Q9HST1 - HALSA - GREMLIN Contacts

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Q9HST1 - L-isoaspartyl protein carboxyl methyltransferase

UniProt:	Q9HST1	Sequences: MEFGALREEMVDSLLDAGTALADARPADAAMRAVPRHEFVDAGHRAYTDQAFEHRGTRVLAPSTVARLVGALEPRAGDDVLVVGAGVGYTVAVVAEIAGPTHVHAVDIDRQVVYDARGNLADAGYEDVLVDCRDGAEGLAEYAPFDRVLVEAGAASVPDALARQLAADGRLVFPEGVGDQRLVSVRDGETVGVHGPVSFAPLLVAGEQASAVERNRTVREDRERVREAAQSRPGWEREWIDWEDA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	245 (197)
Sequences:	3774 (2698)
Seq/√Len:	192.2

ECOLI - PIMT
HALSA - Q9HST1
SULSO - Q97VM3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
85_A	105_A	2.848	1.00
105_A	130_V	2.726	1.00
107_D	113_V	2.688	1.00
113_V	132_C	2.667	1.00
33_A	96_E	2.644	1.00
159_D	163_R	2.470	1.00
22_A	70_G	2.382	1.00
96_E	125_Y	2.314	1.00
78_D	147_R	2.293	1.00
138_G	164_Q	2.230	1.00
115_D	119_N	2.203	1.00
113_V	130_V	2.119	1.00
8_E	32_R	2.117	1.00
150_V	173_F	2.087	1.00
38_E	122_D	2.030	1.00
131_D	139_L	2.024	1.00
29_A	33_A	2.006	1.00
102_H	129_L	1.978	1.00
180_Q	187_D	1.973	1.00
146_D	166_A	1.959	1.00
139_L	145_F	1.953	1.00
72_L	147_R	1.944	1.00
28_D	32_R	1.932	1.00
23_D	26_P	1.881	1.00
55_R	111_Q	1.860	1.00
69_V	93_V	1.807	1.00
150_V	161_L	1.800	1.00
148_V	165_L	1.797	1.00
110_R	114_Y	1.791	1.00
55_R	109_D	1.752	1.00
110_R	132_C	1.687	1.00
15_L	28_D	1.666	1.00
120_L	128_V	1.647	1.00
14_L	18_G	1.617	1.00
147_R	170_R	1.590	1.00
180_Q	185_V	1.580	1.00
120_L	130_V	1.544	1.00
64_T	197_V	1.533	1.00
69_V	90_T	1.522	1.00
10_M	31_M	1.520	1.00
31_M	66_A	1.514	1.00
167_A	188_G	1.490	1.00
108_I	203_L	1.472	1.00
142_Y	145_F	1.462	1.00
71_A	194_H	1.457	1.00
8_E	12_D	1.426	1.00
119_N	123_A	1.422	1.00
138_G	143_A	1.418	1.00
12_D	16_D	1.388	1.00
80_V	94_V	1.368	1.00
167_A	189_E	1.367	1.00
31_M	93_V	1.342	1.00
98_A	127_D	1.338	1.00
144_P	164_Q	1.328	1.00
37_H	47_Y	1.319	1.00
79_D	102_H	1.315	1.00
14_L	21_L	1.315	1.00
68_L	199_F	1.308	1.00
138_G	144_P	1.303	1.00
180_Q	186_R	1.301	1.00
23_D	70_G	1.291	1.00
24_A	29_A	1.287	1.00
154_A	173_F	1.282	1.00
165_L	171_L	1.277	1.00
91_V	130_V	1.265	1.00
49_D	63_S	1.265	1.00
40_V	52_F	1.260	1.00
184_S	187_D	1.260	1.00
23_D	73_E	1.255	1.00
104_H	142_Y	1.254	1.00
74_P	147_R	1.249	1.00
15_L	18_G	1.242	1.00
82_V	151_E	1.213	1.00
143_A	164_Q	1.212	1.00
165_L	169_G	1.205	1.00
181_R	193_V	1.204	1.00
26_P	76_A	1.202	1.00
38_E	123_A	1.201	1.00
179_D	183_V	1.195	1.00
170_R	184_S	1.190	1.00
79_D	142_Y	1.189	1.00
74_P	94_V	1.188	1.00
34_V	96_E	1.188	1.00
152_A	202_L	1.178	1.00
179_D	182_L	1.176	1.00
117_R	121_A	1.165	1.00
89_Y	93_V	1.159	1.00
