Q9HSV1 - HALSA - GREMLIN Contacts

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Q9HSV1 - UDP-glucose 4-epimerase

UniProt:	Q9HSV1	Sequences: MRILVTGGAGFIGGHLAERFVSRGHDVVVLDNFDPFYDTRIKDHTVEVCQNLADDGDGSYRLVEGDVRDAELVEELVADVDYVYHQAGQAGVRPSVEDPRKYNEVNVDGTLNVLDAARKTEIERVVFASSSSVYGKPEYLPYDEVHPTTPVSPYGASKLAAERYVCAYSEVYDLPTVALRYFTVYGPRMRPNMAISNFVSRCLNGEPPVVYGDGTQTRDFTYIEDVVDANEALLTDDAADGEVLNIGSTDNIDILTLAEEIRDQVAPELDIEFAERFEADAEHTHADISKANELLGYEPSRTIREGVQEFVEWYRANRDWYEPLVLES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	328 (293)
Sequences:	58020 (40692)
Seq/√Len:	2377.2

ECOLI - GALE RMLB1 RMLB2 GM4D YBJS FCL HLDD YFCH RMLD YEEZ QOR2 YBJT ARNA YRAR
BACSU - GALE YTCB YFNG RMLB YFHF SPSK YTBQ YWNB YHFK YESF YHEG EPSC
HALSA - Q9HSV1 Q9HSU9 Q9HRD1 Q9HSE7 Q9HML4 Q9HS50 Q9HNV3 Q9HSQ3 Q9HPF1 Q9HR86
SULSO - Q97VN5 Q980W1 Q7LXG5 Q7LXE8 Q97XJ9 Q97XG1 Q97UM3 Q7LX44 Q7LXE6 Q97XF9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
8_G	29_V	3.047	1.00
260_E	304_R	2.960	1.00
19_R	228_D	2.707	1.00
229_A	246_I	2.615	1.00
244_L	294_L	2.551	1.00
104_E	108_D	2.503	1.00
242_E	290_K	2.499	1.00
74_E	119_K	2.408	1.00
82_Y	234_L	2.395	1.00
128_A	230_N	2.305	1.00
98_D	101_K	2.255	1.00
289_S	293_E	2.191	1.00
19_R	231_E	2.190	1.00
264_Q	308_Q	2.181	1.00
30_L	65_G	2.129	1.00
124_R	175_P	2.115	1.00
19_R	23_R	2.114	1.00
263_D	304_R	2.094	1.00
228_D	300_S	2.050	1.00
302_T	305_E	2.042	1.00
85_H	127_F	2.025	1.00
84_Y	234_L	2.003	1.00
255_L	259_E	1.946	1.00
69_D	72_L	1.933	1.00
6_T	85_H	1.926	1.00
143_D	146_H	1.915	1.00
181_Y	230_N	1.892	1.00
28_V	80_V	1.885	1.00
28_V	61_R	1.871	1.00
260_E	263_D	1.857	1.00
4_L	80_V	1.847	1.00
292_N	298_E	1.846	1.00
253_D	256_T	1.844	1.00
65_G	72_L	1.834	1.00
224_E	309_E	1.833	1.00
228_D	232_A	1.832	1.00
179_L	233_L	1.812	1.00
185_Y	306_G	1.802	1.00
165_V	176_T	1.773	1.00
5_V	17_A	1.771	1.00
28_V	63_V	1.753	1.00
23_R	235_T	1.732	1.00
111_L	164_Y	1.730	1.00
23_R	231_E	1.722	1.00
200_S	204_N	1.718	1.00
16_L	227_V	1.677	1.00
16_L	84_Y	1.621	1.00
207_P	272_E	1.614	1.00
68_R	104_E	1.611	1.00
74_E	116_A	1.610	1.00
26_D	61_R	1.591	1.00
111_L	115_D	1.571	1.00
231_E	235_T	1.563	1.00
159_L	163_R	1.558	1.00
222_Y	309_E	1.552	1.00
108_D	111_L	1.552	1.00
70_A	115_D	1.549	1.00
16_L	86_Q	1.535	1.00
110_T	161_A	1.508	1.00
