GREMLIN Database
Q9HSV0 - Glucose-1-phosphate thymidylyltransferase
UniProt: Q9HSV0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 238 (228)
Sequences: 22882 (14527)
Seq/√Len: 962.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_E183_R3.4511.00
31_K39_E3.2441.00
145_E154_G2.7341.00
145_E153_T2.7111.00
48_D72_D2.6681.00
132_E165_N2.5431.00
35_T63_R2.5191.00
82_L86_H2.5031.00
124_A210_E2.4801.00
119_H127_T2.3381.00
132_E213_P2.3021.00
130_V211_T2.2901.00
181_A205_S2.2831.00
147_D151_A2.1931.00
48_D74_E2.1591.00
53_V57_K2.0861.00
57_K61_I2.0561.00
181_A201_L2.0351.00
98_D175_P1.9571.00
89_L92_E1.9511.00
3_A41_L1.9321.00
3_A46_I1.9311.00
38_F49_V1.9301.00
76_A90_T1.9051.00
201_L205_S1.8911.00
200_D204_Y1.8761.00
151_A210_E1.8681.00
147_D153_T1.8661.00
124_A208_S1.7621.00
58_D62_D1.7581.00
122_S210_E1.7521.00
7_A51_V1.7281.00
35_T39_E1.7231.00
88_V101_V1.7211.00
41_L102_L1.7191.00
4_V91_A1.6971.00
154_G200_D1.6791.00
145_E164_S1.6771.00
15_R19_A1.6651.00
113_S117_A1.6651.00
57_K77_H1.6591.00
158_K162_P1.6301.00
21_L27_E1.6211.00
219_V229_R1.6141.00
201_L204_Y1.6031.00
59_K62_D1.5911.00
146_L166_Y1.5841.00
50_V94_Y1.5791.00
125_D175_P1.5741.00
166_Y213_P1.5581.00
95_V99_F1.5361.00
118_H212_Q1.5111.00
21_L59_K1.4941.00
137_E140_S1.4921.00
61_I77_H1.4881.00
32_P35_T1.4861.00
152_V211_T1.4651.00
197_D200_D1.4641.00
25_L59_K1.4351.00
151_A208_S1.4271.00
117_A121_E1.4101.00
130_V144_C1.4081.00
98_D120_T1.4041.00
114_E117_A1.3991.00
74_E94_Y1.3971.00
118_H122_S1.3931.00
144_C152_V1.3911.00
152_V209_V1.3861.00
86_H90_T1.3731.00
50_V76_A1.3731.00
147_D150_R1.3281.00
109_S217_W1.3281.00
115_V129_P1.3171.00
125_D207_Y1.2951.00
99_F176_P1.2921.00
130_V166_Y1.2891.00
10_E81_R1.2841.00
227_I231_E1.2841.00
177_A180_P1.2691.00
98_D176_P1.2551.00
217_W233_L1.2451.00
49_V71_I1.2441.00
228_T232_Q1.2411.00
134_S138_A1.2401.00
118_H210_E1.2341.00
126_I174_L1.2331.00
89_L183_R1.2291.00
125_D208_S1.2281.00
223_T226_D1.2141.00
53_V61_I1.2021.00
103_N170_A1.1991.00
184_V201_L1.1741.00
50_V91_A1.1651.00
65_G75_Y1.1601.00
145_E156_V1.1401.00
181_A184_V1.1381.00
184_V205_S1.1361.00
107_I110_A1.1341.00
156_V163_P1.1341.00
31_K36_H1.1331.00
221_V230_A1.1281.00
181_A198_A1.1241.00
100_V173_V1.1221.00
146_L211_T1.1171.00
42_L71_I1.1131.00
115_V173_V1.0861.00
86_H89_L1.0851.00
142_A157_E1.0851.00
53_V77_H1.0821.00
35_T67_S1.0811.00
177_A207_Y1.0811.00
114_E118_H1.0791.00
226_D229_R1.0751.00
34_L64_Y1.0741.00
