GREMLIN Database
Q9HSV3 - Uncharacterized protein
UniProt: Q9HSV3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 451 (379)
Sequences: 10605 (8170)
Seq/√Len: 419.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
325_D339_S4.8511.00
258_P262_R4.7291.00
174_D256_S3.8441.00
30_R301_S3.7451.00
373_N390_D3.7001.00
166_I186_P3.1231.00
255_D259_E3.1161.00
23_N251_G3.0671.00
373_N388_D3.0281.00
8_V11_L2.9281.00
256_S260_P2.8811.00
59_A336_D2.7731.00
388_D391_T2.7041.00
199_Y248_D2.6541.00
375_K395_E2.6391.00
408_A411_A2.6371.00
37_C314_A2.5711.00
17_T25_S2.4771.00
170_V256_S2.4711.00
197_D201_E2.4571.00
256_S259_E2.3221.00
167_D252_R2.2911.00
168_S171_D2.2711.00
371_S411_A2.2571.00
35_E311_N2.2341.00
33_E310_V2.1791.00
174_D260_P2.1491.00
352_Y415_S2.1451.00
82_E329_I2.1351.00
169_L182_A2.1021.00
3_V327_V2.0961.00
80_R106_T2.0921.00
202_Q244_S2.0881.00
203_F244_S2.0651.00
371_S415_S2.0521.00
326_A341_L2.0461.00
314_A340_V2.0231.00
324_L329_I2.0031.00
398_E402_L1.9911.00
4_L267_L1.9911.00
254_L267_L1.9881.00
262_R301_S1.9721.00
254_L262_R1.9411.00
6_V250_I1.9381.00
11_L269_F1.9301.00
3_V79_L1.8931.00
402_L409_Y1.8671.00
325_D341_L1.8401.00
55_Q72_R1.8321.00
8_V269_F1.8281.00
376_L384_E1.8151.00
75_L181_F1.7851.00
171_D175_E1.7641.00
266_L300_I1.7631.00
85_E178_D1.7581.00
321_P337_G1.7551.00
89_F182_A1.7541.00
7_T270_T1.7491.00
85_E176_R1.7241.00
184_L253_L1.6971.00
384_E413_T1.6931.00
266_L326_A1.6801.00
268_V323_I1.6641.00
24_V269_F1.6471.00
31_S299_A1.6381.00
399_Q405_A1.6331.00
170_V252_R1.6321.00
26_G258_P1.6271.00
26_G30_R1.6241.00
36_R370_R1.6211.00
268_V300_I1.6181.00
249_Q252_R1.6091.00
290_W385_L1.6011.00
23_N26_G1.6001.00
87_A172_W1.5941.00
27_F250_I1.5731.00
47_S316_L1.5661.00
27_F299_A1.5651.00
169_L184_L1.5621.00
88_G183_W1.5601.00
32_I309_T1.5581.00
73_P81_D1.5491.00
8_V246_L1.5481.00
186_P249_Q1.5421.00
4_L180_W1.5231.00
21_M25_S1.5211.00
38_Y294_I1.4941.00
20_L244_S1.4841.00
341_L344_E1.4841.00
409_Y413_T1.4761.00
405_A408_A1.4671.00
5_Y268_V1.4611.00
385_L398_E1.4581.00
166_I253_L1.4581.00
319_I323_I1.4491.00
166_I170_V1.4461.00
77_E103_R1.4451.00
198_D248_D1.4041.00
32_I305_F1.4001.00
174_D259_E1.3991.00
376_L413_T1.3831.00
87_A182_A1.3801.00
302_A305_F1.3771.00
78_V320_P1.3771.00
266_L302_A1.3581.00
35_E310_V1.3491.00
166_I249_Q1.3471.00
107_T175_E1.3441.00
262_R267_L1.3381.00
402_L406_P1.3321.00
