GREMLIN Database
Q9HSV1 - UDP-glucose 4-epimerase
UniProt: Q9HSV1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (293)
Sequences: 58020 (40692)
Seq/√Len: 2377.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_G29_V3.0471.00
260_E304_R2.9601.00
19_R228_D2.7071.00
229_A246_I2.6151.00
244_L294_L2.5511.00
104_E108_D2.5031.00
242_E290_K2.4991.00
74_E119_K2.4081.00
82_Y234_L2.3951.00
128_A230_N2.3051.00
98_D101_K2.2551.00
289_S293_E2.1911.00
19_R231_E2.1901.00
264_Q308_Q2.1811.00
30_L65_G2.1291.00
124_R175_P2.1151.00
19_R23_R2.1141.00
263_D304_R2.0941.00
228_D300_S2.0501.00
302_T305_E2.0421.00
85_H127_F2.0251.00
84_Y234_L2.0031.00
255_L259_E1.9461.00
69_D72_L1.9331.00
6_T85_H1.9261.00
143_D146_H1.9151.00
181_Y230_N1.8921.00
28_V80_V1.8851.00
28_V61_R1.8711.00
260_E263_D1.8571.00
4_L80_V1.8471.00
292_N298_E1.8461.00
253_D256_T1.8441.00
65_G72_L1.8341.00
224_E309_E1.8331.00
228_D232_A1.8321.00
179_L233_L1.8121.00
185_Y306_G1.8021.00
165_V176_T1.7731.00
5_V17_A1.7711.00
28_V63_V1.7531.00
23_R235_T1.7321.00
111_L164_Y1.7301.00
23_R231_E1.7221.00
200_S204_N1.7181.00
16_L227_V1.6771.00
16_L84_Y1.6211.00
207_P272_E1.6141.00
68_R104_E1.6111.00
74_E116_A1.6101.00
26_D61_R1.5911.00
111_L115_D1.5711.00
231_E235_T1.5631.00
159_L163_R1.5581.00
222_Y309_E1.5521.00
108_D111_L1.5521.00
70_A115_D1.5491.00
16_L86_Q1.5351.00
110_T161_A1.5081.00
19_R22_S1.5061.00
118_R172_Y1.5011.00
288_I292_N1.4851.00
103_N160_A1.4821.00
249_T292_N1.4751.00
260_E264_Q1.4691.00
181_Y226_V1.4581.00
33_F62_L1.4561.00
19_R227_V1.4481.00
291_A295_L1.4471.00
308_Q312_E1.4401.00
72_L75_E1.4351.00
81_D123_E1.4251.00
144_E290_K1.4211.00
100_R104_E1.4101.00
70_A74_E1.4081.00
129_S133_V1.4021.00
124_R177_V1.4011.00
74_E120_T1.3981.00
12_I184_V1.3841.00
209_V272_E1.3641.00
86_Q128_A1.3501.00
83_V117_A1.3481.00
179_L230_N1.3391.00
84_Y230_N1.3331.00
242_E294_L1.3321.00
217_T251_N1.3311.00
255_L273_F1.3291.00
222_Y306_G1.3211.00
25_H235_T1.3211.00
128_A181_Y1.3191.00
154_Y158_K1.3111.00
148_T159_L1.3101.00
301_R309_E1.3041.00
8_G17_A1.3021.00
221_T226_V1.3011.00
3_I25_H1.2981.00
17_A29_V1.2861.00
201_R206_E1.2811.00
182_F286_A1.2781.00
256_T259_E1.2701.00
18_E188_R1.2671.00
163_R166_C1.2671.00
70_A112_N1.2661.00
166_C178_A1.2571.00
134_Y245_N1.2571.00
223_I227_V1.2501.00
85_H110_T1.2301.00
127_F161_A1.2211.00
115_D118_R1.2111.00
305_E308_Q1.2071.00
78_A120_T1.2011.00
106_N157_S1.1891.00
305_E309_E1.1851.00
290_K294_L1.1801.00
114_L168_Y1.1761.00
139_Y143_D1.1751.00
67_V109_G1.1711.00
229_A291_A1.1631.00
143_D287_D1.1621.00
115_D119_K1.1581.00
19_R224_E1.1511.00
169_S176_T1.1511.00
77_V80_V1.1401.00
139_Y146_H1.1381.00
180_R243_V1.1341.00
4_L30_L1.1251.00
15_H224_E1.1241.00
20_F231_E1.1171.00
156_A160_A1.1151.00
113_V125_V1.1111.00
215_T255_L1.1071.00
164_Y167_A1.1071.00
142_Y146_H1.0951.00
215_T253_D1.0931.00
262_R268_E1.0871.00
18_E22_S1.0871.00
117_A125_V1.0851.00
29_V60_Y1.0841.00
166_C243_V1.0811.00
67_V87_A1.0751.00
127_F178_A1.0651.00
259_E262_R1.0641.00
9_A31_D1.0621.00
232_A236_D1.0591.00
75_E78_A1.0591.00
288_I299_P1.0551.00
252_I303_I1.0541.00
126_V179_L1.0441.00
