GREMLIN Database
Q9HST2 - Molybdenum cofactor biosynthesis protein
UniProt: Q9HST2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 407 (387)
Sequences: 5337 (4039)
Seq/√Len: 205.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_G244_H3.6061.00
213_V218_G3.5401.00
34_A44_R3.5141.00
166_L174_V3.1151.00
48_A175_A3.1031.00
234_R267_D3.0941.00
159_R162_D3.0831.00
35_R173_A2.9621.00
82_P85_L2.9031.00
331_D399_A2.8491.00
106_L138_V2.7971.00
156_H162_D2.7791.00
81_S85_L2.7691.00
60_E140_P2.7441.00
93_G96_E2.7251.00
331_D397_T2.6441.00
393_D396_T2.5171.00
55_A141_I2.4381.00
345_R384_V2.3791.00
337_K393_D2.3531.00
70_R73_D2.3011.00
82_P96_E2.2941.00
197_G200_E2.2651.00
151_L169_A2.2541.00
49_D153_D2.2481.00
295_V312_L2.2251.00
49_D150_H2.2041.00
55_A147_D2.2011.00
51_E150_H2.1831.00
334_L392_Y2.1771.00
337_K394_A2.1361.00
60_E141_I2.1311.00
49_D154_A2.1171.00
345_R387_E2.1141.00
38_L167_K2.1041.00
270_T288_V2.0471.00
33_T175_A2.0371.00
332_A400_V2.0171.00
120_E127_D1.9971.00
35_R175_A1.9871.00
46_L152_Y1.9721.00
221_T244_H1.9611.00
329_T399_A1.8771.00
381_G400_V1.8761.00
350_V381_G1.8691.00
55_A146_S1.8681.00
350_V383_V1.8591.00
21_E25_S1.8531.00
353_H363_T1.8431.00
164_G208_T1.8161.00
230_E264_V1.8101.00
16_V347_F1.7911.00
239_E243_S1.7741.00
152_Y162_D1.7691.00
146_S149_Q1.7611.00
192_V200_E1.7601.00
36_V44_R1.7391.00
61_R139_A1.7291.00
27_V315_L1.7241.00
68_A110_A1.7121.00
313_R317_K1.6901.00
335_A361_T1.6781.00
115_M118_D1.6771.00
308_A312_L1.6611.00
230_E263_E1.6531.00
333_V397_T1.6461.00
216_W308_A1.6451.00
69_V112_A1.6201.00
295_V315_L1.6021.00
246_V316_L1.5991.00
179_R219_V1.5981.00
71_A112_A1.5971.00
248_V312_L1.5941.00
40_D214_S1.5721.00
71_A111_D1.5701.00
181_T219_V1.5581.00
332_A362_V1.5471.00
335_A363_T1.5421.00
59_Y105_E1.5331.00
276_V311_F1.5301.00
351_T363_T1.5191.00
150_H153_D1.5141.00
80_R127_D1.5131.00
119_A126_V1.5041.00
184_V210_A1.4891.00
92_V110_A1.4891.00
158_L162_D1.4751.00
37_A40_D1.4681.00
305_I376_V1.4511.00
208_T305_I1.4431.00
227_T232_A1.4431.00
80_R125_R1.4081.00
50_V166_L1.4001.00
230_E267_D1.3901.00
34_A178_E1.3861.00
246_V295_V1.3791.00
330_T402_Q1.3781.00
85_L98_V1.3721.00
88_G258_R1.3691.00
265_I294_V1.3541.00
114_V119_A1.3531.00
15_R18_E1.3501.00
332_A352_R1.3501.00
54_R202_V1.3411.00
333_V361_T1.3401.00
351_T380_D1.3381.00
113_V137_N1.3271.00
116_I255_V1.3261.00
229_D232_A1.3191.00
53_P171_V1.3161.00
383_V398_V1.3131.00
234_R238_R1.3071.00
