GREMLIN Database
Q9HSS9 - Uncharacterized protein
UniProt: Q9HSS9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 221 (183)
Sequences: 862 (765)
Seq/√Len: 56.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_V66_D7.4581.00
66_D79_E5.4661.00
63_V79_E4.2491.00
66_D70_F3.5931.00
22_L45_H3.1481.00
3_H7_A3.1301.00
22_L47_H2.7691.00
63_V70_F2.3611.00
76_F79_E2.2991.00
40_C56_T2.2661.00
63_V76_F2.1261.00
24_T50_P2.1181.00
40_C43_C2.1171.00
20_P45_H2.0631.00
43_C56_T2.0091.00
5_V12_G1.9891.00
70_F79_E1.9851.00
5_V8_G1.9501.00
25_V29_V1.9391.00
66_D83_Y1.9061.00
26_H51_I1.8891.00
15_C18_C1.8641.00
12_G35_H1.8420.99
27_E30_T1.8150.99
66_D76_F1.7810.99
63_V83_Y1.7380.99
167_T170_D1.6720.99
70_F83_Y1.6380.99
61_V66_D1.5800.98
45_H48_K1.5770.98
19_S22_L1.5630.98
20_P47_H1.5510.98
119_D122_T1.5460.98
18_C31_T1.5210.98
15_C31_T1.4990.98
179_H182_E1.4860.98
135_V139_P1.4730.97
79_E83_Y1.4650.97
24_T30_T1.4590.97
14_S19_S1.4550.97
39_E42_A1.4430.97
73_Q77_D1.4410.97
20_P34_G1.4360.97
27_E52_K1.3960.96
26_H50_P1.3720.96
113_T116_D1.3440.96
146_G151_E1.3360.95
182_E185_T1.3040.95
34_G48_K1.3020.95
24_T27_E1.2390.93
11_V21_D1.2390.93
24_T29_V1.2060.92
49_D53_T1.1790.91
19_S54_E1.1750.91
24_T49_D1.1670.91
29_V54_E1.1660.91
9_E60_D1.1640.91
122_T132_S1.1640.91
14_S20_P1.1530.90
36_A48_K1.1350.90
11_V17_S1.1340.89
179_H184_A1.1330.89
20_P30_T1.1300.89
21_D49_D1.1250.89
23_E29_V1.1240.89
11_V27_E1.0980.88
48_K54_E1.0950.88
41_G57_E1.0780.87
177_G180_V1.0770.87
35_H46_V1.0750.87
16_P27_E1.0650.86
174_T177_G1.0590.86
25_V48_K1.0520.86
101_V104_I1.0510.86
19_S50_P1.0410.85
61_V79_E1.0390.85
124_W128_V1.0380.85
49_D52_K1.0380.85
7_A12_G1.0360.85
94_E97_A1.0330.85
14_S21_D1.0300.84
50_P54_E1.0200.84
22_L26_H1.0150.83
111_R117_V1.0120.83
39_E46_V1.0100.83
99_V103_S1.0070.83
52_K59_V1.0010.83
144_D149_S0.9780.81
99_V102_T0.9770.81
5_V10_Q0.9710.81
41_G45_H0.9710.81
149_S153_H0.9700.81
27_E48_K0.9660.80
34_G37_T0.9580.80
108_P112_T0.9570.80
39_E44_G0.9560.80
26_H55_D0.9530.79
8_G36_A0.9430.79
5_V9_E0.9430.79
54_E57_E0.9390.78
30_T52_K0.9390.78
27_E49_D0.9380.78
61_V83_Y0.9340.78
13_L27_E0.9290.78
34_G60_D0.9120.76
171_E174_T0.9060.76
124_W127_A0.9040.76
134_D139_P0.9030.76
25_V50_P0.9030.76
112_T116_D0.8990.75
52_K58_A0.8970.75
30_T50_P0.8950.75
169_G175_V0.8840.74
20_P68_E0.8790.74
11_V24_T0.8770.73
6_E9_E0.8720.73
177_G183_S0.8690.73
149_S152_L0.8610.72
44_G57_E0.8580.72
72_G80_E0.8550.72
6_E24_T0.8550.72
137_V141_E0.8550.72
35_H47_H0.8530.71
14_S29_V0.8440.71
8_G12_G0.8440.71
26_H54_E0.8430.70
63_V72_G0.8420.70
26_H30_T0.8350.70
178_I181_R0.8330.70
30_T54_E0.8270.69
21_D25_V0.8230.69
145_E151_E0.8180.68
58_A61_V0.8160.68
97_A100_R0.8140.68
10_Q24_T0.8060.67
181_R184_A0.7990.66
31_T56_T0.7970.66
25_V51_I0.7970.66
6_E23_E0.7940.66
181_R185_T0.7850.65
37_T52_K0.7850.65
8_G22_L0.7750.64
45_H60_D0.7750.64
14_S24_T0.7730.64
155_P159_E0.7680.63
139_P142_G0.7660.63