114_L125_V1.0431.00
74_E78_A1.0421.00
207_P270_D1.0401.00
3_I20_F1.0341.00
21_V60_Y1.0291.00
94_P98_D1.0271.00
145_V290_K1.0261.00
127_F165_V1.0241.00
304_R308_Q1.0191.00
247_G286_A1.0151.00
15_H223_I1.0051.00
11_F186_G1.0011.00
21_V59_S0.9971.00
116_A120_T0.9931.00
228_D297_Y0.9901.00
175_P240_D0.9891.00
89_Q105_V0.9871.00
77_V83_V0.9851.00
222_Y301_R0.9831.00
265_V311_V0.9801.00
86_Q230_N0.9801.00
166_C176_T0.9741.00
251_N285_H0.9731.00
14_G188_R0.9731.00
73_V116_A0.9721.00
167_A171_V0.9681.00
162_E180_R0.9661.00
251_N283_H0.9651.00
33_F36_F0.9651.00
125_V165_V0.9631.00
290_K293_E0.9601.00
180_R245_N0.9601.00
219_D249_T0.9601.00
177_V233_L0.9551.00
232_A295_L0.9541.00
108_D112_N0.9541.00
166_C170_E0.9511.00
105_V109_G0.9511.00
112_N115_D0.9481.00
264_Q311_V0.9441.00
184_V226_V0.9431.00
197_N201_R0.9421.00
70_A119_K0.9361.00
228_D301_R0.9321.00
252_I256_T0.9271.00
63_V76_L0.9271.00
116_A119_K0.9261.00
244_L290_K0.9251.00
232_A235_T0.9201.00
217_T283_H0.9151.00
11_F223_I0.9091.00
264_Q304_R0.9091.00
3_I82_Y0.9071.00
71_E74_E0.9021.00
193_M196_S0.8971.00
15_H18_E0.8961.00
16_L20_F0.8951.00
30_L73_V0.8931.00
103_N108_D0.8921.00
71_E75_E0.8921.00
200_S203_L0.8921.00
225_D248_S0.8911.00
114_L165_V0.8911.00
179_L246_I0.8891.00
56_G60_Y0.8871.00
103_N107_V0.8871.00
6_T113_V0.8841.00
197_N200_S0.8831.00
229_A297_Y0.8821.00
309_E312_E0.8821.00
222_Y225_D0.8811.00
117_A122_I0.8801.00
217_T253_D0.8801.00
224_E301_R0.8791.00
107_V160_A0.8791.00
194_A198_F0.8761.00
289_S292_N0.8691.00
118_R174_L0.8641.00
129_S162_E0.8631.00
178_A243_V0.8611.00
33_F64_E0.8601.00
34_D64_E0.8591.00
77_V116_A0.8591.00
247_G288_I0.8581.00
72_L76_L0.8581.00
184_V221_T0.8541.00
185_Y222_Y0.8521.00
30_L72_L0.8501.00
31_D62_L0.8391.00
77_V120_T0.8311.00
82_Y124_R0.8311.00
123_E175_P0.8301.00
15_H19_R0.8281.00
140_L146_H0.8181.00
83_V113_V0.8171.00
21_V27_V0.8141.00
209_V274_A0.8131.00
25_H81_D0.8091.00
112_N116_A0.8061.00
28_V79_D0.8061.00
32_N66_D0.8051.00
110_T165_V0.8051.00
228_D231_E0.8031.00
262_R267_P0.8031.00
114_L164_Y0.8011.00
214_G255_L0.8001.00
6_T87_A0.7981.00
301_R305_E0.7961.00
102_Y157_S0.7911.00
160_A163_R0.7911.00
30_L76_L0.7911.00
17_A27_V0.7901.00
168_Y172_Y0.7841.00
271_I274_A0.7811.00
68_R105_V0.7741.00
239_A242_E0.7731.00
137_P140_L0.7721.00
256_T260_E0.7701.00
233_L295_L0.7671.00
233_L291_A0.7651.00
264_Q307_V0.7651.00
3_I84_Y0.7641.00
131_S182_F0.7631.00
101_K104_E0.7631.00
163_R167_A0.7611.00
187_P309_E0.7551.00
264_Q312_E0.7551.00
232_A297_Y0.7441.00
85_H113_V0.7391.00
16_L230_N0.7381.00
12_I226_V0.7361.00
249_T288_I0.7361.00
69_D73_V0.7351.00
3_I234_L0.7291.00
199_V203_L0.7291.00
89_Q101_K0.7291.00
15_H227_V0.7251.00
118_R173_D0.7211.00
99_P156_A0.7181.00
250_D302_T0.7161.00
131_S286_A0.7161.00
193_M197_N0.7131.00
259_E263_D0.7091.00
101_K105_V0.7071.00
77_V117_A0.7061.00
138_E146_H0.7031.00
110_T114_L0.7031.00
202_C262_R0.7001.00
150_P155_G0.7001.00
260_E303_I0.6991.00
95_S102_Y0.6981.00
141_P287_D0.6941.00
160_A164_Y0.6931.00
89_Q102_Y0.6931.00
115_D168_Y0.6921.00
20_F234_L0.6901.00
236_D239_A0.6881.00
152_S155_G0.6881.00
227_V231_E0.6871.00
