GREMLIN Database
Q9HSV8 - Uncharacterized protein
UniProt: Q9HSV8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 88 (71)
Sequences: 2995 (2738)
Seq/√Len: 324.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_S70_P4.4561.00
51_G69_V4.1181.00
68_S78_S3.4381.00
71_E75_T3.1331.00
56_S72_Q2.7251.00
80_A83_Q2.4571.00
69_V79_H1.9531.00
59_A68_S1.7801.00
51_G73_D1.7471.00
81_E84_K1.5041.00
58_V67_V1.4501.00
14_R17_G1.4271.00
15_H19_Q1.3871.00
56_S60_Y1.3741.00
53_V56_S1.3541.00
60_Y67_V1.2891.00
35_D38_T1.2661.00
54_V72_Q1.2531.00
60_Y81_E1.2171.00
68_S72_Q1.2061.00
56_S76_I1.1851.00
18_E21_D1.1801.00
22_D26_T1.1441.00
51_G55_V1.1411.00
60_Y66_T1.0921.00
61_S64_G1.0861.00
34_P37_T1.0861.00
71_E79_H1.0741.00
25_N35_D1.0671.00
24_N28_W1.0661.00
66_T80_A1.0551.00
63_D66_T1.0431.00
61_S65_T1.0401.00
50_G79_H1.0281.00
25_N32_D1.0131.00
67_V81_E0.9891.00
53_V72_Q0.9871.00
19_Q23_L0.9811.00
17_G25_N0.9741.00
25_N30_D0.9721.00
17_G27_V0.9471.00
54_V74_V0.9391.00
69_V77_T0.9251.00
35_D39_A0.8891.00
55_V69_V0.8471.00
21_D27_V0.8401.00
31_P34_P0.8271.00
15_H18_E0.8211.00
70_P76_I0.8081.00
69_V76_I0.8071.00
22_D25_N0.8061.00
27_V31_P0.7931.00
69_V73_D0.7891.00
19_Q29_T0.7881.00
30_D35_D0.7881.00
15_H23_L0.7641.00
22_D30_D0.7480.99
28_W32_D0.7410.99
22_D28_W0.7330.99
14_R19_Q0.7330.99
51_G71_E0.7080.99
44_L47_V0.7030.99
48_L55_V0.7000.99
68_S76_I0.6980.99
55_V58_V0.6960.99
42_D46_R0.6900.99
20_E25_N0.6870.99
15_H22_D0.6840.99
62_W78_S0.6800.99
66_T81_E0.6800.99
42_D52_T0.6750.99
43_A46_R0.6660.99
27_V30_D0.6660.99
65_T82_T0.6600.99
38_T41_N0.6500.98
27_V35_D0.6460.98
26_T36_F0.6410.98
26_T33_E0.6320.98
59_A62_W0.6150.98
60_Y64_G0.6120.98
56_S59_A0.6100.98
34_P38_T0.6100.98
61_S68_S0.5950.97
26_T30_D0.5870.97
14_R20_E0.5840.97
19_Q28_W0.5780.97
16_Q22_D0.5780.97
28_W31_P0.5760.97
21_D33_E0.5760.97
18_E23_L0.5740.97
46_R65_T0.5690.96
60_Y72_Q0.5650.96
16_Q23_L0.5640.96
47_V50_G0.5610.96
36_F41_N0.5600.96
60_Y63_D0.5550.96
36_F39_A0.5530.96
21_D24_N0.5520.96
61_S66_T0.5510.96
25_N29_T0.5390.95
38_T43_A0.5330.95
42_D45_S0.5260.94
21_D34_P0.5160.94
69_V74_V0.5140.94
19_Q25_N0.5130.94
33_E49_D0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gotB 1 0.9886 99 0.37 Contact Map
3j60g 1 1 98.9 0.376 Contact Map
2pbiB 1 1 98.9 0.383 Contact Map
4u1eI 1 0.5227 98.9 0.386 Contact Map
4j0wA 1 0.5682 98.9 0.392 Contact Map
1vyhC 1 0.6023 98.8 0.399 Contact Map
4j73A 1 0.5455 98.8 0.402 Contact Map
4yhcA 1 0.7273 98.8 0.412 Contact Map
4j87A 1 0.5341 98.7 0.421 Contact Map
4u7aA 1 0.6591 98.7 0.423 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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