GREMLIN Database
Q9HST1 - L-isoaspartyl protein carboxyl methyltransferase
UniProt: Q9HST1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (197)
Sequences: 3774 (2698)
Seq/√Len: 192.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_A105_A2.8481.00
105_A130_V2.7261.00
107_D113_V2.6881.00
113_V132_C2.6671.00
33_A96_E2.6441.00
159_D163_R2.4701.00
22_A70_G2.3821.00
96_E125_Y2.3141.00
78_D147_R2.2931.00
138_G164_Q2.2301.00
115_D119_N2.2031.00
113_V130_V2.1191.00
8_E32_R2.1171.00
150_V173_F2.0871.00
38_E122_D2.0301.00
131_D139_L2.0241.00
29_A33_A2.0061.00
102_H129_L1.9781.00
180_Q187_D1.9731.00
146_D166_A1.9591.00
139_L145_F1.9531.00
72_L147_R1.9441.00
28_D32_R1.9321.00
23_D26_P1.8811.00
55_R111_Q1.8601.00
69_V93_V1.8071.00
150_V161_L1.8001.00
148_V165_L1.7971.00
110_R114_Y1.7911.00
55_R109_D1.7521.00
110_R132_C1.6871.00
15_L28_D1.6661.00
120_L128_V1.6471.00
14_L18_G1.6171.00
147_R170_R1.5901.00
180_Q185_V1.5801.00
120_L130_V1.5441.00
64_T197_V1.5331.00
69_V90_T1.5221.00
10_M31_M1.5201.00
31_M66_A1.5141.00
167_A188_G1.4901.00
108_I203_L1.4721.00
142_Y145_F1.4621.00
71_A194_H1.4571.00
8_E12_D1.4261.00
119_N123_A1.4221.00
138_G143_A1.4181.00
12_D16_D1.3881.00
80_V94_V1.3681.00
167_A189_E1.3671.00
31_M93_V1.3421.00
98_A127_D1.3381.00
144_P164_Q1.3281.00
37_H47_Y1.3191.00
79_D102_H1.3151.00
14_L21_L1.3151.00
68_L199_F1.3081.00
138_G144_P1.3031.00
180_Q186_R1.3011.00
23_D70_G1.2911.00
24_A29_A1.2871.00
154_A173_F1.2821.00
165_L171_L1.2771.00
91_V130_V1.2651.00
49_D63_S1.2651.00
40_V52_F1.2601.00
184_S187_D1.2601.00
23_D73_E1.2551.00
104_H142_Y1.2541.00
74_P147_R1.2491.00
15_L18_G1.2421.00
82_V151_E1.2131.00
143_A164_Q1.2121.00
165_L169_G1.2051.00
181_R193_V1.2041.00
26_P76_A1.2021.00
38_E123_A1.2011.00
179_D183_V1.1951.00
170_R184_S1.1901.00
79_D142_Y1.1891.00
74_P94_V1.1881.00
34_V96_E1.1881.00
152_A202_L1.1781.00
179_D182_L1.1761.00
117_R121_A1.1651.00
89_Y93_V1.1591.00
90_T149_L1.1571.00
114_Y117_R1.1521.00
170_R186_R1.1391.00
67_R195_G1.1341.00
26_P97_I1.1331.00
154_A202_L1.1221.00
7_R11_V1.1161.00
15_L24_A1.1121.00
10_M14_L1.1061.00
184_S192_G1.1011.00
92_A120_L1.0971.00
182_L187_D1.0971.00
59_V65_V1.0921.00
136_A202_L1.0871.00
118_G122_D1.0771.00
104_H139_L1.0751.00
179_D186_R1.0671.00
95_A127_D1.0641.00
82_V105_A1.0551.00
60_L64_T1.0351.00
129_L142_Y1.0321.00
14_L20_A1.0201.00
181_R184_S1.0011.00
30_A96_E0.9930.99
74_P98_A0.9920.99
182_L185_V0.9910.99
104_H131_D0.9820.99
90_T151_E0.9770.99
186_R192_G0.9750.99
160_A163_R0.9740.99
95_A125_Y0.9670.99
139_L142_Y0.9670.99
40_V59_V0.9660.99
180_Q183_V0.9640.99
27_A70_G0.9630.99
11_V32_R0.9570.99
179_D185_V0.9420.99
106_V133_R0.9410.99
91_V95_A0.9310.99
27_A97_I0.9280.99
159_D162_A0.9270.99
29_A32_R0.9270.99
21_L66_A0.9250.99
105_A151_E0.9190.99
35_P38_E0.9170.99
68_L149_L0.8970.99
6_L9_E0.8940.99
125_Y128_V0.8900.99
60_L174_P0.8830.99
95_A128_V0.8770.99
68_L90_T0.8750.99
73_E170_R0.8740.99
30_A93_V0.8700.99
69_V151_E0.8550.98
157_V173_F0.8520.98
186_R189_E0.8490.98
136_A204_V0.8460.98
105_A120_L0.8460.98
80_V103_V0.8420.98
109_D203_L0.8330.98
57_T200_A0.8310.98
57_T112_V0.8290.98
34_V125_Y0.8290.98
161_L171_L0.8290.98
74_P78_D0.8220.98
180_Q184_S0.8140.98
136_A203_L0.8120.98