213_V220_P1.3061.00
212_Y308_A1.3061.00
183_G223_R1.3041.00
114_V128_V1.2951.00
278_L311_F1.2901.00
16_V311_F1.2821.00
18_E21_E1.2811.00
53_P169_A1.2791.00
69_V74_T1.2791.00
153_D156_H1.2761.00
226_V236_A1.2671.00
343_G388_D1.2641.00
284_V311_F1.2601.00
389_C396_T1.2561.00
70_R111_D1.2481.00
42_D214_S1.2481.00
317_K322_A1.2451.00
24_L318_A1.2421.00
235_T239_E1.2411.00
41_A174_V1.2411.00
100_V104_S1.2361.00
72_A111_D1.2331.00
194_A207_G1.2291.00
133_A136_A1.2291.00
249_T294_V1.2281.00
310_Q401_E1.2261.00
140_P143_E1.2261.00
120_E129_F1.2221.00
306_V382_W1.2221.00
336_R364_P1.2101.00
223_R244_H1.2041.00
329_T401_E1.1981.00
241_V292_T1.1971.00
163_L211_Q1.1911.00
16_V278_L1.1911.00
99_R116_I1.1901.00
163_L207_G1.1871.00
362_V381_G1.1851.00
285_A296_A1.1801.00
17_A345_R1.1791.00
60_E108_A1.1731.00
181_T221_T1.1711.00
352_R362_V1.1661.00
230_E234_R1.1661.00
216_W313_R1.1611.00
238_R268_L1.1581.00
22_R272_L1.1501.00
26_A286_L1.1491.00
88_G91_S1.1481.00
184_V213_V1.1461.00
206_G222_R1.1441.00
149_Q374_S1.1401.00
23_L286_L1.1391.00
37_A173_A1.1311.00
350_V362_V1.1251.00
223_R240_A1.1251.00
195_D202_V1.1231.00
112_A132_A1.1181.00
33_T178_E1.1181.00
106_L113_V1.1181.00
212_Y309_V1.1181.00
115_M137_N1.1101.00
33_T47_A1.1091.00
91_S189_E1.1091.00
158_L163_L1.1071.00
352_R380_D1.1051.00
42_D163_L1.1041.00
99_R257_A1.0951.00
157_R322_A1.0841.00
347_F384_V1.0801.00
234_R268_L1.0761.00
185_L226_V1.0751.00
36_V41_A1.0751.00
334_L338_I1.0741.00
71_A134_G1.0691.00
121_R124_D1.0621.00
45_V157_R1.0591.00
187_T261_V1.0551.00
382_W403_W1.0541.00
247_V292_T1.0541.00
160_P215_R1.0521.00
385_V392_Y1.0481.00
118_D130_A1.0461.00
354_G358_G1.0431.00
182_V213_V1.0411.00
232_A235_T1.0401.00
164_G373_L1.0391.00
286_L295_V1.0381.00
186_P250_T1.0381.00
63_A139_A1.0321.00
221_T243_S1.0311.00
362_V400_V1.0261.00
309_V313_R1.0241.00
45_V322_A1.0191.00
63_A137_N1.0161.00
231_A235_T1.0121.00
223_R243_S1.0101.00
279_Q346_S1.0081.00
349_R368_G1.0081.00
119_A128_V1.0081.00
352_R400_V1.0061.00
84_V96_E1.0001.00
13_R282_H0.9991.00
64_M115_M0.9931.00
263_E266_A0.9921.00
87_V98_V0.9841.00
213_V308_A0.9831.00
64_M137_N0.9781.00
14_T22_R0.9781.00
272_L288_V0.9771.00
182_V218_G0.9711.00
101_H258_R0.9711.00
92_V98_V0.9570.99
218_G316_L0.9570.99
352_R381_G0.9520.99
185_L236_A0.9510.99
364_P383_V0.9480.99
246_V293_P0.9460.99
41_A158_L0.9390.99
336_R394_A0.9380.99
48_A171_V0.9360.99
336_R363_T0.9330.99
