GREMLIN Database
Q9HSV4 - LPS glycosyltransferase
UniProt: Q9HSV4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (307)
Sequences: 56669 (48454)
Seq/√Len: 2765.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_S230_S4.7471.00
191_Q213_N3.5611.00
233_Y249_A3.1011.00
114_R138_S3.0881.00
163_T193_Q2.9521.00
65_V327_I2.9061.00
185_D286_S2.7261.00
193_Q215_Q2.7181.00
309_R313_E2.6961.00
161_N191_Q2.6351.00
166_T176_Y2.6271.00
201_R205_E2.5791.00
181_R207_K2.2201.00
123_M127_V2.2071.00
16_T61_T2.1661.00
175_G178_D2.1631.00
181_R282_I2.1361.00
162_I293_S2.1061.00
163_T191_Q2.0231.00
195_A226_F2.0021.00
260_D265_T1.9931.00
288_R291_Q1.9661.00
193_Q213_N1.9591.00
295_N298_L1.9301.00
16_T38_K1.9181.00
183_A192_F1.9081.00
164_V232_I1.8951.00
273_T309_R1.8791.00
163_T229_N1.8781.00
200_E203_R1.8681.00
162_I231_D1.8621.00
269_V272_E1.8591.00
299_R303_G1.8501.00
185_D283_D1.8491.00
291_Q298_L1.8411.00
268_V274_G1.8281.00
144_G316_Q1.8231.00
253_G307_R1.8151.00
65_V89_V1.8101.00
179_L192_F1.7671.00
275_F288_R1.7641.00
175_G238_K1.7471.00
318_A322_Q1.7181.00
120_D123_M1.7081.00
233_Y254_L1.7061.00
114_R326_A1.6711.00
123_M139_T1.6651.00
291_Q295_N1.6631.00
120_D266_E1.6601.00
117_A137_I1.6411.00
260_D278_R1.6351.00
278_R284_C1.6271.00
167_V223_I1.6211.00
290_Q294_E1.6211.00
269_V309_R1.5951.00
88_L112_A1.5891.00
187_G290_Q1.5721.00
272_E305_A1.5721.00
173_V239_Y1.5661.00
179_L234_F1.5511.00
183_A190_L1.5501.00
219_P222_Q1.5301.00
284_C288_R1.5101.00
281_D284_C1.5081.00
269_V273_T1.4991.00
298_L301_Q1.4821.00
123_M137_I1.4631.00
275_F291_Q1.4561.00
120_D139_T1.4521.00
324_R328_D1.4371.00
195_A215_Q1.4341.00
186_I290_Q1.4291.00
163_T231_D1.4271.00
16_T36_E1.4121.00
301_Q305_A1.4091.00
193_Q226_F1.3891.00
230_S254_L1.3861.00
178_D282_I1.3831.00
258_A264_I1.3811.00
178_D238_K1.3621.00
193_Q230_S1.3621.00
308_K312_S1.3611.00
222_Q225_Q1.3601.00
218_V222_Q1.3501.00
116_L323_F1.3451.00
282_I286_S1.3411.00
176_Y194_I1.3231.00
177_D207_K1.3181.00
185_D282_I1.3151.00
166_T179_L1.3011.00
158_S161_N1.2981.00
277_C288_R1.2921.00
116_L326_A1.2921.00
170_L194_I1.2841.00
224_P252_C1.2811.00
117_A123_M1.2751.00
242_L247_I1.2741.00
182_C285_F1.2721.00
164_V234_F1.2641.00
220_N223_I1.2601.00
305_A308_K1.2461.00
164_V289_L1.2321.00
197_E201_R1.2291.00
165_S195_A1.2121.00
318_A321_R1.2091.00
284_C287_E1.2011.00
322_Q325_K1.2001.00
127_V134_D1.1991.00
228_N252_C1.1981.00
150_Y252_C1.1871.00
162_I232_I1.1801.00
66_C86_K1.1791.00
