Q9HSS8 - HALSA - GREMLIN Contacts

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Q9HSS8 - Uncharacterized protein

UniProt:	Q9HSS8	Sequences: MSLRDAAETAVEQCLGLHPEESCVVVTDDKREEIGRAIYEAARDVSDATTMLQYPPGDQHGEEPPAPVAAAMADADVFVAPTTKSLSHTRARGAANDAGARGATLPGITADVFTTGLDADYETIEAHCEDVLAQVADATEVRVTTPLGTDITFEAGDRAWRDDTGIVREGGEFSNLPAGEVFVSPTDANGTYVVDGTMMPHGKLDDEELRFEVADGVVTEISDDRVREQVEAGSEEVGEDAYNLAELGIGTNVAVTELVGSVLLDEKAAGTVHIAIGDDAGIGGDTDAPLHLDGIIREPTVYADGEEVELPQP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	313 (293)
Sequences:	2187 (1535)
Seq/√Len:	89.7

BACSU - AMPS
HALSA - Q9HSS8 Q9HSK5 Q9HMP2 Q9HMH0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
208_E	224_D	5.357	1.00
212_E	220_E	4.612	1.00
17_L	23_C	3.999	1.00
189_N	215_D	3.810	1.00
218_V	276_I	3.779	1.00
41_A	44_D	3.585	1.00
27_T	35_G	3.416	1.00
8_E	41_A	3.319	1.00
207_E	225_R	3.301	1.00
142_R	150_D	3.246	1.00
227_R	231_E	3.235	1.00
8_E	12_E	3.127	1.00
11_V	45_V	3.124	1.00
140_E	152_T	2.989	1.00
195_D	298_E	2.701	1.00
4_R	41_A	2.693	1.00
235_E	242_Y	2.690	1.00
77_V	81_P	2.494	1.00
125_E	173_F	2.411	1.00
191_T	212_E	2.407	1.00
210_R	222_S	2.407	1.00
191_T	210_R	2.398	1.00
12_E	45_V	2.287	1.00
231_E	235_E	2.254	1.00
138_A	308_V	2.188	1.00
213_V	244_L	2.076	1.00
222_S	227_R	2.061	1.00
138_A	303_A	2.054	1.00
221_I	231_E	2.012	1.00
154_E	186_T	1.965	1.00
129_E	133_A	1.958	1.00
152_T	189_N	1.954	1.00
11_V	38_I	1.951	1.00
22_S	48_A	1.917	1.00
25_V	38_I	1.904	1.00
217_V	242_Y	1.887	1.00
133_A	137_D	1.880	1.00
193_V	210_R	1.880	1.00
228_E	232_A	1.868	1.00
23_C	42_A	1.787	1.00
90_R	97_D	1.785	1.00
234_S	242_Y	1.756	1.00
184_S	285_D	1.722	1.00
217_V	243_N	1.710	1.00
272_V	301_V	1.707	1.00
139_T	156_G	1.682	1.00
142_R	152_T	1.676	1.00
153_F	274_I	1.656	1.00
119_A	123_T	1.656	1.00
158_R	283_G	1.650	1.00
146_P	300_T	1.615	1.00
4_R	37_A	1.606	1.00
192_Y	274_I	1.605	1.00
200_P	205_D	1.604	1.00
11_V	42_A	1.552	1.00
163_D	178_A	1.543	1.00
187_D	243_N	1.539	1.00
142_R	307_E	1.524	1.00
18_H	21_E	1.522	1.00
214_A	219_T	1.519	1.00
4_R	40_E	1.518	1.00
125_E	164_T	1.516	1.00
5_D	8_E	1.508	1.00
221_I	227_R	1.481	1.00
184_S	279_D	1.471	1.00
69_A	73_A	1.463	0.99
220_E	231_E	1.445	0.99
144_T	302_Y	1.439	0.99
42_A	47_D	1.431	0.99
