Q9HSV7 - HALSA - GREMLIN Contacts

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Q9HSV7 - Uncharacterized protein

UniProt:	Q9HSV7	Sequences: MEERIDELEEKIAQKDKRIEEQNERIEEQQERIEELETRLRKYENPHTPPSKRRSGTDESPTSQDDEDDDVRTDGGTPGRKDGHNPEWRSPPDPDEEIEVTSDCCPECGDHFDESVGVSPRLVEEVPDPQPPEVTQYNRHRYQCDSCGTETVATHPDCPDEGQFGVNVIAQSALSRYDHRLPYRKITDRFEQLHGLELSGASAWHATERAARAGRCEYEQIRREIQEAEIVHVDETGIKRDGDQAWIWTFRTDEHTLYAVRESRGSDVPAEVLGEDFAGTVICDGWTAYPAFSSTLQRCWAHLLREAEDVASDHEEAEPVYRYLKQMFVGLQSWLETDPDPRARAQMHRACQDGLRSLVERSVTDEPVATLLGKIEGGLDHWLTFVGEPAVSPTNNAAENALREPVVLRKIIGTLRNDRGMFVHETILSLLATWRQQGRNPYEELTRVVHDNEMISREQTVPVVETSG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	468 (442)
Sequences:	1537 (1160)
Seq/√Len:	55.2

HALSA - Q9HSV7 O54664

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
100_V	137_Y	5.765	1.00
25_R	30_Q	4.576	1.00
12_I	15_K	4.387	1.00
32_R	37_E	4.132	1.00
22_Q	26_I	3.717	1.00
328_F	394_T	3.596	1.00
15_K	19_I	3.352	1.00
33_I	36_L	3.269	1.00
356_R	360_E	3.108	1.00
280_T	391_V	3.104	1.00
19_I	22_Q	3.067	1.00
11_K	16_D	3.038	1.00
144_C	147_C	2.971	1.00
18_R	23_N	2.908	1.00
348_H	385_F	2.887	1.00
218_Y	426_T	2.813	1.00
96_E	133_E	2.769	1.00
26_I	29_Q	2.732	1.00
297_Q	391_V	2.729	1.00
280_T	297_Q	2.703	1.00
333_S	347_M	2.667	1.00
367_P	370_T	2.667	1.00
320_V	358_L	2.655	1.00
282_I	392_S	2.638	1.00
356_R	379_L	2.574	1.00
108_C	144_C	2.564	1.00
122_L	136_Q	2.562	1.00
283_C	296_L	2.510	1.00
434_W	439_R	2.463	1.00
352_Q	386_V	2.461	1.00
303_L	375_I	2.450	1.00
108_C	147_C	2.402	1.00
105_C	144_C	2.399	1.00
173_A	207_T	2.327	1.00
240_R	260_V	2.307	1.00
179_H	192_Q	2.284	1.00
359_V	372_L	2.252	1.00
97_E	136_Q	2.251	1.00
125_E	167_N	2.246	1.00
232_H	398_A	2.184	1.00
125_E	165_G	2.116	1.00
105_C	147_C	2.087	1.00
173_A	210_A	2.066	1.00
408_L	412_I	2.047	1.00
235_E	246_W	2.045	1.00
263_S	268_V	2.033	1.00
97_E	138_N	1.993	1.00
327_M	348_H	1.990	1.00
221_I	429_S	1.980	1.00
52_K	55_S	1.978	1.00
105_C	108_C	1.970	1.00
95_D	122_L	1.940	1.00
235_E	264_R	1.933	1.00
119_S	152_V	1.926	1.00
319_P	323_Y	1.925	1.00
250_F	272_V	1.922	1.00
447_R	451_D	1.909	1.00
233_V	281_V	1.889	1.00
406_V	409_R	1.883	1.00
220_Q	223_R	1.882	1.00
320_V	355_L	1.863	0.99
54_R	57_T	1.863	0.99
267_D	271_E	1.858	0.99
400_N	403_R	1.858	0.99
266_S	288_A	1.855	0.99
75_G	80_R	1.824	0.99
127_P	131_P	1.818	0.99
33_I	37_E	1.792	0.99
