GREMLIN Database
Q9HSV6 - Uncharacterized protein
UniProt: Q9HSV6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (346)
Sequences: 8839 (8070)
Seq/√Len: 433.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
274_A279_H5.3751.00
271_F310_F5.1261.00
313_G317_T4.6111.00
279_H283_N4.5091.00
157_P165_P3.6891.00
308_A312_I3.6301.00
68_V320_A3.5631.00
310_F318_G3.3331.00
166_N205_A2.9221.00
309_I321_Y2.9191.00
176_A193_F2.8961.00
326_F330_R2.7601.00
177_I215_A2.7131.00
267_S307_I2.7101.00
169_S208_S2.7001.00
268_Y272_L2.6541.00
264_W307_I2.6221.00
267_S302_P2.5851.00
61_S323_Y2.4131.00
304_N307_I2.3891.00
369_S373_A2.3361.00
305_S355_A2.3341.00
106_S110_Y2.2661.00
76_N82_F2.2201.00
270_A279_H2.1961.00
302_P308_A2.1901.00
272_L275_P2.1511.00
173_A350_A2.1221.00
279_H311_L2.1031.00
330_R334_C2.1021.00
61_S320_A2.0641.00
281_P313_G2.0141.00
116_T175_S1.9641.00
68_V72_H1.9541.00
267_S271_F1.9501.00
164_N358_S1.9191.00
162_F171_V1.9031.00
316_I319_L1.8981.00
267_S311_L1.8931.00
271_F315_V1.8731.00
119_L160_S1.8451.00
169_S203_S1.8401.00
316_I320_A1.8201.00
306_F356_M1.7641.00
123_A168_L1.7471.00
211_A215_A1.7321.00
204_G209_I1.7131.00
172_C196_N1.6981.00
68_V316_I1.6791.00
113_S179_L1.6741.00
271_F275_P1.6731.00
318_G322_L1.6721.00
207_A357_F1.6411.00
107_A111_R1.6241.00
173_A215_A1.6241.00
269_Y272_L1.6231.00
215_A346_L1.6171.00
354_M358_S1.6001.00
270_A311_L1.5991.00
168_L172_C1.5911.00
301_G358_S1.5831.00
273_E291_Y1.5821.00
277_Y316_I1.5311.00
166_N303_H1.5261.00
340_N343_V1.5131.00
176_A196_N1.5041.00
69_I313_G1.4991.00
96_I100_P1.4941.00
263_L303_H1.4921.00
306_F352_L1.4891.00
176_A212_F1.4871.00
263_L302_P1.4811.00
166_N208_S1.4751.00
72_H76_N1.4661.00
270_A273_E1.4501.00
168_L203_S1.4501.00
172_C203_S1.4331.00
110_Y114_V1.4051.00
215_A350_A1.3991.00
64_F68_V1.3931.00
120_V196_N1.3751.00
183_I193_F1.3571.00
168_L199_G1.3491.00
116_T196_N1.3421.00
271_F311_L1.3361.00
268_Y271_F1.3331.00
175_S196_N1.3301.00
304_N356_M1.3231.00
119_L161_I1.3191.00
265_R269_Y1.3111.00
179_L192_L1.3021.00
343_V347_L1.3011.00
190_R194_A1.2871.00
274_A277_Y1.2841.00
117_S192_L1.2721.00
64_F320_A1.2621.00
55_T59_A1.2521.00
176_A200_L1.2491.00
60_L64_F1.2471.00
373_A377_G1.2461.00
267_S303_H1.2451.00
72_H75_L1.2371.00
177_I347_L1.2331.00
323_Y327_E1.2271.00
40_C44_M1.2171.00
181_R343_V1.2131.00
76_N283_N1.2101.00
182_Q189_S1.2091.00
68_V277_Y1.2081.00
123_A160_S1.2071.00
301_G359_G1.2061.00
47_S50_I1.2041.00
284_L302_P1.2001.00
123_A126_T1.1931.00
164_N303_H1.1931.00
59_A96_I1.1831.00
302_P311_L1.1801.00
354_M359_G1.1731.00
183_I190_R1.1701.00
88_F92_T1.1691.00
266_A269_Y1.1661.00
218_L346_L1.1631.00
43_W46_K1.1621.00
214_A353_I1.1571.00
111_R115_F1.1431.00
309_I318_G1.1421.00
61_S324_F1.1421.00
