Q9HSS9 - HALSA - GREMLIN Contacts

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Q9HSS9 - Uncharacterized protein

UniProt:	Q9HSS9	Sequences: MNHGVEAGEQVGLSCPSCSPDLETVHEVVTTGGGHATVECGACGHVHKDPIKTEDTEAVDVVVSQDGESFTGQTSFDPEETVYEGDEFIVETAETIAQVRVTSIEVGPEDRTTRADVEDIETVWTRAVDNVSVDVTVHPKEGSDEGSRSLELHVPGDFEFVVGETATFGDEEFTVEGIHVRESATGEYKFPKLGNAGDTVFAKDVKRVYGADESSAAWSAW	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	221 (183)
Sequences:	862 (765)
Seq/√Len:	56.5

HALSA - Q9HSS9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
63_V	66_D	7.458	1.00
66_D	79_E	5.466	1.00
63_V	79_E	4.249	1.00
66_D	70_F	3.593	1.00
22_L	45_H	3.148	1.00
3_H	7_A	3.130	1.00
22_L	47_H	2.769	1.00
63_V	70_F	2.361	1.00
76_F	79_E	2.299	1.00
40_C	56_T	2.266	1.00
63_V	76_F	2.126	1.00
24_T	50_P	2.118	1.00
40_C	43_C	2.117	1.00
20_P	45_H	2.063	1.00
43_C	56_T	2.009	1.00
5_V	12_G	1.989	1.00
70_F	79_E	1.985	1.00
5_V	8_G	1.950	1.00
25_V	29_V	1.939	1.00
66_D	83_Y	1.906	1.00
26_H	51_I	1.889	1.00
15_C	18_C	1.864	1.00
12_G	35_H	1.842	0.99
27_E	30_T	1.815	0.99
66_D	76_F	1.781	0.99
63_V	83_Y	1.738	0.99
167_T	170_D	1.672	0.99
70_F	83_Y	1.638	0.99
61_V	66_D	1.580	0.98
45_H	48_K	1.577	0.98
19_S	22_L	1.563	0.98
20_P	47_H	1.551	0.98
119_D	122_T	1.546	0.98
18_C	31_T	1.521	0.98
15_C	31_T	1.499	0.98
179_H	182_E	1.486	0.98
135_V	139_P	1.473	0.97
79_E	83_Y	1.465	0.97
24_T	30_T	1.459	0.97
14_S	19_S	1.455	0.97
39_E	42_A	1.443	0.97
73_Q	77_D	1.441	0.97
20_P	34_G	1.436	0.97
27_E	52_K	1.396	0.96
26_H	50_P	1.372	0.96
113_T	116_D	1.344	0.96
146_G	151_E	1.336	0.95
182_E	185_T	1.304	0.95
34_G	48_K	1.302	0.95
24_T	27_E	1.239	0.93
11_V	21_D	1.239	0.93
24_T	29_V	1.206	0.92
49_D	53_T	1.179	0.91
19_S	54_E	1.175	0.91
24_T	49_D	1.167	0.91
29_V	54_E	1.166	0.91
9_E	60_D	1.164	0.91
122_T	132_S	1.164	0.91
14_S	20_P	1.153	0.90
36_A	48_K	1.135	0.90
11_V	17_S	1.134	0.89
179_H	184_A	1.133	0.89
20_P	30_T	1.130	0.89
21_D	49_D	1.125	0.89
23_E	29_V	1.124	0.89
11_V	27_E	1.098	0.88
48_K	54_E	1.095	0.88
41_G	57_E	1.078	0.87
177_G	180_V	1.077	0.87
35_H	46_V	1.075	0.87
16_P	27_E	1.065	0.86
174_T	177_G	1.059	0.86
25_V	48_K	1.052	0.86
101_V	104_I	1.051	0.86
19_S	50_P	1.041	0.85
61_V	79_E	1.039	0.85
124_W	128_V	1.038	0.85
49_D	52_K	1.038	0.85
7_A	12_G	1.036	0.85
94_E	97_A	1.033	0.85
14_S	21_D	1.030	0.84
50_P	54_E	1.020	0.84
22_L	26_H	1.015	0.83
111_R	117_V	1.012	0.83