19_R	22_S	1.506	1.00
118_R	172_Y	1.501	1.00
288_I	292_N	1.485	1.00
103_N	160_A	1.482	1.00
249_T	292_N	1.475	1.00
260_E	264_Q	1.469	1.00
181_Y	226_V	1.458	1.00
33_F	62_L	1.456	1.00
19_R	227_V	1.448	1.00
291_A	295_L	1.447	1.00
308_Q	312_E	1.440	1.00
72_L	75_E	1.435	1.00
81_D	123_E	1.425	1.00
144_E	290_K	1.421	1.00
100_R	104_E	1.410	1.00
70_A	74_E	1.408	1.00
129_S	133_V	1.402	1.00
124_R	177_V	1.401	1.00
74_E	120_T	1.398	1.00
12_I	184_V	1.384	1.00
209_V	272_E	1.364	1.00
86_Q	128_A	1.350	1.00
83_V	117_A	1.348	1.00
179_L	230_N	1.339	1.00
84_Y	230_N	1.333	1.00
242_E	294_L	1.332	1.00
217_T	251_N	1.331	1.00
255_L	273_F	1.329	1.00
222_Y	306_G	1.321	1.00
25_H	235_T	1.321	1.00
128_A	181_Y	1.319	1.00
154_Y	158_K	1.311	1.00
148_T	159_L	1.310	1.00
301_R	309_E	1.304	1.00
8_G	17_A	1.302	1.00
221_T	226_V	1.301	1.00
3_I	25_H	1.298	1.00
17_A	29_V	1.286	1.00
201_R	206_E	1.281	1.00
182_F	286_A	1.278	1.00
256_T	259_E	1.270	1.00
18_E	188_R	1.267	1.00
163_R	166_C	1.267	1.00
70_A	112_N	1.266	1.00
166_C	178_A	1.257	1.00
134_Y	245_N	1.257	1.00
223_I	227_V	1.250	1.00
85_H	110_T	1.230	1.00
127_F	161_A	1.221	1.00
115_D	118_R	1.211	1.00
305_E	308_Q	1.207	1.00
78_A	120_T	1.201	1.00
106_N	157_S	1.189	1.00
305_E	309_E	1.185	1.00
290_K	294_L	1.180	1.00
114_L	168_Y	1.176	1.00
139_Y	143_D	1.175	1.00
67_V	109_G	1.171	1.00
229_A	291_A	1.163	1.00
143_D	287_D	1.162	1.00
115_D	119_K	1.158	1.00
19_R	224_E	1.151	1.00
169_S	176_T	1.151	1.00
77_V	80_V	1.140	1.00
139_Y	146_H	1.138	1.00
180_R	243_V	1.134	1.00
4_L	30_L	1.125	1.00
15_H	224_E	1.124	1.00
20_F	231_E	1.117	1.00
156_A	160_A	1.115	1.00
113_V	125_V	1.111	1.00
215_T	255_L	1.107	1.00
164_Y	167_A	1.107	1.00
142_Y	146_H	1.095	1.00
215_T	253_D	1.093	1.00
262_R	268_E	1.087	1.00
18_E	22_S	1.087	1.00
117_A	125_V	1.085	1.00
29_V	60_Y	1.084	1.00
166_C	243_V	1.081	1.00
67_V	87_A	1.075	1.00
127_F	178_A	1.065	1.00
259_E	262_R	1.064	1.00
9_A	31_D	1.062	1.00
232_A	236_D	1.059	1.00
75_E	78_A	1.059	1.00
288_I	299_P	1.055	1.00
252_I	303_I	1.054	1.00
126_V	179_L	1.044	1.00
114_L	125_V	1.043	1.00
74_E	78_A	1.042	1.00
207_P	270_D	1.040	1.00
3_I	20_F	1.034	1.00
21_V	60_Y	1.029	1.00
94_P	98_D	1.027	1.00
145_V	290_K	1.026	1.00
127_F	165_V	1.024	1.00
304_R	308_Q	1.019	1.00
247_G	286_A	1.015	1.00
15_H	223_I	1.005	1.00
11_F	186_G	1.001	1.00