309_V327_H0.9320.99
44_R179_R0.9280.99
101_H257_A0.9270.99
210_A214_S0.9260.99
262_P274_H0.9260.99
351_T378_L0.9260.99
203_E206_G0.9230.99
70_R94_P0.9220.99
178_E245_D0.9210.99
184_V220_P0.9150.99
177_Y320_G0.9130.99
170_G202_V0.9120.99
47_A177_Y0.9090.99
278_L307_N0.9060.99
162_D377_A0.9020.99
22_R25_S0.9020.99
234_R264_V0.9010.99
236_A239_E0.9010.99
52_A169_A0.9000.99
67_F119_A0.8970.99
80_R85_L0.8920.99
42_D211_Q0.8900.99
183_G240_A0.8880.99
265_I287_C0.8870.99
232_A236_A0.8780.99
67_F116_I0.8770.99
58_H201_V0.8710.99
33_T48_A0.8710.99
209_V308_A0.8700.99
183_G247_V0.8680.99
143_E369_G0.8680.99
186_P206_G0.8650.99
302_V349_R0.8640.99
71_A74_T0.8610.99
116_I119_A0.8570.99
384_V399_A0.8570.99
231_A234_R0.8530.99
180_P218_G0.8490.99
214_S220_P0.8460.99
17_A21_E0.8430.99
111_D134_G0.8320.99
14_T19_A0.8300.99
286_L293_P0.8280.98
226_V232_A0.8260.98
158_L166_L0.8210.98
86_D258_R0.8200.98
101_H116_I0.8170.98
186_P224_G0.8130.98
166_L171_V0.8120.98
42_D215_R0.8100.98
63_A143_E0.8100.98
33_T177_Y0.8090.98
203_E207_G0.8080.98
367_A372_V0.8080.98
43_G215_R0.8070.98
74_T112_A0.8050.98
122_R125_R0.8050.98
273_V286_L0.8050.98
238_R290_D0.8030.98
354_G360_P0.8030.98
18_E22_R0.8030.98
69_V114_V0.8030.98
60_E106_L0.7990.98
230_E233_L0.7980.98
297_L312_L0.7980.98
212_Y305_I0.7940.98
329_T384_V0.7940.98
240_A247_V0.7910.98
307_N311_F0.7910.98
240_A244_H0.7850.98
233_L264_V0.7840.98
152_Y156_H0.7820.98
214_S219_V0.7810.98
73_D95_G0.7790.98
210_A220_P0.7730.98
105_E198_P0.7720.98
282_H303_A0.7720.98
139_A298_P0.7710.98
44_R176_V0.7690.98
193_A203_E0.7670.98
144_D372_V0.7660.98
298_P303_A0.7660.98
288_V291_D0.7650.97
185_L247_V0.7630.97
30_L319_V0.7620.97
246_V319_V0.7610.97
350_V400_V0.7590.97
276_V284_V0.7590.97
86_D257_A0.7550.97
78_G81_S0.7500.97
254_S283_P0.7480.97
192_V197_G0.7450.97
31_A178_E0.7440.97
189_E227_T0.7420.97
50_V175_A0.7420.97
154_A177_Y0.7410.97
339_A391_G0.7390.97
253_S296_A0.7380.97
71_A132_A0.7370.97
82_P93_G0.7360.97
184_V209_V0.7350.97
279_Q344_T0.7320.97
333_V395_G0.7280.97
288_V293_P0.7280.97
310_Q347_F0.7270.97
190_E228_D0.7250.97
309_V382_W0.7250.97
24_L314_P0.7220.96
372_V375_S0.7210.96
348_V364_P0.7210.96
340_S385_V0.7200.96
144_D302_V0.7180.96
27_V319_V0.7160.96
35_R48_A0.7160.96
392_Y396_T0.7160.96
145_V151_L0.7150.96
122_R127_D0.7150.96
284_V307_N0.7140.96
193_A207_G0.7140.96
350_V380_D0.7110.96
82_P125_R0.7100.96
362_V383_V0.7090.96
52_A55_A0.7090.96