188_A	243_N	1.429	0.99
17_L	77_V	1.413	0.99
272_V	296_I	1.411	0.99
37_A	40_E	1.389	0.99
126_A	130_D	1.386	0.99
211_F	218_V	1.373	0.99
249_I	301_V	1.339	0.99
64_P	72_M	1.315	0.99
234_S	276_I	1.300	0.99
134_Q	138_A	1.291	0.99
141_V	155_A	1.286	0.99
13_Q	122_E	1.275	0.99
278_D	287_D	1.275	0.99
143_V	151_I	1.266	0.99
139_T	154_E	1.264	0.98
11_V	23_C	1.249	0.98
279_D	285_D	1.244	0.98
180_E	273_H	1.228	0.98
58_D	61_G	1.227	0.98
199_M	204_L	1.226	0.98
34_I	38_I	1.207	0.98
145_T	300_T	1.203	0.98
109_T	114_T	1.202	0.98
155_A	183_V	1.196	0.98
140_E	305_G	1.195	0.98
241_A	290_L	1.185	0.98
192_Y	296_I	1.182	0.98
231_E	242_Y	1.175	0.98
120_D	123_T	1.165	0.97
274_I	296_I	1.165	0.97
237_V	289_P	1.162	0.97
58_D	62_E	1.160	0.97
39_Y	59_Q	1.159	0.97
125_E	129_E	1.155	0.97
175_N	263_L	1.148	0.97
148_G	193_V	1.148	0.97
17_L	45_V	1.147	0.97
141_V	247_L	1.142	0.97
37_A	41_A	1.141	0.97
75_A	78_F	1.140	0.97
246_E	273_H	1.130	0.97
119_A	122_E	1.121	0.97
86_L	89_T	1.121	0.97
189_N	214_A	1.120	0.97
184_S	280_A	1.118	0.97
99_G	102_G	1.116	0.97
232_A	235_E	1.109	0.97
25_V	35_G	1.101	0.96
234_S	241_A	1.100	0.96
17_L	42_A	1.100	0.96
115_T	120_D	1.088	0.96
180_E	246_E	1.087	0.96
40_E	44_D	1.085	0.96
207_E	224_D	1.084	0.96
144_T	150_D	1.083	0.96
153_F	188_A	1.073	0.96
175_N	275_A	1.065	0.96
125_E	163_D	1.062	0.96
41_A	45_V	1.061	0.96
125_E	165_G	1.061	0.96
184_S	282_I	1.054	0.95
100_A	103_A	1.041	0.95
61_G	65_P	1.038	0.95
82_T	86_L	1.028	0.95
67_P	71_A	1.028	0.95
221_I	234_S	1.028	0.95
26_V	53_Q	1.022	0.95
81_P	85_S	1.014	0.94
151_I	188_A	1.002	0.94
186_T	243_N	0.990	0.94
179_G	267_K	0.989	0.93
134_Q	306_E	0.987	0.93
163_D	173_F	0.977	0.93
57_G	60_H	0.977	0.93
134_Q	303_A	0.975	0.93
98_A	101_R	0.974	0.93
132_L	136_A	0.973	0.93
75_A	80_A	0.968	0.93
198_M	292_L	0.965	0.93
130_D	134_Q	0.963	0.93
70_A	73_A	0.958	0.92
60_H	64_P	0.948	0.92
151_I	274_I	0.948	0.92
302_Y	307_E	0.947	0.92
185_P	244_L	0.947	0.92
218_V	241_A	0.946	0.92
59_Q	62_E	0.946	0.92
100_A	104_T	0.938	0.92
217_V	239_E	0.938	0.92
252_N	299_P	0.926	0.91
111_D	176_L	0.912	0.90
211_F	234_S	0.911	0.90
154_E	189_N	0.910	0.90
68_V	71_A	0.907	0.90
114_T	117_L	0.904	0.90
75_A	82_T	0.902	0.90
68_V	72_M	0.896	0.90
144_T	152_T	0.892	0.89