39_E	46_V	1.010	0.83
99_V	103_S	1.007	0.83
52_K	59_V	1.001	0.83
144_D	149_S	0.978	0.81
99_V	102_T	0.977	0.81
5_V	10_Q	0.971	0.81
41_G	45_H	0.971	0.81
149_S	153_H	0.970	0.81
27_E	48_K	0.966	0.80
34_G	37_T	0.958	0.80
108_P	112_T	0.957	0.80
39_E	44_G	0.956	0.80
26_H	55_D	0.953	0.79
8_G	36_A	0.943	0.79
5_V	9_E	0.943	0.79
54_E	57_E	0.939	0.78
30_T	52_K	0.939	0.78
27_E	49_D	0.938	0.78
61_V	83_Y	0.934	0.78
13_L	27_E	0.929	0.78
34_G	60_D	0.912	0.76
171_E	174_T	0.906	0.76
124_W	127_A	0.904	0.76
134_D	139_P	0.903	0.76
25_V	50_P	0.903	0.76
112_T	116_D	0.899	0.75
52_K	58_A	0.897	0.75
30_T	50_P	0.895	0.75
169_G	175_V	0.884	0.74
20_P	68_E	0.879	0.74
11_V	24_T	0.877	0.73
6_E	9_E	0.872	0.73
177_G	183_S	0.869	0.73
149_S	152_L	0.861	0.72
44_G	57_E	0.858	0.72
72_G	80_E	0.855	0.72
6_E	24_T	0.855	0.72
137_V	141_E	0.855	0.72
35_H	47_H	0.853	0.71
14_S	29_V	0.844	0.71
8_G	12_G	0.844	0.71
26_H	54_E	0.843	0.70
63_V	72_G	0.842	0.70
26_H	30_T	0.835	0.70
178_I	181_R	0.833	0.70
30_T	54_E	0.827	0.69
21_D	25_V	0.823	0.69
145_E	151_E	0.818	0.68
58_A	61_V	0.816	0.68
97_A	100_R	0.814	0.68
10_Q	24_T	0.806	0.67
181_R	184_A	0.799	0.66
31_T	56_T	0.797	0.66
25_V	51_I	0.797	0.66
6_E	23_E	0.794	0.66
181_R	185_T	0.785	0.65
37_T	52_K	0.785	0.65
8_G	22_L	0.775	0.64
45_H	60_D	0.775	0.64
14_S	24_T	0.773	0.64
155_P	159_E	0.768	0.63
139_P	142_G	0.766	0.63
94_E	107_G	0.764	0.63
153_H	157_D	0.758	0.62
55_D	59_V	0.752	0.62
95_T	107_G	0.751	0.62
163_G	166_A	0.750	0.61
23_E	27_E	0.750	0.61
180_V	183_S	0.748	0.61
11_V	35_H	0.743	0.61
8_G	24_T	0.741	0.60
29_V	49_D	0.740	0.60
37_T	46_V	0.736	0.60
101_V	106_V	0.734	0.60
180_V	184_A	0.733	0.60
18_C	32_G	0.733	0.60
20_P	48_K	0.733	0.60
37_T	50_P	0.727	0.59
100_R	106_V	0.725	0.59
12_G	24_T	0.723	0.59
100_R	107_G	0.722	0.58
111_R	116_D	0.714	0.58
160_F	164_E	0.712	0.57
139_P	153_H	0.712	0.57
118_E	136_T	0.711	0.57
95_T	98_Q	0.711	0.57
6_E	13_L	0.707	0.57
90_V	98_Q	0.705	0.57
86_D	90_V	0.703	0.56
143_S	146_G	0.703	0.56
155_P	158_F	0.702	0.56
21_D	29_V	0.694	0.55
94_E	105_E	0.693	0.55
29_V	52_K	0.689	0.55
155_P	161_V	0.689	0.55
161_V	166_A	0.688	0.55
42_A	48_K	0.686	0.55
62_V	67_G	0.684	0.54
5_V	23_E	0.683	0.54
5_V	11_V	0.680	0.54
39_E	55_D	0.677	0.54
14_S	27_E	0.675	0.53
23_E	26_H	0.674	0.53
27_E	55_D	0.656	0.51
29_V	45_H	0.655	0.51
143_S	147_S	0.652	0.51
19_S	23_E	0.650	0.51
