Q9HST0 - HALSA - GREMLIN Contacts

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Q9HST0 - Uncharacterized protein

UniProt:	Q9HST0	Sequences: MEDFRTLLVLRAARETGVLDALVASADTPAAVAEQAGVTERAAEVVVAVLVDRGFLTWVSGAVEPTNRMLGFITKTDVRSIGSLPHALDVADALVALPAAMEGDDVPAGGDTDRAFRNRLGAAAARDDAAVRAAVTAAVHERPGAESVVVVGDDAGHHAVECARRGFDVAAHHDDRVVDAIRPVLAAEPVELVGGGVAEPVDAAADLAVIPHTLSRRSPTAAQEVVRAASESVSAAGGTVAVVDTFGSAPGLSAALLATTPGGAVRDADRVASWLADAGLTDVRTSDVPGTEHRVVAGRRRAVQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	304 (286)
Sequences:	5513 (4488)
Seq/√Len:	265.4

HALSA - Q9HST0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
196_G	199_E	4.066	1.00
223_Q	277_D	3.766	1.00
149_V	205_A	3.076	1.00
168_D	191_E	2.879	1.00
30_A	40_E	2.759	1.00
228_A	231_E	2.758	1.00
268_A	272_A	2.747	1.00
17_G	20_D	2.711	1.00
233_V	238_G	2.633	1.00
159_A	169_V	2.618	1.00
57_T	64_E	2.539	1.00
221_A	224_E	2.504	1.00
230_S	280_L	2.384	1.00
28_T	31_A	2.331	1.00
172_H	195_G	2.310	1.00
115_A	118_N	2.301	1.00
13_A	50_L	2.300	1.00
218_S	221_A	2.293	1.00
15_E	98_P	2.257	1.00
247_G	251_G	2.254	1.00
114_R	122_A	2.249	1.00
117_R	216_R	2.215	1.00
147_S	170_A	2.205	1.00
153_D	171_A	2.202	1.00
273_S	277_D	2.109	1.00
145_A	207_L	2.099	1.00
21_A	35_Q	2.083	1.00
178_V	192_L	2.082	1.00
96_A	99_A	2.040	1.00
147_S	168_D	2.034	1.00
27_D	35_Q	2.033	1.00
159_A	171_A	2.012	1.00
163_A	169_V	1.977	1.00
65_P	69_M	1.970	1.00
234_S	237_G	1.949	1.00
272_A	276_A	1.943	1.00
175_D	194_G	1.892	1.00
19_L	56_L	1.886	1.00
39_T	42_A	1.884	1.00
20_D	75_K	1.881	1.00
215_S	265_V	1.861	1.00
268_A	285_T	1.830	1.00
47_V	63_V	1.788	1.00
38_V	43_A	1.765	1.00
210_I	213_T	1.761	1.00
223_Q	227_R	1.702	1.00
45_V	253_S	1.690	1.00
22_L	27_D	1.671	1.00
47_V	56_L	1.668	1.00
178_V	194_G	1.657	1.00
148_V	207_L	1.639	1.00
242_V	275_L	1.592	1.00
233_V	280_L	1.566	1.00
148_V	167_F	1.566	1.00
208_A	229_A	1.565	1.00
31_A	34_E	1.552	1.00
130_A	134_A	1.535	1.00
260_T	263_G	1.515	1.00
32_V	43_A	1.513	1.00
66_T	69_M	1.497	1.00
164_R	188_E	1.479	1.00
9_V	49_V	1.475	1.00
83_S	86_H	1.468	1.00
59_V	64_E	1.453	1.00
210_I	229_A	1.452	1.00
207_L	241_A	1.435	1.00
223_Q	278_A	1.428	1.00
161_E	164_R	1.408	1.00
284_R	297_A	1.398	1.00
12_A	98_P	1.388	1.00
171_A	192_L	1.386	1.00
131_V	154_D	1.376	1.00
252_L	255_A	1.376	1.00
208_A	238_G	1.371	1.00
48_A	58_W	1.352	1.00
264_A	270_R	1.351	1.00
227_R	231_E	1.343	1.00
128_D	132_R	1.335	1.00
160_V	185_L	1.327	1.00
170_A	193_V	1.326	1.00
99_A	103_G	1.311	1.00
198_A	217_R	1.295	1.00
210_I	214_L	1.293	1.00
41_R	264_A	1.291	1.00
219_P	266_R	1.290	1.00
91_A	95_V	1.278	1.00
11_R	15_E	1.273	1.00
197_V	217_R	1.243	1.00
147_S	205_A	1.230	1.00
239_T	297_A	1.222	1.00
127_D	131_V	1.220	1.00
58_W	61_G	1.219	1.00