256_N261_Q1.1391.00
282_S312_I1.1371.00
283_N312_I1.1261.00
207_A211_A1.1251.00
211_A353_I1.1241.00
56_Q59_A1.1201.00
23_L27_I1.1201.00
34_V38_G1.1191.00
269_Y273_E1.1131.00
261_Q265_R1.1101.00
243_A247_L1.1051.00
307_I310_F1.1051.00
271_F318_G1.1011.00
306_F318_G1.0991.00
264_W304_N1.0851.00
121_I125_P1.0831.00
123_A158_L1.0821.00
200_L212_F1.0731.00
99_I102_N1.0701.00
192_L196_N1.0701.00
166_N358_S1.0691.00
219_L346_L1.0661.00
284_L288_I1.0631.00
92_T96_I1.0591.00
216_I220_T1.0551.00
107_A110_Y1.0541.00
359_G362_V1.0521.00
179_L193_F1.0521.00
110_Y182_Q1.0511.00
259_G263_L1.0511.00
319_L323_Y1.0431.00
271_F316_I1.0401.00
65_V309_I1.0371.00
332_S344_I1.0351.00
59_A63_G1.0341.00
126_T160_S1.0331.00
257_L264_W1.0311.00
126_T158_L1.0251.00
91_I95_L1.0231.00
179_L196_N1.0221.00
68_V75_L1.0111.00
198_G202_L1.0071.00
258_A261_Q1.0011.00
87_A91_I0.9971.00
344_I347_L0.9961.00
267_S284_L0.9861.00
266_A270_A0.9811.00
309_I313_G0.9811.00
335_F341_G0.9801.00
53_I56_Q0.9741.00
250_W254_P0.9741.00
113_S116_T0.9741.00
284_L312_I0.9741.00
160_S168_L0.9731.00
65_V69_I0.9701.00
181_R185_F0.9681.00
262_D265_R0.9631.00
91_I94_L0.9571.00
194_A198_G0.9521.00
218_L222_Y0.9511.00
263_L299_G0.9471.00
267_S310_F0.9441.00
46_K49_T0.9431.00
308_A359_G0.9391.00
206_R257_L0.9371.00
232_T236_A0.9361.00
125_P129_V0.9331.00
273_E279_H0.9331.00
270_A274_A0.9301.00
166_N169_S0.9301.00
301_G308_A0.9301.00
239_C242_F0.9271.00
310_F313_G0.9251.00
369_S377_G0.9211.00
205_A208_S0.9191.00
342_I346_L0.9161.00
237_G241_V0.9161.00
73_T76_N0.9141.00
158_L199_G0.9141.00
100_P104_D0.9141.00
178_S343_V0.9131.00
178_S182_Q0.9131.00
183_I189_S0.9131.00
72_H281_P0.9011.00
63_G67_A0.9011.00
197_V212_F0.8961.00
170_F354_M0.8951.00
110_Y189_S0.8911.00
207_A354_M0.8901.00
112_V175_S0.8891.00
324_F328_S0.8891.00
22_T26_Q0.8881.00
350_A354_M0.8871.00
242_F245_P0.8841.00
120_V199_G0.8801.00
31_L35_A0.8781.00
245_P248_A0.8781.00
305_S309_I0.8761.00
331_V334_C0.8751.00
261_Q264_W0.8731.00
310_F317_T0.8721.00
257_L261_Q0.8681.00
200_L208_S0.8641.00
177_I350_A0.8631.00
78_E81_R0.8621.00
322_L326_F0.8601.00
167_T301_G0.8601.00
166_N207_A0.8591.00
193_F197_V0.8591.00
310_F316_I0.8561.00
280_G312_I0.8501.00
79_F82_F0.8491.00
260_R303_H0.8471.00
14_G17_F0.8451.00
354_M357_F0.8451.00
206_R256_N0.8441.00
88_F91_I0.8401.00
353_I357_F0.8361.00
11_L15_A0.8341.00
69_I72_H0.8281.00
17_F20_Y0.8251.00
236_A240_I0.8231.00
242_F246_V0.8221.00
36_V40_C0.8201.00
53_I57_P0.8151.00
72_H313_G0.8141.00
200_L203_S0.8141.00
327_E330_R0.8121.00
173_A177_I0.8121.00
303_H308_A0.8081.00
255_I259_G0.8081.00
196_N199_G0.8081.00
96_I99_I0.8071.00
302_P359_G0.8061.00
346_L350_A0.8051.00
327_E331_V0.8011.00
211_A350_A0.7981.00
334_C338_E0.7981.00
207_A358_S0.7981.00
