GREMLIN Database
Q9HSU2 - Uncharacterized protein
UniProt: Q9HSU2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 98 (96)
Sequences: 1871 (1484)
Seq/√Len: 151.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_E73_K3.2761.00
31_F77_L2.9701.00
75_E81_E2.9671.00
42_N56_Y2.9001.00
38_R66_H2.7731.00
85_G88_G2.5321.00
17_A33_V2.4451.00
33_V74_A2.2541.00
45_V54_Q2.1691.00
12_R92_Q2.1601.00
16_Q20_R1.9251.00
3_I42_N1.9121.00
44_L86_F1.7121.00
3_I65_R1.6541.00
16_Q83_E1.6501.00
93_T97_C1.5611.00
46_D87_T1.5441.00
34_G71_I1.5021.00
4_P8_D1.4681.00
29_E77_L1.4301.00
12_R84_V1.3991.00
39_V86_F1.3831.00
11_R15_I1.3821.00
9_C80_Y1.3731.00
45_V50_T1.3621.00
84_V92_Q1.3361.00
88_G92_Q1.3311.00
5_T66_H1.3171.00
40_T43_E1.3111.00
3_I40_T1.3071.00
34_G69_A1.2901.00
71_I82_P1.2881.00
47_A90_L1.2801.00
88_G91_E1.2461.00
59_P65_R1.2391.00
72_S76_N1.2011.00
5_T38_R1.2001.00
9_C13_N1.1641.00
13_N35_T1.1251.00
14_V33_V1.1130.99
9_C14_V1.1040.99
4_P41_V1.0820.99
38_R68_H1.0730.99
63_D67_S1.0650.99
45_V52_I1.0540.99
62_G67_S1.0510.99
73_K77_L1.0460.99
14_V17_A1.0430.99
48_P94_I1.0410.99
64_V67_S1.0350.99
71_I80_Y1.0050.99
69_A80_Y1.0020.99
87_T91_E0.9580.98
92_Q95_P0.9490.98
20_R23_E0.9440.98
60_R64_V0.9160.98
10_T92_Q0.9120.98
84_V89_G0.9120.98
24_S27_T0.8990.98
41_V45_V0.8880.97
46_D49_G0.8870.97
31_F74_A0.8800.97
5_T40_T0.8720.97
4_P59_P0.8450.96
72_S75_E0.8410.96
10_T84_V0.8350.96
8_D69_A0.8300.96
11_R14_V0.8210.96
15_I80_Y0.8100.96
26_V29_E0.8080.95
20_R79_G0.8080.95
13_N86_F0.8080.95
43_E87_T0.8060.95
21_A78_L0.8010.95
39_V44_L0.7910.95
18_N22_A0.7900.95
37_G68_H0.7860.95
35_T85_G0.7820.95
91_E95_P0.7770.94
60_R67_S0.7750.94
19_I23_E0.7740.94
21_A74_A0.7660.94
74_A78_L0.7490.93
6_H63_D0.7380.93
37_G85_G0.7380.93
10_T93_T0.7350.93
55_I58_D0.7290.92
13_N80_Y0.7220.92
8_D34_G0.7200.92
41_V63_D0.7160.92
39_V43_E0.7090.91
36_G68_H0.7050.91
64_V68_H0.7010.91
14_V18_N0.6950.90
41_V67_S0.6900.90
74_A77_L0.6830.90
14_V67_S0.6770.89
6_H62_G0.6640.88
17_A74_A0.6630.88
4_P65_R0.6560.88
15_I19_I0.6540.87
8_D41_V0.6450.87
16_Q80_Y0.6380.86
9_C35_T0.6370.86
52_I55_I0.6330.86
19_I22_A0.6330.86
46_D53_D0.6280.85
9_C63_D0.6260.85
71_I75_E0.6260.85
12_R15_I0.6230.85
13_N18_N0.6200.85
34_G67_S0.6190.84
8_D64_V0.6100.84
48_P51_D0.6040.83
90_L93_T0.6010.83
31_F73_K0.5880.81
67_S93_T0.5800.80
51_D90_L0.5770.80
47_A94_I0.5760.80
26_V31_F0.5760.80
36_G71_I0.5720.80
37_G43_E0.5660.79
41_V62_G0.5630.78
75_E91_E0.5540.77
47_A91_E0.5480.77
35_T39_V0.5460.76
32_N54_Q0.5340.75
38_R69_A0.5330.75
5_T39_V0.5330.75
8_D38_R0.5310.74
35_T93_T0.5270.74
31_F78_L0.5250.74
47_A50_T0.5220.73
17_A45_V0.5210.73
18_N45_V0.5210.73
9_C59_P0.5210.73
37_G87_T0.5200.73
67_S96_Y0.5170.72
64_V96_Y0.5150.72
5_T67_S0.5100.71
25_D28_G0.5050.71
53_D83_E0.5040.71
44_L56_Y0.5030.70
2_G8_D0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p5yA 1 0.9694 99.9 0.456 Contact Map
4lisA 2 1 99.9 0.462 Contact Map
1ek6A 2 1 99.9 0.47 Contact Map
1z45A 2 0.9082 99.9 0.471 Contact Map
1udbA 2 1 99.8 0.474 Contact Map
3enkA 2 1 99.8 0.478 Contact Map
1gy8A 2 1 99.8 0.492 Contact Map
3rufA 2 0.9592 99.8 0.496 Contact Map
1sb8A 2 1 99.8 0.498 Contact Map
2hunA 2 1 99.8 0.502 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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