21_A	32_V	1.206	1.00
197_V	213_T	1.205	1.00
6_T	53_R	1.202	1.00
215_S	244_D	1.201	1.00
170_A	205_A	1.193	1.00
163_A	190_V	1.190	1.00
208_A	233_V	1.185	1.00
29_P	63_V	1.173	1.00
223_Q	274_W	1.168	1.00
217_R	225_V	1.167	1.00
210_I	240_V	1.166	1.00
18_V	43_A	1.164	1.00
51_V	56_L	1.163	1.00
116_F	120_L	1.162	1.00
163_A	189_P	1.161	1.00
14_R	19_L	1.160	1.00
98_P	102_E	1.159	1.00
22_L	56_L	1.158	1.00
270_R	273_S	1.153	1.00
17_G	21_A	1.145	1.00
179_D	182_R	1.138	1.00
172_H	193_V	1.137	1.00
152_G	197_V	1.132	1.00
183_P	187_A	1.127	1.00
109_G	112_T	1.124	1.00
220_T	277_D	1.122	1.00
27_D	31_A	1.114	1.00
44_E	63_V	1.112	1.00
224_E	228_A	1.109	1.00
8_L	91_A	1.108	1.00
36_A	43_A	1.104	1.00
16_T	38_V	1.099	1.00
13_A	19_L	1.090	1.00
214_L	222_A	1.089	1.00
160_V	188_E	1.087	1.00
160_V	184_V	1.086	1.00
282_D	296_V	1.081	1.00
29_P	43_A	1.080	1.00
214_L	242_V	1.073	1.00
20_D	74_T	1.071	1.00
28_T	62_A	1.071	1.00
275_L	282_D	1.065	1.00
170_A	191_E	1.064	1.00
57_T	66_T	1.061	1.00
119_R	123_A	1.060	1.00
15_E	102_E	1.060	1.00
160_V	164_R	1.056	1.00
51_V	63_V	1.051	1.00
179_D	194_G	1.039	1.00
273_S	276_A	1.031	1.00
13_A	56_L	1.029	1.00
240_V	280_L	1.029	1.00
149_V	208_A	1.027	1.00
162_C	167_F	1.027	1.00
227_R	277_D	1.026	1.00
148_V	169_V	1.023	1.00
114_R	118_N	1.011	1.00
209_V	243_V	1.011	1.00
29_P	44_E	1.002	1.00
215_S	256_L	0.998	1.00
83_S	88_L	0.996	1.00
58_W	63_V	0.992	1.00
197_V	225_V	0.992	1.00
226_V	240_V	0.992	1.00
135_V	155_A	0.989	1.00
27_D	32_V	0.987	1.00
178_V	182_R	0.981	1.00
117_R	120_L	0.978	1.00
251_G	269_D	0.978	1.00
21_A	27_D	0.974	1.00
179_D	183_P	0.973	1.00
148_V	209_V	0.971	1.00
195_G	229_A	0.971	1.00
40_E	44_E	0.969	1.00
142_R	145_A	0.968	1.00
17_G	75_K	0.964	1.00
9_V	46_V	0.963	1.00
234_S	238_G	0.959	1.00
13_A	18_V	0.957	1.00
172_H	201_V	0.951	1.00
110_G	113_D	0.949	1.00
158_H	209_V	0.948	1.00
285_T	294_R	0.947	1.00
30_A	34_E	0.939	1.00
151_V	229_A	0.935	1.00
246_F	294_R	0.932	1.00
12_A	46_V	0.927	1.00
276_A	281_T	0.919	1.00
59_V	62_A	0.918	1.00
56_L	69_M	0.915	1.00
139_V	142_R	0.914	1.00
92_D	95_V	0.912	1.00
29_P	33_A	0.908	1.00
145_A	148_V	0.905	1.00
267_D	270_R	0.905	1.00
272_A	282_D	0.902	1.00
123_A	126_R	0.902	1.00
140_H	145_A	0.900	1.00
184_V	188_E	0.898	1.00
255_A	259_T	0.898	1.00
100_A	107_P	0.889	1.00
31_A	62_A	0.888	1.00
49_V	53_R	0.884	1.00
21_A	36_A	0.884	1.00
256_L	265_V	0.881	1.00
178_V	181_I	0.880	1.00
146_E	206_D	0.878	1.00
182_R	186_A	0.877	1.00
198_A	221_A	0.873	1.00
175_D	179_D	0.870	1.00
213_T	216_R	0.869	1.00
200_P	203_A	0.869	1.00
212_H	293_H	0.866	1.00
48_A	253_S	0.865	1.00
65_P	70_L	0.864	1.00
148_V	162_C	0.857	1.00
38_V	101_M	0.854	1.00
23_V	65_P	0.852	1.00
199_E	224_E	0.845	1.00
244_D	271_V	0.845	1.00
183_P	186_A	0.844	1.00