148_G	210_R	0.886	0.89
111_D	115_T	0.883	0.89
57_G	62_E	0.883	0.89
34_I	37_A	0.882	0.89
230_V	233_G	0.878	0.89
141_V	303_A	0.875	0.88
57_G	61_G	0.875	0.88
32_E	36_R	0.870	0.88
221_I	235_E	0.868	0.88
218_V	242_Y	0.867	0.88
66_A	74_D	0.862	0.88
175_N	182_F	0.860	0.88
123_T	126_A	0.857	0.87
40_E	58_D	0.852	0.87
77_V	80_A	0.852	0.87
145_T	193_V	0.851	0.87
218_V	234_S	0.842	0.87
145_T	296_I	0.838	0.86
76_D	82_T	0.831	0.86
175_N	267_K	0.831	0.86
79_V	86_L	0.830	0.86
153_F	247_L	0.830	0.86
140_E	154_E	0.828	0.86
198_M	262_V	0.827	0.86
16_G	166_I	0.826	0.85
83_T	86_L	0.819	0.85
157_D	186_T	0.815	0.85
168_R	172_E	0.811	0.84
198_M	294_G	0.811	0.84
243_N	286_T	0.810	0.84
44_D	66_A	0.809	0.84
212_E	222_S	0.809	0.84
79_V	83_T	0.807	0.84
182_F	263_L	0.803	0.84
79_V	82_T	0.801	0.84
75_A	79_V	0.800	0.84
81_P	84_K	0.800	0.84
76_D	81_P	0.798	0.83
175_N	266_E	0.797	0.83
199_M	203_K	0.796	0.83
85_S	89_T	0.795	0.83
28_D	31_R	0.793	0.83
128_C	251_T	0.793	0.83
169_E	172_E	0.790	0.83
272_V	303_A	0.789	0.83
267_K	275_A	0.786	0.82
12_E	41_A	0.785	0.82
248_G	251_T	0.785	0.82
221_I	242_Y	0.781	0.82
104_T	108_I	0.781	0.82
77_V	82_T	0.777	0.82
209_L	294_G	0.777	0.82
209_L	230_V	0.775	0.82
240_D	288_A	0.775	0.82
24_V	75_A	0.775	0.82
134_Q	137_D	0.773	0.81
128_C	181_V	0.769	0.81
25_V	42_A	0.764	0.81
10_A	38_I	0.764	0.81
205_D	230_V	0.758	0.80
237_V	290_L	0.757	0.80
278_D	281_G	0.755	0.80
187_D	284_G	0.753	0.80
83_T	87_S	0.752	0.80
80_A	87_S	0.751	0.80
132_L	173_F	0.749	0.79
263_L	266_E	0.748	0.79
76_D	80_A	0.745	0.79
43_R	49_T	0.743	0.79
133_A	136_A	0.741	0.79
156_G	159_A	0.740	0.79
208_E	225_R	0.737	0.78
52_L	71_A	0.736	0.78
180_E	266_E	0.736	0.78
140_E	307_E	0.732	0.78
43_R	48_A	0.730	0.78
238_G	289_P	0.730	0.78
223_D	226_V	0.730	0.78
117_L	120_D	0.728	0.77
158_R	187_D	0.727	0.77
203_K	229_Q	0.723	0.77
59_Q	63_E	0.722	0.77
129_E	165_G	0.722	0.77
122_E	126_A	0.721	0.77
72_M	75_A	0.719	0.77
228_E	231_E	0.717	0.76
66_A	70_A	0.717	0.76
200_P	203_K	0.715	0.76
85_S	88_H	0.714	0.76
233_G	237_V	0.708	0.75
214_A	220_E	0.702	0.75
245_A	273_H	0.702	0.75
100_A	105_L	0.700	0.75
19_P	46_S	0.697	0.74
136_A	160_W	0.696	0.74
48_A	74_D	0.695	0.74
262_V	267_K	0.694	0.74
122_E	125_E	0.693	0.74
31_R	35_G	0.691	0.74