14_L26_V1.0691.00
181_A207_Y1.0661.00
25_L63_R1.0641.00
111_N114_E1.0631.00
186_R189_E1.0581.00
196_A200_D1.0561.00
180_P184_V1.0561.00
30_G36_H1.0541.00
118_H121_E1.0471.00
46_I100_V1.0361.00
219_V233_L1.0351.00
8_A52_V1.0321.00
101_V174_L1.0311.00
119_H173_V1.0301.00
97_S176_P1.0291.00
174_L199_I1.0261.00
56_E59_K1.0131.00
180_P183_R1.0001.00
140_S226_D0.9831.00
33_I221_V0.9791.00
53_V75_Y0.9751.00
202_L207_Y0.9721.00
50_V74_E0.9671.00
53_V60_I0.9661.00
139_T158_K0.9651.00
117_A120_T0.9591.00
168_P172_Y0.9461.00
58_D61_I0.9441.00
89_L182_C0.9371.00
213_P216_G0.9341.00
34_L51_V0.9291.00
4_V99_F0.9261.00
39_E42_L0.9181.00
219_V230_A0.9121.00
228_T231_E0.9091.00
190_R193_Y0.8991.00
31_K35_T0.8941.00
34_L60_I0.8871.00
83_G196_A0.8821.00
44_L113_S0.8781.00
92_E179_F0.8781.00
5_V104_G0.8741.00
225_A229_R0.8741.00
61_I75_Y0.8651.00
33_I37_C0.8611.00
14_L18_T0.8591.00
43_D110_A0.8571.00
84_L103_N0.8551.00
100_V116_L0.8531.00
27_E32_P0.8521.00
229_R232_Q0.8471.00
76_A94_Y0.8381.00
63_R66_D0.8381.00
24_P104_G0.8351.00
18_T26_V0.8281.00
96_D176_P0.8271.00
229_R233_L0.8241.00
47_D72_D0.8201.00
124_A151_A0.8141.00
119_H175_P0.8131.00
102_L112_F0.8101.00
139_T160_A0.8051.00
198_A201_L0.8031.00
143_V167_A0.7981.00
123_G175_P0.7911.00
65_G68_F0.7761.00
210_E213_P0.7681.00
42_L49_V0.7671.00
46_I116_L0.7661.00
65_G69_R0.7651.00
32_P63_R0.7621.00
32_P36_H0.7621.00
106_N218_K0.7601.00
35_T64_Y0.7571.00
29_N231_E0.7551.00
29_N36_H0.7541.00
132_E166_Y0.7511.00
199_I209_V0.7471.00
88_V178_I0.7471.00
42_L47_D0.7461.00
6_L103_N0.7421.00
186_R197_D0.7411.00
177_A181_A0.7411.00
116_L120_T0.7391.00
140_S158_K0.7381.00
76_A91_A0.7331.00
76_A79_S0.7321.00
154_G161_E0.7241.00
116_L173_V0.7161.00
4_V50_V0.7141.00
114_E212_Q0.7131.00
212_Q216_G0.7121.00
115_V212_Q0.7111.00
22_P59_K0.7101.00
40_I110_A0.7091.00
115_V127_T0.7081.00
4_V52_V0.7061.00
42_L67_S0.7061.00
62_D65_G0.7031.00
153_T156_V0.7021.00
92_E99_F0.7011.00
116_L119_H0.6991.00
162_P165_N0.6981.00
17_R21_L0.6981.00
133_V138_A0.6981.00
38_F73_I0.6971.00
40_I44_L0.6851.00
38_F64_Y0.6841.00
26_V227_I0.6801.00
166_Y211_T0.6791.00
156_V159_P0.6711.00
176_P179_F0.6711.00
175_P178_I0.6711.00
43_D113_S0.6701.00
95_V179_F0.6691.00
52_V87_A0.6691.00
150_R213_P0.6691.00
127_T210_E0.6681.00
155_L168_P0.6641.00
36_H39_E0.6641.00
178_I202_L0.6611.00
6_L84_L0.6491.00
182_C185_I0.6421.00
54_G81_R0.6411.00
17_R224_E0.6391.00
145_E163_P0.6361.00
81_R86_H0.6361.00