94_E107_G0.7640.63
153_H157_D0.7580.62
55_D59_V0.7520.62
95_T107_G0.7510.62
163_G166_A0.7500.61
23_E27_E0.7500.61
180_V183_S0.7480.61
11_V35_H0.7430.61
8_G24_T0.7410.60
29_V49_D0.7400.60
37_T46_V0.7360.60
101_V106_V0.7340.60
180_V184_A0.7330.60
18_C32_G0.7330.60
20_P48_K0.7330.60
37_T50_P0.7270.59
100_R106_V0.7250.59
12_G24_T0.7230.59
100_R107_G0.7220.58
111_R116_D0.7140.58
160_F164_E0.7120.57
139_P153_H0.7120.57
118_E136_T0.7110.57
95_T98_Q0.7110.57
6_E13_L0.7070.57
90_V98_Q0.7050.57
86_D90_V0.7030.56
143_S146_G0.7030.56
155_P158_F0.7020.56
21_D29_V0.6940.55
94_E105_E0.6930.55
29_V52_K0.6890.55
155_P161_V0.6890.55
161_V166_A0.6880.55
42_A48_K0.6860.55
62_V67_G0.6840.54
5_V23_E0.6830.54
5_V11_V0.6800.54
39_E55_D0.6770.54
14_S27_E0.6750.53
23_E26_H0.6740.53
27_E55_D0.6560.51
29_V45_H0.6550.51
143_S147_S0.6520.51
19_S23_E0.6500.51
15_C43_C0.6460.50
29_V34_G0.6460.50
23_E39_E0.6390.50
121_E124_W0.6390.50
12_G34_G0.6360.49
94_E100_R0.6330.49
64_S72_G0.6290.48
115_A120_I0.6280.48
23_E48_K0.6270.48
145_E149_S0.6260.48
138_H142_G0.6250.48
33_G58_A0.6240.48
38_V52_K0.6230.48
49_D54_E0.6220.48
148_R153_H0.6200.47
30_T55_D0.6180.47
18_C43_C0.6180.47
22_L58_A0.6170.47
44_G58_A0.6150.47
81_T84_E0.6150.47
131_V153_H0.6100.46
23_E42_A0.6090.46
66_D78_P0.6060.46
175_V178_I0.6040.46
12_G53_T0.6030.46
49_D55_D0.6020.45
149_S163_G0.6010.45
33_G47_H0.5950.45
29_V35_H0.5940.45
13_L25_V0.5930.45
46_V52_K0.5920.44
48_K52_K0.5910.44
19_S44_G0.5850.44
15_C32_G0.5830.43
46_V59_V0.5830.43
31_T43_C0.5790.43
163_G167_T0.5780.43
34_G47_H0.5780.43
10_Q21_D0.5760.43
135_V141_E0.5740.42
168_F171_E0.5700.42
144_D150_L0.5690.42
9_E51_I0.5670.42
32_G36_A0.5670.42
27_E44_G0.5650.42
52_K57_E0.5610.41
140_K143_S0.5590.41
38_V51_I0.5590.41
24_T46_V0.5570.41
21_D26_H0.5540.40
34_G50_P0.5480.40
42_A53_T0.5420.39
114_R117_V0.5410.39
16_P35_H0.5400.39
99_V106_V0.5400.39
23_E51_I0.5370.39
38_V49_D0.5340.38
114_R121_E0.5340.38
25_V52_K0.5330.38
176_E179_H0.5330.38
25_V55_D0.5320.38
152_L155_P0.5310.38
121_E136_T0.5300.38
144_D154_V0.5290.38
170_D177_G0.5230.37
26_H60_D0.5190.37
4_G12_G0.5150.36
14_S54_E0.5150.36
17_S30_T0.5130.36
12_G20_P0.5130.36
24_T48_K0.5120.36
16_P52_K0.5110.36
15_C40_C0.5090.36
160_F166_A0.5090.36
147_S153_H0.5070.36
26_H49_D0.5070.36
147_S150_L0.5050.35
26_H29_V0.5040.35
136_T140_K0.5030.35
121_E125_T0.5020.35
48_K51_I0.5010.35
113_T117_V0.5010.35
17_S54_E0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i13A 1 0.3756 99.8 0.539 Contact Map
2n25A 1 0.1176 99.8 0.556 Contact Map
2dlqA 1 0.4072 99.8 0.563 Contact Map
3w5kB 1 0.3846 99.7 0.573 Contact Map
2gliA 1 0.3846 99.7 0.575 Contact Map
2jp9A 1 0.3756 99.7 0.575 Contact Map
1ubdC 1 0.3756 99.7 0.579 Contact Map
2lt7A 1 0.5204 99.7 0.586 Contact Map
2dmiA 1 0.4208 99.7 0.587 Contact Map
1wjpA 1 0.4253 99.7 0.591 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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