33_T37_I0.7981.00
173_A212_F0.7961.00
65_V313_G0.7961.00
38_G42_L0.7911.00
180_L193_F0.7891.00
126_T159_V0.7881.00
241_V245_P0.7871.00
173_A208_S0.7841.00
92_T95_L0.7841.00
213_L217_A0.7831.00
93_P97_F0.7821.00
354_M360_S0.7801.00
184_E219_L0.7801.00
367_T371_V0.7791.00
306_F322_L0.7771.00
13_I17_F0.7761.00
30_Y34_V0.7741.00
188_V192_L0.7721.00
61_S64_F0.7701.00
237_G240_I0.7691.00
355_A358_S0.7681.00
109_F178_S0.7671.00
306_F355_A0.7591.00
61_S327_E0.7551.00
157_P205_A0.7551.00
271_F317_T0.7551.00
339_P343_V0.7531.00
333_A345_H0.7521.00
306_F310_F0.7491.00
270_A288_I0.7471.00
256_N259_G0.7461.00
313_G316_I0.7391.00
109_F113_S0.7381.00
302_P307_I0.7371.00
172_C199_G0.7361.00
320_A324_F0.7331.00
176_A179_L0.7321.00
310_F315_V0.7321.00
166_N354_M0.7301.00
174_I177_I0.7301.00
305_S321_Y0.7281.00
158_L202_L0.7271.00
56_Q61_S0.7261.00
275_P279_H0.7261.00
165_P205_A0.7231.00
120_V195_I0.7221.00
307_I311_L0.7221.00
333_A336_L0.7201.00
275_P310_F0.7201.00
23_L26_Q0.7191.00
75_L277_Y0.7171.00
217_A221_V0.7141.00
270_A284_L0.7141.00
264_W302_P0.7141.00
54_T57_P0.7131.00
284_L311_L0.7101.00
164_N167_T0.7091.00
234_S241_V0.7091.00
42_L46_K0.7071.00
239_C243_A0.7071.00
365_L368_V0.7061.00
345_H349_V0.7061.00
124_I128_F0.7051.00
368_V373_A0.7041.00
244_L248_A0.7021.00
191_I195_I0.7021.00
177_I181_R0.7011.00
211_A354_M0.7011.00
263_L267_S0.6991.00
234_S238_L0.6991.00
355_A360_S0.6951.00
279_H312_I0.6921.00
303_H358_S0.6891.00
246_V249_I0.6881.00
236_A239_C0.6871.00
255_I258_A0.6821.00
120_V172_C0.6801.00
331_V335_F0.6761.00
245_P249_I0.6761.00
357_F361_T0.6731.00
109_F182_Q0.6731.00
211_A346_L0.6711.00
358_S361_T0.6711.00
287_V290_P0.6701.00
58_A61_S0.6701.00
236_A247_L0.6671.00
264_W301_G0.6661.00
306_F321_Y0.6641.00
88_F100_P0.6631.00
276_L316_I0.6621.00
115_F171_V0.6621.00
305_S362_V0.6621.00
279_H287_V0.6611.00
120_V192_L0.6581.00
218_L345_H0.6550.99
87_A90_F0.6540.99
234_S237_G0.6530.99
67_A71_T0.6520.99
156_P303_H0.6480.99
126_T303_H0.6460.99
264_W303_H0.6430.99
274_A311_L0.6410.99
266_A288_I0.6400.99
65_V320_A0.6400.99
19_T23_L0.6400.99
157_P203_S0.6390.99
181_R184_E0.6380.99
371_V375_V0.6370.99
169_S173_A0.6370.99
169_S205_A0.6350.99
68_V313_G0.6350.99
315_V319_L0.6330.99
302_P305_S0.6320.99
43_W47_S0.6310.99
76_N79_F0.6300.99
164_N205_A0.6300.99
127_L130_G0.6300.99
122_L160_S0.6300.99
68_V317_T0.6280.99
94_L97_F0.6280.99
333_A337_D0.6270.99
207_A267_S0.6260.99
263_L311_L0.6240.99
165_P169_S0.6220.99
179_L189_S0.6220.99
370_V374_L0.6210.99
59_A100_P0.6200.99
165_P203_S0.6190.99
126_T157_P0.6190.99
336_L341_G0.6180.99
104_D107_A0.6180.99
127_L158_L0.6150.99
68_V76_N0.6130.99
73_T82_F0.6110.99
57_P61_S0.6060.99
169_S172_C0.6050.99
268_Y310_F0.6030.99
113_S196_N0.6030.99
241_V244_L0.6020.99