163_E249_Q1.3071.00
4_L257_F1.3071.00
374_W408_A1.3061.00
320_P335_W1.3011.00
34_Y298_C1.2971.00
140_R168_S1.2931.00
172_W176_R1.2811.00
11_L243_C1.2811.00
352_Y371_S1.2741.00
37_C298_C1.2631.00
403_N406_P1.2611.00
189_T243_C1.2591.00
415_S418_N1.2341.00
291_E370_R1.2321.00
56_Y317_I1.2101.00
39_A47_S1.1981.00
23_N255_D1.1921.00
27_F301_S1.1901.00
374_W405_A1.1891.00
160_T245_Y1.1881.00
39_A296_V1.1881.00
5_Y270_T1.1771.00
20_L203_F1.1761.00
196_P199_Y1.1741.00
11_L189_T1.1701.00
369_R415_S1.1601.00
78_V324_L1.1531.00
199_Y244_S1.1531.00
374_W386_L1.1491.00
7_T51_L1.1471.00
414_D418_N1.1471.00
186_P246_L1.1441.00
27_F31_S1.1391.00
165_L184_L1.1391.00
302_A326_A1.1371.00
200_Q241_A1.1341.00
402_L405_A1.1201.00
375_K389_L1.1181.00
163_E245_Y1.1181.00
17_T21_M1.1151.00
411_A415_S1.1141.00
6_V253_L1.1131.00
162_A188_D1.0971.00
371_S412_L1.0961.00
45_P62_G1.0911.00
201_E204_L1.0901.00
406_P410_R1.0881.00
161_R165_L1.0821.00
58_G356_D1.0751.00
419_H422_E1.0751.00
410_R414_D1.0711.00
13_A295_H1.0711.00
291_E295_H1.0691.00
205_D237_Q1.0661.00
257_F267_L1.0641.00
4_L265_T1.0611.00
5_Y181_F1.0571.00
28_V33_E1.0571.00
40_N315_A1.0571.00
376_L412_L1.0541.00
170_V174_D1.0401.00
257_F262_R1.0361.00
298_C319_I1.0291.00
79_L323_I1.0281.00
250_I254_L1.0281.00
30_R262_R1.0271.00
291_E375_K1.0261.00
26_G255_D1.0141.00
4_L182_A1.0121.00
376_L409_Y1.0051.00
410_R413_T1.0041.00
119_R122_Q1.0021.00
355_V368_V0.9991.00
73_P78_V0.9961.00
374_W399_Q0.9941.00
338_M349_E0.9921.00
196_P245_Y0.9881.00
87_A107_T0.9871.00
44_T48_F0.9861.00
244_S248_D0.9811.00
38_Y291_E0.9801.00
50_A60_N0.9771.00
300_I305_F0.9741.00
197_D200_Q0.9701.00
25_S29_D0.9681.00
89_F107_T0.9591.00
20_L206_E0.9581.00
384_E409_Y0.9521.00
19_E240_K0.9521.00
121_K124_V0.9511.00
88_G185_H0.9491.00
204_L237_Q0.9481.00
73_P77_E0.9441.00
370_R373_N0.9431.00
369_R376_L0.9361.00
3_V323_I0.9281.00
2_N180_W0.9271.00
386_L409_Y0.9271.00
20_L202_Q0.9261.00
120_L123_A0.9261.00
200_Q238_L0.9251.00
50_A57_S0.9221.00
245_Y249_Q0.9211.00
386_L408_A0.9201.00
373_N408_A0.9181.00
26_G254_L0.9161.00
79_L329_I0.9141.00
252_R255_D0.9121.00
343_D349_E0.9121.00
78_V81_D0.9101.00
283_G286_P0.9091.00
166_I252_R0.9081.00
30_R258_P0.9081.00
315_A353_V0.9081.00
109_F168_S0.9051.00
254_L301_S0.9011.00
3_V266_L0.9001.00
50_A317_I0.9001.00
24_V299_A0.8971.00
79_L327_V0.8951.00
24_V250_I0.8941.00