120_D124_E1.1781.00
223_I227_L1.1771.00
133_P136_K1.1721.00
91_Q244_M1.1441.00
303_G306_G1.1371.00
178_D259_S1.1351.00
246_V264_I1.1351.00
124_E127_V1.1341.00
316_Q319_L1.1341.00
235_Q246_V1.1321.00
149_E224_P1.1281.00
169_R173_V1.1181.00
118_D122_V1.1141.00
237_S240_E1.1121.00
270_P288_R1.1121.00
78_L82_L1.1111.00
177_D181_R1.1071.00
259_S277_C1.1051.00
286_S290_Q1.1041.00
319_L322_Q1.0961.00
300_K304_T1.0961.00
162_I190_L1.0941.00
178_D181_R1.0941.00
235_Q245_A1.0841.00
253_G304_T1.0841.00
296_P299_R1.0841.00
117_A126_L1.0841.00
238_K280_R1.0831.00
315_S318_A1.0801.00
236_P285_F1.0771.00
243_C264_I1.0741.00
163_T230_S1.0741.00
178_D280_R1.0691.00
298_L302_M1.0681.00
227_L252_C1.0681.00
118_D143_A1.0641.00
67_S91_Q1.0541.00
319_L323_F1.0511.00
277_C285_F1.0491.00
258_A276_L1.0461.00
275_F302_M1.0391.00
292_L302_M1.0371.00
164_V183_A1.0351.00
202_E205_E1.0341.00
117_A122_V1.0311.00
215_Q226_F1.0281.00
254_L303_G1.0251.00
143_A244_M1.0231.00
202_E206_S1.0191.00
233_Y245_A1.0151.00
150_Y224_P1.0131.00
118_D241_G1.0111.00
162_I189_D1.0051.00
55_S59_K1.0021.00
193_Q229_N0.9981.00
263_G266_E0.9971.00
250_M256_V0.9961.00
167_V227_L0.9811.00
161_N189_D0.9791.00
165_S226_F0.9771.00
195_A218_V0.9751.00
177_D238_K0.9731.00
224_P228_N0.9641.00
208_T214_F0.9631.00
112_A115_V0.9621.00
186_I190_L0.9601.00
275_F292_L0.9591.00
125_M128_D0.9571.00
287_E291_Q0.9561.00
246_V258_A0.9561.00
147_V315_S0.9521.00
187_G294_E0.9491.00
144_G319_L0.9471.00
167_V195_A0.9311.00
250_M306_G0.9311.00
179_L236_P0.9251.00
296_P300_K0.9231.00
124_E128_D0.9211.00
174_K240_E0.9191.00
166_T194_I0.9161.00
86_K112_A0.9151.00
249_A254_L0.9141.00
302_M305_A0.9081.00
257_V277_C0.9071.00
183_A211_N0.9051.00
321_R325_K0.9031.00
273_T306_G0.9021.00
190_L293_S0.9011.00
262_G265_T0.8931.00
138_S326_A0.8921.00
174_K245_A0.8911.00
303_G307_R0.8911.00
218_V226_F0.8901.00
304_T308_K0.8901.00
177_D203_R0.8861.00
235_Q264_I0.8831.00
240_E243_C0.8831.00
191_Q211_N0.8791.00
186_I289_L0.8781.00
258_A268_V0.8771.00
178_D285_F0.8741.00
246_V256_V0.8731.00
300_K303_G0.8721.00
203_R207_K0.8711.00
275_F298_L0.8691.00
66_C88_L0.8671.00
215_Q218_V0.8621.00
182_C286_S0.8591.00
186_I293_S0.8581.00
255_P303_G0.8581.00
227_L254_L0.8551.00
146_D149_E0.8501.00
77_P81_L0.8441.00
55_S81_L0.8421.00
250_M309_R0.8411.00
315_S319_L0.8411.00
232_I292_L0.8381.00
246_V267_S0.8351.00
159_H162_I0.8331.00
174_K237_S0.8331.00
180_I208_T0.8321.00
261_V264_I0.8301.00
226_F229_N0.8271.00