381_G403_W0.7020.96
277_A387_E0.7020.96
233_L260_H0.6990.96
242_D290_D0.6960.96
50_V171_V0.6950.96
241_V247_V0.6950.96
289_V293_P0.6940.96
186_P225_V0.6940.96
186_P203_E0.6940.96
330_T360_P0.6930.96
386_P389_C0.6930.96
112_A134_G0.6850.95
81_S87_V0.6830.95
101_H104_S0.6820.95
67_F121_R0.6810.95
274_H285_A0.6800.95
83_V121_R0.6780.95
369_G372_V0.6770.95
23_L315_L0.6770.95
262_P266_A0.6750.95
213_V216_W0.6740.95
337_K391_G0.6720.95
72_A134_G0.6710.95
230_E260_H0.6700.95
271_V285_A0.6690.95
92_V96_E0.6670.95
261_V294_V0.6660.94
102_T117_E0.6650.94
67_F126_V0.6630.94
172_D194_A0.6620.94
58_H142_G0.6610.94
224_G236_A0.6600.94
237_I247_V0.6590.94
49_D156_H0.6590.94
365_T379_A0.6590.94
248_V308_A0.6570.94
262_P285_A0.6570.94
22_R26_A0.6550.94
15_R277_A0.6530.94
191_L203_E0.6510.94
212_Y216_W0.6500.94
46_L174_V0.6500.94
338_I383_V0.6490.94
60_E138_V0.6490.94
73_D94_P0.6470.94
353_H361_T0.6470.94
236_A240_A0.6470.94
20_R24_L0.6450.93
185_L224_G0.6440.93
272_L286_L0.6430.93
374_S378_L0.6390.93
332_A353_H0.6380.93
30_L177_Y0.6380.93
238_R242_D0.6370.93
70_R110_A0.6360.93
56_V144_D0.6360.93
249_T253_S0.6360.93
264_V268_L0.6350.93
271_V287_C0.6350.93
56_V145_V0.6340.93
196_P202_V0.6340.93
249_T261_V0.6330.93
30_L178_E0.6330.93
335_A353_H0.6290.93
143_E371_G0.6280.93
210_A222_R0.6270.92
102_T283_P0.6270.92
71_A75_F0.6270.92
315_L319_V0.6260.92
67_F97_A0.6240.92
39_G210_A0.6230.92
203_E225_V0.6220.92
59_Y201_V0.6200.92
185_L223_R0.6190.92
46_L49_D0.6190.92
183_G224_G0.6170.92
194_A202_V0.6170.92
54_R58_H0.6150.92
112_A136_A0.6120.92
70_R93_G0.6110.92
97_A126_V0.6100.91
161_S305_I0.6100.91
144_D374_S0.6080.91
106_L109_G0.6080.91
14_T273_V0.6060.91
189_E225_V0.6060.91
81_S86_D0.6030.91
241_V289_V0.6010.91
349_R372_V0.6010.91
283_P370_S0.6000.91
44_R178_E0.5990.91
239_E242_D0.5980.91
260_H263_E0.5970.91
302_V376_V0.5970.91
27_V293_P0.5950.90
205_N250_T0.5950.90
152_Y166_L0.5950.90
384_V387_E0.5940.90
26_A288_V0.5940.90
209_V248_V0.5930.90
208_T304_A0.5930.90
237_I264_V0.5910.90
340_S346_S0.5890.90
82_P124_D0.5880.90
74_T132_A0.5880.90
356_E361_T0.5860.90
181_T244_H0.5860.90
282_H344_T0.5860.90
82_P86_D0.5850.90
144_D168_S0.5850.90
350_V398_V0.5840.90
62_A300_Y0.5830.90
15_R387_E0.5820.89
353_H356_E0.5810.89
183_G221_T0.5810.89
137_N143_E0.5800.89
298_P346_S0.5800.89
191_L202_V0.5800.89
264_V267_D0.5790.89
379_A403_W0.5760.89
39_G214_S0.5750.89
167_K207_G0.5740.89
76_G131_A0.5740.89