201_E241_A0.8941.00
11_L16_V0.8941.00
413_T417_D0.8931.00
415_S419_H0.8911.00
5_Y51_L0.8891.00
306_E309_T0.8871.00
313_Q353_V0.8831.00
26_G29_D0.8801.00
78_V82_E0.8761.00
271_A296_V0.8751.00
383_G398_E0.8721.00
10_A275_E0.8671.00
37_C316_L0.8581.00
294_I355_V0.8581.00
84_Y327_V0.8581.00
34_Y343_D0.8581.00
120_L124_V0.8571.00
246_L269_F0.8561.00
75_L320_P0.8551.00
21_M24_V0.8541.00
258_P301_S0.8541.00
374_W388_D0.8531.00
10_A286_P0.8531.00
7_T185_H0.8491.00
38_Y370_R0.8481.00
10_A273_H0.8471.00
173_I176_R0.8451.00
408_A412_L0.8451.00
97_S102_D0.8411.00
248_D252_R0.8391.00
173_I253_L0.8391.00
342_P346_T0.8371.00
171_D174_D0.8361.00
55_Q59_A0.8331.00
339_S342_P0.8311.00
289_F368_V0.8311.00
356_D359_S0.8271.00
36_R295_H0.8271.00
180_W265_T0.8221.00
55_Q60_N0.8211.00
199_Y245_Y0.8181.00
27_F254_L0.8161.00
275_E278_G0.8141.00
399_Q402_L0.8071.00
320_P324_L0.8051.00
202_Q248_D0.8031.00
79_L181_F0.8021.00
31_S301_S0.8021.00
24_V27_F0.7981.00
21_M243_C0.7971.00
255_D258_P0.7971.00
49_P62_G0.7971.00
406_P409_Y0.7961.00
28_V299_A0.7941.00
5_Y323_I0.7921.00
85_E172_W0.7921.00
122_Q125_R0.7891.00
195_A241_A0.7851.00
52_L183_W0.7841.00
39_A316_L0.7841.00
92_N95_A0.7831.00
40_N50_A0.7821.00
298_C314_A0.7791.00
198_D201_E0.7781.00
254_L258_P0.7781.00
195_A200_Q0.7771.00
289_F377_M0.7761.00
49_P60_N0.7751.00
237_Q241_A0.7721.00
266_L323_I0.7711.00
371_S408_A0.7711.00
5_Y319_I0.7701.00
3_V326_A0.7671.00
6_V267_L0.7631.00
167_D170_V0.7621.00
386_L412_L0.7621.00
15_H239_Y0.7611.00
32_I307_A0.7611.00
369_R416_L0.7591.00
389_L395_E0.7581.00
55_Q334_Y0.7561.00
164_T168_S0.7541.00
253_L256_S0.7521.00
321_P335_W0.7511.00
233_E237_Q0.7501.00
283_G290_W0.7501.00
176_R260_P0.7501.00
19_E244_S0.7461.00
156_D159_F0.7451.00
228_S231_E0.7441.00
76_A79_L0.7431.00
312_E343_D0.7431.00
2_N265_T0.7421.00
159_F164_T0.7391.00
348_Q351_E0.7381.00
78_V329_I0.7371.00
405_A409_Y0.7341.00
173_I256_S0.7321.00
160_T163_E0.7301.00
89_F172_W0.7291.00
119_R123_A0.7261.00
167_D171_D0.7241.00
121_K126_K0.7231.00
56_Y315_A0.7231.00
16_V24_V0.7221.00
76_A80_R0.7211.00
121_K125_R0.7211.00
170_V253_L0.7191.00
399_Q408_A0.7181.00
30_R307_A0.7161.00
286_P293_V0.7151.00
257_F260_P0.7141.00
162_A249_Q0.7131.00
169_L173_I0.7131.00
324_L331_A0.7131.00
85_E106_T0.7111.00
234_L237_Q0.7101.00
414_D417_D0.7091.00
159_F167_D0.7091.00
368_V375_K0.7051.00
198_D202_Q0.7051.00
