GREMLIN Database
Q9HSV7 - Uncharacterized protein
UniProt: Q9HSV7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 468 (442)
Sequences: 1537 (1160)
Seq/√Len: 55.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_V137_Y5.7651.00
25_R30_Q4.5761.00
12_I15_K4.3871.00
32_R37_E4.1321.00
22_Q26_I3.7171.00
328_F394_T3.5961.00
15_K19_I3.3521.00
33_I36_L3.2691.00
356_R360_E3.1081.00
280_T391_V3.1041.00
19_I22_Q3.0671.00
11_K16_D3.0381.00
144_C147_C2.9711.00
18_R23_N2.9081.00
348_H385_F2.8871.00
218_Y426_T2.8131.00
96_E133_E2.7691.00
26_I29_Q2.7321.00
297_Q391_V2.7291.00
280_T297_Q2.7031.00
333_S347_M2.6671.00
367_P370_T2.6671.00
320_V358_L2.6551.00
282_I392_S2.6381.00
356_R379_L2.5741.00
108_C144_C2.5641.00
122_L136_Q2.5621.00
283_C296_L2.5101.00
434_W439_R2.4631.00
352_Q386_V2.4611.00
303_L375_I2.4501.00
108_C147_C2.4021.00
105_C144_C2.3991.00
173_A207_T2.3271.00
240_R260_V2.3071.00
179_H192_Q2.2841.00
359_V372_L2.2521.00
97_E136_Q2.2511.00
125_E167_N2.2461.00
232_H398_A2.1841.00
125_E165_G2.1161.00
105_C147_C2.0871.00
173_A210_A2.0661.00
408_L412_I2.0471.00
235_E246_W2.0451.00
263_S268_V2.0331.00
97_E138_N1.9931.00
327_M348_H1.9901.00
221_I429_S1.9801.00
52_K55_S1.9781.00
105_C108_C1.9701.00
95_D122_L1.9401.00
235_E264_R1.9331.00
119_S152_V1.9261.00
319_P323_Y1.9251.00
250_F272_V1.9221.00
447_R451_D1.9091.00
233_V281_V1.8891.00
406_V409_R1.8831.00
220_Q223_R1.8821.00
320_V355_L1.8630.99
54_R57_T1.8630.99
267_D271_E1.8580.99
400_N403_R1.8580.99
266_S288_A1.8550.99
75_G80_R1.8240.99
127_P131_P1.8180.99
33_I37_E1.7920.99
349_R353_D1.7850.99
95_D134_V1.7840.99
307_A375_I1.7790.99
384_T391_V1.7600.99
432_A435_R1.7200.99
379_L383_L1.7170.99
385_F393_P1.7140.99
298_R381_H1.7020.99
235_E289_Y1.6990.99
323_Y354_G1.6910.99
306_E309_D1.6690.99
11_K14_Q1.6680.99
75_G78_P1.6300.99
183_Y207_T1.6210.98
172_S203_A1.6040.98
222_R226_Q1.6020.98
237_G244_Q1.6020.98
355_L375_I1.5900.98
159_P162_G1.5870.98
101_T140_H1.5810.98
16_D19_I1.5510.98
300_W324_L1.5450.98
282_I297_Q1.5430.98
442_Y446_T1.5350.98
52_K56_G1.5340.98
245_A260_V1.5170.98
340_D343_A1.5080.98
384_T387_G1.5060.98
113_D145_D1.4930.97
261_R268_V1.4900.97
233_V250_F1.4740.97
224_E227_E1.4730.97
215_R219_E1.4730.97
23_N26_I1.4720.97
349_R386_V1.4540.97
99_E140_H1.4530.97
326_Q351_C1.4500.97
179_H189_R1.4500.97
330_G333_S1.4480.97
173_A427_I1.4430.97
327_M385_F1.4430.97
9_E12_I1.4170.96
11_K15_K1.4100.96
19_I23_N1.3930.96
278_A294_S1.3870.96
256_T436_Q1.3850.96
339_P342_R1.3770.96
298_R378_G1.3730.96
229_E390_A1.3730.96
171_Q442_Y1.3680.96
395_N398_A1.3570.95
42_K46_P1.3540.95
178_D431_L1.3530.95
29_Q33_I1.3510.95
285_G378_G1.3440.95
187_T200_G1.3260.95
403_R406_V1.3250.95
41_R46_P1.3200.95
164_F206_A1.3130.95
424_H428_L1.3120.95
247_I405_P1.3070.94