162_C	209_V	0.842	0.99
21_A	24_A	0.837	0.99
89_D	126_R	0.830	0.99
255_A	258_A	0.828	0.99
204_A	234_S	0.827	0.99
15_E	86_H	0.826	0.99
148_V	159_A	0.820	0.99
246_F	268_A	0.817	0.99
197_V	216_R	0.813	0.99
8_L	11_R	0.812	0.99
238_G	280_L	0.801	0.99
159_A	163_A	0.801	0.99
71_G	74_T	0.800	0.99
206_D	234_S	0.799	0.99
185_L	190_V	0.795	0.99
133_A	138_A	0.794	0.99
26_A	64_E	0.791	0.99
176_R	179_D	0.788	0.99
229_A	238_G	0.788	0.99
210_I	225_V	0.780	0.99
147_S	206_D	0.780	0.99
55_F	69_M	0.779	0.99
240_V	275_L	0.775	0.99
117_R	215_S	0.772	0.99
42_A	257_L	0.766	0.99
45_V	257_L	0.763	0.99
195_G	201_V	0.760	0.99
283_V	297_A	0.759	0.99
119_R	122_A	0.758	0.99
7_L	11_R	0.757	0.99
118_N	121_G	0.755	0.99
9_V	254_A	0.754	0.99
185_L	192_L	0.745	0.99
266_R	274_W	0.743	0.99
140_H	143_P	0.743	0.99
41_R	45_V	0.743	0.99
158_H	162_C	0.743	0.99
219_P	264_A	0.743	0.99
172_H	194_G	0.737	0.99
29_P	51_V	0.731	0.99
155_A	180_A	0.729	0.99
271_V	296_V	0.725	0.98
202_D	205_A	0.720	0.98
112_T	119_R	0.719	0.98
203_A	231_E	0.719	0.98
173_H	178_V	0.712	0.98
200_P	231_E	0.711	0.98
50_L	55_F	0.705	0.98
109_G	113_D	0.705	0.98
32_V	36_A	0.705	0.98
43_A	47_V	0.704	0.98
177_V	194_G	0.701	0.98
37_G	102_E	0.699	0.98
104_D	108_A	0.698	0.98
131_V	155_A	0.698	0.98
128_D	131_V	0.697	0.98
42_A	104_D	0.694	0.98
49_V	254_A	0.693	0.98
12_A	97_L	0.691	0.98
142_R	162_C	0.689	0.98
140_H	241_A	0.683	0.98
141_E	144_G	0.683	0.98
146_E	166_G	0.683	0.98
285_T	296_V	0.683	0.98
29_P	40_E	0.679	0.98
242_V	271_V	0.679	0.98
125_A	128_D	0.677	0.98
181_I	192_L	0.676	0.98
27_D	62_A	0.675	0.98
9_V	50_L	0.673	0.98
48_A	63_V	0.672	0.98
171_A	181_I	0.671	0.97
131_V	180_A	0.669	0.97
195_G	200_P	0.668	0.97
222_A	266_R	0.667	0.97
224_E	227_R	0.665	0.97
253_S	256_L	0.665	0.97
215_S	222_A	0.664	0.97
28_T	34_E	0.661	0.97
134_A	138_A	0.661	0.97
22_L	26_A	0.658	0.97
138_A	211_P	0.658	0.97
216_R	244_D	0.656	0.97
269_D	273_S	0.655	0.97
246_F	285_T	0.649	0.97
147_S	204_A	0.649	0.97
117_R	124_A	0.644	0.97
6_T	49_V	0.640	0.97
222_A	274_W	0.638	0.97
214_L	226_V	0.635	0.97
271_V	275_L	0.633	0.96
160_V	163_A	0.631	0.96
144_G	166_G	0.629	0.96
174_D	196_G	0.627	0.96
24_A	35_Q	0.626	0.96
25_S	35_Q	0.625	0.96
159_A	190_V	0.625	0.96
145_A	239_T	0.623	0.96
103_G	107_P	0.622	0.96
125_A	129_A	0.622	0.96
138_A	212_H	0.621	0.96
129_A	133_A	0.617	0.96
141_E	145_A	0.615	0.96
147_S	191_E	0.615	0.96
231_E	234_S	0.612	0.96
96_A	111_D	0.611	0.96
221_A	262_G	0.611	0.96
85_P	88_L	0.611	0.96
160_V	190_V	0.608	0.96
219_P	274_W	0.608	0.96
99_A	105_D	0.608	0.96
84_L	87_A	0.606	0.95
94_L	258_A	0.604	0.95
93_A	259_T	0.604	0.95
23_V	70_L	0.603	0.95
12_A	16_T	0.602	0.95
180_A	183_P	0.600	0.95
84_L	88_L	0.599	0.95
131_V	135_V	0.599	0.95
