GREMLIN Database
Q9HSS8 - Uncharacterized protein
UniProt: Q9HSS8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 313 (293)
Sequences: 2187 (1535)
Seq/√Len: 89.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
208_E224_D5.3571.00
212_E220_E4.6121.00
17_L23_C3.9991.00
189_N215_D3.8101.00
218_V276_I3.7791.00
41_A44_D3.5851.00
27_T35_G3.4161.00
8_E41_A3.3191.00
207_E225_R3.3011.00
142_R150_D3.2461.00
227_R231_E3.2351.00
8_E12_E3.1271.00
11_V45_V3.1241.00
140_E152_T2.9891.00
195_D298_E2.7011.00
4_R41_A2.6931.00
235_E242_Y2.6901.00
77_V81_P2.4941.00
125_E173_F2.4111.00
191_T212_E2.4071.00
210_R222_S2.4071.00
191_T210_R2.3981.00
12_E45_V2.2871.00
231_E235_E2.2541.00
138_A308_V2.1881.00
213_V244_L2.0761.00
222_S227_R2.0611.00
138_A303_A2.0541.00
221_I231_E2.0121.00
154_E186_T1.9651.00
129_E133_A1.9581.00
152_T189_N1.9541.00
11_V38_I1.9511.00
22_S48_A1.9171.00
25_V38_I1.9041.00
217_V242_Y1.8871.00
133_A137_D1.8801.00
193_V210_R1.8801.00
228_E232_A1.8681.00
23_C42_A1.7871.00
90_R97_D1.7851.00
234_S242_Y1.7561.00
184_S285_D1.7221.00
217_V243_N1.7101.00
272_V301_V1.7071.00
139_T156_G1.6821.00
142_R152_T1.6761.00
153_F274_I1.6561.00
119_A123_T1.6561.00
158_R283_G1.6501.00
146_P300_T1.6151.00
4_R37_A1.6061.00
192_Y274_I1.6051.00
200_P205_D1.6041.00
11_V42_A1.5521.00
163_D178_A1.5431.00
187_D243_N1.5391.00
142_R307_E1.5241.00
18_H21_E1.5221.00
214_A219_T1.5191.00
4_R40_E1.5181.00
125_E164_T1.5161.00
5_D8_E1.5081.00
221_I227_R1.4811.00
184_S279_D1.4711.00
69_A73_A1.4630.99
220_E231_E1.4450.99
144_T302_Y1.4390.99
42_A47_D1.4310.99
188_A243_N1.4290.99
17_L77_V1.4130.99
272_V296_I1.4110.99
37_A40_E1.3890.99
126_A130_D1.3860.99
211_F218_V1.3730.99
249_I301_V1.3390.99
64_P72_M1.3150.99
234_S276_I1.3000.99
134_Q138_A1.2910.99
141_V155_A1.2860.99
13_Q122_E1.2750.99
278_D287_D1.2750.99
143_V151_I1.2660.99
139_T154_E1.2640.98
11_V23_C1.2490.98
279_D285_D1.2440.98
180_E273_H1.2280.98
58_D61_G1.2270.98
199_M204_L1.2260.98
34_I38_I1.2070.98
145_T300_T1.2030.98
109_T114_T1.2020.98
155_A183_V1.1960.98
140_E305_G1.1950.98
241_A290_L1.1850.98
192_Y296_I1.1820.98
231_E242_Y1.1750.98
120_D123_T1.1650.97
274_I296_I1.1650.97
237_V289_P1.1620.97
58_D62_E1.1600.97
39_Y59_Q1.1590.97
125_E129_E1.1550.97
175_N263_L1.1480.97
148_G193_V1.1480.97
17_L45_V1.1470.97
141_V247_L1.1420.97
37_A41_A1.1410.97
75_A78_F1.1400.97
246_E273_H1.1300.97
119_A122_E1.1210.97
86_L89_T1.1210.97
189_N214_A1.1200.97
184_S280_A1.1180.97
99_G102_G1.1160.97
232_A235_E1.1090.97
25_V35_G1.1010.96
234_S241_A1.1000.96
17_L42_A1.1000.96
115_T120_D1.0880.96
180_E246_E1.0870.96
40_E44_D1.0850.96
207_E224_D1.0840.96
144_T150_D1.0830.96
153_F188_A1.0730.96
175_N275_A1.0650.96
125_E163_D1.0620.96
41_A45_V1.0610.96
125_E165_G1.0610.96
184_S282_I1.0540.95
100_A103_A1.0410.95
61_G65_P1.0380.95
82_T86_L1.0280.95
67_P71_A1.0280.95
221_I234_S1.0280.95
26_V53_Q1.0220.95
81_P85_S1.0140.94
151_I188_A1.0020.94
186_T243_N0.9900.94
179_G267_K0.9890.93
134_Q306_E0.9870.93
163_D173_F0.9770.93
57_G60_H0.9770.93
134_Q303_A0.9750.93
98_A101_R0.9740.93
132_L136_A0.9730.93
75_A80_A0.9680.93
198_M292_L0.9650.93
