Q9HSV6 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HSV6 - Uncharacterized protein

UniProt:	Q9HSV6	Sequences: MREIANWLVALIIGASFLTYSTLVPQIVGYLMTVAVIGVCLLWMAKSGTITSITTQPAALSLGFVAAVIFTHTLLNPEFQRFQRMLAFAFITPLLIFLIPPNTDLSAVFYRVSVFTSGLVILAIPTLFVGELAIGPLAISSWHTTTTLPVLGLEYPPLVSIFSNPNTLSFVCAISAISLLRQIEFDTVSRILFAINVGGLYLSGARASILAFLAAIALLTVYKVLGTWATVTSSIAGLCIVFALPVLAIWELVPINLAGRQDLWRASYYAFLEAPLYGHGPSNLGQVIAPYVEKTSRVGVGPHNSFIAIFLIGGVITGLAYLYFLFESFRVSACFLDEPNGIVIHLLLVATLIMAMFSGSTVFGLSTVSVVSALVAGYALSQVRTQTHFQS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	391 (346)
Sequences:	8839 (8070)
Seq/√Len:	433.8

ECOLI - RFAL
BACSU - TUAE
HALSA - Q9HSV6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
274_A	279_H	5.375	1.00
271_F	310_F	5.126	1.00
313_G	317_T	4.611	1.00
279_H	283_N	4.509	1.00
157_P	165_P	3.689	1.00
308_A	312_I	3.630	1.00
68_V	320_A	3.563	1.00
310_F	318_G	3.333	1.00
166_N	205_A	2.922	1.00
309_I	321_Y	2.919	1.00
176_A	193_F	2.896	1.00
326_F	330_R	2.760	1.00
177_I	215_A	2.713	1.00
267_S	307_I	2.710	1.00
169_S	208_S	2.700	1.00
268_Y	272_L	2.654	1.00
264_W	307_I	2.622	1.00
267_S	302_P	2.585	1.00
61_S	323_Y	2.413	1.00
304_N	307_I	2.389	1.00
369_S	373_A	2.336	1.00
305_S	355_A	2.334	1.00
106_S	110_Y	2.266	1.00
76_N	82_F	2.220	1.00
270_A	279_H	2.196	1.00
302_P	308_A	2.190	1.00
272_L	275_P	2.151	1.00
173_A	350_A	2.122	1.00
279_H	311_L	2.103	1.00
330_R	334_C	2.102	1.00
61_S	320_A	2.064	1.00
281_P	313_G	2.014	1.00
116_T	175_S	1.964	1.00
68_V	72_H	1.954	1.00
267_S	271_F	1.950	1.00
164_N	358_S	1.919	1.00
162_F	171_V	1.903	1.00
316_I	319_L	1.898	1.00
267_S	311_L	1.893	1.00
271_F	315_V	1.873	1.00
119_L	160_S	1.845	1.00
169_S	203_S	1.840	1.00
316_I	320_A	1.820	1.00
306_F	356_M	1.764	1.00
123_A	168_L	1.747	1.00
211_A	215_A	1.732	1.00
204_G	209_I	1.713	1.00
172_C	196_N	1.698	1.00
68_V	316_I	1.679	1.00
113_S	179_L	1.674	1.00
271_F	275_P	1.673	1.00
318_G	322_L	1.672	1.00
207_A	357_F	1.641	1.00
107_A	111_R	1.624	1.00
173_A	215_A	1.624	1.00
269_Y	272_L	1.623	1.00
215_A	346_L	1.617	1.00
354_M	358_S	1.600	1.00
270_A	311_L	1.599	1.00
168_L	172_C	1.591	1.00
301_G	358_S	1.583	1.00
273_E	291_Y	1.582	1.00
277_Y	316_I	1.531	1.00
166_N	303_H	1.526	1.00
340_N	343_V	1.513	1.00
176_A	196_N	1.504	1.00
69_I	313_G	1.499	1.00
96_I	100_P	1.494	1.00
263_L	303_H	1.492	1.00
306_F	352_L	1.489	1.00
176_A	212_F	1.487	1.00
263_L	302_P	1.481	1.00
166_N	208_S	1.475	1.00
72_H	76_N	1.466	1.00
270_A	273_E	1.450	1.00
168_L	203_S	1.450	1.00
172_C	203_S	1.433	1.00
110_Y	114_V	1.405	1.00
215_A	350_A	1.399	1.00
64_F	68_V	1.393	1.00
120_V	196_N	1.375	1.00
183_I	193_F	1.357	1.00