21_V	59_S	0.997	1.00
116_A	120_T	0.993	1.00
228_D	297_Y	0.990	1.00
175_P	240_D	0.989	1.00
89_Q	105_V	0.987	1.00
77_V	83_V	0.985	1.00
222_Y	301_R	0.983	1.00
265_V	311_V	0.980	1.00
86_Q	230_N	0.980	1.00
166_C	176_T	0.974	1.00
251_N	285_H	0.973	1.00
14_G	188_R	0.973	1.00
73_V	116_A	0.972	1.00
167_A	171_V	0.968	1.00
162_E	180_R	0.966	1.00
251_N	283_H	0.965	1.00
33_F	36_F	0.965	1.00
125_V	165_V	0.963	1.00
290_K	293_E	0.960	1.00
180_R	245_N	0.960	1.00
219_D	249_T	0.960	1.00
177_V	233_L	0.955	1.00
232_A	295_L	0.954	1.00
108_D	112_N	0.954	1.00
166_C	170_E	0.951	1.00
105_V	109_G	0.951	1.00
112_N	115_D	0.948	1.00
264_Q	311_V	0.944	1.00
184_V	226_V	0.943	1.00
197_N	201_R	0.942	1.00
70_A	119_K	0.936	1.00
228_D	301_R	0.932	1.00
252_I	256_T	0.927	1.00
63_V	76_L	0.927	1.00
116_A	119_K	0.926	1.00
244_L	290_K	0.925	1.00
232_A	235_T	0.920	1.00
217_T	283_H	0.915	1.00
11_F	223_I	0.909	1.00
264_Q	304_R	0.909	1.00
3_I	82_Y	0.907	1.00
71_E	74_E	0.902	1.00
193_M	196_S	0.897	1.00
15_H	18_E	0.896	1.00
16_L	20_F	0.895	1.00
30_L	73_V	0.893	1.00
103_N	108_D	0.892	1.00
71_E	75_E	0.892	1.00
200_S	203_L	0.892	1.00
225_D	248_S	0.891	1.00
114_L	165_V	0.891	1.00
179_L	246_I	0.889	1.00
56_G	60_Y	0.887	1.00
103_N	107_V	0.887	1.00
6_T	113_V	0.884	1.00
197_N	200_S	0.883	1.00
229_A	297_Y	0.882	1.00
309_E	312_E	0.882	1.00
222_Y	225_D	0.881	1.00
117_A	122_I	0.880	1.00
217_T	253_D	0.880	1.00
224_E	301_R	0.879	1.00
107_V	160_A	0.879	1.00
194_A	198_F	0.876	1.00
289_S	292_N	0.869	1.00
118_R	174_L	0.864	1.00
129_S	162_E	0.863	1.00
178_A	243_V	0.861	1.00
33_F	64_E	0.860	1.00
34_D	64_E	0.859	1.00
77_V	116_A	0.859	1.00
247_G	288_I	0.858	1.00
72_L	76_L	0.858	1.00
184_V	221_T	0.854	1.00
185_Y	222_Y	0.852	1.00
30_L	72_L	0.850	1.00
31_D	62_L	0.839	1.00
77_V	120_T	0.831	1.00
82_Y	124_R	0.831	1.00
123_E	175_P	0.830	1.00
15_H	19_R	0.828	1.00
140_L	146_H	0.818	1.00
83_V	113_V	0.817	1.00
21_V	27_V	0.814	1.00
209_V	274_A	0.813	1.00
25_H	81_D	0.809	1.00
112_N	116_A	0.806	1.00
28_V	79_D	0.806	1.00
32_N	66_D	0.805	1.00
110_T	165_V	0.805	1.00
228_D	231_E	0.803	1.00
262_R	267_P	0.803	1.00
114_L	164_Y	0.801	1.00
214_G	255_L	0.800	1.00
6_T	87_A	0.798	1.00
301_R	305_E	0.796	1.00
102_Y	157_S	0.791	1.00
160_A	163_R	0.791	1.00
30_L	76_L	0.791	1.00
17_A	27_V	0.790	1.00
168_Y	172_Y	0.784	1.00
