GREMLIN Database
MOAA - Probable cyclic pyranopterin monophosphate synthase
UniProt: Q9HST4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 357 (290)
Sequences: 8998 (6879)
Seq/√Len: 403.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_F100_T4.2781.00
53_V86_R3.6651.00
57_S86_R2.9811.00
126_N139_D2.8831.00
48_S51_R2.6591.00
107_A111_D2.6241.00
88_P115_E2.4831.00
130_A136_G2.4331.00
147_A150_D2.4321.00
128_A169_Y2.3841.00
22_N98_N2.3831.00
81_E105_R2.3481.00
81_E108_D2.3481.00
104_G147_A2.3131.00
125_D139_D2.3111.00
285_Y295_D2.2061.00
13_V59_A2.2021.00
160_M173_M2.1681.00
103_P143_E2.1671.00
54_R58_V2.1391.00
56_L87_T2.0671.00
122_D133_T2.0611.00
285_Y298_G1.9981.00
107_A151_A1.9891.00
65_D91_M1.9851.00
138_Y142_L1.9831.00
51_R302_T1.9811.00
305_S308_A1.9791.00
169_Y172_E1.9681.00
105_R108_D1.9581.00
271_F289_C1.9411.00
146_E180_R1.9391.00
302_T305_S1.9371.00
171_P217_R1.9011.00
158_L177_V1.8661.00
125_D169_Y1.8621.00
49_T79_D1.8501.00
52_V83_I1.7991.00
60_H90_D1.7931.00
85_R108_D1.7711.00
108_D111_D1.7651.00
146_E149_L1.7451.00
61_E307_R1.7321.00
69_L87_T1.7171.00
86_R89_D1.7141.00
124_M169_Y1.7011.00
49_T82_A1.6701.00
172_E175_D1.6571.00
139_D143_E1.6561.00
79_D82_A1.6511.00
126_N136_G1.6511.00
295_D298_G1.6481.00
119_I145_V1.6281.00
146_E150_D1.6261.00
175_D179_A1.6181.00
20_R46_E1.6161.00
110_V151_A1.6161.00
22_N101_F1.6121.00
85_R89_D1.6121.00
82_A85_R1.5981.00
304_Q308_A1.5951.00
49_T53_V1.5931.00
27_Y122_D1.5911.00
124_M128_A1.5911.00
84_I114_L1.5651.00
143_E146_E1.5441.00
146_E181_D1.5351.00
128_A168_G1.5341.00
147_A151_A1.5171.00
140_A143_E1.5121.00
119_I144_G1.5021.00
11_S65_D1.4911.00
99_G119_I1.4901.00
26_V131_E1.4891.00
207_V210_W1.4841.00
53_V82_A1.4821.00
138_Y176_H1.4801.00
281_T287_K1.4591.00
164_E210_W1.4521.00
106_A147_A1.4481.00
104_G150_D1.4461.00
75_M95_M1.4261.00
53_V57_S1.4251.00
51_R54_R1.4111.00
88_P93_V1.4071.00
123_A128_A1.3961.00
67_V87_T1.3921.00
281_T285_Y1.3861.00
17_L80_L1.3601.00
17_L69_L1.3551.00
129_F141_V1.3461.00
149_L181_D1.3451.00
56_L67_V1.3321.00
308_A312_E1.3261.00
307_R311_R1.3211.00
106_A144_G1.3161.00
69_L84_I1.2941.00
216_D220_T1.2901.00
175_D228_R1.2801.00
117_V148_A1.2661.00
75_M101_F1.2481.00
160_M185_L1.2471.00
15_V280_L1.2451.00
149_L183_L1.2411.00
108_D112_A1.2381.00
299_I309_A1.2301.00
128_A131_E1.2131.00
96_T118_N1.2121.00
58_V305_S1.2111.00
15_V52_V1.2091.00
213_D217_R1.1931.00
87_T93_V1.1921.00
149_L156_V1.1841.00
177_V182_G1.1741.00
142_L146_E1.1701.00
110_V153_L1.1621.00
54_R303_T1.1601.00
131_E165_P1.1441.00
77_R83_I1.1431.00
215_A218_I1.1411.00
45_N283_D1.1281.00
58_V307_R1.1181.00
125_D172_E1.1121.00
127_D131_E1.1071.00
53_V89_D1.1071.00
129_F137_A1.1061.00
130_A137_A1.1051.00
49_T86_R1.1041.00
103_P147_A1.0921.00
141_V144_G1.0851.00
206_R210_W1.0771.00
212_A216_D1.0741.00
59_A64_V1.0671.00
211_L214_R1.0651.00
82_A86_R1.0561.00
149_L182_G1.0551.00
22_N73_E1.0541.00
217_R220_T1.0521.00
304_Q312_E1.0471.00
46_E77_R1.0421.00
313_T317_R1.0321.00
117_V153_L1.0271.00
49_T83_I1.0271.00
213_D216_D1.0211.00
75_M80_L1.0151.00
