GREMLIN Database
Q9HST5 - Molybdenum cofactor biosynthesis protein
UniProt: Q9HST5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (236)
Sequences: 6804 (4527)
Seq/√Len: 294.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_D111_R3.2451.00
59_T104_D3.2131.00
86_E94_A3.1991.00
93_A97_D3.1801.00
35_A59_T3.0811.00
79_H91_S2.9541.00
61_G124_Y2.9481.00
10_Q32_R2.9261.00
35_A61_G2.8611.00
59_T106_Q2.8611.00
87_Q109_D2.6981.00
211_E214_K2.5641.00
81_T101_P2.5111.00
38_V49_I2.4481.00
48_V128_V2.4461.00
83_D86_E2.4061.00
128_V212_T2.4001.00
154_G204_I2.3081.00
49_I96_V2.2861.00
226_R239_T2.2221.00
126_V212_T2.1671.00
118_T146_L2.1661.00
78_I92_A2.1591.00
127_V144_C2.0691.00
93_A107_R2.0271.00
61_G108_H2.0251.00
37_L124_Y2.0081.00
174_C177_C1.9411.00
154_G208_Q1.9291.00
41_A62_I1.9131.00
10_Q102_D1.8991.00
34_A216_I1.8771.00
90_D109_D1.8401.00
174_C248_C1.8361.00
23_V217_L1.8341.00
161_G204_I1.8291.00
142_D176_R1.7271.00
131_S136_T1.7261.00
51_Y202_G1.6921.00
23_V27_G1.6861.00
29_A33_E1.6781.00
165_T215_H1.6781.00
14_Y100_N1.6721.00
89_V109_D1.6711.00
163_V207_I1.6521.00
15_S19_I1.6461.00
82_D98_T1.6421.00
118_T147_A1.6191.00
89_V107_R1.6041.00
122_A147_A1.6021.00
80_G98_T1.5931.00
80_G95_F1.5921.00
46_S78_I1.5741.00
90_D107_R1.5491.00
49_I62_I1.5271.00
177_C248_C1.5121.00
47_P50_Q1.4911.00
112_V117_V1.4561.00
95_F98_T1.4511.00
53_A103_V1.4451.00
48_V130_A1.4311.00
83_D95_F1.3901.00
37_L63_A1.3821.00
35_A124_Y1.3781.00
36_V126_V1.3741.00
86_E90_D1.3721.00
31_L213_V1.3601.00
207_I237_F1.3361.00
87_Q90_D1.3221.00
230_Y235_M1.3071.00
61_G106_Q1.3061.00
143_A147_A1.2941.00
80_G83_D1.2791.00
199_V210_T1.2361.00
50_Q77_T1.2281.00
110_Q116_T1.2171.00
126_V152_S1.2151.00
53_A96_V1.2091.00
83_D94_A1.1951.00
17_H74_Q1.1951.00
96_V105_V1.1651.00
156_I201_P1.1641.00
205_G209_A1.1631.00
67_A87_Q1.1621.00
231_D234_D1.1591.00
173_P177_C1.1521.00
100_N103_V1.1441.00
50_Q54_A1.1431.00
113_T116_T1.1411.00
68_V91_S1.1391.00
72_N88_K1.1131.00
39_V140_I1.1111.00
41_A92_A1.1071.00
230_Y237_F1.1071.00
203_T230_Y1.1011.00
11_L25_A1.1001.00
37_L121_I1.0851.00
117_V143_A1.0831.00
114_A142_D1.0811.00
17_H28_Q1.0761.00
79_H83_D1.0681.00
141_N145_T1.0601.00
165_T211_E1.0561.00
190_D193_T1.0511.00
138_Y180_P1.0511.00
173_P225_G1.0401.00
97_D103_V1.0361.00
66_D72_N1.0321.00
118_T143_A1.0261.00
66_D88_K1.0241.00
78_I96_V1.0241.00
152_S215_H1.0211.00
144_C151_F1.0091.00
210_T232_A1.0041.00
152_S212_T1.0041.00
129_D140_I1.0001.00
55_A213_V0.9991.00
138_Y176_R0.9971.00
30_A34_A0.9961.00