368_V377_M0.7041.00
369_R419_H0.7031.00
42_P289_F0.7001.00
163_E196_P0.6961.00
108_M111_A0.6961.00
40_N316_L0.6961.00
391_T397_P0.6911.00
399_Q404_D0.6911.00
313_Q350_R0.6871.00
195_A238_L0.6861.00
44_T91_D0.6861.00
418_N422_E0.6831.00
74_T77_E0.6811.00
246_L250_I0.6811.00
338_M350_R0.6811.00
162_A186_P0.6801.00
33_E309_T0.6801.00
163_E198_D0.6791.00
188_D246_L0.6781.00
138_L142_H0.6771.00
52_L105_M0.6751.00
75_L79_L0.6751.00
16_V21_M0.6741.00
170_V249_Q0.6741.00
7_T183_W0.6721.00
352_Y369_R0.6711.00
386_L399_Q0.6711.00
267_L301_S0.6691.00
138_L141_G0.6670.99
276_M280_H0.6660.99
122_Q126_K0.6640.99
16_V25_S0.6640.99
52_L76_A0.6640.99
312_E349_E0.6630.99
365_H369_R0.6600.99
78_V332_P0.6580.99
88_G92_N0.6570.99
141_G144_L0.6570.99
189_T239_Y0.6560.99
239_Y243_C0.6550.99
173_I182_A0.6530.99
40_N56_Y0.6520.99
355_V370_R0.6490.99
4_L253_L0.6490.99
354_F369_R0.6480.99
204_L207_P0.6480.99
139_L144_L0.6470.99
105_M183_W0.6470.99
278_G281_G0.6460.99
52_L94_F0.6450.99
166_I184_L0.6450.99
325_D342_P0.6450.99
68_E74_T0.6440.99
352_Y355_V0.6390.99
33_E299_A0.6390.99
81_D86_T0.6380.99
107_T141_G0.6380.99
186_P250_I0.6370.99
300_I340_V0.6330.99
332_P335_W0.6330.99
295_H393_P0.6310.99
251_G255_D0.6300.99
166_I169_L0.6300.99
270_T316_L0.6280.99
354_F419_H0.6270.99
18_P240_K0.6260.99
199_Y202_Q0.6260.99
34_Y300_I0.6250.99
89_F169_L0.6250.99
323_I327_V0.6240.99
140_R144_L0.6240.99
80_R86_T0.6220.99
340_V349_E0.6190.99
7_T316_L0.6180.99
170_V260_P0.6170.99
417_D421_D0.6160.99
291_E389_L0.6140.99
397_P404_D0.6140.99
6_V184_L0.6130.99
51_L319_I0.6130.99
11_L15_H0.6110.99
63_V66_P0.6090.99
53_G72_R0.6090.99
188_D242_E0.6080.99
89_F165_L0.6030.99
277_H280_H0.6020.99
84_Y179_Q0.6010.99
163_E167_D0.5990.99
294_I368_V0.5990.99
284_G288_Q0.5980.99
369_R412_L0.5970.99
163_E252_R0.5960.99
77_E81_D0.5950.99
17_T20_L0.5940.99
289_F366_A0.5930.99
367_G416_L0.5910.99
37_C296_V0.5910.99
99_Y102_D0.5900.99
195_A242_E0.5900.99
100_N105_M0.5890.99
349_E352_Y0.5890.99
404_D407_E0.5890.99
180_W257_F0.5870.99
229_D233_E0.5870.99
257_F261_E0.5860.99
111_A114_T0.5860.99
162_A245_Y0.5850.99
137_M141_G0.5850.99
338_M343_D0.5850.99
107_T140_R0.5840.99
162_A166_I0.5840.99
34_Y314_A0.5840.99
48_F91_D0.5830.99
206_E237_Q0.5810.99
88_G108_M0.5800.99
270_T298_C0.5800.99
19_E203_F0.5790.99
273_H296_V0.5780.99
409_Y416_L0.5770.99
76_A88_G0.5770.99
15_H240_K0.5770.99