168_L	199_G	1.349	1.00
116_T	196_N	1.342	1.00
271_F	311_L	1.336	1.00
268_Y	271_F	1.333	1.00
175_S	196_N	1.330	1.00
304_N	356_M	1.323	1.00
119_L	161_I	1.319	1.00
265_R	269_Y	1.311	1.00
179_L	192_L	1.302	1.00
343_V	347_L	1.301	1.00
190_R	194_A	1.287	1.00
274_A	277_Y	1.284	1.00
117_S	192_L	1.272	1.00
64_F	320_A	1.262	1.00
55_T	59_A	1.252	1.00
176_A	200_L	1.249	1.00
60_L	64_F	1.247	1.00
373_A	377_G	1.246	1.00
267_S	303_H	1.245	1.00
72_H	75_L	1.237	1.00
177_I	347_L	1.233	1.00
323_Y	327_E	1.227	1.00
40_C	44_M	1.217	1.00
181_R	343_V	1.213	1.00
76_N	283_N	1.210	1.00
182_Q	189_S	1.209	1.00
68_V	277_Y	1.208	1.00
123_A	160_S	1.207	1.00
301_G	359_G	1.206	1.00
47_S	50_I	1.204	1.00
284_L	302_P	1.200	1.00
123_A	126_T	1.193	1.00
164_N	303_H	1.193	1.00
59_A	96_I	1.183	1.00
302_P	311_L	1.180	1.00
354_M	359_G	1.173	1.00
183_I	190_R	1.170	1.00
88_F	92_T	1.169	1.00
266_A	269_Y	1.166	1.00
218_L	346_L	1.163	1.00
43_W	46_K	1.162	1.00
214_A	353_I	1.157	1.00
111_R	115_F	1.143	1.00
309_I	318_G	1.142	1.00
61_S	324_F	1.142	1.00
256_N	261_Q	1.139	1.00
282_S	312_I	1.137	1.00
283_N	312_I	1.126	1.00
207_A	211_A	1.125	1.00
211_A	353_I	1.124	1.00
56_Q	59_A	1.120	1.00
23_L	27_I	1.120	1.00
34_V	38_G	1.119	1.00
269_Y	273_E	1.113	1.00
261_Q	265_R	1.110	1.00
243_A	247_L	1.105	1.00
307_I	310_F	1.105	1.00
271_F	318_G	1.101	1.00
306_F	318_G	1.099	1.00
264_W	304_N	1.085	1.00
121_I	125_P	1.083	1.00
123_A	158_L	1.082	1.00
200_L	212_F	1.073	1.00
99_I	102_N	1.070	1.00
192_L	196_N	1.070	1.00
166_N	358_S	1.069	1.00
219_L	346_L	1.066	1.00
284_L	288_I	1.063	1.00
92_T	96_I	1.059	1.00
216_I	220_T	1.055	1.00
107_A	110_Y	1.054	1.00
359_G	362_V	1.052	1.00
179_L	193_F	1.052	1.00
110_Y	182_Q	1.051	1.00
259_G	263_L	1.051	1.00
319_L	323_Y	1.043	1.00
271_F	316_I	1.040	1.00
65_V	309_I	1.037	1.00
332_S	344_I	1.035	1.00
59_A	63_G	1.034	1.00
126_T	160_S	1.033	1.00
257_L	264_W	1.031	1.00
126_T	158_L	1.025	1.00
91_I	95_L	1.023	1.00
179_L	196_N	1.022	1.00
68_V	75_L	1.011	1.00
198_G	202_L	1.007	1.00
258_A	261_Q	1.001	1.00
87_A	91_I	0.997	1.00
344_I	347_L	0.996	1.00
267_S	284_L	0.986	1.00
266_A	270_A	0.981	1.00
309_I	313_G	0.981	1.00
335_F	341_G	0.980	1.00
53_I	56_Q	0.974	1.00
250_W	254_P	0.974	1.00
113_S	116_T	0.974	1.00
284_L	312_I	0.974	1.00
160_S	168_L	0.973	1.00
65_V	69_I	0.970	1.00
181_R	185_F	0.968	1.00
262_D	265_R	0.963	1.00
91_I	94_L	0.957	1.00
194_A	198_G	0.952	1.00
218_L	222_Y	0.951	1.00
263_L	299_G	0.947	1.00
267_S	310_F	0.944	1.00
46_K	49_T	0.943	1.00
308_A	359_G	0.939	1.00
206_R	257_L	0.937	1.00
232_T	236_A	0.936	1.00
125_P	129_V	0.933	1.00
273_E	279_H	0.933	1.00
270_A	274_A	0.930	1.00