130_D134_Q0.9630.93
70_A73_A0.9580.92
60_H64_P0.9480.92
151_I274_I0.9480.92
302_Y307_E0.9470.92
185_P244_L0.9470.92
218_V241_A0.9460.92
59_Q62_E0.9460.92
100_A104_T0.9380.92
217_V239_E0.9380.92
252_N299_P0.9260.91
111_D176_L0.9120.90
211_F234_S0.9110.90
154_E189_N0.9100.90
68_V71_A0.9070.90
114_T117_L0.9040.90
75_A82_T0.9020.90
68_V72_M0.8960.90
144_T152_T0.8920.89
148_G210_R0.8860.89
111_D115_T0.8830.89
57_G62_E0.8830.89
34_I37_A0.8820.89
230_V233_G0.8780.89
141_V303_A0.8750.88
57_G61_G0.8750.88
32_E36_R0.8700.88
221_I235_E0.8680.88
218_V242_Y0.8670.88
66_A74_D0.8620.88
175_N182_F0.8600.88
123_T126_A0.8570.87
40_E58_D0.8520.87
77_V80_A0.8520.87
145_T193_V0.8510.87
218_V234_S0.8420.87
145_T296_I0.8380.86
76_D82_T0.8310.86
175_N267_K0.8310.86
79_V86_L0.8300.86
153_F247_L0.8300.86
140_E154_E0.8280.86
198_M262_V0.8270.86
16_G166_I0.8260.85
83_T86_L0.8190.85
157_D186_T0.8150.85
168_R172_E0.8110.84
198_M294_G0.8110.84
243_N286_T0.8100.84
44_D66_A0.8090.84
212_E222_S0.8090.84
79_V83_T0.8070.84
182_F263_L0.8030.84
79_V82_T0.8010.84
75_A79_V0.8000.84
81_P84_K0.8000.84
76_D81_P0.7980.83
175_N266_E0.7970.83
199_M203_K0.7960.83
85_S89_T0.7950.83
28_D31_R0.7930.83
128_C251_T0.7930.83
169_E172_E0.7900.83
272_V303_A0.7890.83
267_K275_A0.7860.82
12_E41_A0.7850.82
248_G251_T0.7850.82
221_I242_Y0.7810.82
104_T108_I0.7810.82
77_V82_T0.7770.82
209_L294_G0.7770.82
209_L230_V0.7750.82
240_D288_A0.7750.82
24_V75_A0.7750.82
134_Q137_D0.7730.81
128_C181_V0.7690.81
25_V42_A0.7640.81
10_A38_I0.7640.81
205_D230_V0.7580.80
237_V290_L0.7570.80
278_D281_G0.7550.80
187_D284_G0.7530.80
83_T87_S0.7520.80
80_A87_S0.7510.80
132_L173_F0.7490.79
263_L266_E0.7480.79
76_D80_A0.7450.79
43_R49_T0.7430.79
133_A136_A0.7410.79
156_G159_A0.7400.79
208_E225_R0.7370.78
52_L71_A0.7360.78
180_E266_E0.7360.78
140_E307_E0.7320.78
43_R48_A0.7300.78
238_G289_P0.7300.78
223_D226_V0.7300.78
117_L120_D0.7280.77
158_R187_D0.7270.77
203_K229_Q0.7230.77
59_Q63_E0.7220.77
129_E165_G0.7220.77
122_E126_A0.7210.77
72_M75_A0.7190.77
228_E231_E0.7170.76
66_A70_A0.7170.76
200_P203_K0.7150.76
85_S88_H0.7140.76
233_G237_V0.7080.75
214_A220_E0.7020.75
245_A273_H0.7020.75
100_A105_L0.7000.75
19_P46_S0.6970.74
136_A160_W0.6960.74
48_A74_D0.6950.74
262_V267_K0.6940.74
122_E125_E0.6930.74
31_R35_G0.6910.74
229_Q232_A0.6900.74
132_L164_T0.6880.73
160_W181_V0.6840.73
145_T148_G0.6820.73
266_E273_H0.6820.73
33_E37_A0.6820.73
249_I272_V0.6810.73
158_R284_G0.6800.72
101_R105_L0.6790.72
262_V266_E0.6750.72
125_E132_L0.6700.71
106_P109_T0.6700.71
276_I290_L0.6700.71
146_P298_E0.6690.71
5_D116_G0.6680.71
210_R220_E0.6660.71
166_I174_S0.6630.71
102_G105_L0.6620.70
70_A222_S0.6620.70
145_T195_D0.6610.70
32_E54_Y0.6610.70
78_F82_T0.6610.70
265_D268_A0.6570.70
187_D285_D0.6560.70
82_T85_S0.6480.69
69_A72_M0.6470.69
193_V208_E0.6430.68
297_R300_T0.6380.68
302_Y305_G0.6380.68
248_G271_T0.6370.68
75_A83_T0.6370.68
11_V41_A0.6370.68
204_L207_E0.6340.67
180_E267_K0.6330.67
123_T127_H0.6310.67
263_L267_K0.6310.67
32_E133_A0.6300.67
17_L47_D0.6290.67
242_Y276_I0.6280.66
83_T89_T0.6270.66
165_G173_F0.6270.66