349_R	353_D	1.785	0.99
95_D	134_V	1.784	0.99
307_A	375_I	1.779	0.99
384_T	391_V	1.760	0.99
432_A	435_R	1.720	0.99
379_L	383_L	1.717	0.99
385_F	393_P	1.714	0.99
298_R	381_H	1.702	0.99
235_E	289_Y	1.699	0.99
323_Y	354_G	1.691	0.99
306_E	309_D	1.669	0.99
11_K	14_Q	1.668	0.99
75_G	78_P	1.630	0.99
183_Y	207_T	1.621	0.98
172_S	203_A	1.604	0.98
222_R	226_Q	1.602	0.98
237_G	244_Q	1.602	0.98
355_L	375_I	1.590	0.98
159_P	162_G	1.587	0.98
101_T	140_H	1.581	0.98
16_D	19_I	1.551	0.98
300_W	324_L	1.545	0.98
282_I	297_Q	1.543	0.98
442_Y	446_T	1.535	0.98
52_K	56_G	1.534	0.98
245_A	260_V	1.517	0.98
340_D	343_A	1.508	0.98
384_T	387_G	1.506	0.98
113_D	145_D	1.493	0.97
261_R	268_V	1.490	0.97
233_V	250_F	1.474	0.97
224_E	227_E	1.473	0.97
215_R	219_E	1.473	0.97
23_N	26_I	1.472	0.97
349_R	386_V	1.454	0.97
99_E	140_H	1.453	0.97
326_Q	351_C	1.450	0.97
179_H	189_R	1.450	0.97
330_G	333_S	1.448	0.97
173_A	427_I	1.443	0.97
327_M	385_F	1.443	0.97
9_E	12_I	1.417	0.96
11_K	15_K	1.410	0.96
19_I	23_N	1.393	0.96
278_A	294_S	1.387	0.96
256_T	436_Q	1.385	0.96
339_P	342_R	1.377	0.96
298_R	378_G	1.373	0.96
229_E	390_A	1.373	0.96
171_Q	442_Y	1.368	0.96
395_N	398_A	1.357	0.95
42_K	46_P	1.354	0.95
178_D	431_L	1.353	0.95
29_Q	33_I	1.351	0.95
285_G	378_G	1.344	0.95
187_T	200_G	1.326	0.95
403_R	406_V	1.325	0.95
41_R	46_P	1.320	0.95
164_F	206_A	1.313	0.95
424_H	428_L	1.312	0.95
247_I	405_P	1.307	0.94
296_L	381_H	1.296	0.94
167_N	446_T	1.294	0.94
303_L	382_W	1.282	0.94
211_A	426_T	1.272	0.94
230_I	282_I	1.272	0.94
155_H	158_C	1.271	0.94
308_E	321_Y	1.270	0.93
240_R	245_A	1.268	0.93
369_A	373_G	1.266	0.93
360_E	376_E	1.265	0.93
250_F	268_V	1.263	0.93
363_V	373_G	1.259	0.93
76_G	79_G	1.242	0.93
57_T	60_S	1.238	0.93
338_D	342_R	1.231	0.92
270_A	291_A	1.230	0.92
112_F	147_C	1.228	0.92
337_T	341_P	1.226	0.92
187_T	203_A	1.224	0.92
439_R	444_E	1.221	0.92
266_S	291_A	1.212	0.92
451_D	454_M	1.196	0.91
175_S	189_R	1.195	0.91
215_R	422_F	1.193	0.91
297_Q	385_F	1.188	0.91
338_D	341_P	1.186	0.91
248_W	264_R	1.186	0.91
123_V	165_G	1.183	0.91
174_L	179_H	1.182	0.91
169_I	210_A	1.180	0.91
12_I	19_I	1.179	0.91
118_V	138_N	1.173	0.90
101_T	142_Y	1.169	0.90
325_K	328_F	1.164	0.90
250_F	259_A	1.163	0.90
300_W	352_Q	1.158	0.90
300_W	393_P	1.150	0.90
240_R	421_M	1.143	0.89
372_L	376_E	1.138	0.89
127_P	133_E	1.137	0.89
23_N	27_E	1.133	0.89
