GREMLIN Database
Q9HSW1 - LPS biosynthesis
UniProt: Q9HSW1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 403 (348)
Sequences: 53763 (45396)
Seq/√Len: 2433.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
232_L305_H4.7661.00
261_E288_D3.7421.00
184_G207_H3.2421.00
308_F325_A3.1821.00
89_H398_Y3.0721.00
230_N263_T3.0321.00
263_T290_A2.7951.00
381_H384_R2.7891.00
228_P261_E2.7841.00
252_G359_V2.7501.00
248_P277_Q2.7011.00
271_Q275_E2.6731.00
233_Y243_V2.6291.00
256_R363_A2.4201.00
254_R286_Y2.3921.00
193_R197_T2.3021.00
248_P355_I2.2311.00
229_I366_I2.2111.00
37_D85_Y2.1971.00
242_G245_K2.1661.00
37_D83_R2.1371.00
336_E341_E2.1191.00
277_Q281_R2.0891.00
265_V301_V2.0861.00
230_N261_E2.0821.00
361_T364_E2.0711.00
344_I348_G2.0521.00
263_T288_D2.0461.00
250_I262_L2.0391.00
252_G356_D2.0301.00
230_N304_S2.0041.00
34_H395_E1.9511.00
231_I307_V1.9501.00
229_I306_D1.9491.00
364_E370_K1.9291.00
4_A85_Y1.9041.00
371_L375_S1.8871.00
89_H113_T1.8641.00
242_G313_I1.8421.00
37_D56_Y1.8131.00
270_L273_K1.8071.00
329_G379_R1.8061.00
389_Q393_Q1.8041.00
190_G193_R1.7961.00
336_E352_D1.7861.00
349_V361_T1.7541.00
279_V284_E1.7511.00
184_G397_L1.7451.00
212_P387_R1.7291.00
32_L392_S1.7251.00
308_F330_T1.7201.00
352_D357_G1.7151.00
112_V182_I1.7081.00
251_Q281_R1.7051.00
246_L262_L1.6811.00
363_A367_N1.6701.00
187_A206_I1.6661.00
345_G381_H1.6621.00
193_R208_V1.6441.00
250_I260_V1.6381.00
190_G342_T1.6371.00
234_V298_L1.6241.00
28_G388_S1.5551.00
349_V364_E1.5511.00
28_G391_V1.5511.00
4_A39_Y1.5301.00
246_L309_I1.5281.00
193_R206_I1.5231.00
354_S357_G1.5231.00
395_E399_G1.5201.00
357_G361_T1.5071.00
28_G31_E1.5051.00
32_L395_E1.5001.00
294_S297_Q1.4841.00
265_V290_A1.4781.00
240_H314_W1.4671.00
23_T27_S1.4671.00
297_Q300_S1.4611.00
257_E363_A1.4551.00
253_L363_A1.4541.00
370_K373_A1.4521.00
190_G208_V1.4421.00
380_S383_E1.4411.00
334_T340_I1.4291.00
245_K355_I1.4241.00
263_T301_V1.4231.00
245_K313_I1.4191.00
244_D277_Q1.4191.00
37_D54_N1.4101.00
373_A377_G1.4071.00
305_H330_T1.3941.00
230_N306_D1.3911.00
351_T361_T1.3471.00
293_V297_Q1.3461.00
90_S110_T1.3331.00
231_I362_I1.3331.00
197_T203_E1.3251.00
249_I358_F1.3221.00
243_V264_V1.3181.00
5_F29_L1.3151.00
355_I359_V1.3151.00
299_P328_T1.3151.00
252_G355_I1.3051.00
263_T305_H1.3031.00
231_I309_I1.3031.00
186_R394_V1.3001.00
276_E280_N1.2981.00
186_R397_L1.2961.00
187_A193_R1.2911.00
377_G380_S1.2901.00
277_Q280_N1.2841.00
232_L265_V1.2831.00
237_L264_V1.2811.00
233_Y246_L1.2721.00
5_F91_Y1.2711.00
393_Q396_D1.2541.00
357_G360_Q1.2521.00
318_L323_I1.2441.00
202_E205_K1.2401.00
190_G194_D1.2361.00
218_L328_T1.2341.00
389_Q392_S1.2281.00
229_I307_V1.2201.00
375_S378_G1.2071.00
295_N298_L1.1941.00
30_S33_D1.1911.00
275_E279_V1.1731.00
322_Y340_I1.1661.00