166_N	169_S	0.930	1.00
301_G	308_A	0.930	1.00
239_C	242_F	0.927	1.00
310_F	313_G	0.925	1.00
369_S	377_G	0.921	1.00
205_A	208_S	0.919	1.00
342_I	346_L	0.916	1.00
237_G	241_V	0.916	1.00
73_T	76_N	0.914	1.00
158_L	199_G	0.914	1.00
100_P	104_D	0.914	1.00
178_S	343_V	0.913	1.00
178_S	182_Q	0.913	1.00
183_I	189_S	0.913	1.00
72_H	281_P	0.901	1.00
63_G	67_A	0.901	1.00
197_V	212_F	0.896	1.00
170_F	354_M	0.895	1.00
110_Y	189_S	0.891	1.00
207_A	354_M	0.890	1.00
112_V	175_S	0.889	1.00
324_F	328_S	0.889	1.00
22_T	26_Q	0.888	1.00
350_A	354_M	0.887	1.00
242_F	245_P	0.884	1.00
120_V	199_G	0.880	1.00
31_L	35_A	0.878	1.00
245_P	248_A	0.878	1.00
305_S	309_I	0.876	1.00
331_V	334_C	0.875	1.00
261_Q	264_W	0.873	1.00
310_F	317_T	0.872	1.00
257_L	261_Q	0.868	1.00
200_L	208_S	0.864	1.00
177_I	350_A	0.863	1.00
78_E	81_R	0.862	1.00
322_L	326_F	0.860	1.00
167_T	301_G	0.860	1.00
166_N	207_A	0.859	1.00
193_F	197_V	0.859	1.00
310_F	316_I	0.856	1.00
280_G	312_I	0.850	1.00
79_F	82_F	0.849	1.00
260_R	303_H	0.847	1.00
14_G	17_F	0.845	1.00
354_M	357_F	0.845	1.00
206_R	256_N	0.844	1.00
88_F	91_I	0.840	1.00
353_I	357_F	0.836	1.00
11_L	15_A	0.834	1.00
69_I	72_H	0.828	1.00
17_F	20_Y	0.825	1.00
236_A	240_I	0.823	1.00
242_F	246_V	0.822	1.00
36_V	40_C	0.820	1.00
53_I	57_P	0.815	1.00
72_H	313_G	0.814	1.00
200_L	203_S	0.814	1.00
327_E	330_R	0.812	1.00
173_A	177_I	0.812	1.00
303_H	308_A	0.808	1.00
255_I	259_G	0.808	1.00
196_N	199_G	0.808	1.00
96_I	99_I	0.807	1.00
302_P	359_G	0.806	1.00
346_L	350_A	0.805	1.00
327_E	331_V	0.801	1.00
211_A	350_A	0.798	1.00
334_C	338_E	0.798	1.00
207_A	358_S	0.798	1.00
33_T	37_I	0.798	1.00
173_A	212_F	0.796	1.00
65_V	313_G	0.796	1.00
38_G	42_L	0.791	1.00
180_L	193_F	0.789	1.00
126_T	159_V	0.788	1.00
241_V	245_P	0.787	1.00
173_A	208_S	0.784	1.00
92_T	95_L	0.784	1.00
213_L	217_A	0.783	1.00
93_P	97_F	0.782	1.00
354_M	360_S	0.780	1.00
184_E	219_L	0.780	1.00
367_T	371_V	0.779	1.00
306_F	322_L	0.777	1.00
13_I	17_F	0.776	1.00
30_Y	34_V	0.774	1.00
188_V	192_L	0.772	1.00
61_S	64_F	0.770	1.00
237_G	240_I	0.769	1.00
355_A	358_S	0.768	1.00
109_F	178_S	0.767	1.00
306_F	355_A	0.759	1.00
61_S	327_E	0.755	1.00
157_P	205_A	0.755	1.00
271_F	317_T	0.755	1.00
339_P	343_V	0.753	1.00
333_A	345_H	0.752	1.00
306_F	310_F	0.749	1.00
270_A	288_I	0.747	1.00
256_N	259_G	0.746	1.00
313_G	316_I	0.739	1.00
109_F	113_S	0.738	1.00
302_P	307_I	0.737	1.00
172_C	199_G	0.736	1.00
320_A	324_F	0.733	1.00
176_A	179_L	0.732	1.00
310_F	315_V	0.732	1.00
166_N	354_M	0.730	1.00
174_I	177_I	0.730	1.00
305_S	321_Y	0.728	1.00
158_L	202_L	0.727	1.00
56_Q	61_S	0.726	1.00
275_P	279_H	0.726	1.00