229_Q	232_A	0.690	0.74
132_L	164_T	0.688	0.73
160_W	181_V	0.684	0.73
145_T	148_G	0.682	0.73
266_E	273_H	0.682	0.73
33_E	37_A	0.682	0.73
249_I	272_V	0.681	0.73
158_R	284_G	0.680	0.72
101_R	105_L	0.679	0.72
262_V	266_E	0.675	0.72
125_E	132_L	0.670	0.71
106_P	109_T	0.670	0.71
276_I	290_L	0.670	0.71
146_P	298_E	0.669	0.71
5_D	116_G	0.668	0.71
210_R	220_E	0.666	0.71
166_I	174_S	0.663	0.71
102_G	105_L	0.662	0.70
70_A	222_S	0.662	0.70
145_T	195_D	0.661	0.70
32_E	54_Y	0.661	0.70
78_F	82_T	0.661	0.70
265_D	268_A	0.657	0.70
187_D	285_D	0.656	0.70
82_T	85_S	0.648	0.69
69_A	72_M	0.647	0.69
193_V	208_E	0.643	0.68
297_R	300_T	0.638	0.68
302_Y	305_G	0.638	0.68
248_G	271_T	0.637	0.68
75_A	83_T	0.637	0.68
11_V	41_A	0.637	0.68
204_L	207_E	0.634	0.67
180_E	267_K	0.633	0.67
123_T	127_H	0.631	0.67
263_L	267_K	0.631	0.67
32_E	133_A	0.630	0.67
17_L	47_D	0.629	0.67
242_Y	276_I	0.628	0.66
83_T	89_T	0.627	0.66
165_G	173_F	0.627	0.66
143_V	153_F	0.627	0.66
15_L	77_V	0.626	0.66
143_V	301_V	0.625	0.66
143_V	303_A	0.625	0.66
213_V	216_G	0.624	0.66
151_I	244_L	0.624	0.66
202_G	265_D	0.623	0.66
241_A	276_I	0.622	0.66
77_V	85_S	0.622	0.66
151_I	189_N	0.620	0.65
135_V	181_V	0.620	0.65
192_Y	213_V	0.619	0.65
155_A	160_W	0.618	0.65
132_L	163_D	0.617	0.65
67_P	72_M	0.617	0.65
212_E	215_D	0.616	0.65
106_P	110_A	0.614	0.65
80_A	85_S	0.613	0.65
146_P	193_V	0.612	0.64
180_E	245_A	0.612	0.64
246_E	275_A	0.612	0.64
29_D	54_Y	0.612	0.64
220_E	235_E	0.610	0.64
71_A	74_D	0.608	0.64
61_G	64_P	0.606	0.64
179_G	250_G	0.606	0.64
262_V	295_I	0.606	0.64
224_D	227_R	0.603	0.63
76_D	79_V	0.601	0.63
126_A	129_E	0.601	0.63
200_P	292_L	0.600	0.63
4_R	44_D	0.600	0.63
200_P	290_L	0.599	0.63
182_F	275_A	0.597	0.63
173_F	176_L	0.596	0.62
241_A	288_A	0.596	0.62
145_T	298_E	0.594	0.62
244_L	276_I	0.593	0.62
36_R	56_P	0.593	0.62
18_H	172_E	0.592	0.62
25_V	49_T	0.592	0.62
22_S	51_M	0.592	0.62
234_S	238_G	0.591	0.62
220_E	227_R	0.590	0.62
175_N	273_H	0.590	0.62
188_A	274_I	0.590	0.62
180_E	275_A	0.589	0.61
77_V	86_L	0.586	0.61
142_R	302_Y	0.586	0.61
244_L	274_I	0.580	0.60
84_K	88_H	0.580	0.60
70_A	74_D	0.579	0.60
139_T	306_E	0.576	0.60
17_L	21_E	0.575	0.60
175_N	180_E	0.574	0.60
175_N	262_V	0.571	0.59
82_T	88_H	0.566	0.58