54_A99_L0.9961.00
131_S140_I0.9901.00
83_D91_S0.9881.00
142_D146_L0.9861.00
86_E91_S0.9821.00
24_G27_G0.9741.00
46_S50_Q0.9731.00
126_V216_I0.9691.00
20_M159_F0.9651.00
90_D93_A0.9591.00
93_A105_V0.9561.00
18_I25_A0.9521.00
39_V63_A0.9441.00
35_A106_Q0.9441.00
163_V204_I0.9361.00
133_N136_T0.9251.00
210_T230_Y0.9241.00
117_V139_L0.9191.00
215_H222_S0.9181.00
123_A149_V0.9151.00
236_S239_T0.9091.00
140_I151_F0.9071.00
11_L18_I0.9051.00
129_D137_R0.9041.00
32_R102_D0.9031.00
68_V79_H0.9001.00
51_Y77_T0.9001.00
30_A218_G0.9001.00
13_R81_T0.8981.00
53_A60_I0.8951.00
46_S79_H0.8951.00
125_D149_V0.8941.00
110_Q119_D0.8931.00
94_A98_T0.8921.00
106_Q123_A0.8901.00
37_L61_G0.8821.00
202_G206_S0.8801.00
25_A29_A0.8641.00
159_F233_A0.8511.00
152_S165_T0.8471.00
119_D122_A0.8461.00
156_I196_V0.8441.00
126_V215_H0.8421.00
108_H124_Y0.8401.00
167_T172_G0.8391.00
50_Q95_F0.8371.00
189_P194_A0.8341.00
141_N151_F0.8171.00
127_V149_V0.8171.00
118_T122_A0.8151.00
44_L208_Q0.8151.00
228_L239_T0.8141.00
49_I92_A0.8081.00
200_L232_A0.8061.00
121_I124_Y0.8021.00
65_D109_D0.8011.00
50_Q99_L0.8011.00
228_L237_F0.8001.00
54_A74_Q0.7990.99
133_N137_R0.7940.99
176_R179_F0.7940.99
26_T30_A0.7870.99
41_A49_I0.7820.99
30_A33_E0.7780.99
63_A112_V0.7740.99
121_I143_A0.7720.99
60_I96_V0.7710.99
121_I144_C0.7640.99
63_A120_L0.7600.99
70_L81_T0.7590.99
139_L143_A0.7550.99
47_P202_G0.7440.99
141_N174_C0.7430.99
203_T207_I0.7410.99
17_H55_A0.7410.99
168_G171_D0.7400.99
81_T84_V0.7370.99
167_T171_D0.7350.99
72_N75_R0.7340.99
229_F240_V0.7310.99
143_A146_L0.7280.99
112_V116_T0.7270.99
168_G172_G0.7230.99
51_Y209_A0.7150.99
137_R155_A0.7130.99
228_L235_M0.7070.99
70_L84_V0.7060.99
57_V216_I0.7010.99
129_D153_H0.7010.99
14_Y103_V0.7000.99
94_A97_D0.6990.99
196_V201_P0.6980.99
219_V233_A0.6920.99
49_I78_I0.6910.99
48_V205_G0.6890.99
96_V103_V0.6890.99
158_Q200_L0.6890.99
62_I105_V0.6880.98
190_D194_A0.6870.98
75_R88_K0.6850.98
39_V112_V0.6840.98
138_Y142_D0.6820.98
53_A105_V0.6800.98
49_I60_I0.6790.98
42_G45_G0.6790.98
226_R241_A0.6790.98
55_A198_G0.6790.98
47_P51_Y0.6750.98
121_I127_V0.6730.98
41_A79_H0.6730.98
201_P206_S0.6730.98
174_C179_F0.6710.98
51_Y206_S0.6700.98
197_L210_T0.6690.98
31_L58_G0.6690.98
121_I147_A0.6690.98
120_L124_Y0.6680.98
127_V140_I0.6670.98
12_D70_L0.6670.98
153_H164_T0.6660.98
89_V105_V0.6630.98
66_D75_R0.6630.98
196_V200_L0.6600.98
78_I95_F0.6580.98
213_V217_L0.6560.98
171_D244_Q0.6510.98
229_F238_E0.6490.98
27_G217_L0.6470.98
138_Y179_F0.6470.98
90_D94_A0.6430.98
30_A217_L0.6420.98