296_L381_H1.2960.94
167_N446_T1.2940.94
303_L382_W1.2820.94
211_A426_T1.2720.94
230_I282_I1.2720.94
155_H158_C1.2710.94
308_E321_Y1.2700.93
240_R245_A1.2680.93
369_A373_G1.2660.93
360_E376_E1.2650.93
250_F268_V1.2630.93
363_V373_G1.2590.93
76_G79_G1.2420.93
57_T60_S1.2380.93
338_D342_R1.2310.92
270_A291_A1.2300.92
112_F147_C1.2280.92
337_T341_P1.2260.92
187_T203_A1.2240.92
439_R444_E1.2210.92
266_S291_A1.2120.92
451_D454_M1.1960.91
175_S189_R1.1950.91
215_R422_F1.1930.91
297_Q385_F1.1880.91
338_D341_P1.1860.91
248_W264_R1.1860.91
123_V165_G1.1830.91
174_L179_H1.1820.91
169_I210_A1.1800.91
12_I19_I1.1790.91
118_V138_N1.1730.90
101_T142_Y1.1690.90
325_K328_F1.1640.90
250_F259_A1.1630.90
300_W352_Q1.1580.90
300_W393_P1.1500.90
240_R421_M1.1430.89
372_L376_E1.1380.89
127_P133_E1.1370.89
23_N27_E1.1330.89
308_E312_S1.1330.89
258_Y432_A1.1320.89
120_P136_Q1.1270.89
440_N443_E1.1060.88
330_G334_W1.1040.88
264_R286_W1.1030.87
250_F273_L1.1010.87
355_L358_L1.0950.87
297_Q384_T1.0930.87
320_V324_L1.0910.87
325_K332_Q1.0890.87
9_E16_D1.0890.87
132_P190_F1.0830.87
226_Q277_F1.0790.86
98_I135_T1.0750.86
25_R28_E1.0710.86
126_V130_Q1.0650.86
250_F269_P1.0620.85
237_G246_W1.0610.85
326_Q354_G1.0610.85
378_G381_H1.0600.85
10_E14_Q1.0580.85
401_A432_A1.0560.85
208_E423_V1.0460.85
124_E196_L1.0390.84
451_D455_I1.0380.84
231_V277_F1.0340.84
14_Q17_K1.0320.84
36_L40_L1.0300.84
433_T437_Q1.0270.83
114_E118_V1.0150.83
327_M351_C1.0140.83
235_E263_S1.0070.82
182_P185_K1.0050.82
52_K58_D1.0030.82
301_A394_T1.0010.82
125_E133_E0.9920.81
75_G79_G0.9920.81
444_E448_V0.9880.81
123_V158_C0.9840.81
42_K45_N0.9810.81
38_T312_S0.9720.80
430_L444_E0.9720.80
352_Q385_F0.9690.80
34_E38_T0.9680.80
301_A393_P0.9670.80
415_L421_M0.9620.79
72_R75_G0.9590.79
371_L374_K0.9580.79
352_Q379_L0.9570.79
249_T401_A0.9510.78
143_Q150_E0.9460.78
238_I415_L0.9460.78
372_L375_I0.9450.78
385_F391_V0.9450.78
117_G141_R0.9430.78
184_R200_G0.9410.78
171_Q175_S0.9410.78
176_R183_Y0.9390.78
260_V428_L0.9360.77
230_I392_S0.9350.77
323_Y355_L0.9330.77
348_H351_C0.9250.76
64_Q67_E0.9210.76
238_I412_I0.9210.76
70_D73_T0.9200.76
51_S60_S0.9200.76
239_K242_G0.9190.76
27_E30_Q0.9150.76
352_Q356_R0.9140.76
301_A396_N0.9130.76
30_Q34_E0.9070.75
403_R407_V0.9070.75
215_R426_T0.9050.75
232_H395_N0.9040.75
105_C112_F0.9040.75
251_R397_A0.9040.75
364_T369_A0.9000.74
43_Y47_H0.9000.74
52_K57_T0.8990.74
201_A205_H0.8990.74
373_G377_G0.8950.74
228_A252_T0.8930.74
13_A17_K0.8870.73
246_W263_S0.8850.73
99_E138_N0.8830.73
329_V332_Q0.8810.73
28_E32_R0.8810.73
349_R387_G0.8800.73
89_R93_D0.8760.72
177_Y183_Y0.8760.72
221_I430_L0.8760.72
207_T427_I0.8760.72
114_E140_H0.8760.72
9_E18_R0.8750.72
337_T342_R0.8710.72
126_V171_Q0.8700.72
9_E13_A0.8670.72
269_P272_V0.8660.72