308_E	312_S	1.133	0.89
258_Y	432_A	1.132	0.89
120_P	136_Q	1.127	0.89
440_N	443_E	1.106	0.88
330_G	334_W	1.104	0.88
264_R	286_W	1.103	0.87
250_F	273_L	1.101	0.87
355_L	358_L	1.095	0.87
297_Q	384_T	1.093	0.87
320_V	324_L	1.091	0.87
325_K	332_Q	1.089	0.87
9_E	16_D	1.089	0.87
132_P	190_F	1.083	0.87
226_Q	277_F	1.079	0.86
98_I	135_T	1.075	0.86
25_R	28_E	1.071	0.86
126_V	130_Q	1.065	0.86
250_F	269_P	1.062	0.85
237_G	246_W	1.061	0.85
326_Q	354_G	1.061	0.85
378_G	381_H	1.060	0.85
10_E	14_Q	1.058	0.85
401_A	432_A	1.056	0.85
208_E	423_V	1.046	0.85
124_E	196_L	1.039	0.84
451_D	455_I	1.038	0.84
231_V	277_F	1.034	0.84
14_Q	17_K	1.032	0.84
36_L	40_L	1.030	0.84
433_T	437_Q	1.027	0.83
114_E	118_V	1.015	0.83
327_M	351_C	1.014	0.83
235_E	263_S	1.007	0.82
182_P	185_K	1.005	0.82
52_K	58_D	1.003	0.82
301_A	394_T	1.001	0.82
125_E	133_E	0.992	0.81
75_G	79_G	0.992	0.81
444_E	448_V	0.988	0.81
123_V	158_C	0.984	0.81
42_K	45_N	0.981	0.81
38_T	312_S	0.972	0.80
430_L	444_E	0.972	0.80
352_Q	385_F	0.969	0.80
34_E	38_T	0.968	0.80
301_A	393_P	0.967	0.80
415_L	421_M	0.962	0.79
72_R	75_G	0.959	0.79
371_L	374_K	0.958	0.79
352_Q	379_L	0.957	0.79
249_T	401_A	0.951	0.78
143_Q	150_E	0.946	0.78
238_I	415_L	0.946	0.78
372_L	375_I	0.945	0.78
385_F	391_V	0.945	0.78
117_G	141_R	0.943	0.78
184_R	200_G	0.941	0.78
171_Q	175_S	0.941	0.78
176_R	183_Y	0.939	0.78
260_V	428_L	0.936	0.77
230_I	392_S	0.935	0.77
323_Y	355_L	0.933	0.77
348_H	351_C	0.925	0.76
64_Q	67_E	0.921	0.76
238_I	412_I	0.921	0.76
70_D	73_T	0.920	0.76
51_S	60_S	0.920	0.76
239_K	242_G	0.919	0.76
27_E	30_Q	0.915	0.76
352_Q	356_R	0.914	0.76
301_A	396_N	0.913	0.76
30_Q	34_E	0.907	0.75
403_R	407_V	0.907	0.75
215_R	426_T	0.905	0.75
232_H	395_N	0.904	0.75
105_C	112_F	0.904	0.75
251_R	397_A	0.904	0.75
364_T	369_A	0.900	0.74
43_Y	47_H	0.900	0.74
52_K	57_T	0.899	0.74
201_A	205_H	0.899	0.74
373_G	377_G	0.895	0.74
228_A	252_T	0.893	0.74
13_A	17_K	0.887	0.73
246_W	263_S	0.885	0.73
99_E	138_N	0.883	0.73
329_V	332_Q	0.881	0.73
28_E	32_R	0.881	0.73
349_R	387_G	0.880	0.73
89_R	93_D	0.876	0.72
177_Y	183_Y	0.876	0.72
221_I	430_L	0.876	0.72
207_T	427_I	0.876	0.72
114_E	140_H	0.876	0.72
9_E	18_R	0.875	0.72
337_T	342_R	0.871	0.72
126_V	171_Q	0.870	0.72
9_E	13_A	0.867	0.72
269_P	272_V	0.866	0.72
188_D	435_R	0.864	0.71
283_C	288_A	0.864	0.71
18_R	22_Q	0.864	0.71
327_M	330_G	0.861	0.71
26_I	30_Q	0.860	0.71