184_S194_H0.8120.98
77_G99_G0.8080.98
21_L70_G0.8050.98
41_D115_D0.8040.98
137_E160_A0.8030.98
75_R78_D0.8020.98
7_R37_H0.8000.98
21_L28_D0.7980.98
91_V105_A0.7970.98
82_V90_T0.7910.97
118_G121_A0.7890.97
59_V87_V0.7820.97
69_V94_V0.7820.97
83_V152_A0.7750.97
15_L20_A0.7720.97
85_A151_E0.7680.97
11_V15_L0.7660.97
71_A172_V0.7660.97
15_L32_R0.7640.97
113_V117_R0.7630.97
17_A49_D0.7600.97
65_V90_T0.7590.97
104_H129_L0.7530.97
82_V94_V0.7530.97
73_E147_R0.7500.97
156_S159_D0.7470.96
136_A154_A0.7450.96
91_V128_V0.7450.96
116_A119_N0.7300.96
113_V116_A0.7280.96
12_D32_R0.7280.96
15_L21_L0.7250.96
185_V188_G0.7230.96
80_V98_A0.7220.96
141_E144_P0.7210.96
74_P77_G0.7190.96
81_L145_F0.7150.95
150_V154_A0.7120.95
77_G98_A0.7090.95
82_V85_A0.7080.95
179_D187_D0.6980.95
23_D74_P0.6960.95
72_L94_V0.6960.95
11_V31_M0.6960.95
10_M49_D0.6960.95
74_P80_V0.6870.94
99_G102_H0.6850.94
26_P29_A0.6810.94
183_V186_R0.6770.94
83_V135_G0.6760.94
138_G145_F0.6740.94
174_P199_F0.6730.94
13_S17_A0.6720.94
61_A64_T0.6710.94
78_D146_D0.6650.93
47_Y51_A0.6650.93
133_R137_E0.6630.93
131_D141_E0.6560.93
119_N122_D0.6540.93
150_V202_L0.6430.92
114_Y118_G0.6420.92
180_Q188_G0.6350.92
186_R190_T0.6310.91
157_V185_V0.6300.91
182_L197_V0.6290.91
154_A161_L0.6280.91
46_A59_V0.6260.91
64_T67_R0.6230.91
135_G161_L0.6220.91
13_S16_D0.6180.91
30_A97_I0.6170.91
31_M89_Y0.6140.90
58_R200_A0.6130.90
13_S49_D0.6100.90
135_G144_P0.6090.90
26_P75_R0.6090.90
135_G164_Q0.6070.90
14_L17_A0.6060.90
179_D184_S0.6060.90
171_L185_V0.6060.90
104_H145_F0.6040.90
51_A60_L0.6000.89
140_A144_P0.5990.89
57_T108_I0.5980.89
10_M18_G0.5960.89
176_G197_V0.5940.89
45_R50_Q0.5920.89
79_D166_A0.5910.89
31_M62_P0.5830.88
149_L199_F0.5830.88
39_F92_A0.5800.88
183_V191_V0.5800.88
178_G197_V0.5800.88
69_V97_I0.5790.88
85_A116_A0.5780.87
147_R172_V0.5770.87
49_D52_F0.5770.87
40_V45_R0.5750.87
40_V46_A0.5750.87
183_V193_V0.5640.86
5_A8_E0.5640.86
16_D32_R0.5630.86
157_V175_E0.5590.86
60_L68_L0.5590.86
150_V153_G0.5570.86
167_A187_D0.5540.85
11_V66_A0.5530.85
153_G173_F0.5520.85
83_V202_L0.5510.85
12_D15_L0.5490.85
60_L199_F0.5490.85
67_R70_G0.5460.84
108_I195_G0.5420.84
21_L63_S0.5420.84
9_E12_D0.5360.83
153_G197_V0.5350.83
72_L172_V0.5350.83
60_L200_A0.5310.83
27_A98_A0.5310.83
185_V189_E0.5300.83
139_L143_A0.5300.83
6_L16_D0.5250.82
135_G138_G0.5250.82
155_A204_V0.5250.82
184_S189_E0.5240.82
99_G127_D0.5240.82
57_T109_D0.5210.82
14_L49_D0.5210.82
9_E13_S0.5200.81
131_D142_Y0.5180.81
104_H141_E0.5150.81
102_H142_Y0.5120.80
145_F164_Q0.5110.80
26_P30_A0.5100.80
106_V131_D0.5090.80
181_R185_V0.5080.80
152_A199_F0.5080.80
87_V119_N0.5080.80
185_V191_V0.5060.80
79_D104_H0.5050.80
108_I136_A0.5030.79
5_A9_E0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o29A 1 0.8082 100 0.525 Contact Map
1jg1A 1 0.8408 100 0.526 Contact Map
4l7vA 1 0.7469 100 0.542 Contact Map
2yxeA 2 0.8449 100 0.561 Contact Map
1r18A 2 0.8082 100 0.566 Contact Map
1i1nA 1 0.849 100 0.579 Contact Map
2pbfA 1 0.8041 100 0.579 Contact Map
3lbfA 1 0.8204 100 0.594 Contact Map
1dl5A 2 0.9306 100 0.617 Contact Map
1vbfA 5 0.8857 99.9 0.623 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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