GREMLIN Database
Q9HSU3 - Uncharacterized protein
UniProt: Q9HSU3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 144 (124)
Sequences: 449 (387)
Seq/√Len: 34.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_R98_E4.0021.00
9_V125_L3.3391.00
42_S115_L3.2761.00
89_V118_R3.1551.00
113_V124_V3.0011.00
47_D108_T2.9841.00
105_L134_L2.8451.00
11_Y52_L2.6491.00
103_Q133_G2.6371.00
4_L112_T2.5941.00
24_A127_F2.5241.00
5_V10_L2.4881.00
47_D51_T2.3190.99
93_A111_T2.1870.99
106_S130_D1.9050.97
126_S132_D1.8480.97
42_S112_T1.8400.97
5_V9_V1.7980.96
11_Y15_D1.7430.96
12_A18_A1.7160.95
10_L49_A1.6860.95
93_A107_F1.6580.94
97_F110_A1.6190.94
7_T11_Y1.6060.93
51_T106_S1.5730.93
113_V116_M1.5450.92
96_V114_A1.4990.91
67_G94_V1.4910.90
63_A93_A1.4480.89
116_M124_V1.4470.89
105_L133_G1.4070.88
112_T124_V1.4060.88
50_V106_S1.3970.87
107_F111_T1.3840.87
51_T97_F1.3680.86
112_T130_D1.3470.85
105_L113_V1.3430.85
46_Y67_G1.3240.84
4_L41_V1.2770.82
10_L41_V1.2600.81
4_L42_S1.2490.81
44_Y47_D1.2340.80
38_Q81_R1.2180.79
102_D133_G1.2110.78
84_D90_F1.2020.78
43_D90_F1.2010.78
85_V111_T1.1700.76
15_D57_S1.1680.76
107_F126_S1.1580.75
93_A116_M1.1530.75
51_T108_T1.1520.75
22_E26_G1.1170.73
95_G120_D1.0950.71
13_D28_L1.0900.71
105_L110_A1.0860.70
130_D133_G1.0580.68
92_D117_R1.0580.68
128_D131_F0.9880.63
113_V134_L0.9780.62
52_L56_R0.9780.62
27_A125_L0.9490.60
83_L119_H0.9370.59
115_L120_D0.9360.59
4_L10_L0.9290.58
5_V8_G0.9180.57
5_V70_L0.8790.54
40_Y83_L0.8790.54
111_T116_M0.8700.53
49_A66_L0.8620.52
70_L99_R0.8600.52
42_S116_M0.8570.52
25_A66_L0.8520.52
63_A97_F0.8500.51
20_R23_A0.8470.51
100_L134_L0.8450.51
3_V93_A0.8400.51
51_T107_F0.8260.49
92_D95_G0.8220.49
16_T33_D0.8220.49
47_D106_S0.8170.49
43_D84_D0.8110.48
112_T116_M0.8090.48
54_L126_S0.8050.48
108_T130_D0.8020.47
43_D111_T0.7970.47
110_A130_D0.7940.47
10_L42_S0.7910.46
110_A113_V0.7890.46
9_V28_L0.7770.45
67_G71_R0.7770.45
40_Y92_D0.7710.45
43_D85_V0.7700.45
86_T98_E0.7660.44
26_G30_A0.7650.44
115_L130_D0.7630.44
70_L118_R0.7380.42
11_Y49_A0.7380.42
11_Y71_R0.7350.42
65_R95_G0.7320.41
41_V45_L0.7210.41
106_S134_L0.7150.40
3_V132_D0.7120.40
13_D18_A0.7120.40
7_T102_D0.7100.40
44_Y106_S0.7090.40
9_V52_L0.6960.38
52_L97_F0.6930.38
17_D108_T0.6870.38
5_V79_T0.6830.37
51_T54_L0.6790.37
71_R91_D0.6770.37
62_V120_D0.6770.37
71_R94_V0.6740.37
29_D88_A0.6690.36
3_V40_Y0.6670.36
5_V127_F0.6660.36
63_A103_Q0.6660.36
89_V119_H0.6590.36
43_D108_T0.6550.35
64_Q94_V0.6530.35
32_Y68_R0.6530.35
100_L105_L0.6510.35
86_T120_D0.6430.34
20_R127_F0.6430.34
41_V118_R0.6420.34
25_A29_D0.6370.34
17_D68_R0.6250.33
22_E69_R0.6200.33
30_A121_V0.6190.32
50_V66_L0.6150.32
70_L122_D0.6130.32
23_A46_Y0.6120.32
130_D134_L0.5990.31
63_A106_S0.5990.31
56_R106_S0.5930.31
22_E70_L0.5860.30
7_T52_L0.5820.30
24_A38_Q0.5800.30
27_A31_V0.5800.30
19_A31_V0.5790.30
45_L68_R0.5780.29
53_A124_V0.5700.29
24_A83_L0.5680.29
47_D97_F0.5670.29
16_T26_G0.5670.29
105_L114_A0.5660.29
34_G83_L0.5640.29
41_V83_L0.5630.28
7_T108_T0.5630.28
44_Y90_F0.5620.28
9_V15_D0.5620.28
114_A120_D0.5620.28
33_D41_V0.5610.28
22_E120_D0.5600.28
14_H27_A0.5550.28
29_D117_R0.5540.28
18_A82_M0.5510.28
50_V97_F0.5510.28
96_V100_L0.5500.28
23_A120_D0.5470.27
71_R95_G0.5430.27
103_Q113_V0.5400.27
92_D118_R0.5320.26
45_L112_T0.5320.26
65_R69_R0.5310.26
19_A64_Q0.5290.26
45_L114_A0.5280.26
71_R98_E0.5270.26
40_Y119_H0.5260.26
125_L132_D0.5260.26
124_V134_L0.5250.26
105_L124_V0.5230.26
29_D64_Q0.5230.26
50_V63_A0.5220.26
106_S127_F0.5210.26
9_V126_S0.5160.25
109_D128_D0.5130.25
98_E101_D0.5110.25
4_L9_V0.5110.25
8_G127_F0.5080.25
55_A63_A0.5050.25
46_Y90_F0.5050.25
17_D91_D0.5050.25
10_L43_D0.5020.24
51_T116_M0.5010.24
9_V132_D0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w8iA 2 0.9375 99.8 0.57 Contact Map
2fe1A 2 0.8472 99.5 0.658 Contact Map
3zvkA 3 0.9028 99.5 0.659 Contact Map
3tndA 3 0.8819 99.5 0.668 Contact Map
2h1cA 2 0.9236 99.4 0.681 Contact Map
3dboB 1 0.8472 99.4 0.687 Contact Map
4chgA 2 0.8611 99.3 0.694 Contact Map
1v8pA 4 0.8264 99.2 0.71 Contact Map
3h87A 3 0.8681 99.2 0.712 Contact Map
1v96A 2 0.8681 99 0.741 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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