GREMLIN Database
Q9HSW0 - Uncharacterized protein
UniProt: Q9HSW0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 151 (130)
Sequences: 199 (175)
Seq/√Len: 15.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_T21_Y6.6971.00
56_W105_N3.8051.00
5_A19_V3.4710.99
106_Y127_D3.4380.99
28_F105_N3.1980.99
30_P77_D2.8410.97
59_K71_L2.3210.91
67_S70_D2.2700.90
5_A17_L2.1170.87
90_L142_S2.0990.86
90_L97_T2.0670.86
33_T77_D2.0070.84
105_N122_P1.9820.83
56_W120_G1.9720.83
29_V81_Y1.7120.73
125_L130_V1.7080.72
58_Q62_G1.7020.72
21_Y97_T1.7000.72
84_E90_L1.6260.68
72_W105_N1.5930.67
75_Y105_N1.5730.66
13_P143_R1.5500.65
87_E90_L1.5020.62
96_K144_R1.5020.62
26_Y105_N1.4760.61
55_V107_V1.4520.59
72_W107_V1.3880.56
12_F15_K1.3470.54
105_N120_G1.3470.54
130_V137_E1.3330.53
86_V91_D1.3030.51
61_R69_E1.2800.50
106_Y125_L1.2660.49
18_V69_E1.2600.49
22_M105_N1.2550.48
6_L92_G1.2350.47
15_K95_G1.2350.47
61_R130_V1.2330.47
28_F56_W1.2320.47
4_A7_D1.2320.47
30_P81_Y1.2140.46
15_K143_R1.2080.46
96_K143_R1.2070.46
62_G122_P1.1670.43
18_V78_N1.1630.43
98_V130_V1.1610.43
82_A99_V1.1590.43
92_G142_S1.1490.42
13_P98_V1.1480.42
138_Y141_G1.1320.41
78_N105_N1.1270.41
60_F145_I1.1270.41
47_G101_S1.1220.41
99_V136_F1.1170.41
81_Y100_T1.1130.40
15_K106_Y1.1110.40
106_Y109_E1.0950.39
56_W62_G1.0920.39
61_R100_T1.0840.39
18_V128_P1.0830.39
67_S105_N1.0680.38
56_W72_W1.0600.38
57_A67_S1.0580.37
66_V76_T1.0560.37
101_S111_A1.0290.36
106_Y130_V1.0260.36
29_V96_K1.0170.35
18_V145_I1.0150.35
11_Q69_E1.0150.35
9_S140_Q1.0120.35
26_Y120_G0.9990.34
97_T140_Q0.9980.34
54_N66_V0.9920.34
2_T92_G0.9920.34
11_Q62_G0.9750.33
79_L89_L0.9720.33
71_L118_E0.9640.33
21_Y85_N0.9350.31
14_H97_T0.9240.31
17_L124_G0.9200.30
26_Y56_W0.9120.30
17_L50_P0.9010.29
54_N58_Q0.8950.29
18_V57_A0.8910.29
93_L97_T0.8860.29
82_A92_G0.8850.29
36_D144_R0.8790.28
12_F143_R0.8470.27
60_F123_R0.8460.27
14_H21_Y0.8440.27
32_D77_D0.8410.27
12_F96_K0.8370.27
50_P54_N0.8170.26
9_S93_L0.8160.26
139_E142_S0.8070.25
96_K137_E0.8040.25
16_R143_R0.8010.25
10_E88_D0.7970.25
2_T89_L0.7930.25
10_E138_Y0.7870.24
2_T85_N0.7770.24
15_K110_R0.7620.23
2_T5_A0.7580.23
99_V139_E0.7520.23
128_P132_Q0.7520.23
94_T138_Y0.7510.23
34_D77_D0.7430.23
106_Y118_E0.7380.22
94_T109_E0.7370.22
62_G126_Y0.7290.22
82_A140_Q0.7280.22
66_V132_Q0.7210.22
2_T97_T0.7140.21
90_L138_Y0.7120.21
87_E104_G0.7030.21
28_F48_S0.7000.21
33_T78_N0.6970.21
31_G77_D0.6810.20
91_D99_V0.6800.20
71_L119_Y0.6800.20
21_Y119_Y0.6790.20
39_H101_S0.6710.20
60_F70_D0.6700.20
15_K126_Y0.6700.20
29_V61_R0.6670.20
15_K97_T0.6590.19
68_Q105_N0.6580.19
55_V59_K0.6570.19
10_E95_G0.6450.19
28_F74_I0.6420.19
55_V58_Q0.6400.19
17_L101_S0.6340.19
6_L88_D0.6330.19
69_E137_E0.6310.18
80_E101_S0.6250.18
31_G100_T0.6200.18
57_A73_S0.6180.18
4_A9_S0.6170.18
61_R65_D0.6140.18
7_D145_I0.6120.18
65_D83_L0.6090.18
65_D90_L0.6050.18
71_L105_N0.6050.18
13_P144_R0.6040.18
26_Y37_K0.6040.18
60_F71_L0.6030.18
58_Q66_V0.6020.17
76_T107_V0.6020.17
74_I110_R0.5970.17
22_M79_L0.5920.17
21_Y138_Y0.5920.17
51_S60_F0.5900.17
30_P33_T0.5890.17
18_V107_V0.5890.17
70_D125_L0.5780.17
53_E111_A0.5780.17
57_A132_Q0.5760.17
66_V123_R0.5720.17
4_A8_A0.5710.17
88_D99_V0.5710.17
13_P93_L0.5700.16
58_Q65_D0.5700.16
70_D137_E0.5700.16
2_T10_E0.5690.16
2_T99_V0.5680.16
29_V137_E0.5680.16
17_L119_Y0.5650.16
65_D101_S0.5530.16
95_G127_D0.5500.16
66_V71_L0.5500.16
31_G96_K0.5490.16
67_S71_L0.5480.16
91_D106_Y0.5460.16
57_A119_Y0.5420.16
8_A13_P0.5400.16
47_G100_T0.5400.16
48_S107_V0.5390.16
110_R144_R0.5340.15
37_K105_N0.5340.15
62_G105_N0.5330.15
70_D94_T0.5320.15
5_A137_E0.5320.15
49_E80_E0.5260.15
35_F96_K0.5250.15
106_Y129_P0.5230.15
13_P96_K0.5230.15
101_S137_E0.5210.15
95_G143_R0.5170.15
111_A133_I0.5160.15
49_E132_Q0.5110.15
15_K144_R0.5070.15
6_L93_L0.5030.14
7_D118_E0.5020.14
94_T104_G0.5020.14
3_E6_L0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4upkA 3 0.9338 98.9 0.808 Contact Map
2vqrA 3 0.947 98.9 0.811 Contact Map
4upiA 2 0.947 98.9 0.812 Contact Map
2qzuA 2 0.9205 98.8 0.818 Contact Map
4uplA 2 0.9404 98.7 0.819 Contact Map
4uphA 2 0.9404 98.7 0.825 Contact Map
1fsuA 1 0.8079 98.6 0.826 Contact Map
4tn0A 1 0.8543 98.6 0.827 Contact Map
3b5qA 1 0.9404 98.6 0.828 Contact Map
4kavA 1 0.8675 98.6 0.829 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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