116_T120_L0.6420.98
88_K132_D0.6420.98
131_S137_R0.6400.98
47_P205_G0.6400.98
116_T139_L0.6400.98
172_G179_F0.6350.97
148_G169_G0.6340.97
46_S68_V0.6290.97
41_A89_V0.6290.97
97_D104_D0.6260.97
26_T29_A0.6240.97
13_R102_D0.6230.97
232_A235_M0.6160.97
58_G100_N0.6140.97
69_E72_N0.6050.97
128_V208_Q0.6050.97
160_E231_D0.6040.97
63_A117_V0.6040.97
212_T216_I0.6030.97
14_Y28_Q0.5990.96
199_V206_S0.5980.96
34_A57_V0.5980.96
72_N132_D0.5960.96
34_A125_D0.5960.96
36_V216_I0.5930.96
66_D132_D0.5910.96
36_V212_T0.5890.96
17_H20_M0.5870.96
83_D98_T0.5850.96
43_G201_P0.5810.96
66_D71_S0.5800.96
219_V222_S0.5750.95
12_D15_S0.5750.95
114_A139_L0.5740.95
28_Q31_L0.5700.95
77_T202_G0.5700.95
20_M23_V0.5680.95
121_I149_V0.5670.95
112_V121_I0.5670.95
182_A185_A0.5670.95
61_G120_L0.5660.95
214_K220_G0.5640.95
95_F99_L0.5610.95
203_T210_T0.5610.95
50_Q78_I0.5610.95
159_F197_L0.5600.95
117_V120_L0.5590.95
36_V57_V0.5570.95
97_D105_V0.5570.95
11_L15_S0.5570.95
31_L217_L0.5530.94
207_I228_L0.5530.94
172_G176_R0.5520.94
226_R229_F0.5520.94
23_V159_F0.5520.94
35_A123_A0.5500.94
54_A77_T0.5470.94
91_S94_A0.5450.94
41_A60_I0.5440.94
15_S18_I0.5440.94
47_P77_T0.5440.94
43_G74_Q0.5440.94
156_I200_L0.5430.94
107_R110_Q0.5410.94
48_V212_T0.5410.94
164_T173_P0.5410.94
42_G76_Q0.5400.94
159_F219_V0.5400.94
91_S95_F0.5370.94
36_V128_V0.5360.94
108_H120_L0.5350.93
177_C180_P0.5320.93
51_Y54_A0.5320.93
61_G123_A0.5310.93
40_G45_G0.5310.93
44_L154_G0.5290.93
129_D132_D0.5280.93
189_P193_T0.5260.93
34_A212_T0.5260.93
43_G76_Q0.5250.93
206_S210_T0.5250.93
221_D234_D0.5250.93
145_T166_F0.5250.93
54_A198_G0.5190.92
62_I92_A0.5180.92
112_V120_L0.5170.92
75_R132_D0.5160.92
42_G75_R0.5140.92
173_P176_R0.5140.92
158_Q194_A0.5120.92
211_E223_L0.5110.92
64_D89_V0.5110.92
128_V154_G0.5080.92
176_R181_E0.5030.91
72_N76_Q0.5030.91
47_P206_S0.5030.91
174_C178_L0.5020.91
12_D71_S0.5020.91
23_V213_V0.5010.91
203_T232_A0.5010.91
166_F242_L0.5010.91
202_G209_A0.5000.91
42_G66_D0.5000.91
23_V197_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zud1 2 0.8633 100 0.247 Contact Map
1jw9B 2 0.8633 100 0.258 Contact Map
1tt5B 1 0.9712 100 0.266 Contact Map
4gslA 2 0.9784 100 0.279 Contact Map
2nvuB 1 0.9856 100 0.28 Contact Map
3h8vA 2 0.7662 100 0.294 Contact Map
3h5nA 3 0.8885 100 0.295 Contact Map
3ruiA 2 0.9784 100 0.299 Contact Map
1y8qB 1 0.9245 100 0.332 Contact Map
1y8qA 1 0.8381 100 0.336 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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