15_C	43_C	0.646	0.50
29_V	34_G	0.646	0.50
23_E	39_E	0.639	0.50
121_E	124_W	0.639	0.50
12_G	34_G	0.636	0.49
94_E	100_R	0.633	0.49
64_S	72_G	0.629	0.48
115_A	120_I	0.628	0.48
23_E	48_K	0.627	0.48
145_E	149_S	0.626	0.48
138_H	142_G	0.625	0.48
33_G	58_A	0.624	0.48
38_V	52_K	0.623	0.48
49_D	54_E	0.622	0.48
148_R	153_H	0.620	0.47
30_T	55_D	0.618	0.47
18_C	43_C	0.618	0.47
22_L	58_A	0.617	0.47
44_G	58_A	0.615	0.47
81_T	84_E	0.615	0.47
131_V	153_H	0.610	0.46
23_E	42_A	0.609	0.46
66_D	78_P	0.606	0.46
175_V	178_I	0.604	0.46
12_G	53_T	0.603	0.46
49_D	55_D	0.602	0.45
149_S	163_G	0.601	0.45
33_G	47_H	0.595	0.45
29_V	35_H	0.594	0.45
13_L	25_V	0.593	0.45
46_V	52_K	0.592	0.44
48_K	52_K	0.591	0.44
19_S	44_G	0.585	0.44
15_C	32_G	0.583	0.43
46_V	59_V	0.583	0.43
31_T	43_C	0.579	0.43
163_G	167_T	0.578	0.43
34_G	47_H	0.578	0.43
10_Q	21_D	0.576	0.43
135_V	141_E	0.574	0.42
168_F	171_E	0.570	0.42
144_D	150_L	0.569	0.42
9_E	51_I	0.567	0.42
32_G	36_A	0.567	0.42
27_E	44_G	0.565	0.42
52_K	57_E	0.561	0.41
140_K	143_S	0.559	0.41
38_V	51_I	0.559	0.41
24_T	46_V	0.557	0.41
21_D	26_H	0.554	0.40
34_G	50_P	0.548	0.40
42_A	53_T	0.542	0.39
114_R	117_V	0.541	0.39
16_P	35_H	0.540	0.39
99_V	106_V	0.540	0.39
23_E	51_I	0.537	0.39
38_V	49_D	0.534	0.38
114_R	121_E	0.534	0.38
25_V	52_K	0.533	0.38
176_E	179_H	0.533	0.38
25_V	55_D	0.532	0.38
152_L	155_P	0.531	0.38
121_E	136_T	0.530	0.38
144_D	154_V	0.529	0.38
170_D	177_G	0.523	0.37
26_H	60_D	0.519	0.37
4_G	12_G	0.515	0.36
14_S	54_E	0.515	0.36
17_S	30_T	0.513	0.36
12_G	20_P	0.513	0.36
24_T	48_K	0.512	0.36
16_P	52_K	0.511	0.36
15_C	40_C	0.509	0.36
160_F	166_A	0.509	0.36
147_S	153_H	0.507	0.36
26_H	49_D	0.507	0.36
147_S	150_L	0.505	0.35
26_H	29_V	0.504	0.35
136_T	140_K	0.503	0.35
121_E	125_T	0.502	0.35
48_K	51_I	0.501	0.35
113_T	117_V	0.501	0.35
17_S	54_E	0.500	0.35

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i13A	1	0.3756	99.8	0.539	Contact Map
2n25A	1	0.1176	99.8	0.556	Contact Map
2dlqA	1	0.4072	99.8	0.563	Contact Map
3w5kB	1	0.3846	99.7	0.573	Contact Map
2gliA	1	0.3846	99.7	0.575	Contact Map
2jp9A	1	0.3756	99.7	0.575	Contact Map
1ubdC	1	0.3756	99.7	0.579	Contact Map
2lt7A	1	0.5204	99.7	0.586	Contact Map
2dmiA	1	0.4208	99.7	0.587	Contact Map
1wjpA	1	0.4253	99.7	0.591	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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