GREMLIN Database
Q9HSU9 - GDP-D-mannose dehydratase
UniProt: Q9HSU9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 309 (287)
Sequences: 59220 (40958)
Seq/√Len: 2417.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
254_V298_S2.8701.00
9_V30_G2.8641.00
20_A223_Q2.6011.00
3_T27_D2.5251.00
95_D99_T2.4771.00
224_A240_V2.4251.00
73_Y229_A2.3221.00
119_A225_N2.3071.00
236_E284_K2.2891.00
20_A226_I2.2431.00
89_D92_T2.2401.00
296_G299_E2.2131.00
65_A110_E2.1751.00
283_S287_E2.1181.00
258_L302_E2.1111.00
115_T166_D2.0451.00
20_A24_R2.0301.00
31_V56_A2.0211.00
257_D298_S1.9821.00
76_H118_V1.9501.00
75_F229_A1.9451.00
223_Q294_E1.9451.00
249_N253_D1.9321.00
29_R71_V1.9021.00
3_T29_R1.8871.00
172_Y225_N1.8841.00
29_R52_S1.8261.00
254_V257_D1.8011.00
286_R292_E1.7931.00
24_R226_I1.7911.00
247_T250_E1.7891.00
102_A155_L1.7841.00
29_R54_Y1.7711.00
170_L228_A1.7691.00
5_L71_V1.7571.00
7_T76_H1.7561.00
156_A167_T1.7541.00
56_A63_L1.7451.00
219_D303_Q1.7431.00
223_Q227_R1.7421.00
60_D63_L1.7331.00
243_G286_R1.7211.00
65_A107_A1.6411.00
150_H154_K1.6391.00
226_I230_E1.6301.00
24_R230_E1.6291.00
27_D52_S1.6241.00
176_Y300_G1.6231.00
6_V18_A1.6171.00
17_L222_I1.6161.00
102_A106_D1.5941.00
99_T102_A1.5881.00
94_T151_Y1.5721.00
217_F303_Q1.5691.00
134_V137_M1.5631.00
17_L75_F1.5581.00
4_A26_Y1.5491.00
195_S199_D1.5391.00
59_R95_D1.5151.00
101_T152_T1.5111.00
61_A106_D1.5091.00
227_R231_G1.4961.00
17_L77_Q1.4921.00
285_A289_L1.4871.00
254_V258_L1.4851.00
109_R163_Y1.4851.00
282_I286_R1.4811.00
135_E284_K1.4531.00
61_A103_T1.4421.00
115_T168_A1.4411.00
20_A222_I1.4401.00
91_V95_D1.4341.00
20_A23_D1.4301.00
63_L66_D1.3951.00
77_Q119_A1.3951.00
13_I175_I1.3931.00
172_Y221_A1.3901.00
34_F53_F1.3821.00
74_V108_A1.3781.00
65_A111_A1.3711.00
72_D114_D1.3471.00
212_S245_R1.3441.00
119_A172_Y1.3301.00
120_S124_I1.3271.00
61_A65_A1.3221.00
216_T221_A1.3181.00
139_E150_H1.3151.00
18_A30_G1.3081.00
154_K157_L1.2891.00
9_V18_A1.2891.00
204_V266_I1.2861.00
26_Y230_E1.2851.00
217_F300_G1.2781.00
157_L169_A1.2711.00
75_F225_N1.2701.00
19_A179_R1.2681.00
196_L201_E1.2631.00
202_R266_I1.2601.00
69_N111_A1.2591.00
145_Y149_K1.2531.00
170_L225_N1.2511.00
173_F280_A1.2401.00
147_L151_Y1.2271.00
250_E253_D1.2231.00
118_V152_T1.2121.00
299_E302_E1.2091.00
218_I222_I1.2011.00
160_S167_T1.2001.00
299_E303_Q1.1881.00
58_I100_G1.1721.00
76_H101_T1.1661.00
210_E247_T1.1621.00
155_L158_Q1.1591.00
20_A219_D1.1541.00
105_I159_A1.1531.00
68_T71_V1.1521.00
106_D109_R1.1481.00
21_L226_I1.1471.00
16_H219_D1.1371.00
30_G51_F1.1321.00
5_L31_V1.1301.00
249_N267_Y1.1231.00
97_N148_S1.1221.00
166_D234_T1.1201.00
246_V297_F1.1121.00
4_A21_L1.1111.00
171_R237_A1.1031.00
106_D110_E1.1001.00
157_L237_A1.0971.00
16_H218_I1.0971.00
118_V169_A1.0941.00
134_V281_D1.0931.00
108_A116_V1.0851.00
85_R89_D1.0841.00
117_V170_L1.0831.00
125_Y239_N1.0791.00
210_E249_N1.0741.00
256_N262_D1.0671.00
241_G280_A1.0651.00
282_I293_P1.0651.00
58_I78_A1.0591.00
104_V116_V1.0581.00
19_A23_D1.0571.00
118_V156_A1.0571.00