127_V137_I0.8261.00
87_L116_L0.8241.00
171_A199_E0.8221.00
270_P273_T0.8211.00
166_T236_P0.8201.00
14_D36_E0.8201.00
203_R206_S0.8201.00
268_V276_L0.8191.00
181_R185_D0.8191.00
220_N224_P0.8161.00
250_M273_T0.8141.00
116_L140_L0.8131.00
121_A124_E0.8081.00
257_V288_R0.8071.00
234_F289_L0.8061.00
79_G86_K0.8031.00
278_R281_D0.8001.00
186_I286_S0.7951.00
138_S322_Q0.7941.00
168_G174_K0.7931.00
52_G56_K0.7921.00
316_Q320_A0.7821.00
260_D276_L0.7751.00
158_S191_Q0.7751.00
61_T84_V0.7741.00
140_L326_A0.7721.00
166_T192_F0.7711.00
181_R184_R0.7711.00
165_S227_L0.7711.00
225_Q229_N0.7701.00
182_C282_I0.7701.00
309_R314_Y0.7651.00
52_G55_S0.7631.00
153_S228_N0.7621.00
255_P292_L0.7611.00
225_Q228_N0.7591.00
118_D244_M0.7571.00
65_V323_F0.7541.00
166_T233_Y0.7541.00
232_I289_L0.7511.00
302_M306_G0.7511.00
172_N238_K0.7491.00
87_L114_R0.7491.00
48_L52_G0.7471.00
103_A106_R0.7441.00
103_A107_L0.7431.00
231_D299_R0.7421.00
167_V233_Y0.7421.00
172_N177_D0.7411.00
121_A125_M0.7381.00
287_E290_Q0.7381.00
323_F327_I0.7331.00
283_D287_E0.7321.00
259_S279_P0.7301.00
307_R310_V0.7271.00
141_P322_Q0.7261.00
242_L314_Y0.7261.00
85_P113_D0.7251.00
271_G291_Q0.7251.00
63_I327_I0.7241.00
270_P275_F0.7211.00
301_Q304_T0.7201.00
107_L111_A0.7191.00
259_S285_F0.7181.00
68_L71_A0.7171.00
146_D150_Y0.7171.00
265_T276_L0.7161.00
67_S89_V0.7121.00
247_I314_Y0.7081.00
164_V190_L0.7061.00
257_V292_L0.7051.00
79_G82_L0.7051.00
168_G176_Y0.7051.00
91_Q118_D0.7031.00
51_L55_S0.6981.00
140_L143_A0.6901.00
140_L323_F0.6901.00
320_A324_R0.6891.00
184_R209_P0.6881.00
291_Q294_E0.6871.00
177_D200_E0.6861.00
243_C246_V0.6851.00
63_I87_L0.6721.00
87_L327_I0.6701.00
66_C72_T0.6691.00
273_T305_A0.6671.00
283_D286_S0.6661.00
89_V323_F0.6661.00
99_Q103_A0.6661.00
325_K328_D0.6651.00
297_A301_Q0.6641.00
169_R174_K0.6641.00
295_N299_R0.6621.00
198_G201_R0.6561.00
235_Q243_C0.6551.00
204_L208_T0.6551.00
147_V251_A0.6541.00
250_M303_G0.6531.00
121_A265_T0.6521.00
164_V293_S0.6521.00
49_L53_E0.6501.00
123_M134_D0.6481.00
292_L299_R0.6481.00
162_I296_P0.6481.00
183_A186_I0.6471.00
234_F285_F0.6461.00
187_G190_L0.6461.00
127_V131_G0.6441.00
321_R324_R0.6431.00
61_T64_L0.6401.00
106_R110_R0.6401.00
165_S233_Y0.6401.00
205_E208_T0.6381.00
90_W122_V0.6371.00
196_G216_G0.6351.00
188_D290_Q0.6331.00
237_S245_A0.6331.00
180_I212_V0.6311.00
64_L84_V0.6291.00
162_I165_S0.6291.00
306_G309_R0.6281.00
140_L322_Q0.6281.00
122_V125_M0.6271.00
268_V273_T0.6261.00