258_Y	403_R	0.860	0.71
335_L	392_S	0.860	0.71
32_R	35_E	0.860	0.71
266_S	270_A	0.859	0.71
366_E	369_A	0.859	0.71
222_R	259_A	0.858	0.71
11_K	18_R	0.857	0.71
285_G	298_R	0.855	0.71
259_A	272_V	0.854	0.71
412_I	428_L	0.850	0.70
180_R	411_I	0.850	0.70
168_V	172_S	0.849	0.70
307_A	320_V	0.849	0.70
225_I	231_V	0.847	0.70
230_I	254_E	0.844	0.70
86_P	89_R	0.844	0.70
308_E	311_A	0.844	0.70
301_A	395_N	0.843	0.70
285_G	382_W	0.843	0.70
300_W	382_W	0.841	0.69
141_R	152_V	0.840	0.69
132_P	196_L	0.832	0.68
73_T	76_G	0.831	0.68
249_T	398_A	0.831	0.68
35_E	39_R	0.830	0.68
106_P	109_G	0.827	0.68
177_Y	204_W	0.825	0.68
167_N	171_Q	0.822	0.68
397_A	400_N	0.819	0.67
15_K	18_R	0.817	0.67
218_Y	257_L	0.815	0.67
304_L	321_Y	0.811	0.67
217_E	448_V	0.810	0.66
285_G	290_P	0.810	0.66
106_P	151_T	0.809	0.66
412_I	424_H	0.807	0.66
189_R	192_Q	0.805	0.66
109_G	147_C	0.803	0.66
33_I	40_L	0.802	0.66
285_G	374_K	0.801	0.66
51_S	56_G	0.800	0.65
290_P	296_L	0.800	0.65
264_R	289_Y	0.799	0.65
219_E	223_R	0.797	0.65
431_L	444_E	0.796	0.65
331_L	374_K	0.796	0.65
9_E	15_K	0.795	0.65
145_D	148_G	0.795	0.65
230_I	391_V	0.794	0.65
258_Y	402_L	0.794	0.65
183_Y	204_W	0.792	0.65
210_A	449_V	0.792	0.65
139_R	152_V	0.792	0.65
251_R	256_T	0.791	0.65
235_E	293_S	0.790	0.64
260_V	421_M	0.787	0.64
355_L	359_V	0.786	0.64
245_A	418_D	0.784	0.64
20_E	24_E	0.784	0.64
108_C	112_F	0.784	0.64
175_S	179_H	0.780	0.63
420_G	423_V	0.777	0.63
300_W	385_F	0.771	0.63
98_I	137_Y	0.767	0.62
301_A	306_E	0.767	0.62
14_Q	18_R	0.767	0.62
265_G	268_V	0.765	0.62
232_H	282_I	0.758	0.61
16_D	20_E	0.758	0.61
56_G	60_S	0.758	0.61
334_W	342_R	0.756	0.61
402_L	405_P	0.755	0.61
280_T	384_T	0.755	0.61
282_I	391_V	0.753	0.61
364_T	373_G	0.752	0.61
345_A	349_R	0.750	0.60
232_H	397_A	0.749	0.60
330_G	348_H	0.744	0.60
119_S	139_R	0.743	0.60
13_A	16_D	0.743	0.60
123_V	137_Y	0.740	0.59
40_L	44_E	0.740	0.59
139_R	153_A	0.739	0.59
234_D	302_H	0.738	0.59
10_E	17_K	0.735	0.59
287_T	290_P	0.733	0.59
180_R	407_V	0.731	0.58
43_Y	46_P	0.729	0.58
242_G	416_R	0.725	0.58
343_A	387_G	0.725	0.58
116_V	150_E	0.724	0.58
258_Y	400_N	0.723	0.58
235_E	248_W	0.722	0.58
24_E	27_E	0.722	0.58
38_T	41_R	0.721	0.57
404_E	435_R	0.720	0.57
300_W	327_M	0.720	0.57
295_T	384_T	0.718	0.57
17_K	21_E	0.717	0.57
260_V	418_D	0.716	0.57
28_E	33_I	0.716	0.57
21_E	24_E	0.716	0.57
118_V	140_H	0.713	0.57