5_V102_L0.6351.00
113_S116_L0.6321.00
125_D177_A0.6281.00
189_E197_D0.6271.00
185_I201_L0.6271.00
178_I207_Y0.6251.00
115_V119_H0.6231.00
192_E195_L0.6181.00
11_G23_K0.6151.00
128_F144_C0.6151.00
154_G204_Y0.6141.00
140_S223_T0.6131.00
38_F51_V0.6121.00
28_V231_E0.6121.00
103_N106_N0.6121.00
220_N226_D0.6111.00
134_S165_N0.6071.00
54_G57_K0.6051.00
108_Y111_N0.6031.00
17_R26_V0.6011.00
197_D201_L0.6011.00
3_A49_V0.5991.00
131_E169_T0.5981.00
177_A205_S0.5971.00
180_P205_S0.5951.00
61_I65_G0.5951.00
53_V58_D0.5911.00
41_L100_V0.5901.00
224_E228_T0.5901.00
130_V152_V0.5881.00
92_E180_P0.5881.00
112_F115_V0.5871.00
52_V91_A0.5821.00
124_A127_T0.5821.00
17_R20_D0.5821.00
51_V64_Y0.5811.00
102_L171_F0.5791.00
26_V231_E0.5771.00
51_V73_I0.5751.00
127_T130_V0.5751.00
78_Q87_A0.5741.00
130_V213_P0.5721.00
13_R23_K0.5721.00
27_E30_G0.5711.00
88_V179_F0.5701.00
38_F71_I0.5701.00
37_C40_I0.5701.00
40_I171_F0.5691.00
181_A202_L0.5601.00
84_L168_P0.5581.00
209_V216_G0.5571.00
195_L198_A0.5561.00
200_D203_I0.5551.00
131_E167_A0.5551.00
5_V37_C0.5541.00
110_A113_S0.5541.00
122_S125_D0.5531.00
112_F119_H0.5521.00
36_H40_I0.5511.00
67_S75_Y0.5511.00
64_Y68_F0.5511.00
80_E86_H0.5481.00
188_S195_L0.5471.00
10_E15_R0.5461.00
126_I202_L0.5451.00
150_R153_T0.5431.00
89_L193_Y0.5421.00
82_L193_Y0.5421.00
91_A94_Y0.5381.00
122_S208_S0.5361.00
83_G197_D0.5361.00
74_E77_H0.5341.00
39_E43_D0.5321.00
191_G195_L0.5321.00
185_I198_A0.5301.00
131_E218_K0.5301.00
8_A81_R0.5291.00
185_I193_Y0.5281.00
133_V167_A0.5271.00
24_P60_I0.5251.00
40_I43_D0.5251.00
127_T131_E0.5211.00
52_V76_A0.5201.00
209_V214_F0.5181.00
122_S127_T0.5171.00
129_P214_F0.5161.00
126_I209_V0.5161.00
100_V112_F0.5141.00
98_D173_V0.5131.00
73_I76_A0.5091.00
42_L70_A0.5091.00
225_A228_T0.5091.00
23_K105_D0.5091.00
37_C102_L0.5081.00
64_Y73_I0.5081.00
21_L26_V0.5061.00
78_Q81_R0.5041.00
125_D178_I0.5021.00
129_P169_T0.5011.00
64_Y67_S0.5011.00
50_V95_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jukA 3 0.9916 100 0.242 Contact Map
2e3dA 3 0.9832 100 0.26 Contact Map
2ux8A 4 0.9916 100 0.262 Contact Map
1lvwA 3 0.9916 100 0.279 Contact Map
2pa4A 3 0.9958 100 0.281 Contact Map
4ho4A 3 0.9874 100 0.282 Contact Map
1iimA 3 0.9874 100 0.283 Contact Map
1mc3A 3 0.9874 100 0.29 Contact Map
1yp2A 4 0.979 100 0.296 Contact Map
3brkX 2 0.9496 100 0.297 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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