90_T	149_L	1.157	1.00
114_Y	117_R	1.152	1.00
170_R	186_R	1.139	1.00
67_R	195_G	1.134	1.00
26_P	97_I	1.133	1.00
154_A	202_L	1.122	1.00
7_R	11_V	1.116	1.00
15_L	24_A	1.112	1.00
10_M	14_L	1.106	1.00
184_S	192_G	1.101	1.00
92_A	120_L	1.097	1.00
182_L	187_D	1.097	1.00
59_V	65_V	1.092	1.00
136_A	202_L	1.087	1.00
118_G	122_D	1.077	1.00
104_H	139_L	1.075	1.00
179_D	186_R	1.067	1.00
95_A	127_D	1.064	1.00
82_V	105_A	1.055	1.00
60_L	64_T	1.035	1.00
129_L	142_Y	1.032	1.00
14_L	20_A	1.020	1.00
181_R	184_S	1.001	1.00
30_A	96_E	0.993	0.99
74_P	98_A	0.992	0.99
182_L	185_V	0.991	0.99
104_H	131_D	0.982	0.99
90_T	151_E	0.977	0.99
186_R	192_G	0.975	0.99
160_A	163_R	0.974	0.99
95_A	125_Y	0.967	0.99
139_L	142_Y	0.967	0.99
40_V	59_V	0.966	0.99
180_Q	183_V	0.964	0.99
27_A	70_G	0.963	0.99
11_V	32_R	0.957	0.99
179_D	185_V	0.942	0.99
106_V	133_R	0.941	0.99
91_V	95_A	0.931	0.99
27_A	97_I	0.928	0.99
159_D	162_A	0.927	0.99
29_A	32_R	0.927	0.99
21_L	66_A	0.925	0.99
105_A	151_E	0.919	0.99
35_P	38_E	0.917	0.99
68_L	149_L	0.897	0.99
6_L	9_E	0.894	0.99
125_Y	128_V	0.890	0.99
60_L	174_P	0.883	0.99
95_A	128_V	0.877	0.99
68_L	90_T	0.875	0.99
73_E	170_R	0.874	0.99
30_A	93_V	0.870	0.99
69_V	151_E	0.855	0.98
157_V	173_F	0.852	0.98
186_R	189_E	0.849	0.98
136_A	204_V	0.846	0.98
105_A	120_L	0.846	0.98
80_V	103_V	0.842	0.98
109_D	203_L	0.833	0.98
57_T	200_A	0.831	0.98
57_T	112_V	0.829	0.98
34_V	125_Y	0.829	0.98
161_L	171_L	0.829	0.98
74_P	78_D	0.822	0.98
180_Q	184_S	0.814	0.98
136_A	203_L	0.812	0.98
184_S	194_H	0.812	0.98
77_G	99_G	0.808	0.98
21_L	70_G	0.805	0.98
41_D	115_D	0.804	0.98
137_E	160_A	0.803	0.98
75_R	78_D	0.802	0.98
7_R	37_H	0.800	0.98
21_L	28_D	0.798	0.98
91_V	105_A	0.797	0.98
82_V	90_T	0.791	0.97
118_G	121_A	0.789	0.97
59_V	87_V	0.782	0.97
69_V	94_V	0.782	0.97
83_V	152_A	0.775	0.97
15_L	20_A	0.772	0.97
85_A	151_E	0.768	0.97
11_V	15_L	0.766	0.97
71_A	172_V	0.766	0.97
15_L	32_R	0.764	0.97
113_V	117_R	0.763	0.97
17_A	49_D	0.760	0.97
65_V	90_T	0.759	0.97
104_H	129_L	0.753	0.97
82_V	94_V	0.753	0.97
73_E	147_R	0.750	0.97
156_S	159_D	0.747	0.96
136_A	154_A	0.745	0.96
91_V	128_V	0.745	0.96
116_A	119_N	0.730	0.96
113_V	116_A	0.728	0.96
12_D	32_R	0.728	0.96
15_L	21_L	0.725	0.96
185_V	188_G	0.723	0.96
80_V	98_A	0.722	0.96
141_E	144_P	0.721	0.96
74_P	77_G	0.719	0.96
81_L	145_F	0.715	0.95
150_V	154_A	0.712	0.95
77_G	98_A	0.709	0.95
82_V	85_A	0.708	0.95
179_D	187_D	0.698	0.95
23_D	74_P	0.696	0.95
72_L	94_V	0.696	0.95
11_V	31_M	0.696	0.95
10_M	49_D	0.696	0.95
74_P	80_V	0.687	0.94
99_G	102_H	0.685	0.94
26_P	29_A	0.681	0.94
183_V	186_R	0.677	0.94