249_T	402_L	0.712	0.56
12_I	16_D	0.711	0.56
365_D	370_T	0.711	0.56
143_Q	148_G	0.711	0.56
247_I	425_E	0.709	0.56
231_V	300_W	0.708	0.56
248_W	286_W	0.708	0.56
419_R	422_F	0.707	0.56
214_G	427_I	0.706	0.56
126_V	132_P	0.704	0.56
167_N	199_S	0.704	0.56
58_D	63_S	0.703	0.56
121_R	139_R	0.703	0.56
269_P	315_E	0.702	0.55
176_R	408_L	0.702	0.55
34_E	37_E	0.700	0.55
440_N	450_H	0.699	0.55
182_P	411_I	0.699	0.55
311_A	318_E	0.699	0.55
60_S	67_E	0.697	0.55
239_K	245_A	0.696	0.55
300_W	435_R	0.695	0.55
356_R	383_L	0.695	0.55
112_F	144_C	0.692	0.54
85_N	88_W	0.691	0.54
232_H	251_R	0.691	0.54
283_C	293_S	0.690	0.54
174_L	189_R	0.690	0.54
240_R	262_E	0.689	0.54
240_R	428_L	0.689	0.54
235_E	286_W	0.688	0.54
123_V	135_T	0.687	0.54
173_A	449_V	0.685	0.54
164_F	198_L	0.685	0.54
300_W	303_L	0.685	0.54
60_S	63_S	0.685	0.54
137_Y	153_A	0.684	0.53
198_L	202_S	0.683	0.53
293_S	296_L	0.683	0.53
54_R	58_D	0.680	0.53
415_L	424_H	0.679	0.53
448_V	453_E	0.679	0.53
277_F	281_V	0.679	0.53
58_D	65_D	0.679	0.53
407_V	410_K	0.679	0.53
406_V	415_L	0.675	0.53
408_L	428_L	0.674	0.52
166_V	450_H	0.674	0.52
334_W	339_P	0.673	0.52
331_L	389_P	0.672	0.52
304_L	331_L	0.671	0.52
235_E	283_C	0.671	0.52
51_S	54_R	0.671	0.52
31_E	35_E	0.670	0.52
191_E	197_E	0.665	0.51
324_L	328_F	0.664	0.51
118_V	139_R	0.662	0.51
38_T	308_E	0.661	0.51
270_A	347_M	0.661	0.51
68_D	71_V	0.658	0.51
315_E	440_N	0.658	0.51
51_S	57_T	0.655	0.50
67_E	70_D	0.655	0.50
246_W	264_R	0.654	0.50
320_V	323_Y	0.652	0.50
399_E	403_R	0.650	0.50
180_R	404_E	0.649	0.50
69_D	73_T	0.648	0.50
397_A	401_A	0.645	0.49
94_P	429_S	0.644	0.49
350_A	353_D	0.642	0.49
243_D	418_D	0.642	0.49
152_V	165_G	0.640	0.49
234_D	284_D	0.640	0.49
211_A	218_Y	0.639	0.49
84_H	88_W	0.639	0.49
276_D	361_R	0.636	0.48
331_L	393_P	0.634	0.48
43_Y	50_P	0.634	0.48
365_D	369_A	0.634	0.48
184_R	411_I	0.634	0.48
174_L	178_D	0.633	0.48
409_R	420_G	0.632	0.48
269_P	288_A	0.631	0.48
178_D	188_D	0.629	0.48
87_E	197_E	0.629	0.48
339_P	343_A	0.629	0.48
38_T	42_K	0.628	0.47
113_D	400_N	0.627	0.47
204_W	208_E	0.626	0.47
41_R	45_N	0.626	0.47
261_R	271_E	0.626	0.47
184_R	188_D	0.623	0.47
297_Q	393_P	0.622	0.47
228_A	429_S	0.622	0.47
374_K	414_T	0.622	0.47
42_K	47_H	0.621	0.47
445_L	449_V	0.621	0.47
71_V	74_D	0.620	0.47
267_D	270_A	0.619	0.46
250_F	261_R	0.615	0.46
235_E	288_A	0.614	0.46
323_Y	326_Q	0.613	0.46