165_P	205_A	0.723	1.00
120_V	195_I	0.722	1.00
307_I	311_L	0.722	1.00
333_A	336_L	0.720	1.00
275_P	310_F	0.720	1.00
23_L	26_Q	0.719	1.00
75_L	277_Y	0.717	1.00
217_A	221_V	0.714	1.00
270_A	284_L	0.714	1.00
264_W	302_P	0.714	1.00
54_T	57_P	0.713	1.00
284_L	311_L	0.710	1.00
164_N	167_T	0.709	1.00
234_S	241_V	0.709	1.00
42_L	46_K	0.707	1.00
239_C	243_A	0.707	1.00
365_L	368_V	0.706	1.00
345_H	349_V	0.706	1.00
124_I	128_F	0.705	1.00
368_V	373_A	0.704	1.00
244_L	248_A	0.702	1.00
191_I	195_I	0.702	1.00
177_I	181_R	0.701	1.00
211_A	354_M	0.701	1.00
263_L	267_S	0.699	1.00
234_S	238_L	0.699	1.00
355_A	360_S	0.695	1.00
279_H	312_I	0.692	1.00
303_H	358_S	0.689	1.00
246_V	249_I	0.688	1.00
236_A	239_C	0.687	1.00
255_I	258_A	0.682	1.00
120_V	172_C	0.680	1.00
331_V	335_F	0.676	1.00
245_P	249_I	0.676	1.00
357_F	361_T	0.673	1.00
109_F	182_Q	0.673	1.00
211_A	346_L	0.671	1.00
358_S	361_T	0.671	1.00
287_V	290_P	0.670	1.00
58_A	61_S	0.670	1.00
236_A	247_L	0.667	1.00
264_W	301_G	0.666	1.00
306_F	321_Y	0.664	1.00
88_F	100_P	0.663	1.00
276_L	316_I	0.662	1.00
115_F	171_V	0.662	1.00
305_S	362_V	0.662	1.00
279_H	287_V	0.661	1.00
120_V	192_L	0.658	1.00
218_L	345_H	0.655	0.99
87_A	90_F	0.654	0.99
234_S	237_G	0.653	0.99
67_A	71_T	0.652	0.99
156_P	303_H	0.648	0.99
126_T	303_H	0.646	0.99
264_W	303_H	0.643	0.99
274_A	311_L	0.641	0.99
266_A	288_I	0.640	0.99
65_V	320_A	0.640	0.99
19_T	23_L	0.640	0.99
157_P	203_S	0.639	0.99
181_R	184_E	0.638	0.99
371_V	375_V	0.637	0.99
169_S	173_A	0.637	0.99
169_S	205_A	0.635	0.99
68_V	313_G	0.635	0.99
315_V	319_L	0.633	0.99
302_P	305_S	0.632	0.99
43_W	47_S	0.631	0.99
76_N	79_F	0.630	0.99
164_N	205_A	0.630	0.99
127_L	130_G	0.630	0.99
122_L	160_S	0.630	0.99
68_V	317_T	0.628	0.99
94_L	97_F	0.628	0.99
333_A	337_D	0.627	0.99
207_A	267_S	0.626	0.99
263_L	311_L	0.624	0.99
165_P	169_S	0.622	0.99
179_L	189_S	0.622	0.99
370_V	374_L	0.621	0.99
59_A	100_P	0.620	0.99
165_P	203_S	0.619	0.99
126_T	157_P	0.619	0.99
336_L	341_G	0.618	0.99
104_D	107_A	0.618	0.99
127_L	158_L	0.615	0.99
68_V	76_N	0.613	0.99
73_T	82_F	0.611	0.99
57_P	61_S	0.606	0.99
169_S	172_C	0.605	0.99
268_Y	310_F	0.603	0.99
113_S	196_N	0.603	0.99
241_V	244_L	0.602	0.99
73_T	79_F	0.601	0.99
65_V	317_T	0.601	0.99
179_L	182_Q	0.600	0.99
270_A	287_V	0.598	0.99
69_I	73_T	0.597	0.99
16_S	19_T	0.596	0.99
120_V	124_I	0.595	0.99
329_F	349_V	0.594	0.99
30_Y	33_T	0.594	0.99
205_A	260_R	0.592	0.99
87_A	93_P	0.589	0.99
206_R	357_F	0.589	0.99
40_C	43_W	0.589	0.99
89_A	92_T	0.587	0.99
369_S	375_V	0.586	0.99
116_T	120_V	0.586	0.99
14_G	19_T	0.585	0.99
223_K	227_T	0.583	0.99
264_W	355_A	0.580	0.99
