GREMLIN Database
Q9HST0 - Uncharacterized protein
UniProt: Q9HST0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (286)
Sequences: 5513 (4488)
Seq/√Len: 265.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_G199_E4.0661.00
223_Q277_D3.7661.00
149_V205_A3.0761.00
168_D191_E2.8791.00
30_A40_E2.7591.00
228_A231_E2.7581.00
268_A272_A2.7471.00
17_G20_D2.7111.00
233_V238_G2.6331.00
159_A169_V2.6181.00
57_T64_E2.5391.00
221_A224_E2.5041.00
230_S280_L2.3841.00
28_T31_A2.3311.00
172_H195_G2.3101.00
115_A118_N2.3011.00
13_A50_L2.3001.00
218_S221_A2.2931.00
15_E98_P2.2571.00
247_G251_G2.2541.00
114_R122_A2.2491.00
117_R216_R2.2151.00
147_S170_A2.2051.00
153_D171_A2.2021.00
273_S277_D2.1091.00
145_A207_L2.0991.00
21_A35_Q2.0831.00
178_V192_L2.0821.00
96_A99_A2.0401.00
147_S168_D2.0341.00
27_D35_Q2.0331.00
159_A171_A2.0121.00
163_A169_V1.9771.00
65_P69_M1.9701.00
234_S237_G1.9491.00
272_A276_A1.9431.00
175_D194_G1.8921.00
19_L56_L1.8861.00
39_T42_A1.8841.00
20_D75_K1.8811.00
215_S265_V1.8611.00
268_A285_T1.8301.00
47_V63_V1.7881.00
38_V43_A1.7651.00
210_I213_T1.7611.00
223_Q227_R1.7021.00
45_V253_S1.6901.00
22_L27_D1.6711.00
47_V56_L1.6681.00
178_V194_G1.6571.00
148_V207_L1.6391.00
242_V275_L1.5921.00
233_V280_L1.5661.00
148_V167_F1.5661.00
208_A229_A1.5651.00
31_A34_E1.5521.00
130_A134_A1.5351.00
260_T263_G1.5151.00
32_V43_A1.5131.00
66_T69_M1.4971.00
164_R188_E1.4791.00
9_V49_V1.4751.00
83_S86_H1.4681.00
59_V64_E1.4531.00
210_I229_A1.4521.00
207_L241_A1.4351.00
223_Q278_A1.4281.00
161_E164_R1.4081.00
284_R297_A1.3981.00
12_A98_P1.3881.00
171_A192_L1.3861.00
131_V154_D1.3761.00
252_L255_A1.3761.00
208_A238_G1.3711.00
48_A58_W1.3521.00
264_A270_R1.3511.00
227_R231_E1.3431.00
128_D132_R1.3351.00
160_V185_L1.3271.00
170_A193_V1.3261.00
99_A103_G1.3111.00
198_A217_R1.2951.00
210_I214_L1.2931.00
41_R264_A1.2911.00
219_P266_R1.2901.00
91_A95_V1.2781.00
11_R15_E1.2731.00
197_V217_R1.2431.00
147_S205_A1.2301.00
239_T297_A1.2221.00
127_D131_V1.2201.00
58_W61_G1.2191.00
21_A32_V1.2061.00
197_V213_T1.2051.00
6_T53_R1.2021.00
215_S244_D1.2011.00
170_A205_A1.1931.00
163_A190_V1.1901.00
208_A233_V1.1851.00
29_P63_V1.1731.00
223_Q274_W1.1681.00
217_R225_V1.1671.00
210_I240_V1.1661.00
18_V43_A1.1641.00
51_V56_L1.1631.00
116_F120_L1.1621.00
163_A189_P1.1611.00
14_R19_L1.1601.00
98_P102_E1.1591.00
22_L56_L1.1581.00
270_R273_S1.1531.00
17_G21_A1.1451.00
179_D182_R1.1381.00
172_H193_V1.1371.00
152_G197_V1.1321.00
183_P187_A1.1271.00
109_G112_T1.1241.00
220_T277_D1.1221.00
27_D31_A1.1141.00
44_E63_V1.1121.00
224_E228_A1.1091.00
8_L91_A1.1081.00
36_A43_A1.1041.00
16_T38_V1.0991.00
13_A19_L1.0901.00
214_L222_A1.0891.00
160_V188_E1.0871.00
160_V184_V1.0861.00
282_D296_V1.0811.00
29_P43_A1.0801.00
214_L242_V1.0731.00
20_D74_T1.0711.00
28_T62_A1.0711.00
275_L282_D1.0651.00
170_A191_E1.0641.00
57_T66_T1.0611.00
119_R123_A1.0601.00
15_E102_E1.0601.00
160_V164_R1.0561.00
51_V63_V1.0511.00
179_D194_G1.0391.00
273_S276_A1.0311.00
13_A56_L1.0291.00
240_V280_L1.0291.00
149_V208_A1.0271.00
