0.7051.00
291_F345_F0.7041.00
154_L186_F0.7011.00
348_Y351_Q0.7011.00
252_T255_S0.7001.00
391_T395_G0.7001.00
7_F10_A0.6991.00
30_I167_Y0.6971.00
180_A184_I0.6961.00
120_P180_A0.6961.00
302_A305_G0.6961.00
60_H214_A0.6951.00
118_M122_A0.6951.00
135_S139_R0.6941.00
223_S363_T0.6931.00
402_F406_K0.6931.00
76_Q79_S0.6921.00
269_Y352_A0.6891.00
350_L405_S0.6881.00
252_T256_F0.6871.00
158_E178_A0.6861.00
14_A18_I0.6851.00
305_G451_G0.6841.00
30_I163_A0.6831.00
378_L385_G0.6801.00
210_Y214_A0.6791.00
111_G114_S0.6791.00
69_S74_A0.6791.00
165_T168_L0.6791.00
336_G394_F0.6791.00
19_V23_R0.6781.00
89_S129_L0.6781.00
74_A141_L0.6771.00
429_V432_L0.6751.00
201_I204_I0.6741.00
71_S277_E0.6691.00
439_S443_L0.6691.00
439_S442_L0.6681.00
29_S317_I0.6681.00
404_L408_I0.6671.00
15_L19_V0.6671.00
254_S257_L0.6661.00
19_V156_G0.6661.00
81_T85_T0.6661.00
444_L448_P0.6651.00
221_E225_T0.6621.00
54_A58_G0.6581.00
432_L435_M0.6581.00
16_R152_I0.6581.00
41_G245_G0.6561.00
119_I122_A0.6551.00
312_A443_L0.6541.00
295_Y345_F0.6541.00
50_V125_T0.6531.00
369_L372_C0.6501.00
43_W176_F0.6461.00
130_L187_D0.6461.00
301_P425_T0.6461.00
227_L367_V0.6441.00
212_R357_T0.6421.00
114_S119_I0.6421.00
139_R147_Y0.6411.00
232_K248_T0.6411.00
420_K424_A0.6401.00
346_L398_T0.6381.00
243_A246_I0.6381.00
138_P146_R0.6371.00
101_G104_L0.6361.00
263_I266_S0.6341.00
356_T359_L0.6311.00
335_V339_F0.6301.00
346_L405_S0.6301.00
45_T48_A0.6291.00
150_L186_F0.6291.00
74_A78_F0.6261.00
40_Q249_V0.6251.00
131_S187_D0.6251.00
287_F290_N0.6251.00
330_V334_A0.6231.00
78_F81_T0.6221.00
238_F375_L0.6211.00
193_V197_D0.6201.00
174_D177_W0.6171.00
66_I70_P0.6171.00
427_I430_I0.6161.00
62_H136_N0.6161.00
149_A153_A0.6161.00
220_K224_G0.6141.00
120_P173_L0.6131.00
365_F368_I0.6121.00
192_F195_S0.6091.00
96_F100_S0.6071.00
93_G126_G0.6061.00
101_G114_S0.6061.00
80_D83_T0.6061.00
249_V322_I0.6051.00
99_L103_I0.6011.00
441_P445_V0.6001.00
120_P176_F0.5991.00
343_E398_T0.5981.00
220_K363_T0.5971.00
92_T96_F0.5971.00
252_T318_S0.5961.00
90_I126_G0.5961.00
135_S151_L0.5941.00
155_N159_V0.5911.00
100_S118_M0.5901.00
390_T393_S0.5901.00
421_A424_A0.5891.00
315_R320_P0.5891.00
340_Q344_G0.5881.00
262_G266_S0.5861.00
120_P177_W0.5861.00
24_S28_I0.5851.00
275_A284_L0.5831.00
374_N389_A0.5831.00
91_L94_A0.5811.00
31_I40_Q0.5811.00
423_A426_T0.5801.00
86_L89_S0.5801.00
271_N287_F0.5781.00
358_R362_I0.5761.00
122_A125_T0.5751.00
217_M351_Q0.5741.00
295_Y299_A0.5731.00
136_N140_A0.5711.00
17_V263_I0.5711.00
286_R289_S0.5701.00
387_A391_T0.5701.00
231_D234_L0.5701.00
186_F189_V0.5701.00
270_P274_A0.5701.00
432_L447_A0.5701.00
305_G452_V0.5691.00
150_L154_L0.5661.00
260_L263_I0.5661.00
303_I334_A0.5651.00
364_F367_V0.5651.00
426_T430_I0.5641.00
50_V54_A0.5641.00
100_S122_A0.5631.00
13_S144_V0.5631.00
339_F391_T0.5601.00
224_G228_S0.5591.00
31_I35_I0.5571.00
249_V326_G0.5561.00
454_I457_V0.5551.00
230_A234_L0.5551.00
128_S183_H0.5531.00
28_I40_Q0.5511.00
39_A172_L0.5491.00
120_P124_Y0.5481.00
157_I160_I0.5481.00
35_I40_Q0.5471.00
65_L77_V0.5471.00
406_K410_D0.5461.00
359_L401_L0.5451.00
304_G307_S0.5441.00
209_L213_Y0.5431.00
144_V148_E0.5431.00
20_L24_S0.5431.00
220_K360_S0.5401.00
52_L225_T0.5401.00
67_R352_A0.5391.00
74_A81_T0.5361.00
84_V89_S0.5361.00
165_T178_A0.5351.00
431_V434_M0.5351.00
431_V450_T0.5351.00
110_S113_I0.5341.00
38_G42_I0.5341.00
315_R327_E0.5321.00
223_S227_L0.5321.00
45_T232_K0.5321.00
144_V147_Y0.5301.00
232_K251_Y0.5291.00
394_F397_R0.5281.00
19_V22_I0.5271.00
349_P353_A0.5271.00
162_L166_L0.5271.00
104_L118_M0.5251.00
77_V80_D0.5241.00
8_S11_G0.5221.00
13_S17_V0.5221.00
16_R19_V0.5211.00
369_L393_S0.5211.00
5_R142_R0.5191.00
293_R417_M0.5191.00
407_S410_D0.5181.00
347_S351_Q0.5171.00
301_P305_G0.5161.00
264_F268_L0.5161.00
261_A344_G0.5161.00
268_L272_V0.5151.00
366_A393_S0.5151.00
443_L446_V0.5141.00
239_L382_G0.5131.00
125_T129_L0.5131.00
445_V448_P0.5120.99
363_T367_V0.5110.99
133_F136_N0.5100.99
347_S359_L0.5080.99
438_N442_L0.5070.99
308_F311_V0.5070.99
73_D77_V0.5060.99
300_L338_A0.5060.99
449_V452_V0.5060.99
405_S408_I0.5050.99
11_G18_I0.5050.99
153_A189_V0.5040.99
450_T453_L0.5040.99
334_A337_F0.5020.99
243_A325_N0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.8625 100 0.39 Contact Map
3w4tA 1 0.8458 100 0.396 Contact Map
4humA 1 0.8729 100 0.397 Contact Map
3mktA 1 0.8646 100 0.416 Contact Map
2cfqA 1 0.8187 77 0.931 Contact Map
3o7qA 1 0.7708 61.8 0.938 Contact Map
1pw4A 1 0.8083 55.4 0.941 Contact Map
3wdoA 1 0.8 53.6 0.941 Contact Map
4m64A 1 0.8125 21.2 0.953 Contact Map
4tphA 2 0.3854 12.5 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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