83_I87_T1.0111.00
55_F280_L1.0101.00
184_R259_M1.0101.00
143_E147_A1.0071.00
137_A140_A1.0021.00
286_L309_A0.9991.00
88_P112_A0.9991.00
125_D128_A0.9981.00
80_L84_I0.9931.00
209_D213_D0.9891.00
123_A138_Y0.9861.00
314_V317_R0.9861.00
126_N138_Y0.9851.00
162_V170_V0.9831.00
215_A219_E0.9821.00
142_L176_H0.9741.00
144_G147_A0.9741.00
19_D282_H0.9731.00
148_A156_V0.9731.00
322_G325_M0.9591.00
95_M114_L0.9531.00
104_G151_A0.9481.00
158_L182_G0.9471.00
145_V156_V0.9421.00
62_F307_R0.9361.00
102_L144_G0.9341.00
27_Y132_L0.9321.00
315_A319_P0.9281.00
79_D83_I0.9261.00
230_W233_S0.9251.00
229_Y233_S0.9251.00
278_V306_M0.9201.00
163_F166_T0.9181.00
102_L106_A0.9151.00
58_V306_M0.9121.00
85_R112_A0.9091.00
298_G302_T0.9091.00
287_K295_D0.9081.00
66_A94_S0.9061.00
271_F275_C0.8991.00
118_N159_N0.8971.00
84_I112_A0.8951.00
210_W213_D0.8911.00
124_M176_H0.8911.00
59_A67_V0.8901.00
212_A215_A0.8891.00
18_T46_E0.8861.00
239_T242_D0.8841.00
106_A110_V0.8801.00
317_R321_Y0.8791.00
59_A310_F0.8761.00
211_L215_A0.8751.00
171_P175_D0.8701.00
106_A151_A0.8661.00
47_L51_R0.8591.00
139_D142_L0.8581.00
241_D245_Q0.8521.00
92_A116_R0.8481.00
148_A153_L0.8471.00
92_A115_E0.8451.00
13_V278_V0.8421.00
66_A92_A0.8421.00
97_T119_I0.8411.00
125_D130_A0.8251.00
295_D299_I0.8191.00
54_R57_S0.8191.00
240_A243_A0.8191.00
208_H212_A0.8181.00
176_H180_R0.8171.00
243_A247_V0.8161.00
75_M144_G0.8161.00
69_L93_V0.8161.00
216_D219_E0.8111.00
73_E98_N0.8101.00
306_M310_F0.8061.00
50_D53_V0.8011.00
15_V56_L0.8011.00
119_I148_A0.7921.00
319_P322_G0.7901.00
17_L83_I0.7881.00
126_N130_A0.7861.00
107_A110_V0.7861.00
170_V187_L0.7841.00
85_R111_D0.7841.00
13_V280_L0.7841.00
207_V211_L0.7821.00
73_E76_L0.7801.00
232_S248_T0.7801.00
211_L218_I0.7721.00
81_E112_A0.7701.00
102_L148_A0.7681.00
123_A169_Y0.7671.00
175_D180_R0.7651.00
132_L163_F0.7641.00
123_A133_T0.7641.00
95_M109_L0.7641.00
102_L109_L0.7631.00
58_V61_E0.7591.00
107_A147_A0.7571.00
120_S161_V0.7561.00
16_S279_R0.7531.00
175_D178_A0.7491.00
22_N100_T0.7441.00
205_D208_H0.7421.00
145_V183_L0.7421.00
121_Q158_L0.7411.00
140_A144_G0.7371.00
129_F133_T0.7351.00
110_V115_E0.7351.00
54_R302_T0.7341.00
90_D93_V0.7341.00
142_L180_R0.7311.00
60_H91_M0.7301.00
125_D168_G0.7301.00
56_L69_L0.7281.00
272_C289_C0.7281.00
305_S309_A0.7271.00
26_V134_Q0.7271.00
62_F311_R0.7251.00
246_S249_P0.7221.00
279_R290_L0.7211.00
171_P174_V0.7211.00
81_E84_I0.7191.00
145_V158_L0.7171.00
144_G148_A0.7121.00
286_L306_M0.7091.00
130_A138_Y0.7071.00
75_M109_L0.7021.00
103_P144_G0.7001.00
21_C25_C0.7001.00
249_P252_G0.7001.00
23_F137_A0.6991.00
130_A135_S0.6981.00
17_L52_V0.6961.00
50_D86_R0.6931.00
116_R155_P0.6921.00
228_R232_S0.6901.00
214_R218_I0.6901.00
29_H70_T0.6851.00
208_H264_D0.6800.99
229_Y232_S0.6800.99
14_R70_T0.6800.99
81_E85_R0.6790.99
110_V152_G0.6770.99
308_A311_R0.6730.99
278_V310_F0.6720.99
103_P140_A0.6710.99
201_A204_I0.6710.99
57_S61_E0.6710.99
298_G303_T0.6650.99
177_V185_L0.6640.99
70_T290_L0.6630.99
105_R109_L0.6620.99
16_S282_H0.6610.99
27_Y133_T0.6610.99
297_R309_A0.6600.99