188_D435_R0.8640.71
283_C288_A0.8640.71
18_R22_Q0.8640.71
327_M330_G0.8610.71
26_I30_Q0.8600.71
258_Y403_R0.8600.71
335_L392_S0.8600.71
32_R35_E0.8600.71
266_S270_A0.8590.71
366_E369_A0.8590.71
222_R259_A0.8580.71
11_K18_R0.8570.71
285_G298_R0.8550.71
259_A272_V0.8540.71
412_I428_L0.8500.70
180_R411_I0.8500.70
168_V172_S0.8490.70
307_A320_V0.8490.70
225_I231_V0.8470.70
230_I254_E0.8440.70
86_P89_R0.8440.70
308_E311_A0.8440.70
301_A395_N0.8430.70
285_G382_W0.8430.70
300_W382_W0.8410.69
141_R152_V0.8400.69
132_P196_L0.8320.68
73_T76_G0.8310.68
249_T398_A0.8310.68
35_E39_R0.8300.68
106_P109_G0.8270.68
177_Y204_W0.8250.68
167_N171_Q0.8220.68
397_A400_N0.8190.67
15_K18_R0.8170.67
218_Y257_L0.8150.67
304_L321_Y0.8110.67
217_E448_V0.8100.66
285_G290_P0.8100.66
106_P151_T0.8090.66
412_I424_H0.8070.66
189_R192_Q0.8050.66
109_G147_C0.8030.66
33_I40_L0.8020.66
285_G374_K0.8010.66
51_S56_G0.8000.65
290_P296_L0.8000.65
264_R289_Y0.7990.65
219_E223_R0.7970.65
431_L444_E0.7960.65
331_L374_K0.7960.65
9_E15_K0.7950.65
145_D148_G0.7950.65
230_I391_V0.7940.65
258_Y402_L0.7940.65
183_Y204_W0.7920.65
210_A449_V0.7920.65
139_R152_V0.7920.65
251_R256_T0.7910.65
235_E293_S0.7900.64
260_V421_M0.7870.64
355_L359_V0.7860.64
245_A418_D0.7840.64
20_E24_E0.7840.64
108_C112_F0.7840.64
175_S179_H0.7800.63
420_G423_V0.7770.63
300_W385_F0.7710.63
98_I137_Y0.7670.62
301_A306_E0.7670.62
14_Q18_R0.7670.62
265_G268_V0.7650.62
232_H282_I0.7580.61
16_D20_E0.7580.61
56_G60_S0.7580.61
334_W342_R0.7560.61
402_L405_P0.7550.61
280_T384_T0.7550.61
282_I391_V0.7530.61
364_T373_G0.7520.61
345_A349_R0.7500.60
232_H397_A0.7490.60
330_G348_H0.7440.60
119_S139_R0.7430.60
13_A16_D0.7430.60
123_V137_Y0.7400.59
40_L44_E0.7400.59
139_R153_A0.7390.59
234_D302_H0.7380.59
10_E17_K0.7350.59
287_T290_P0.7330.59
180_R407_V0.7310.58
43_Y46_P0.7290.58
242_G416_R0.7250.58
343_A387_G0.7250.58
116_V150_E0.7240.58
258_Y400_N0.7230.58
235_E248_W0.7220.58
24_E27_E0.7220.58
38_T41_R0.7210.57
404_E435_R0.7200.57
300_W327_M0.7200.57
295_T384_T0.7180.57
17_K21_E0.7170.57
260_V418_D0.7160.57
28_E33_I0.7160.57
21_E24_E0.7160.57
118_V140_H0.7130.57
249_T402_L0.7120.56
12_I16_D0.7110.56
365_D370_T0.7110.56
143_Q148_G0.7110.56
247_I425_E0.7090.56
231_V300_W0.7080.56
248_W286_W0.7080.56
419_R422_F0.7070.56
214_G427_I0.7060.56
126_V132_P0.7040.56
167_N199_S0.7040.56
58_D63_S0.7030.56
121_R139_R0.7030.56
269_P315_E0.7020.55
176_R408_L0.7020.55
34_E37_E0.7000.55
440_N450_H0.6990.55
182_P411_I0.6990.55
311_A318_E0.6990.55
60_S67_E0.6970.55
239_K245_A0.6960.55
300_W435_R0.6950.55
356_R383_L0.6950.55
112_F144_C0.6920.54
85_N88_W0.6910.54
232_H251_R0.6910.54
283_C293_S0.6900.54
174_L189_R0.6900.54
240_R262_E0.6890.54
240_R428_L0.6890.54
235_E286_W0.6880.54
123_V135_T0.6870.54