83_V	135_G	0.676	0.94
138_G	145_F	0.674	0.94
174_P	199_F	0.673	0.94
13_S	17_A	0.672	0.94
61_A	64_T	0.671	0.94
78_D	146_D	0.665	0.93
47_Y	51_A	0.665	0.93
133_R	137_E	0.663	0.93
131_D	141_E	0.656	0.93
119_N	122_D	0.654	0.93
150_V	202_L	0.643	0.92
114_Y	118_G	0.642	0.92
180_Q	188_G	0.635	0.92
186_R	190_T	0.631	0.91
157_V	185_V	0.630	0.91
182_L	197_V	0.629	0.91
154_A	161_L	0.628	0.91
46_A	59_V	0.626	0.91
64_T	67_R	0.623	0.91
135_G	161_L	0.622	0.91
13_S	16_D	0.618	0.91
30_A	97_I	0.617	0.91
31_M	89_Y	0.614	0.90
58_R	200_A	0.613	0.90
13_S	49_D	0.610	0.90
135_G	144_P	0.609	0.90
26_P	75_R	0.609	0.90
135_G	164_Q	0.607	0.90
14_L	17_A	0.606	0.90
179_D	184_S	0.606	0.90
171_L	185_V	0.606	0.90
104_H	145_F	0.604	0.90
51_A	60_L	0.600	0.89
140_A	144_P	0.599	0.89
57_T	108_I	0.598	0.89
10_M	18_G	0.596	0.89
176_G	197_V	0.594	0.89
45_R	50_Q	0.592	0.89
79_D	166_A	0.591	0.89
31_M	62_P	0.583	0.88
149_L	199_F	0.583	0.88
39_F	92_A	0.580	0.88
183_V	191_V	0.580	0.88
178_G	197_V	0.580	0.88
69_V	97_I	0.579	0.88
85_A	116_A	0.578	0.87
147_R	172_V	0.577	0.87
49_D	52_F	0.577	0.87
40_V	45_R	0.575	0.87
40_V	46_A	0.575	0.87
183_V	193_V	0.564	0.86
5_A	8_E	0.564	0.86
16_D	32_R	0.563	0.86
157_V	175_E	0.559	0.86
60_L	68_L	0.559	0.86
150_V	153_G	0.557	0.86
167_A	187_D	0.554	0.85
11_V	66_A	0.553	0.85
153_G	173_F	0.552	0.85
83_V	202_L	0.551	0.85
12_D	15_L	0.549	0.85
60_L	199_F	0.549	0.85
67_R	70_G	0.546	0.84
108_I	195_G	0.542	0.84
21_L	63_S	0.542	0.84
9_E	12_D	0.536	0.83
153_G	197_V	0.535	0.83
72_L	172_V	0.535	0.83
60_L	200_A	0.531	0.83
27_A	98_A	0.531	0.83
185_V	189_E	0.530	0.83
139_L	143_A	0.530	0.83
6_L	16_D	0.525	0.82
135_G	138_G	0.525	0.82
155_A	204_V	0.525	0.82
184_S	189_E	0.524	0.82
99_G	127_D	0.524	0.82
57_T	109_D	0.521	0.82
14_L	49_D	0.521	0.82
9_E	13_S	0.520	0.81
131_D	142_Y	0.518	0.81
104_H	141_E	0.515	0.81
102_H	142_Y	0.512	0.80
145_F	164_Q	0.511	0.80
26_P	30_A	0.510	0.80
106_V	131_D	0.509	0.80
181_R	185_V	0.508	0.80
152_A	199_F	0.508	0.80
87_V	119_N	0.508	0.80
185_V	191_V	0.506	0.80
79_D	104_H	0.505	0.80
108_I	136_A	0.503	0.79
5_A	9_E	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4o29A	1	0.8082	100	0.525	Contact Map
1jg1A	1	0.8408	100	0.526	Contact Map
4l7vA	1	0.7469	100	0.542	Contact Map
2yxeA	2	0.8449	100	0.561	Contact Map
1r18A	2	0.8082	100	0.566	Contact Map
1i1nA	1	0.849	100	0.579	Contact Map
2pbfA	1	0.8041	100	0.579	Contact Map
3lbfA	1	0.8204	100	0.594	Contact Map
1dl5A	2	0.9306	100	0.617	Contact Map
1vbfA	5	0.8857	99.9	0.623	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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