313_I353_G1.1661.00
267_T271_Q1.1571.00
245_K353_G1.1571.00
21_S320_R1.1551.00
257_E367_N1.1541.00
359_V363_A1.1531.00
310_H322_Y1.1511.00
303_A328_T1.1461.00
272_S275_E1.1441.00
298_L302_Y1.1431.00
338_G341_E1.1371.00
349_V374_L1.1311.00
387_R390_I1.1261.00
272_S276_E1.1171.00
330_T375_S1.1131.00
28_G32_L1.0991.00
188_P192_V1.0981.00
194_D197_T1.0961.00
386_D389_Q1.0961.00
115_N320_R1.0951.00
372_P376_E1.0951.00
368_A371_L1.0921.00
5_F26_V1.0911.00
230_N305_H1.0881.00
245_K335_R1.0861.00
252_G256_R1.0851.00
187_A196_Y1.0851.00
390_I393_Q1.0801.00
244_D248_P1.0801.00
329_G376_E1.0761.00
229_I260_V1.0721.00
245_K248_P1.0691.00
319_A340_I1.0621.00
302_Y328_T1.0591.00
217_F299_P1.0581.00
346_D361_T1.0471.00
308_F321_V1.0441.00
370_K374_L1.0431.00
365_L374_L1.0421.00
351_T358_F1.0401.00
335_R351_T1.0381.00
24_Q27_S1.0251.00
334_T350_T1.0251.00
263_T304_S1.0241.00
299_P303_A1.0241.00
232_L301_V1.0181.00
278_S289_F1.0161.00
310_H321_V1.0141.00
360_Q364_E1.0091.00
188_P211_H1.0071.00
339_S342_T1.0061.00
229_I259_D1.0061.00
311_P358_F1.0011.00
244_D273_K1.0011.00
390_I394_V0.9991.00
290_A301_V0.9981.00
24_Q387_R0.9981.00
228_P259_D0.9931.00
374_L377_G0.9891.00
326_L332_I0.9881.00
234_V265_V0.9881.00
236_S240_H0.9851.00
265_V293_V0.9821.00
231_I250_I0.9811.00
376_E380_S0.9811.00
248_P281_R0.9801.00
234_V302_Y0.9781.00
188_P317_P0.9781.00
90_S112_V0.9751.00
247_V278_S0.9721.00
246_L311_P0.9701.00
244_D313_I0.9681.00
253_L362_I0.9681.00
110_T182_I0.9671.00
253_L260_V0.9671.00
325_A330_T0.9601.00
91_Y115_N0.9601.00
375_S379_R0.9581.00
392_S396_D0.9571.00
21_S115_N0.9521.00
293_V301_V0.9511.00
250_I286_Y0.9471.00
187_A192_V0.9431.00
16_T19_T0.9331.00
349_V365_L0.9301.00
211_H320_R0.9301.00
278_S283_V0.9241.00
111_V186_R0.9211.00
334_T344_I0.9201.00
368_A372_P0.9101.00
326_L381_H0.9091.00
212_P390_I0.9091.00
245_K358_F0.9061.00
26_V38_V0.9061.00
218_L299_P0.9041.00
22_A91_Y0.9021.00
26_V30_S0.9021.00
290_A293_V0.9021.00
322_Y332_I0.9011.00
261_E286_Y0.8971.00
21_S113_T0.8961.00
326_L378_G0.8941.00
260_V366_I0.8901.00
253_L366_I0.8881.00
249_I359_V0.8851.00
76_K105_N0.8831.00
20_H24_Q0.8831.00
333_V351_T0.8801.00
349_V370_K0.8791.00
254_R257_E0.8781.00
182_I185_F0.8781.00
372_P375_S0.8781.00
344_I350_T0.8771.00
307_V365_L0.8751.00
374_L378_G0.8731.00
207_H397_L0.8731.00
273_K276_E0.8721.00
103_G110_T0.8711.00
302_Y330_T0.8701.00
322_Y334_T0.8701.00
337_Y340_I0.8661.00
315_E319_A0.8651.00
253_L359_V0.8631.00
3_I34_H0.8621.00
233_Y264_V0.8611.00
238_E269_G0.8591.00
232_L302_Y0.8561.00
333_V361_T0.8551.00
273_K277_Q0.8511.00
215_D386_D0.8501.00
195_N198_K0.8471.00
186_R209_I0.8471.00
392_S395_E0.8431.00
295_N299_P0.8401.00
322_Y343_I0.8371.00
360_Q363_A0.8311.00
214_N217_F0.8301.00
241_K321_V0.8291.00
276_E279_V0.8281.00