39_R	44_E	0.612	0.46
176_R	185_K	0.611	0.46
323_Y	351_C	0.610	0.46
176_R	186_I	0.610	0.46
39_R	309_D	0.609	0.45
50_P	228_A	0.609	0.45
331_L	371_L	0.607	0.45
303_L	306_E	0.607	0.45
116_V	143_Q	0.606	0.45
45_N	51_S	0.604	0.45
248_W	263_S	0.602	0.45
284_D	302_H	0.602	0.45
135_T	420_G	0.601	0.45
69_D	72_R	0.600	0.44
32_R	36_L	0.600	0.44
200_G	204_W	0.599	0.44
235_E	261_R	0.598	0.44
125_E	166_V	0.598	0.44
37_E	41_R	0.598	0.44
241_D	416_R	0.596	0.44
336_E	341_P	0.595	0.44
74_D	77_T	0.594	0.44
335_L	376_E	0.594	0.44
60_S	64_Q	0.593	0.44
232_H	258_Y	0.591	0.43
180_R	408_L	0.590	0.43
61_P	64_Q	0.589	0.43
181_L	190_F	0.587	0.43
360_E	373_G	0.587	0.43
410_K	413_G	0.587	0.43
331_L	344_R	0.586	0.43
333_S	346_Q	0.583	0.43
418_D	422_F	0.583	0.43
240_R	419_R	0.582	0.43
448_V	451_D	0.581	0.42
334_W	348_H	0.580	0.42
96_E	135_T	0.579	0.42
50_P	91_P	0.578	0.42
349_R	357_S	0.577	0.42
233_V	273_L	0.577	0.42
110_D	146_S	0.576	0.42
246_W	265_G	0.576	0.42
240_R	418_D	0.575	0.42
431_L	441_P	0.574	0.42
434_W	438_G	0.573	0.42
64_Q	69_D	0.573	0.42
304_L	371_L	0.573	0.42
405_P	424_H	0.572	0.41
238_I	247_I	0.572	0.41
322_R	326_Q	0.572	0.41
409_R	413_G	0.571	0.41
266_S	269_P	0.570	0.41
77_T	80_R	0.569	0.41
48_T	325_K	0.569	0.41
302_H	305_R	0.569	0.41
307_A	376_E	0.568	0.41
362_S	372_L	0.568	0.41
258_Y	309_D	0.566	0.41
344_R	374_K	0.565	0.41
132_P	194_H	0.564	0.41
447_R	450_H	0.563	0.41
203_A	291_A	0.562	0.40
234_D	399_E	0.562	0.40
207_T	359_V	0.562	0.40
321_Y	394_T	0.561	0.40
225_I	252_T	0.560	0.40
372_L	377_G	0.559	0.40
89_R	124_E	0.559	0.40
303_L	359_V	0.557	0.40
435_R	442_Y	0.557	0.40
232_H	392_S	0.556	0.40
360_E	379_L	0.556	0.40
26_I	33_I	0.554	0.40
214_G	426_T	0.554	0.40
371_L	414_T	0.553	0.40
248_W	289_Y	0.552	0.39
338_D	343_A	0.552	0.39
184_R	413_G	0.552	0.39
314_H	368_V	0.552	0.39
263_S	288_A	0.551	0.39
177_Y	207_T	0.549	0.39
46_P	52_K	0.549	0.39
429_S	442_Y	0.548	0.39
219_E	272_V	0.547	0.39
251_R	386_V	0.547	0.39
119_S	141_R	0.547	0.39
324_L	327_M	0.547	0.39
452_N	455_I	0.546	0.39
41_R	55_S	0.545	0.39
296_L	378_G	0.544	0.39
53_R	60_S	0.544	0.39
139_R	154_T	0.544	0.39
152_V	155_H	0.544	0.39
285_G	306_E	0.542	0.38
109_G	144_C	0.542	0.38
251_R	398_A	0.542	0.38
58_D	61_P	0.542	0.38
429_S	433_T	0.542	0.38
153_A	156_P	0.541	0.38
303_L	429_S	0.541	0.38
238_I	406_V	0.540	0.38
354_G	361_R	0.540	0.38