214_D243_G1.0501.00
253_D256_N1.0481.00
107_A111_A1.0341.00
130_T134_V1.0331.00
158_Q162_L1.0331.00
107_A110_E1.0301.00
136_S284_K1.0251.00
105_I116_V1.0211.00
245_R279_H1.0211.00
245_R277_H1.0171.00
34_F37_G1.0171.00
133_K137_M1.0161.00
22_L51_F1.0151.00
10_A32_D1.0141.00
22_L50_D1.0131.00
224_A285_A1.0111.00
4_A73_Y1.0101.00
94_T98_C1.0101.00
298_S302_E1.0031.00
80_D96_V1.0021.00
157_L167_T0.9991.00
246_V250_E0.9961.00
99_T103_T0.9951.00
65_A69_N0.9911.00
66_D69_N0.9891.00
212_S277_H0.9881.00
212_S247_T0.9841.00
168_A228_A0.9841.00
103_T106_D0.9821.00
175_I221_A0.9731.00
94_T99_T0.9691.00
108_A113_V0.9631.00
116_V156_A0.9551.00
157_L161_E0.9541.00
15_S179_R0.9511.00
77_Q225_N0.9501.00
7_T104_V0.9401.00
12_F218_I0.9381.00
73_Y115_T0.9371.00
232_D235_G0.9361.00
68_T107_A0.9331.00
227_R230_E0.9291.00
98_C151_Y0.9281.00
12_F177_G0.9281.00
3_T72_D0.9271.00
96_V100_G0.9251.00
64_V107_A0.9211.00
109_R165_I0.9201.00
283_S286_R0.9161.00
220_N242_C0.9141.00
153_E171_R0.9141.00
256_N263_I0.9121.00
105_I156_A0.9121.00
202_R264_D0.9121.00
3_T71_V0.9111.00
16_H19_A0.9061.00
171_R239_N0.9041.00
223_Q226_I0.9021.00
284_K287_E0.9021.00
258_L298_S0.9021.00
35_A55_E0.9011.00
3_T26_Y0.9011.00
169_A237_A0.8951.00
68_T74_V0.8911.00
62_D66_D0.8861.00
31_V63_L0.8851.00
238_F284_K0.8821.00
217_F220_N0.8791.00
62_D65_A0.8771.00
241_G282_I0.8751.00
54_Y67_V0.8751.00
34_F55_E0.8731.00
18_A28_V0.8701.00
223_Q291_Y0.8691.00
31_V64_V0.8671.00
151_Y154_K0.8661.00
61_A110_E0.8651.00
17_L21_L0.8551.00
209_G249_N0.8521.00
250_E254_V0.8491.00
176_Y217_F0.8491.00
32_D53_F0.8491.00
224_A291_Y0.8481.00
63_L67_V0.8471.00
68_T111_A0.8461.00
194_I198_L0.8451.00
170_L240_V0.8431.00
103_T107_A0.8421.00
268_D271_R0.8371.00
192_K195_S0.8371.00
74_V104_V0.8361.00
93_T148_S0.8361.00
192_K196_L0.8341.00
130_T137_M0.8341.00
16_H20_A0.8331.00
189_V193_F0.8331.00
33_N57_D0.8311.00
114_D166_D0.8301.00
101_T156_A0.8291.00
256_N261_T0.8271.00
175_I216_T0.8261.00
154_K158_Q0.8261.00
29_R70_G0.8251.00
227_R289_L0.8231.00
31_V67_V0.8231.00
228_A289_L0.8171.00
80_D92_T0.8171.00
22_L28_V0.8161.00
7_T78_A0.8111.00
4_A75_F0.8081.00
244_G296_G0.8061.00
195_S198_L0.8021.00
188_A191_P0.8021.00
204_V268_D0.7931.00
120_S153_E0.7891.00
197_M256_N0.7871.00
159_A163_Y0.7841.00
92_T95_D0.7831.00
101_T105_I0.7781.00
17_L225_N0.7741.00
90_P147_L0.7731.00
4_A229_A0.7721.00
59_R96_V0.7691.00
16_H222_I0.7661.00
92_T96_V0.7571.00
151_Y155_L0.7551.00
13_I221_A0.7531.00
80_D93_T0.7531.00
76_H104_V0.7491.00
109_R164_D0.7471.00
243_G282_I0.7441.00
47_G51_F0.7391.00
105_I155_L0.7361.00
228_A285_A0.7351.00
122_A173_F0.7341.00
258_L301_L0.7311.00
143_S146_A0.7301.00
138_T141_P0.7291.00
222_I226_I0.7271.00
227_R290_S0.7261.00
57_D60_D0.7201.00
253_D257_D0.7191.00
106_D159_A0.7151.00
144_P147_L0.7131.00
286_R293_P0.7101.00
178_P217_F0.7101.00
172_Y175_I0.7081.00
60_D64_V0.7071.00
147_L154_K0.7021.00
227_R291_Y0.6981.00
86_S93_T0.6971.00
122_A280_A0.6971.00
15_S19_A0.6931.00
254_V297_F0.6931.00
129_E137_M0.6891.00
124_I139_E0.6881.00