386_D390_I0.8281.00
197_T206_I0.8281.00
209_I397_L0.8271.00
331_P375_S0.8261.00
233_Y311_P0.8251.00
356_D360_Q0.8231.00
300_S304_S0.8231.00
381_H385_Y0.8181.00
251_Q254_R0.8121.00
309_I362_I0.8091.00
16_T236_S0.8081.00
207_H393_Q0.8041.00
249_I355_I0.8031.00
254_R258_H0.8021.00
251_Q283_V0.8011.00
73_R77_A0.7991.00
331_P365_L0.7991.00
310_H340_I0.7981.00
300_S303_A0.7961.00
306_D371_L0.7921.00
109_S183_D0.7881.00
235_G243_V0.7871.00
35_D54_N0.7861.00
312_G315_E0.7841.00
20_H295_N0.7811.00
301_V304_S0.7811.00
233_Y308_F0.7801.00
307_V362_I0.7781.00
387_R391_V0.7711.00
256_R360_Q0.7711.00
21_S211_H0.7701.00
188_P320_R0.7701.00
239_R244_D0.7691.00
248_P251_Q0.7691.00
177_D181_Y0.7681.00
388_S392_S0.7671.00
278_S287_V0.7651.00
394_V398_Y0.7641.00
278_S281_R0.7641.00
32_L388_S0.7621.00
257_E260_V0.7591.00
24_Q28_G0.7561.00
248_P252_G0.7541.00
191_H194_D0.7521.00
210_P393_Q0.7521.00
173_N177_D0.7491.00
244_D270_L0.7401.00
256_R359_V0.7321.00
24_Q214_N0.7321.00
30_S52_D0.7311.00
241_K312_G0.7291.00
69_T73_R0.7281.00
78_R83_R0.7271.00
210_P342_T0.7271.00
234_V308_F0.7241.00
364_E367_N0.7221.00
319_A322_Y0.7221.00
333_V365_L0.7211.00
191_H195_N0.7191.00
336_E350_T0.7191.00
173_N176_E0.7191.00
111_V184_G0.7161.00
254_R259_D0.7141.00
233_Y262_L0.7131.00
231_I260_V0.7101.00
21_S394_V0.7101.00
37_D41_A0.7101.00
116_A240_H0.7091.00
87_I398_Y0.7091.00
7_H18_A0.7081.00
91_Y113_T0.7071.00
365_L371_L0.7061.00
5_F36_I0.7051.00
30_S36_I0.7021.00
115_N188_P0.7011.00
101_N105_N0.6971.00
102_L106_L0.6971.00
335_R358_F0.6901.00
32_L391_V0.6901.00
209_I394_V0.6881.00
310_H319_A0.6801.00
89_H394_V0.6801.00
373_A376_E0.6791.00
210_P385_Y0.6781.00
103_G183_D0.6781.00
221_H303_A0.6771.00
20_H23_T0.6751.00
237_L271_Q0.6741.00
356_D359_V0.6731.00
341_E350_T0.6711.00
379_R382_V0.6701.00
323_I385_Y0.6661.00
70_K74_E0.6661.00
25_I394_V0.6641.00
229_I232_L0.6621.00
207_H210_P0.6611.00
326_L375_S0.6591.00
396_D399_G0.6571.00
87_I111_V0.6561.00
104_K181_Y0.6561.00
318_L385_Y0.6531.00
31_E388_S0.6531.00
275_E289_F0.6521.00
72_N76_K0.6521.00
176_E180_E0.6511.00
239_R313_I0.6501.00
377_G381_H0.6491.00
88_V103_G0.6491.00
242_G353_G0.6481.00
27_S51_S0.6471.00
7_H22_A0.6451.00
242_G311_P0.6451.00
378_G381_H0.6441.00
346_D349_V0.6421.00
26_V36_I0.6401.00
309_I358_F0.6391.00
231_I366_I0.6391.00
239_R270_L0.6371.00
241_K315_E0.6341.00
247_V287_V0.6341.00
249_I362_I0.6321.00
69_T72_N0.6311.00
27_S31_E0.6301.00
229_I368_A0.6291.00
259_D286_Y0.6281.00
266_G291_G0.6271.00
209_I393_Q0.6261.00
301_V305_H0.6261.00
235_G241_K0.6251.00
308_F332_I0.6191.00
250_I253_L0.6171.00
90_S99_V0.6171.00
193_R203_E0.6131.00
111_V398_Y0.6131.00
268_G271_Q0.6091.00
391_V395_E0.6081.00
190_G210_P0.6081.00
30_S34_H0.6061.00
110_T183_D0.6051.00
88_V108_L0.6051.00