198_D245_Y0.5760.99
280_H292_E0.5760.99
378_R384_E0.5760.99
4_L184_L0.5760.99
45_P93_H0.5750.99
75_L323_I0.5720.98
123_A126_K0.5720.98
8_V24_V0.5700.98
19_E189_T0.5700.98
199_Y241_A0.5680.98
77_E80_R0.5680.98
23_N254_L0.5670.98
105_M109_F0.5660.98
88_G110_D0.5650.98
386_L398_E0.5640.98
16_V33_E0.5640.98
100_N104_G0.5640.98
4_L173_I0.5630.98
397_P402_L0.5630.98
40_N317_I0.5620.98
19_E243_C0.5620.98
226_E229_D0.5600.98
282_L393_P0.5600.98
392_N397_P0.5570.98
275_E280_H0.5560.98
27_F269_F0.5560.98
10_A91_D0.5560.98
60_N72_R0.5560.98
417_D420_L0.5550.98
27_F267_L0.5550.98
120_L125_R0.5550.98
155_R158_R0.5540.98
238_L242_E0.5540.98
302_A307_A0.5530.98
136_Q139_L0.5480.98
409_Y412_L0.5470.98
7_T47_S0.5470.98
330_D334_Y0.5460.98
296_V316_L0.5450.98
262_R303_P0.5450.98
204_L234_L0.5450.98
137_M144_L0.5440.98
322_T340_V0.5420.98
270_T296_V0.5400.98
250_I269_F0.5400.98
40_N57_S0.5390.98
155_R159_F0.5390.98
100_N108_M0.5380.98
109_F164_T0.5380.98
408_A415_S0.5340.98
350_R353_V0.5320.98
202_Q241_A0.5320.98
326_A344_E0.5310.98
160_T242_E0.5300.97
43_G357_V0.5300.97
313_Q370_R0.5290.97
41_G57_S0.5290.97
263_E304_G0.5270.97
100_N103_R0.5260.97
173_I260_P0.5250.97
318_D337_G0.5250.97
10_A293_V0.5240.97
153_Q156_D0.5240.97
76_A105_M0.5230.97
398_E403_N0.5220.97
203_F240_K0.5220.97
3_V181_F0.5210.97
37_C270_T0.5200.97
29_D308_T0.5190.97
16_V299_A0.5190.97
180_W260_P0.5180.97
167_D249_Q0.5170.97
26_G262_R0.5160.97
45_P65_I0.5150.97
43_G46_W0.5140.97
301_S304_G0.5140.97
164_T167_D0.5120.97
193_Y275_E0.5120.97
199_Y203_F0.5120.97
30_R254_L0.5110.97
110_D114_T0.5100.97
112_G116_S0.5100.97
36_R311_N0.5100.97
268_V319_I0.5100.97
44_T90_T0.5090.97
104_G108_M0.5090.97
82_E324_L0.5090.97
367_G378_R0.5060.97
98_D102_D0.5040.97
85_E107_T0.5040.97
279_E292_E0.5030.97
237_Q240_K0.5030.97
101_Y108_M0.5020.97
82_E330_D0.5020.97
8_V189_T0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uplA 2 0.9933 100 0.241 Contact Map
4upiA 2 0.9911 100 0.242 Contact Map
2vqrA 3 0.9778 100 0.246 Contact Map
4uphA 2 0.9756 100 0.249 Contact Map
4upkA 3 0.9778 100 0.254 Contact Map
2qzuA 2 0.8936 100 0.272 Contact Map
3b5qA 1 0.9091 100 0.275 Contact Map
1hdhA 1 0.9091 100 0.278 Contact Map
1aukA 3 0.9069 100 0.285 Contact Map
1p49A 3 0.8736 100 0.291 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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