126_G140_Q0.6851.00
26_Y72_D0.6831.00
240_V285_A0.6811.00
100_G103_T0.6801.00
74_V116_V0.6751.00
24_R223_Q0.6731.00
233_V236_E0.6721.00
94_T148_S0.6721.00
109_R159_A0.6691.00
246_V251_L0.6691.00
135_E285_A0.6651.00
68_T108_A0.6651.00
269_D272_P0.6651.00
117_V229_A0.6631.00
128_T133_K0.6601.00
275_V278_S0.6581.00
124_I153_E0.6581.00
26_Y73_Y0.6571.00
115_T232_D0.6571.00
220_N223_Q0.6491.00
251_L297_F0.6471.00
27_D50_D0.6471.00
148_S152_T0.6461.00
178_P303_Q0.6431.00
64_V68_T0.6421.00
24_R227_R0.6421.00
117_V225_N0.6411.00
174_N213_R0.6371.00
87_V144_P0.6351.00
123_A146_A0.6341.00
134_V283_S0.6331.00
158_Q161_E0.6331.00
173_F241_G0.6291.00
246_V254_V0.6261.00
5_L74_V0.6251.00
137_M140_Q0.6251.00
21_L229_A0.6241.00
131_F277_H0.6231.00
268_D273_G0.6231.00
155_L159_A0.6231.00
211_Q248_V0.6201.00
152_T156_A0.6201.00
252_V256_N0.6171.00
73_Y117_V0.6161.00
194_I255_L0.6131.00
5_L67_V0.6121.00
294_E299_E0.6121.00
16_H179_R0.6111.00
18_A22_L0.6111.00
196_L199_D0.6111.00
25_G28_V0.6101.00
200_G261_T0.6101.00
6_V21_L0.6091.00
76_H116_V0.6081.00
5_L56_A0.6071.00
147_L158_Q0.6071.00
212_S279_H0.6051.00
94_T147_L0.6051.00
214_D242_C0.6041.00
90_P144_P0.6021.00
266_I269_D0.6011.00
117_V228_A0.6011.00
144_P148_S0.6001.00
170_L224_A0.5991.00
30_G53_F0.5951.00
139_E154_K0.5941.00
64_V103_T0.5921.00
256_N259_L0.5911.00
188_A192_K0.5911.00
191_P195_S0.5911.00
168_A238_F0.5901.00
262_D265_P0.5901.00
47_G50_D0.5861.00
3_T70_G0.5841.00
79_A97_N0.5811.00
48_T51_F0.5801.00
73_Y114_D0.5791.00
5_L68_T0.5781.00
17_L226_I0.5771.00
270_P273_G0.5761.00
159_A165_I0.5731.00
214_D245_R0.5701.00
54_Y63_L0.5681.00
196_L200_G0.5651.00
61_A107_A0.5641.00
221_A240_V0.5631.00
19_A219_D0.5621.00
135_E239_N0.5611.00
56_A64_V0.5601.00
156_A169_A0.5581.00
226_I229_A0.5541.00
238_F285_A0.5521.00
10_A34_F0.5521.00
285_A293_P0.5521.00
98_C102_A0.5511.00
178_P219_D0.5501.00
141_P146_A0.5501.00
217_F304_T0.5491.00
160_S165_I0.5471.00
149_K152_T0.5461.00
256_N265_P0.5431.00
21_L26_Y0.5391.00
244_G298_S0.5371.00
220_N294_E0.5371.00
80_D97_N0.5361.00
254_V301_L0.5361.00
268_D272_P0.5361.00
90_P94_T0.5351.00
157_L160_S0.5341.00
255_L301_L0.5301.00
101_T118_V0.5281.00
194_I259_L0.5241.00
147_L150_H0.5221.00
121_S149_K0.5221.00
190_I251_L0.5151.00
67_V71_V0.5151.00
124_I171_R0.5141.00
176_Y242_C0.5131.00
29_R67_V0.5101.00
26_Y226_I0.5101.00
269_D273_G0.5091.00
285_A291_Y0.5081.00
145_Y148_S0.5081.00
108_A111_A0.5071.00
74_V113_V0.5041.00
68_T104_V0.5031.00
19_A22_L0.5021.00
197_M203_P0.5021.00
173_F214_D0.5021.00
131_F137_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 1 100 0.131 Contact Map
3rufA 2 0.9935 100 0.136 Contact Map
1orrA 3 0.9935 100 0.151 Contact Map
1rkxA 3 0.9741 100 0.158 Contact Map
1oc2A 2 0.9838 100 0.158 Contact Map
2hunA 2 0.9871 100 0.16 Contact Map
2q1sA 2 0.9547 100 0.162 Contact Map
1rpnA 4 0.9935 100 0.165 Contact Map
2c20A 2 0.9806 100 0.166 Contact Map
3m2pA 2 0.932 100 0.166 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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