173_A449_V0.6850.54
164_F198_L0.6850.54
300_W303_L0.6850.54
60_S63_S0.6850.54
137_Y153_A0.6840.53
198_L202_S0.6830.53
293_S296_L0.6830.53
54_R58_D0.6800.53
415_L424_H0.6790.53
448_V453_E0.6790.53
277_F281_V0.6790.53
58_D65_D0.6790.53
407_V410_K0.6790.53
406_V415_L0.6750.53
408_L428_L0.6740.52
166_V450_H0.6740.52
334_W339_P0.6730.52
331_L389_P0.6720.52
304_L331_L0.6710.52
235_E283_C0.6710.52
51_S54_R0.6710.52
31_E35_E0.6700.52
191_E197_E0.6650.51
324_L328_F0.6640.51
118_V139_R0.6620.51
38_T308_E0.6610.51
270_A347_M0.6610.51
68_D71_V0.6580.51
315_E440_N0.6580.51
51_S57_T0.6550.50
67_E70_D0.6550.50
246_W264_R0.6540.50
320_V323_Y0.6520.50
399_E403_R0.6500.50
180_R404_E0.6490.50
69_D73_T0.6480.50
397_A401_A0.6450.49
94_P429_S0.6440.49
350_A353_D0.6420.49
243_D418_D0.6420.49
152_V165_G0.6400.49
234_D284_D0.6400.49
211_A218_Y0.6390.49
84_H88_W0.6390.49
276_D361_R0.6360.48
331_L393_P0.6340.48
43_Y50_P0.6340.48
365_D369_A0.6340.48
184_R411_I0.6340.48
174_L178_D0.6330.48
409_R420_G0.6320.48
269_P288_A0.6310.48
178_D188_D0.6290.48
87_E197_E0.6290.48
339_P343_A0.6290.48
38_T42_K0.6280.47
113_D400_N0.6270.47
204_W208_E0.6260.47
41_R45_N0.6260.47
261_R271_E0.6260.47
184_R188_D0.6230.47
297_Q393_P0.6220.47
228_A429_S0.6220.47
374_K414_T0.6220.47
42_K47_H0.6210.47
445_L449_V0.6210.47
71_V74_D0.6200.47
267_D270_A0.6190.46
250_F261_R0.6150.46
235_E288_A0.6140.46
323_Y326_Q0.6130.46
39_R44_E0.6120.46
176_R185_K0.6110.46
323_Y351_C0.6100.46
176_R186_I0.6100.46
39_R309_D0.6090.45
50_P228_A0.6090.45
331_L371_L0.6070.45
303_L306_E0.6070.45
116_V143_Q0.6060.45
45_N51_S0.6040.45
248_W263_S0.6020.45
284_D302_H0.6020.45
135_T420_G0.6010.45
69_D72_R0.6000.44
32_R36_L0.6000.44
200_G204_W0.5990.44
235_E261_R0.5980.44
125_E166_V0.5980.44
37_E41_R0.5980.44
241_D416_R0.5960.44
336_E341_P0.5950.44
74_D77_T0.5940.44
335_L376_E0.5940.44
60_S64_Q0.5930.44
232_H258_Y0.5910.43
180_R408_L0.5900.43
61_P64_Q0.5890.43
181_L190_F0.5870.43
360_E373_G0.5870.43
410_K413_G0.5870.43
331_L344_R0.5860.43
333_S346_Q0.5830.43
418_D422_F0.5830.43
240_R419_R0.5820.43
448_V451_D0.5810.42
334_W348_H0.5800.42
96_E135_T0.5790.42
50_P91_P0.5780.42
349_R357_S0.5770.42
233_V273_L0.5770.42
110_D146_S0.5760.42
246_W265_G0.5760.42
240_R418_D0.5750.42
431_L441_P0.5740.42
434_W438_G0.5730.42
64_Q69_D0.5730.42
304_L371_L0.5730.42
405_P424_H0.5720.41
238_I247_I0.5720.41
322_R326_Q0.5720.41
409_R413_G0.5710.41
266_S269_P0.5700.41
77_T80_R0.5690.41
48_T325_K0.5690.41
302_H305_R0.5690.41
307_A376_E0.5680.41
362_S372_L0.5680.41
258_Y309_D0.5660.41
344_R374_K0.5650.41
132_P194_H0.5640.41
447_R450_H0.5630.41
203_A291_A0.5620.40
234_D399_E0.5620.40
207_T359_V0.5620.40
321_Y394_T0.5610.40
225_I252_T0.5600.40
372_L377_G0.5590.40
89_R124_E0.5590.40