145_T	272_V	0.566	0.58
283_G	287_D	0.566	0.58
175_N	246_E	0.565	0.58
154_E	188_A	0.565	0.58
82_T	89_T	0.564	0.58
212_E	219_T	0.563	0.58
78_F	81_P	0.563	0.58
151_I	192_Y	0.561	0.58
279_D	283_G	0.561	0.58
51_M	86_L	0.560	0.58
246_E	266_E	0.560	0.58
13_Q	173_F	0.558	0.57
81_P	86_L	0.557	0.57
72_M	80_A	0.557	0.57
127_H	253_V	0.557	0.57
187_D	283_G	0.556	0.57
199_M	202_G	0.554	0.57
233_G	301_V	0.553	0.57
83_T	88_H	0.551	0.56
205_D	233_G	0.551	0.56
143_V	149_T	0.550	0.56
73_A	80_A	0.549	0.56
4_R	73_A	0.546	0.56
39_Y	43_R	0.545	0.56
132_L	162_D	0.545	0.56
281_G	290_L	0.544	0.55
27_T	31_R	0.540	0.55
25_V	36_R	0.538	0.55
138_A	155_A	0.536	0.54
266_E	291_H	0.536	0.54
275_A	293_D	0.535	0.54
121_Y	171_G	0.534	0.54
226_V	229_Q	0.534	0.54
129_E	163_D	0.534	0.54
138_A	250_G	0.533	0.54
39_Y	52_L	0.533	0.54
6_A	10_A	0.532	0.54
213_V	276_I	0.531	0.54
9_T	118_D	0.530	0.54
29_D	32_E	0.527	0.53
10_A	23_C	0.525	0.53
235_E	238_G	0.525	0.53
132_L	160_W	0.525	0.53
134_Q	308_V	0.525	0.53
142_R	272_V	0.524	0.53
216_G	277_G	0.524	0.53
215_D	231_E	0.523	0.53
204_L	260_G	0.523	0.53
238_G	288_A	0.520	0.52
122_E	137_D	0.519	0.52
53_Q	82_T	0.519	0.52
187_D	279_D	0.518	0.52
165_G	168_R	0.518	0.52
139_T	215_D	0.517	0.52
76_D	85_S	0.514	0.51
9_T	41_A	0.514	0.51
60_H	63_E	0.514	0.51
143_V	247_L	0.514	0.51
21_E	76_D	0.513	0.51
19_P	222_S	0.512	0.51
75_A	81_P	0.512	0.51
5_D	9_T	0.512	0.51
82_T	87_S	0.512	0.51
279_D	287_D	0.509	0.51
246_E	263_L	0.509	0.51
157_D	160_W	0.508	0.51
100_A	109_T	0.507	0.50
248_G	279_D	0.506	0.50
113_F	117_L	0.506	0.50
195_D	271_T	0.505	0.50
135_V	263_L	0.504	0.50
79_V	222_S	0.502	0.50
26_V	78_F	0.502	0.50
131_V	134_Q	0.502	0.50
179_G	251_T	0.501	0.50
5_D	113_F	0.500	0.49

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zjcA	2	0.984	100	0.266	Contact Map
4icsA	2	0.9808	100	0.269	Contact Map
2ayiA	2	0.9681	100	0.274	Contact Map
3shoA	4	0.3802	43.1	0.958	Contact Map
3d8tA	1	0.4249	42.7	0.958	Contact Map
2iw1A	1	0.5048	41.6	0.958	Contact Map
1wcwA	1	0.4313	40.4	0.959	Contact Map
4ivnA	2	0.3898	37.1	0.96	Contact Map
3cvjA	2	0.4856	32.9	0.961	Contact Map
3gohA	1	0.4888	32.2	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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