271_I	274_A	0.781	1.00
68_R	105_V	0.774	1.00
239_A	242_E	0.773	1.00
137_P	140_L	0.772	1.00
256_T	260_E	0.770	1.00
233_L	295_L	0.767	1.00
233_L	291_A	0.765	1.00
264_Q	307_V	0.765	1.00
3_I	84_Y	0.764	1.00
131_S	182_F	0.763	1.00
101_K	104_E	0.763	1.00
163_R	167_A	0.761	1.00
187_P	309_E	0.755	1.00
264_Q	312_E	0.755	1.00
232_A	297_Y	0.744	1.00
85_H	113_V	0.739	1.00
16_L	230_N	0.738	1.00
12_I	226_V	0.736	1.00
249_T	288_I	0.736	1.00
69_D	73_V	0.735	1.00
3_I	234_L	0.729	1.00
199_V	203_L	0.729	1.00
89_Q	101_K	0.729	1.00
15_H	227_V	0.725	1.00
118_R	173_D	0.721	1.00
99_P	156_A	0.718	1.00
250_D	302_T	0.716	1.00
131_S	286_A	0.716	1.00
193_M	197_N	0.713	1.00
259_E	263_D	0.709	1.00
101_K	105_V	0.707	1.00
77_V	117_A	0.706	1.00
138_E	146_H	0.703	1.00
110_T	114_L	0.703	1.00
202_C	262_R	0.700	1.00
150_P	155_G	0.700	1.00
260_E	303_I	0.699	1.00
95_S	102_Y	0.698	1.00
141_P	287_D	0.694	1.00
160_A	164_Y	0.693	1.00
89_Q	102_Y	0.693	1.00
115_D	168_Y	0.692	1.00
20_F	234_L	0.690	1.00
236_D	239_A	0.688	1.00
152_S	155_G	0.688	1.00
227_V	231_E	0.687	1.00
239_A	294_L	0.687	1.00
24_G	59_S	0.685	1.00
133_V	162_E	0.684	1.00
118_R	168_Y	0.681	1.00
23_R	228_D	0.677	1.00
252_I	257_L	0.675	1.00
103_N	157_S	0.675	1.00
133_V	148_T	0.673	1.00
262_R	269_L	0.671	1.00
96_V	153_P	0.671	1.00
14_G	18_E	0.668	1.00
83_V	125_V	0.667	1.00
31_D	35_P	0.666	1.00
176_T	241_G	0.666	1.00
301_R	306_G	0.664	1.00
109_G	112_N	0.664	1.00
273_F	276_R	0.663	1.00
225_D	228_D	0.659	1.00
82_Y	123_E	0.656	1.00
232_A	296_G	0.651	1.00
57_D	60_Y	0.650	1.00
272_E	275_E	0.650	1.00
217_T	285_H	0.648	1.00
196_S	200_S	0.647	1.00
156_A	163_R	0.642	1.00
292_N	299_P	0.642	1.00
187_P	222_Y	0.641	1.00
182_F	247_G	0.640	1.00
144_E	291_A	0.639	1.00
181_Y	184_V	0.637	1.00
4_L	65_G	0.637	1.00
257_L	303_I	0.634	1.00
23_R	232_A	0.629	1.00
132_S	155_G	0.627	1.00
126_V	234_L	0.621	1.00
103_N	156_A	0.619	1.00
25_H	82_Y	0.616	1.00
216_Q	254_I	0.613	1.00
205_G	267_P	0.609	1.00
73_V	112_N	0.606	1.00
85_H	125_V	0.604	1.00
4_L	83_V	0.604	1.00
126_V	230_N	0.602	1.00
278_E	281_A	0.601	1.00
262_R	265_V	0.601	1.00
225_D	300_S	0.600	1.00
161_A	165_V	0.599	1.00
167_A	170_E	0.599	1.00
26_D	59_S	0.599	1.00
258_A	262_R	0.596	1.00
157_S	161_A	0.595	1.00
153_P	156_A	0.594	1.00
246_I	291_A	0.593	1.00
148_T	163_R	0.592	1.00