303_L359_V0.5570.40
435_R442_Y0.5570.40
232_H392_S0.5560.40
360_E379_L0.5560.40
26_I33_I0.5540.40
214_G426_T0.5540.40
371_L414_T0.5530.40
248_W289_Y0.5520.39
338_D343_A0.5520.39
184_R413_G0.5520.39
314_H368_V0.5520.39
263_S288_A0.5510.39
177_Y207_T0.5490.39
46_P52_K0.5490.39
429_S442_Y0.5480.39
219_E272_V0.5470.39
251_R386_V0.5470.39
119_S141_R0.5470.39
324_L327_M0.5470.39
452_N455_I0.5460.39
41_R55_S0.5450.39
296_L378_G0.5440.39
53_R60_S0.5440.39
139_R154_T0.5440.39
152_V155_H0.5440.39
285_G306_E0.5420.38
109_G144_C0.5420.38
251_R398_A0.5420.38
58_D61_P0.5420.38
429_S433_T0.5420.38
153_A156_P0.5410.38
303_L429_S0.5410.38
238_I406_V0.5400.38
354_G361_R0.5400.38
257_L272_V0.5400.38
304_L307_A0.5390.38
220_Q224_E0.5390.38
394_T400_N0.5380.38
403_R440_N0.5380.38
188_D191_E0.5370.38
360_E377_G0.5370.38
288_A296_L0.5370.38
306_E371_L0.5370.38
22_Q25_R0.5350.38
21_E219_E0.5350.38
26_I223_R0.5330.37
234_D299_C0.5330.37
142_Y352_Q0.5330.37
90_S95_D0.5320.37
318_E322_R0.5320.37
400_N407_V0.5310.37
304_L374_K0.5290.37
421_M424_H0.5290.37
251_R400_N0.5290.37
241_D245_A0.5280.37
168_V206_A0.5280.37
10_E19_I0.5280.37
24_E150_E0.5270.37
313_D384_T0.5270.37
10_E322_R0.5270.37
17_K170_A0.5270.37
108_C232_H0.5260.37
14_Q32_R0.5260.37
434_W437_Q0.5260.37
222_R276_D0.5250.37
363_V419_R0.5250.37
72_R77_T0.5250.37
157_D454_M0.5240.37
126_V133_E0.5230.36
73_T80_R0.5220.36
76_G80_R0.5220.36
327_M393_P0.5220.36
89_R122_L0.5220.36
246_W289_Y0.5220.36
368_V433_T0.5210.36
423_V447_R0.5200.36
27_E51_S0.5190.36
233_V272_V0.5180.36
18_R21_E0.5160.36
307_A400_N0.5160.36
107_E146_S0.5160.36
11_K17_K0.5150.36
114_E142_Y0.5150.36
253_D342_R0.5140.36
263_S286_W0.5130.35
87_E199_S0.5130.35
176_R182_P0.5130.35
411_I414_T0.5130.35
230_I253_D0.5120.35
218_Y429_S0.5120.35
37_E300_W0.5120.35
180_R406_V0.5110.35
31_E34_E0.5110.35
74_D79_G0.5100.35
13_A24_E0.5090.35
172_S204_W0.5090.35
73_T79_G0.5090.35
403_R435_R0.5090.35
374_K389_P0.5080.35
12_I18_R0.5080.35
43_Y49_P0.5070.35
268_V288_A0.5060.35
401_A436_Q0.5050.35
356_R376_E0.5050.35
177_Y424_H0.5040.35
204_W416_R0.5040.35
47_H51_S0.5030.35
45_N49_P0.5020.34
207_T211_A0.5020.34
72_R329_V0.5020.34
175_S186_I0.5010.34
373_G376_E0.5010.34
323_Y358_L0.5010.34
77_T81_K0.5000.34
351_C354_G0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4iloA 3 0.2885 93.9 0.954 Contact Map
3na7A 1 0.2906 93 0.956 Contact Map
3mq7A 6 0.0876 83.6 0.963 Contact Map
4u7bA 2 0.5278 83.1 0.963 Contact Map
3nmdA 2 0.1026 81.7 0.964 Contact Map
1i84S 2 0 81 0.964 Contact Map
1hjbA 2 0.094 80.7 0.964 Contact Map
2dfsA 2 0.1966 80.5 0.964 Contact Map
1gd2E 2 0.0791 80.3 0.964 Contact Map
3hnwA 2 0.1068 78.7 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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