162_C167_F1.0271.00
227_R277_D1.0261.00
148_V169_V1.0231.00
114_R118_N1.0111.00
209_V243_V1.0111.00
29_P44_E1.0021.00
215_S256_L0.9981.00
83_S88_L0.9961.00
58_W63_V0.9921.00
197_V225_V0.9921.00
226_V240_V0.9921.00
135_V155_A0.9891.00
27_D32_V0.9871.00
178_V182_R0.9811.00
117_R120_L0.9781.00
251_G269_D0.9781.00
21_A27_D0.9741.00
179_D183_P0.9731.00
148_V209_V0.9711.00
195_G229_A0.9711.00
40_E44_E0.9691.00
142_R145_A0.9681.00
17_G75_K0.9641.00
9_V46_V0.9631.00
234_S238_G0.9591.00
13_A18_V0.9571.00
172_H201_V0.9511.00
110_G113_D0.9491.00
158_H209_V0.9481.00
285_T294_R0.9471.00
30_A34_E0.9391.00
151_V229_A0.9351.00
246_F294_R0.9321.00
12_A46_V0.9271.00
276_A281_T0.9191.00
59_V62_A0.9181.00
56_L69_M0.9151.00
139_V142_R0.9141.00
92_D95_V0.9121.00
29_P33_A0.9081.00
145_A148_V0.9051.00
267_D270_R0.9051.00
272_A282_D0.9021.00
123_A126_R0.9021.00
140_H145_A0.9001.00
184_V188_E0.8981.00
255_A259_T0.8981.00
100_A107_P0.8891.00
31_A62_A0.8881.00
49_V53_R0.8841.00
21_A36_A0.8841.00
256_L265_V0.8811.00
178_V181_I0.8801.00
146_E206_D0.8781.00
182_R186_A0.8771.00
198_A221_A0.8731.00
175_D179_D0.8701.00
213_T216_R0.8691.00
200_P203_A0.8691.00
212_H293_H0.8661.00
48_A253_S0.8651.00
65_P70_L0.8641.00
148_V162_C0.8571.00
38_V101_M0.8541.00
23_V65_P0.8521.00
199_E224_E0.8451.00
244_D271_V0.8451.00
183_P186_A0.8441.00
162_C209_V0.8420.99
21_A24_A0.8370.99
89_D126_R0.8300.99
255_A258_A0.8280.99
204_A234_S0.8270.99
15_E86_H0.8260.99
148_V159_A0.8200.99
246_F268_A0.8170.99
197_V216_R0.8130.99
8_L11_R0.8120.99
238_G280_L0.8010.99
159_A163_A0.8010.99
71_G74_T0.8000.99
206_D234_S0.7990.99
185_L190_V0.7950.99
133_A138_A0.7940.99
26_A64_E0.7910.99
176_R179_D0.7880.99
229_A238_G0.7880.99
210_I225_V0.7800.99
147_S206_D0.7800.99
55_F69_M0.7790.99
240_V275_L0.7750.99
117_R215_S0.7720.99
42_A257_L0.7660.99
45_V257_L0.7630.99
195_G201_V0.7600.99
283_V297_A0.7590.99
119_R122_A0.7580.99
7_L11_R0.7570.99
118_N121_G0.7550.99
9_V254_A0.7540.99
185_L192_L0.7450.99
266_R274_W0.7430.99
140_H143_P0.7430.99
41_R45_V0.7430.99
158_H162_C0.7430.99
219_P264_A0.7430.99
172_H194_G0.7370.99
29_P51_V0.7310.99
155_A180_A0.7290.99
271_V296_V0.7250.98
202_D205_A0.7200.98
112_T119_R0.7190.98
203_A231_E0.7190.98
173_H178_V0.7120.98
200_P231_E0.7110.98
50_L55_F0.7050.98
109_G113_D0.7050.98
32_V36_A0.7050.98
43_A47_V0.7040.98
177_V194_G0.7010.98
37_G102_E0.6990.98
104_D108_A0.6980.98
131_V155_A0.6980.98
128_D131_V0.6970.98
42_A104_D0.6940.98
49_V254_A0.6930.98
12_A97_L0.6910.98
142_R162_C0.6890.98
140_H241_A0.6830.98
141_E144_G0.6830.98
146_E166_G0.6830.98
285_T296_V0.6830.98
29_P40_E0.6790.98
242_V271_V0.6790.98
125_A128_D0.6770.98
181_I192_L0.6760.98
27_D62_A0.6750.98
9_V50_L0.6730.98
48_A63_V0.6720.98
171_A181_I0.6710.97
131_V180_A0.6690.97
195_G200_P0.6680.97
222_A266_R0.6670.97
224_E227_R0.6650.97
253_S256_L0.6650.97
215_S222_A0.6640.97
28_T34_E0.6610.97
134_A138_A0.6610.97
22_L26_A0.6580.97
138_A211_P0.6580.97
216_R244_D0.6560.97
269_D273_S0.6550.97
246_F285_T0.6490.97
147_S204_A0.6490.97
117_R124_A0.6440.97
6_T49_V0.6400.97