239_A294_L0.6871.00
24_G59_S0.6851.00
133_V162_E0.6841.00
118_R168_Y0.6811.00
23_R228_D0.6771.00
252_I257_L0.6751.00
103_N157_S0.6751.00
133_V148_T0.6731.00
262_R269_L0.6711.00
96_V153_P0.6711.00
14_G18_E0.6681.00
83_V125_V0.6671.00
31_D35_P0.6661.00
176_T241_G0.6661.00
301_R306_G0.6641.00
109_G112_N0.6641.00
273_F276_R0.6631.00
225_D228_D0.6591.00
82_Y123_E0.6561.00
232_A296_G0.6511.00
57_D60_Y0.6501.00
272_E275_E0.6501.00
217_T285_H0.6481.00
196_S200_S0.6471.00
156_A163_R0.6421.00
292_N299_P0.6421.00
187_P222_Y0.6411.00
182_F247_G0.6401.00
144_E291_A0.6391.00
181_Y184_V0.6371.00
4_L65_G0.6371.00
257_L303_I0.6341.00
23_R232_A0.6291.00
132_S155_G0.6271.00
126_V234_L0.6211.00
103_N156_A0.6191.00
25_H82_Y0.6161.00
216_Q254_I0.6131.00
205_G267_P0.6091.00
73_V112_N0.6061.00
85_H125_V0.6041.00
4_L83_V0.6041.00
126_V230_N0.6021.00
278_E281_A0.6011.00
262_R265_V0.6011.00
225_D300_S0.6001.00
161_A165_V0.5991.00
167_A170_E0.5991.00
26_D59_S0.5991.00
258_A262_R0.5961.00
157_S161_A0.5951.00
153_P156_A0.5941.00
246_I291_A0.5931.00
148_T163_R0.5921.00
143_D289_S0.5921.00
199_V311_V0.5911.00
219_D248_S0.5911.00
179_L229_A0.5911.00
183_T218_R0.5901.00
156_A167_A0.5861.00
82_Y126_V0.5841.00
219_D251_N0.5831.00
16_L231_E0.5811.00
137_P142_Y0.5791.00
135_G149_T0.5791.00
5_V20_F0.5781.00
88_G106_N0.5751.00
277_F280_D0.5741.00
270_D273_F0.5721.00
89_Q106_N0.5711.00
15_H188_R0.5691.00
201_R204_N0.5661.00
262_R271_I0.5651.00
126_V233_L0.5631.00
4_L77_V0.5631.00
29_V62_L0.5631.00
300_S305_E0.5631.00
164_Y168_Y0.5621.00
199_V261_I0.5601.00
130_S133_V0.5591.00
260_E307_V0.5541.00
4_L76_L0.5541.00
144_E245_N0.5511.00
252_I260_E0.5491.00
272_E276_R0.5491.00
18_E224_E0.5491.00
141_P285_H0.5471.00
165_V178_A0.5471.00
17_A21_V0.5451.00
150_P159_L0.5441.00
194_A202_C0.5441.00
130_S158_K0.5441.00
66_D69_D0.5431.00
274_A277_F0.5371.00
153_P157_S0.5371.00
187_P224_E0.5341.00
277_F281_A0.5321.00
250_D304_R0.5311.00
73_V77_V0.5301.00
210_V273_F0.5291.00
63_V72_L0.5281.00
56_G59_S0.5281.00
33_F37_Y0.5271.00
70_A116_A0.5271.00
178_A241_G0.5271.00
154_Y157_S0.5241.00
99_P153_P0.5241.00
148_T243_V0.5191.00
275_E278_E0.5191.00
24_G27_V0.5181.00
198_F202_C0.5181.00
17_A60_Y0.5181.00
110_T127_F0.5171.00
140_L283_H0.5151.00
226_V246_I0.5141.00
28_V76_L0.5141.00
86_Q181_Y0.5141.00
291_A299_P0.5131.00
175_P239_A0.5121.00
240_D244_L0.5121.00
117_A121_E0.5121.00
166_C169_S0.5111.00
231_E234_L0.5111.00
177_V244_L0.5101.00
83_V122_I0.5091.00
32_N35_P0.5071.00
261_I307_V0.5071.00
169_S241_G0.5051.00
117_A120_T0.5041.00
202_C208_P0.5031.00
169_S174_L0.5031.00
222_Y310_F0.5021.00
76_L80_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 0.9573 100 0.17 Contact Map
3rufA 2 0.9512 100 0.175 Contact Map
2c20A 2 0.939 100 0.19 Contact Map
2q1sA 2 0.9238 100 0.19 Contact Map
1r6dA 2 0.9604 100 0.19 Contact Map
2hunA 2 0.9695 100 0.19 Contact Map
3m2pA 2 0.9024 100 0.193 Contact Map
1oc2A 2 0.9695 100 0.193 Contact Map
1orrA 3 0.939 100 0.197 Contact Map
4wokA 1 0.9207 100 0.198 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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