143_D	289_S	0.592	1.00
199_V	311_V	0.591	1.00
219_D	248_S	0.591	1.00
179_L	229_A	0.591	1.00
183_T	218_R	0.590	1.00
156_A	167_A	0.586	1.00
82_Y	126_V	0.584	1.00
219_D	251_N	0.583	1.00
16_L	231_E	0.581	1.00
137_P	142_Y	0.579	1.00
135_G	149_T	0.579	1.00
5_V	20_F	0.578	1.00
88_G	106_N	0.575	1.00
277_F	280_D	0.574	1.00
270_D	273_F	0.572	1.00
89_Q	106_N	0.571	1.00
15_H	188_R	0.569	1.00
201_R	204_N	0.566	1.00
262_R	271_I	0.565	1.00
126_V	233_L	0.563	1.00
4_L	77_V	0.563	1.00
29_V	62_L	0.563	1.00
300_S	305_E	0.563	1.00
164_Y	168_Y	0.562	1.00
199_V	261_I	0.560	1.00
130_S	133_V	0.559	1.00
260_E	307_V	0.554	1.00
4_L	76_L	0.554	1.00
144_E	245_N	0.551	1.00
252_I	260_E	0.549	1.00
272_E	276_R	0.549	1.00
18_E	224_E	0.549	1.00
141_P	285_H	0.547	1.00
165_V	178_A	0.547	1.00
17_A	21_V	0.545	1.00
150_P	159_L	0.544	1.00
194_A	202_C	0.544	1.00
130_S	158_K	0.544	1.00
66_D	69_D	0.543	1.00
274_A	277_F	0.537	1.00
153_P	157_S	0.537	1.00
187_P	224_E	0.534	1.00
277_F	281_A	0.532	1.00
250_D	304_R	0.531	1.00
73_V	77_V	0.530	1.00
210_V	273_F	0.529	1.00
63_V	72_L	0.528	1.00
56_G	59_S	0.528	1.00
33_F	37_Y	0.527	1.00
70_A	116_A	0.527	1.00
178_A	241_G	0.527	1.00
154_Y	157_S	0.524	1.00
99_P	153_P	0.524	1.00
148_T	243_V	0.519	1.00
275_E	278_E	0.519	1.00
24_G	27_V	0.518	1.00
198_F	202_C	0.518	1.00
17_A	60_Y	0.518	1.00
110_T	127_F	0.517	1.00
140_L	283_H	0.515	1.00
226_V	246_I	0.514	1.00
28_V	76_L	0.514	1.00
86_Q	181_Y	0.514	1.00
291_A	299_P	0.513	1.00
175_P	239_A	0.512	1.00
240_D	244_L	0.512	1.00
117_A	121_E	0.512	1.00
166_C	169_S	0.511	1.00
231_E	234_L	0.511	1.00
177_V	244_L	0.510	1.00
83_V	122_I	0.509	1.00
32_N	35_P	0.507	1.00
261_I	307_V	0.507	1.00
169_S	241_G	0.505	1.00
117_A	120_T	0.504	1.00
202_C	208_P	0.503	1.00
169_S	174_L	0.503	1.00
222_Y	310_F	0.502	1.00
76_L	80_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sb8A	2	0.9573	100	0.17	Contact Map
3rufA	2	0.9512	100	0.175	Contact Map
2c20A	2	0.939	100	0.19	Contact Map
2q1sA	2	0.9238	100	0.19	Contact Map
1r6dA	2	0.9604	100	0.19	Contact Map
2hunA	2	0.9695	100	0.19	Contact Map
3m2pA	2	0.9024	100	0.193	Contact Map
1oc2A	2	0.9695	100	0.193	Contact Map
1orrA	3	0.939	100	0.197	Contact Map
4wokA	1	0.9207	100	0.198	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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