222_A274_W0.6380.97
214_L226_V0.6350.97
271_V275_L0.6330.96
160_V163_A0.6310.96
144_G166_G0.6290.96
174_D196_G0.6270.96
24_A35_Q0.6260.96
25_S35_Q0.6250.96
159_A190_V0.6250.96
145_A239_T0.6230.96
103_G107_P0.6220.96
125_A129_A0.6220.96
138_A212_H0.6210.96
129_A133_A0.6170.96
141_E145_A0.6150.96
147_S191_E0.6150.96
231_E234_S0.6120.96
96_A111_D0.6110.96
221_A262_G0.6110.96
85_P88_L0.6110.96
160_V190_V0.6080.96
219_P274_W0.6080.96
99_A105_D0.6080.96
84_L87_A0.6060.95
94_L258_A0.6040.95
93_A259_T0.6040.95
23_V70_L0.6030.95
12_A16_T0.6020.95
180_A183_P0.6000.95
84_L88_L0.5990.95
131_V135_V0.5990.95
12_A101_M0.5980.95
25_S31_A0.5980.95
135_V138_A0.5960.95
44_E270_R0.5950.95
216_R225_V0.5950.95
252_L259_T0.5950.95
269_D272_A0.5940.95
130_A133_A0.5910.95
117_R130_A0.5910.95
275_L280_L0.5900.95
139_V143_P0.5870.95
233_V240_V0.5860.95
145_A167_F0.5860.95
56_L65_P0.5840.94
121_G124_A0.5830.94
94_L255_A0.5830.94
131_V134_A0.5800.94
132_R135_V0.5800.94
151_V197_V0.5790.94
111_D116_F0.5790.94
254_A257_L0.5780.94
31_A35_Q0.5770.94
245_T252_L0.5750.94
129_A135_V0.5730.94
158_H211_P0.5730.94
109_G115_A0.5720.94
123_A130_A0.5710.94
130_A137_A0.5700.94
77_D80_S0.5700.94
51_V59_V0.5690.94
149_V195_G0.5690.94
100_A104_D0.5670.94
83_S87_A0.5610.93
214_L225_V0.5600.93
119_R126_R0.5600.93
116_F260_T0.5600.93
220_T223_Q0.5600.93
143_P166_G0.5600.93
25_S64_E0.5590.93
230_S233_V0.5570.93
182_R191_E0.5570.93
109_G119_R0.5560.93
23_V74_T0.5550.93
158_H243_V0.5540.93
73_I78_V0.5540.93
229_A233_V0.5530.93
205_A208_A0.5520.93
100_A105_D0.5520.93
270_R274_W0.5500.93
195_G228_A0.5480.92
18_V36_A0.5480.92
19_L50_L0.5470.92
212_H245_T0.5470.92
184_V187_A0.5470.92
108_A112_T0.5440.92
198_A225_V0.5430.92
252_L256_L0.5420.92
45_V48_A0.5420.92
143_P146_E0.5390.92
181_I185_L0.5340.91
23_V26_A0.5330.91
44_E48_A0.5330.91
244_D265_V0.5330.91
42_A101_M0.5310.91
219_P277_D0.5310.91
229_A240_V0.5290.91
246_F271_V0.5290.91
149_V170_A0.5280.91
10_L50_L0.5270.91
127_D130_A0.5240.91
29_P47_V0.5240.91
255_A260_T0.5210.90
218_S262_G0.5200.90
222_A264_A0.5180.90
173_H194_G0.5180.90
282_D285_T0.5170.90
92_D96_A0.5160.90
216_R256_L0.5160.90
229_A280_L0.5160.90
230_S234_S0.5160.90
253_S265_V0.5160.90
116_F119_R0.5130.90
116_F123_A0.5100.89
162_C169_V0.5090.89
263_G266_R0.5090.89
223_Q226_V0.5080.89
288_V294_R0.5070.89
195_G202_D0.5060.89
133_A137_A0.5050.89
211_P243_V0.5040.89
227_R230_S0.5030.89
16_T102_E0.5030.89
241_A295_V0.5030.89
275_L283_V0.5030.89
193_V200_P0.5000.89
115_A120_L0.5000.89
172_H200_P0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3p9cA 2 0.9671 100 0.339 Contact Map
3reoA 2 0.9704 100 0.344 Contact Map
4z2yA 2 0.8487 100 0.347 Contact Map
1fp2A 2 0.9572 100 0.348 Contact Map
4u1qA 2 0.9868 100 0.348 Contact Map
4wxhA 2 0.977 100 0.348 Contact Map
1zg3A 2 0.9638 100 0.35 Contact Map
3gwzA 3 0.9803 100 0.35 Contact Map
3dp7A 2 0.9803 100 0.352 Contact Map
1qzzA 2 0.9638 100 0.355 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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