74_L	77_P	0.580	0.99
329_F	348_L	0.578	0.99
154_E	157_P	0.578	0.99
154_E	159_V	0.578	0.99
243_A	248_A	0.577	0.99
222_Y	342_I	0.574	0.99
306_F	325_L	0.572	0.99
302_P	312_I	0.571	0.99
244_L	247_L	0.569	0.99
238_L	242_F	0.568	0.99
367_T	370_V	0.567	0.99
29_G	32_M	0.564	0.98
259_G	264_W	0.564	0.98
62_L	324_F	0.561	0.98
158_L	161_I	0.561	0.98
164_N	305_S	0.559	0.98
323_Y	326_F	0.558	0.98
305_S	360_S	0.556	0.98
173_A	354_M	0.555	0.98
99_I	103_T	0.555	0.98
124_I	199_G	0.555	0.98
79_F	83_Q	0.554	0.98
266_A	291_Y	0.554	0.98
325_L	352_L	0.553	0.98
224_V	227_T	0.553	0.98
375_V	379_A	0.552	0.98
56_Q	60_L	0.551	0.98
284_L	308_A	0.551	0.98
231_V	234_S	0.550	0.98
364_G	369_S	0.550	0.98
97_F	101_P	0.549	0.98
101_P	104_D	0.547	0.98
123_A	199_G	0.546	0.98
367_T	373_A	0.544	0.98
305_S	308_A	0.541	0.98
86_L	89_A	0.540	0.98
349_V	353_I	0.539	0.98
91_I	102_N	0.538	0.98
164_N	308_A	0.537	0.98
66_A	70_F	0.536	0.98
188_V	191_I	0.536	0.98
123_A	161_I	0.534	0.98
116_T	199_G	0.534	0.98
341_G	344_I	0.533	0.98
82_F	283_N	0.533	0.98
22_T	27_I	0.532	0.98
157_P	160_S	0.531	0.98
155_Y	158_L	0.530	0.98
267_S	270_A	0.530	0.98
343_V	346_L	0.529	0.98
207_A	210_L	0.529	0.98
233_S	237_G	0.528	0.98
301_G	312_I	0.528	0.98
111_R	114_V	0.528	0.98
71_T	75_L	0.527	0.98
37_I	41_L	0.527	0.98
280_G	284_L	0.526	0.98
89_A	93_P	0.526	0.98
284_L	287_V	0.525	0.98
41_L	50_I	0.525	0.98
305_S	359_G	0.524	0.98
49_T	52_S	0.524	0.98
268_Y	307_I	0.523	0.98
59_A	62_L	0.522	0.98
126_T	130_G	0.522	0.98
24_V	28_V	0.522	0.98
332_S	336_L	0.521	0.97
170_F	358_S	0.521	0.97
32_M	36_V	0.517	0.97
242_F	247_L	0.516	0.97
292_V	295_T	0.516	0.97
231_V	236_A	0.513	0.97
170_F	360_S	0.513	0.97
351_T	359_G	0.511	0.97
77_P	82_F	0.511	0.97
158_L	204_G	0.509	0.97
92_T	100_P	0.509	0.97
288_I	302_P	0.508	0.97
159_V	165_P	0.508	0.97
218_L	349_V	0.507	0.97
61_S	65_V	0.507	0.97
158_L	165_P	0.506	0.97
117_S	195_I	0.506	0.97
32_M	35_A	0.506	0.97
11_L	14_G	0.505	0.97
237_G	248_A	0.505	0.97
366_S	369_S	0.505	0.97
98_L	102_N	0.505	0.97
90_F	93_P	0.503	0.97
95_L	98_L	0.502	0.97
285_G	289_A	0.502	0.97
96_I	102_N	0.502	0.97
355_A	359_G	0.502	0.97
58_A	324_F	0.501	0.97
117_S	121_I	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wxwA	1	0.2992	4.4	0.956	Contact Map
2ks1B	1	0.1125	2.4	0.962	Contact Map
2l2tA	2	0.1125	2.3	0.962	Contact Map
4qncA	2	0.1918	2.3	0.962	Contact Map
2ksfA	1	0.2558	1.9	0.963	Contact Map
1afoA	2	0.1023	1.7	0.964	Contact Map
2k1eA	3	0.2583	1.5	0.965	Contact Map
2mc7A	1	0.0767	1.5	0.966	Contact Map
2k9pA	1	0.2046	1.4	0.966	Contact Map
2jwaA	2	0.1125	1.3	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.