143_V153_F0.6270.66
15_L77_V0.6260.66
143_V301_V0.6250.66
143_V303_A0.6250.66
213_V216_G0.6240.66
151_I244_L0.6240.66
202_G265_D0.6230.66
241_A276_I0.6220.66
77_V85_S0.6220.66
151_I189_N0.6200.65
135_V181_V0.6200.65
192_Y213_V0.6190.65
155_A160_W0.6180.65
132_L163_D0.6170.65
67_P72_M0.6170.65
212_E215_D0.6160.65
106_P110_A0.6140.65
80_A85_S0.6130.65
146_P193_V0.6120.64
180_E245_A0.6120.64
246_E275_A0.6120.64
29_D54_Y0.6120.64
220_E235_E0.6100.64
71_A74_D0.6080.64
61_G64_P0.6060.64
179_G250_G0.6060.64
262_V295_I0.6060.64
224_D227_R0.6030.63
76_D79_V0.6010.63
126_A129_E0.6010.63
200_P292_L0.6000.63
4_R44_D0.6000.63
200_P290_L0.5990.63
182_F275_A0.5970.63
173_F176_L0.5960.62
241_A288_A0.5960.62
145_T298_E0.5940.62
244_L276_I0.5930.62
36_R56_P0.5930.62
18_H172_E0.5920.62
25_V49_T0.5920.62
22_S51_M0.5920.62
234_S238_G0.5910.62
220_E227_R0.5900.62
175_N273_H0.5900.62
188_A274_I0.5900.62
180_E275_A0.5890.61
77_V86_L0.5860.61
142_R302_Y0.5860.61
244_L274_I0.5800.60
84_K88_H0.5800.60
70_A74_D0.5790.60
139_T306_E0.5760.60
17_L21_E0.5750.60
175_N180_E0.5740.60
175_N262_V0.5710.59
82_T88_H0.5660.58
145_T272_V0.5660.58
283_G287_D0.5660.58
175_N246_E0.5650.58
154_E188_A0.5650.58
82_T89_T0.5640.58
212_E219_T0.5630.58
78_F81_P0.5630.58
151_I192_Y0.5610.58
279_D283_G0.5610.58
51_M86_L0.5600.58
246_E266_E0.5600.58
13_Q173_F0.5580.57
81_P86_L0.5570.57
72_M80_A0.5570.57
127_H253_V0.5570.57
187_D283_G0.5560.57
199_M202_G0.5540.57
233_G301_V0.5530.57
83_T88_H0.5510.56
205_D233_G0.5510.56
143_V149_T0.5500.56
73_A80_A0.5490.56
4_R73_A0.5460.56
39_Y43_R0.5450.56
132_L162_D0.5450.56
281_G290_L0.5440.55
27_T31_R0.5400.55
25_V36_R0.5380.55
138_A155_A0.5360.54
266_E291_H0.5360.54
275_A293_D0.5350.54
121_Y171_G0.5340.54
226_V229_Q0.5340.54
129_E163_D0.5340.54
138_A250_G0.5330.54
39_Y52_L0.5330.54
6_A10_A0.5320.54
213_V276_I0.5310.54
9_T118_D0.5300.54
29_D32_E0.5270.53
10_A23_C0.5250.53
235_E238_G0.5250.53
132_L160_W0.5250.53
134_Q308_V0.5250.53
142_R272_V0.5240.53
216_G277_G0.5240.53
215_D231_E0.5230.53
204_L260_G0.5230.53
238_G288_A0.5200.52
122_E137_D0.5190.52
53_Q82_T0.5190.52
187_D279_D0.5180.52
165_G168_R0.5180.52
139_T215_D0.5170.52
76_D85_S0.5140.51
9_T41_A0.5140.51
60_H63_E0.5140.51
143_V247_L0.5140.51
21_E76_D0.5130.51
19_P222_S0.5120.51
75_A81_P0.5120.51
5_D9_T0.5120.51
82_T87_S0.5120.51
279_D287_D0.5090.51
246_E263_L0.5090.51
157_D160_W0.5080.51
100_A109_T0.5070.50
248_G279_D0.5060.50
113_F117_L0.5060.50
195_D271_T0.5050.50
135_V263_L0.5040.50
79_V222_S0.5020.50
26_V78_F0.5020.50
131_V134_Q0.5020.50
179_G251_T0.5010.50
5_D113_F0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zjcA 2 0.984 100 0.266 Contact Map
4icsA 2 0.9808 100 0.269 Contact Map
2ayiA 2 0.9681 100 0.274 Contact Map
3shoA 4 0.3802 43.1 0.958 Contact Map
3d8tA 1 0.4249 42.7 0.958 Contact Map
2iw1A 1 0.5048 41.6 0.958 Contact Map
1wcwA 1 0.4313 40.4 0.959 Contact Map
4ivnA 2 0.3898 37.1 0.96 Contact Map
3cvjA 2 0.4856 32.9 0.961 Contact Map
3gohA 1 0.4888 32.2 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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