257_L	272_V	0.540	0.38
304_L	307_A	0.539	0.38
220_Q	224_E	0.539	0.38
394_T	400_N	0.538	0.38
403_R	440_N	0.538	0.38
188_D	191_E	0.537	0.38
360_E	377_G	0.537	0.38
288_A	296_L	0.537	0.38
306_E	371_L	0.537	0.38
22_Q	25_R	0.535	0.38
21_E	219_E	0.535	0.38
26_I	223_R	0.533	0.37
234_D	299_C	0.533	0.37
142_Y	352_Q	0.533	0.37
90_S	95_D	0.532	0.37
318_E	322_R	0.532	0.37
400_N	407_V	0.531	0.37
304_L	374_K	0.529	0.37
421_M	424_H	0.529	0.37
251_R	400_N	0.529	0.37
241_D	245_A	0.528	0.37
168_V	206_A	0.528	0.37
10_E	19_I	0.528	0.37
24_E	150_E	0.527	0.37
313_D	384_T	0.527	0.37
10_E	322_R	0.527	0.37
17_K	170_A	0.527	0.37
108_C	232_H	0.526	0.37
14_Q	32_R	0.526	0.37
434_W	437_Q	0.526	0.37
222_R	276_D	0.525	0.37
363_V	419_R	0.525	0.37
72_R	77_T	0.525	0.37
157_D	454_M	0.524	0.37
126_V	133_E	0.523	0.36
73_T	80_R	0.522	0.36
76_G	80_R	0.522	0.36
327_M	393_P	0.522	0.36
89_R	122_L	0.522	0.36
246_W	289_Y	0.522	0.36
368_V	433_T	0.521	0.36
423_V	447_R	0.520	0.36
27_E	51_S	0.519	0.36
233_V	272_V	0.518	0.36
18_R	21_E	0.516	0.36
307_A	400_N	0.516	0.36
107_E	146_S	0.516	0.36
11_K	17_K	0.515	0.36
114_E	142_Y	0.515	0.36
253_D	342_R	0.514	0.36
263_S	286_W	0.513	0.35
87_E	199_S	0.513	0.35
176_R	182_P	0.513	0.35
411_I	414_T	0.513	0.35
230_I	253_D	0.512	0.35
218_Y	429_S	0.512	0.35
37_E	300_W	0.512	0.35
180_R	406_V	0.511	0.35
31_E	34_E	0.511	0.35
74_D	79_G	0.510	0.35
13_A	24_E	0.509	0.35
172_S	204_W	0.509	0.35
73_T	79_G	0.509	0.35
403_R	435_R	0.509	0.35
374_K	389_P	0.508	0.35
12_I	18_R	0.508	0.35
43_Y	49_P	0.507	0.35
268_V	288_A	0.506	0.35
401_A	436_Q	0.505	0.35
356_R	376_E	0.505	0.35
177_Y	424_H	0.504	0.35
204_W	416_R	0.504	0.35
47_H	51_S	0.503	0.35
45_N	49_P	0.502	0.34
207_T	211_A	0.502	0.34
72_R	329_V	0.502	0.34
175_S	186_I	0.501	0.34
373_G	376_E	0.501	0.34
323_Y	358_L	0.501	0.34
77_T	81_K	0.500	0.34
351_C	354_G	0.500	0.34

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4iloA	3	0.2885	93.9	0.954	Contact Map
3na7A	1	0.2906	93	0.956	Contact Map
3mq7A	6	0.0876	83.6	0.963	Contact Map
4u7bA	2	0.5278	83.1	0.963	Contact Map
3nmdA	2	0.1026	81.7	0.964	Contact Map
1i84S	2	0	81	0.964	Contact Map
1hjbA	2	0.094	80.7	0.964	Contact Map
2dfsA	2	0.1966	80.5	0.964	Contact Map
1gd2E	2	0.0791	80.3	0.964	Contact Map
3hnwA	2	0.1068	78.7	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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