139_A262_P0.5730.89
213_V219_V0.5720.89
178_E181_T0.5700.88
114_V132_A0.5680.88
193_A225_V0.5670.88
151_L165_L0.5670.88
217_G220_P0.5660.88
187_T228_D0.5660.88
24_L27_V0.5630.88
317_K320_G0.5620.88
119_A129_F0.5620.88
126_V129_F0.5610.88
189_E258_R0.5610.88
61_R371_G0.5600.88
259_D282_H0.5590.88
61_R262_P0.5590.88
16_V345_R0.5540.87
29_P318_A0.5530.87
300_Y370_S0.5520.87
74_T128_V0.5520.87
293_P315_L0.5510.87
64_M139_A0.5510.87
303_A370_S0.5500.87
74_T79_D0.5500.87
322_A325_T0.5490.87
334_L396_T0.5480.86
362_V398_V0.5480.86
39_G42_D0.5480.86
46_L156_H0.5470.86
255_V275_G0.5470.86
287_C296_A0.5450.86
62_A100_V0.5440.86
149_Q378_L0.5440.86
226_V233_L0.5430.86
252_G261_V0.5430.86
263_E267_D0.5410.86
64_M282_H0.5360.85
58_H141_I0.5350.85
101_H253_S0.5350.85
334_L398_V0.5350.85
213_V316_L0.5320.85
16_V20_R0.5310.85
29_P319_V0.5310.85
115_M136_A0.5290.85
216_W317_K0.5280.84
316_L320_G0.5270.84
139_A300_Y0.5260.84
31_A177_Y0.5260.84
256_G299_G0.5260.84
73_D110_A0.5260.84
92_V95_G0.5260.84
20_R311_F0.5250.84
59_Y104_S0.5250.84
330_T400_V0.5250.84
228_D252_G0.5230.84
389_C392_Y0.5200.84
266_A270_T0.5190.83
102_T190_E0.5190.83
156_H159_R0.5190.83
130_A136_A0.5190.83
71_A138_V0.5180.83
85_L90_G0.5180.83
180_P319_V0.5170.83
85_L89_T0.5160.83
210_A213_V0.5150.83
293_P319_V0.5150.83
250_T304_A0.5140.83
64_M102_T0.5140.83
345_R386_P0.5130.83
244_H247_V0.5110.82
106_L110_A0.5110.82
191_L201_V0.5100.82
53_P147_D0.5100.82
241_V290_D0.5100.82
392_Y398_V0.5090.82
86_D96_E0.5090.82
84_V92_V0.5080.82
241_V294_V0.5070.82
72_A94_P0.5070.82
48_A154_A0.5070.82
81_S90_G0.5060.82
61_R298_P0.5060.82
161_S373_L0.5050.82
352_R402_Q0.5050.82
153_D323_P0.5050.82
313_R327_H0.5050.82
327_H401_E0.5050.82
283_P298_P0.5040.82
26_A270_T0.5030.81
349_R375_S0.5030.81
61_R101_H0.5030.81
240_A243_S0.5030.81
34_A179_R0.5030.81
310_Q382_W0.5030.81
16_V310_Q0.5020.81
247_V294_V0.5020.81
89_T253_S0.5010.81
346_S349_R0.5010.81
383_V400_V0.5010.81
53_P202_V0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g8lA 2 0.9681 100 0.142 Contact Map
1uz5A 1 0.9337 100 0.16 Contact Map
4pd0A 2 0.9607 100 0.165 Contact Map
1wu2A 2 0.9115 100 0.173 Contact Map
3rfqA 5 0.3538 100 0.675 Contact Map
1jljA 3 0.3735 100 0.684 Contact Map
4lhbA 4 0.3514 100 0.703 Contact Map
3iwtA 4 0.3661 100 0.709 Contact Map
1y5eA 4 0.3563 100 0.71 Contact Map
4xcwA 3 0.3907 100 0.713 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.011 seconds.