99_Q102_S0.6241.00
189_D211_N0.6241.00
170_L201_R0.6231.00
204_L207_K0.6221.00
182_C289_L0.6211.00
245_A249_A0.6211.00
170_L176_Y0.6201.00
226_F230_S0.6201.00
237_S241_G0.6191.00
208_T212_V0.6181.00
86_K113_D0.6171.00
178_D182_C0.6171.00
151_Q228_N0.6141.00
80_L111_A0.6121.00
66_C75_G0.6101.00
175_G280_R0.6101.00
227_L245_A0.6041.00
119_S122_V0.6021.00
165_S254_L0.6001.00
47_A50_Q0.5981.00
200_E204_L0.5981.00
54_I57_I0.5981.00
233_Y256_V0.5951.00
188_D294_E0.5941.00
182_C234_F0.5921.00
197_E217_M0.5911.00
297_A300_K0.5891.00
313_E318_A0.5891.00
277_C284_C0.5881.00
151_Q154_K0.5871.00
232_I257_V0.5851.00
304_T307_R0.5841.00
95_S98_N0.5831.00
165_S193_Q0.5831.00
169_R245_A0.5801.00
243_C247_I0.5801.00
100_I103_A0.5791.00
172_N200_E0.5771.00
53_E56_K0.5771.00
236_P259_S0.5761.00
127_V130_V0.5761.00
117_A139_T0.5751.00
162_I299_R0.5751.00
179_L183_A0.5751.00
19_A37_V0.5731.00
317_K321_R0.5731.00
175_G259_S0.5731.00
305_A309_R0.5721.00
205_E214_F0.5711.00
182_C186_I0.5691.00
187_G211_N0.5671.00
195_A223_I0.5671.00
175_G236_P0.5661.00
163_T226_F0.5651.00
64_L79_G0.5621.00
247_I310_V0.5621.00
232_I299_R0.5591.00
121_A266_E0.5591.00
299_R302_M0.5571.00
261_V265_T0.5561.00
249_A256_V0.5551.00
257_V289_L0.5541.00
91_Q143_A0.5541.00
176_Y200_E0.5531.00
250_M310_V0.5531.00
122_V241_G0.5501.00
107_L110_R0.5491.00
53_E58_V0.5471.00
148_K151_Q0.5461.00
255_P299_R0.5391.00
231_D296_P0.5381.00
160_E189_D0.5371.00
31_L34_H0.5361.00
237_S243_C0.5351.00
192_F212_V0.5321.00
89_V327_I0.5311.00
89_V116_L0.5301.00
118_D243_C0.5291.00
75_G79_G0.5271.00
30_M39_H0.5271.00
53_E57_I0.5261.00
161_N229_N0.5261.00
177_D204_L0.5251.00
227_L233_Y0.5251.00
220_N226_F0.5221.00
218_V223_I0.5221.00
94_T97_S0.5211.00
247_I267_S0.5151.00
261_V279_P0.5151.00
50_Q53_E0.5141.00
244_M248_E0.5131.00
160_E163_T0.5131.00
188_D211_N0.5091.00
104_Y107_L0.5081.00
147_V310_V0.5071.00
39_H42_M0.5071.00
219_P223_I0.5061.00
149_E220_N0.5051.00
184_R207_K0.5041.00
260_D279_P0.5031.00
227_L249_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r60A 1 0.994 100 0.171 Contact Map
4n9wA 1 0.9399 100 0.181 Contact Map
3c48A 2 0.982 100 0.195 Contact Map
1rzuA 1 0.985 100 0.2 Contact Map
3froA 3 0.988 100 0.203 Contact Map
2qzsA 1 0.976 100 0.205 Contact Map
2x0dA 2 0.9279 100 0.22 Contact Map
3okpA 1 0.979 100 0.226 Contact Map
2x6qA 1 0.961 100 0.226 Contact Map
2jjmA 4 0.9489 100 0.226 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0107 seconds.