12_A	101_M	0.598	0.95
25_S	31_A	0.598	0.95
135_V	138_A	0.596	0.95
44_E	270_R	0.595	0.95
216_R	225_V	0.595	0.95
252_L	259_T	0.595	0.95
269_D	272_A	0.594	0.95
130_A	133_A	0.591	0.95
117_R	130_A	0.591	0.95
275_L	280_L	0.590	0.95
139_V	143_P	0.587	0.95
233_V	240_V	0.586	0.95
145_A	167_F	0.586	0.95
56_L	65_P	0.584	0.94
121_G	124_A	0.583	0.94
94_L	255_A	0.583	0.94
131_V	134_A	0.580	0.94
132_R	135_V	0.580	0.94
151_V	197_V	0.579	0.94
111_D	116_F	0.579	0.94
254_A	257_L	0.578	0.94
31_A	35_Q	0.577	0.94
245_T	252_L	0.575	0.94
129_A	135_V	0.573	0.94
158_H	211_P	0.573	0.94
109_G	115_A	0.572	0.94
123_A	130_A	0.571	0.94
130_A	137_A	0.570	0.94
77_D	80_S	0.570	0.94
51_V	59_V	0.569	0.94
149_V	195_G	0.569	0.94
100_A	104_D	0.567	0.94
83_S	87_A	0.561	0.93
214_L	225_V	0.560	0.93
119_R	126_R	0.560	0.93
116_F	260_T	0.560	0.93
220_T	223_Q	0.560	0.93
143_P	166_G	0.560	0.93
25_S	64_E	0.559	0.93
230_S	233_V	0.557	0.93
182_R	191_E	0.557	0.93
109_G	119_R	0.556	0.93
23_V	74_T	0.555	0.93
158_H	243_V	0.554	0.93
73_I	78_V	0.554	0.93
229_A	233_V	0.553	0.93
205_A	208_A	0.552	0.93
100_A	105_D	0.552	0.93
270_R	274_W	0.550	0.93
195_G	228_A	0.548	0.92
18_V	36_A	0.548	0.92
19_L	50_L	0.547	0.92
212_H	245_T	0.547	0.92
184_V	187_A	0.547	0.92
108_A	112_T	0.544	0.92
198_A	225_V	0.543	0.92
252_L	256_L	0.542	0.92
45_V	48_A	0.542	0.92
143_P	146_E	0.539	0.92
181_I	185_L	0.534	0.91
23_V	26_A	0.533	0.91
44_E	48_A	0.533	0.91
244_D	265_V	0.533	0.91
42_A	101_M	0.531	0.91
219_P	277_D	0.531	0.91
229_A	240_V	0.529	0.91
246_F	271_V	0.529	0.91
149_V	170_A	0.528	0.91
10_L	50_L	0.527	0.91
127_D	130_A	0.524	0.91
29_P	47_V	0.524	0.91
255_A	260_T	0.521	0.90
218_S	262_G	0.520	0.90
222_A	264_A	0.518	0.90
173_H	194_G	0.518	0.90
282_D	285_T	0.517	0.90
92_D	96_A	0.516	0.90
216_R	256_L	0.516	0.90
229_A	280_L	0.516	0.90
230_S	234_S	0.516	0.90
253_S	265_V	0.516	0.90
116_F	119_R	0.513	0.90
116_F	123_A	0.510	0.89
162_C	169_V	0.509	0.89
263_G	266_R	0.509	0.89
223_Q	226_V	0.508	0.89
288_V	294_R	0.507	0.89
195_G	202_D	0.506	0.89
133_A	137_A	0.505	0.89
211_P	243_V	0.504	0.89
227_R	230_S	0.503	0.89
16_T	102_E	0.503	0.89
241_A	295_V	0.503	0.89
275_L	283_V	0.503	0.89
193_V	200_P	0.500	0.89
115_A	120_L	0.500	0.89
172_H	200_P	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3p9cA	2	0.9671	100	0.339	Contact Map
3reoA	2	0.9704	100	0.344	Contact Map
4z2yA	2	0.8487	100	0.347	Contact Map
1fp2A	2	0.9572	100	0.348	Contact Map
4u1qA	2	0.9868	100	0.348	Contact Map
4wxhA	2	0.977	100	0.348	Contact Map
1zg3A	2	0.9638	100	0.35	Contact Map
3gwzA	3	0.9803	100	0.35	Contact Map
3dp7A	2	0.9803	100	0.352	Contact Map
1qzzA	2	0.9638	100	0.355	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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