103_G106_L0.6041.00
267_T292_F0.6041.00
189_S192_V0.6031.00
369_N373_A0.6031.00
307_V333_V0.6021.00
191_H341_E0.6011.00
51_S54_N0.5981.00
258_H363_A0.5951.00
321_V325_A0.5951.00
28_G387_R0.5931.00
258_H367_N0.5921.00
214_N218_L0.5911.00
293_V298_L0.5911.00
169_L172_I0.5891.00
24_Q320_R0.5871.00
21_S91_Y0.5861.00
90_S96_I0.5851.00
230_N301_V0.5851.00
311_P335_R0.5851.00
9_S19_T0.5841.00
229_I371_L0.5821.00
5_F89_H0.5801.00
384_R389_Q0.5801.00
115_N211_H0.5801.00
302_Y321_V0.5791.00
351_T357_G0.5791.00
18_A92_L0.5791.00
371_L374_L0.5771.00
232_L308_F0.5771.00
256_R367_N0.5741.00
26_V53_I0.5741.00
85_Y108_L0.5731.00
245_K249_I0.5721.00
113_T186_R0.5711.00
274_M289_F0.5691.00
113_T394_V0.5691.00
34_H399_G0.5691.00
306_D368_A0.5681.00
242_G335_R0.5671.00
347_G364_E0.5641.00
265_V298_L0.5631.00
33_D36_I0.5621.00
210_P318_L0.5621.00
219_V222_T0.5621.00
275_E278_S0.5621.00
257_E366_I0.5621.00
232_L330_T0.5611.00
223_S226_S0.5611.00
262_L287_V0.5591.00
365_L370_K0.5591.00
237_L243_V0.5591.00
274_M277_Q0.5581.00
4_A37_D0.5581.00
5_F398_Y0.5571.00
333_V362_I0.5551.00
96_I99_V0.5531.00
337_Y341_E0.5521.00
247_V274_M0.5501.00
246_L250_I0.5501.00
325_A332_I0.5501.00
302_Y308_F0.5501.00
215_D327_A0.5491.00
192_V195_N0.5481.00
228_P304_S0.5481.00
219_V303_A0.5471.00
239_R273_K0.5451.00
21_S25_I0.5451.00
278_S284_E0.5441.00
54_N57_H0.5431.00
244_D274_M0.5431.00
73_R76_K0.5431.00
243_V270_L0.5431.00
117_Y120_V0.5401.00
70_K73_R0.5401.00
25_I28_G0.5391.00
298_L301_V0.5391.00
4_A88_V0.5381.00
232_L263_T0.5381.00
197_T200_G0.5361.00
326_L382_V0.5361.00
331_P371_L0.5351.00
236_S241_K0.5351.00
40_C55_L0.5341.00
118_G121_C0.5301.00
253_L258_H0.5301.00
253_L257_E0.5281.00
187_A208_V0.5281.00
376_E379_R0.5261.00
247_V277_Q0.5261.00
15_G292_F0.5251.00
237_L266_G0.5241.00
319_A323_I0.5241.00
312_G319_A0.5231.00
249_I253_L0.5221.00
384_R393_Q0.5211.00
323_I382_V0.5211.00
177_D180_E0.5191.00
216_D219_V0.5191.00
30_S53_I0.5171.00
52_D57_H0.5171.00
68_N71_L0.5141.00
49_L52_D0.5131.00
270_L274_M0.5131.00
369_N372_P0.5121.00
217_F295_N0.5101.00
184_G188_P0.5101.00
10_F23_T0.5091.00
27_S30_S0.5071.00
74_E78_R0.5041.00
27_S50_S0.5041.00
188_P319_A0.5031.00
307_V366_I0.5031.00
265_V305_H0.5021.00
295_N301_V0.5011.00
192_V317_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c48A 2 0.8809 100 0.188 Contact Map
2r60A 1 0.928 100 0.192 Contact Map
3froA 3 0.9156 100 0.198 Contact Map
1rzuA 1 0.9231 100 0.203 Contact Map
4n9wA 1 0.8362 100 0.204 Contact Map
2qzsA 1 0.9181 100 0.218 Contact Map
3okpA 1 0.8685 100 0.232 Contact Map
2x0dA 2 0.8288 100 0.239 Contact Map
2x6qA 1 0.8511 100 0.239 Contact Map
3s28A 4 0.9206 100 0.241 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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