73_T79_F0.6010.99
65_V317_T0.6010.99
179_L182_Q0.6000.99
270_A287_V0.5980.99
69_I73_T0.5970.99
16_S19_T0.5960.99
120_V124_I0.5950.99
329_F349_V0.5940.99
30_Y33_T0.5940.99
205_A260_R0.5920.99
87_A93_P0.5890.99
206_R357_F0.5890.99
40_C43_W0.5890.99
89_A92_T0.5870.99
369_S375_V0.5860.99
116_T120_V0.5860.99
14_G19_T0.5850.99
223_K227_T0.5830.99
264_W355_A0.5800.99
74_L77_P0.5800.99
329_F348_L0.5780.99
154_E157_P0.5780.99
154_E159_V0.5780.99
243_A248_A0.5770.99
222_Y342_I0.5740.99
306_F325_L0.5720.99
302_P312_I0.5710.99
244_L247_L0.5690.99
238_L242_F0.5680.99
367_T370_V0.5670.99
29_G32_M0.5640.98
259_G264_W0.5640.98
62_L324_F0.5610.98
158_L161_I0.5610.98
164_N305_S0.5590.98
323_Y326_F0.5580.98
305_S360_S0.5560.98
173_A354_M0.5550.98
99_I103_T0.5550.98
124_I199_G0.5550.98
79_F83_Q0.5540.98
266_A291_Y0.5540.98
325_L352_L0.5530.98
224_V227_T0.5530.98
375_V379_A0.5520.98
56_Q60_L0.5510.98
284_L308_A0.5510.98
231_V234_S0.5500.98
364_G369_S0.5500.98
97_F101_P0.5490.98
101_P104_D0.5470.98
123_A199_G0.5460.98
367_T373_A0.5440.98
305_S308_A0.5410.98
86_L89_A0.5400.98
349_V353_I0.5390.98
91_I102_N0.5380.98
164_N308_A0.5370.98
66_A70_F0.5360.98
188_V191_I0.5360.98
123_A161_I0.5340.98
116_T199_G0.5340.98
341_G344_I0.5330.98
82_F283_N0.5330.98
22_T27_I0.5320.98
157_P160_S0.5310.98
155_Y158_L0.5300.98
267_S270_A0.5300.98
343_V346_L0.5290.98
207_A210_L0.5290.98
233_S237_G0.5280.98
301_G312_I0.5280.98
111_R114_V0.5280.98
71_T75_L0.5270.98
37_I41_L0.5270.98
280_G284_L0.5260.98
89_A93_P0.5260.98
284_L287_V0.5250.98
41_L50_I0.5250.98
305_S359_G0.5240.98
49_T52_S0.5240.98
268_Y307_I0.5230.98
59_A62_L0.5220.98
126_T130_G0.5220.98
24_V28_V0.5220.98
332_S336_L0.5210.97
170_F358_S0.5210.97
32_M36_V0.5170.97
242_F247_L0.5160.97
292_V295_T0.5160.97
231_V236_A0.5130.97
170_F360_S0.5130.97
351_T359_G0.5110.97
77_P82_F0.5110.97
158_L204_G0.5090.97
92_T100_P0.5090.97
288_I302_P0.5080.97
159_V165_P0.5080.97
218_L349_V0.5070.97
61_S65_V0.5070.97
158_L165_P0.5060.97
117_S195_I0.5060.97
32_M35_A0.5060.97
11_L14_G0.5050.97
237_G248_A0.5050.97
366_S369_S0.5050.97
98_L102_N0.5050.97
90_F93_P0.5030.97
95_L98_L0.5020.97
285_G289_A0.5020.97
96_I102_N0.5020.97
355_A359_G0.5020.97
58_A324_F0.5010.97
117_S121_I0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wxwA 1 0.2992 4.4 0.956 Contact Map
2ks1B 1 0.1125 2.4 0.962 Contact Map
2l2tA 2 0.1125 2.3 0.962 Contact Map
4qncA 2 0.1918 2.3 0.962 Contact Map
2ksfA 1 0.2558 1.9 0.963 Contact Map
1afoA 2 0.1023 1.7 0.964 Contact Map
2k1eA 3 0.2583 1.5 0.965 Contact Map
2mc7A 1 0.0767 1.5 0.966 Contact Map
2k9pA 1 0.2046 1.4 0.966 Contact Map
2jwaA 2 0.1125 1.3 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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