280_L286_L0.6600.99
31_E134_Q0.6590.99
21_C28_C0.6560.99
18_T77_R0.6560.99
123_A129_F0.6550.99
100_T144_G0.6520.99
16_S70_T0.6490.99
47_L284_G0.6490.99
118_N157_K0.6480.99
208_H211_L0.6460.99
95_M117_V0.6420.99
316_N320_Y0.6420.99
248_T252_G0.6420.99
173_M185_L0.6390.99
77_R80_L0.6380.99
242_D246_S0.6350.99
75_M105_R0.6310.99
23_F129_F0.6300.99
80_L95_M0.6290.99
101_F104_G0.6270.99
25_C28_C0.6260.99
11_S276_H0.6260.99
69_L83_I0.6250.99
68_K94_S0.6220.99
55_F58_V0.6210.99
244_A248_T0.6170.99
316_N319_P0.6150.99
49_T77_R0.6150.99
220_T228_R0.6140.99
52_V77_R0.6140.99
171_P220_T0.6130.99
310_F314_V0.6130.99
238_S241_D0.6120.99
129_F136_G0.6120.99
77_R82_A0.6100.99
248_T251_G0.6070.99
174_V249_P0.6060.99
252_G257_Q0.6060.99
129_F138_Y0.6050.99
98_N101_F0.6030.99
206_R212_A0.6030.99
315_A318_V0.6020.99
96_T159_N0.6010.99
242_D245_Q0.6000.99
68_K96_T0.6000.99
232_S250_D0.6000.99
209_D212_A0.5990.99
311_R315_A0.5970.99
84_I93_V0.5970.99
30_N70_T0.5940.99
149_L180_R0.5930.99
228_R231_V0.5910.99
96_T290_L0.5910.99
312_E316_N0.5900.99
310_F319_P0.5890.99
55_F59_A0.5890.99
14_R277_R0.5880.99
243_A246_S0.5870.99
240_A244_A0.5860.99
26_V132_L0.5810.98
240_A246_S0.5810.98
241_D244_A0.5810.98
102_L119_I0.5800.98
159_N290_L0.5790.98
313_T316_N0.5760.98
10_V310_F0.5730.98
27_Y161_V0.5710.98
159_N188_I0.5690.98
287_K293_N0.5680.98
104_G107_A0.5640.98
67_V91_M0.5630.98
161_V188_I0.5610.98
16_S30_N0.5600.98
273_A289_C0.5580.98
93_V114_L0.5570.98
121_Q142_L0.5560.98
204_I208_H0.5560.98
304_Q309_A0.5510.98
130_A133_T0.5470.98
52_V55_F0.5470.98
212_A219_E0.5450.98
127_D130_A0.5440.98
17_L77_R0.5430.98
106_A148_A0.5430.98
242_D249_P0.5420.98
93_V115_E0.5420.98
320_Y323_E0.5420.98
24_D29_H0.5420.98
174_V178_A0.5390.97
70_T96_T0.5380.97
245_Q251_G0.5380.97
243_A249_P0.5380.97
49_T52_V0.5370.97
96_T291_N0.5370.97
67_V93_V0.5360.97
239_T243_A0.5360.97
51_R55_F0.5350.97
124_M172_E0.5340.97
244_A250_D0.5320.97
18_T72_G0.5310.97
122_D129_F0.5310.97
100_T140_A0.5300.97
288_G292_R0.5290.97
309_A312_E0.5290.97
12_G66_A0.5280.97
73_E97_T0.5260.97
168_G213_D0.5240.97
56_L60_H0.5230.97
202_I205_D0.5230.97
134_Q137_A0.5220.97
158_L185_L0.5190.97
121_Q138_Y0.5190.97
306_M309_A0.5180.97
160_M177_V0.5180.97
73_E99_G0.5170.97
168_G171_P0.5170.97
121_Q141_V0.5160.97
75_M102_L0.5150.97
116_R157_K0.5130.97
188_I191_M0.5120.97
87_T91_M0.5110.96
170_V214_R0.5110.96
312_E315_A0.5090.96
314_V319_P0.5080.96
47_L52_V0.5080.96
201_A205_D0.5040.96
50_D54_R0.5030.96
51_R58_V0.5020.96
70_T159_N0.5010.96
27_Y30_N0.5010.96
145_V148_A0.5010.96
14_R290_L0.5010.96
16_S290_L0.5010.96
246_S259_M0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.8964 100 0.408 Contact Map
1tv8A 2 0.8711 100 0.424 Contact Map
4m7tA 1 0.6471 100 0.504 Contact Map
3c8fA 1 0.6134 100 0.588 Contact Map
4rtbA 2 0.8207 100 0.596 Contact Map
2yx0A 1 0.6863 99.9 0.617 Contact Map
4wcxA 1 0.8739 99.9 0.625 Contact Map
2z2uA 1 0.5966 99.9 0.629 Contact Map
2qgqA 1 0.7115 99.9 0.629 Contact Map
3rfaA 1 0.6611 99.9 0.636 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0106 seconds.