GREMLIN Database
G3P - Glyceraldehyde-3-phosphate dehydrogenase
UniProt: Q9HSS7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (332)
Sequences: 272 (178)
Seq/√Len: 9.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_A117_D4.6661.00
148_L295_C4.6541.00
24_P328_T4.6261.00
5_G79_S4.3070.99
5_G82_V3.9680.99
6_I28_V3.9200.98
95_R99_A3.2840.95
4_V81_V3.2540.95
162_R292_D3.2330.95
148_L241_L3.1130.94
75_L79_S3.1040.94
135_V316_I3.0080.92
247_I281_L2.9820.92
29_A75_L2.6960.87
152_L212_M2.6130.86
123_R244_Q2.4920.83
182_D260_G2.4410.81
319_D324_E2.4330.81
149_L158_I2.3890.80
5_G75_L2.3220.78
228_L293_F2.2940.77
181_N185_P2.2800.77
160_K227_T2.2020.74
263_K267_Q2.1860.73
144_G299_I2.1480.72
279_N297_Q2.1390.72
321_D324_E2.1250.71
31_V262_L2.0340.68
18_D46_R1.9790.65
89_G93_E1.9710.65
122_A325_S1.9180.63
81_V317_A1.9040.62
107_Y134_H1.8940.62
159_E324_E1.8900.62
14_K264_E1.8710.61
238_R286_V1.8430.60
50_L276_L1.8050.58
148_L279_N1.7970.58
55_E73_D1.7780.57
22_A332_A1.7690.56
6_I79_S1.7460.55
251_D283_G1.7400.55
194_H219_M1.7290.55
181_N218_L1.6810.52
91_G177_R1.6570.51
28_V48_F1.6510.51
73_D100_A1.6420.51
190_I213_K1.6090.49
185_P282_W1.6070.49
20_V265_Y1.5960.48
159_E229_E1.5870.48
75_L274_G1.5840.48
175_T261_P1.5520.46
323_A327_A1.5510.46
42_Q236_D1.5450.46
14_K268_D1.5440.46
6_I265_Y1.5390.46
145_L297_Q1.5390.46
149_L232_P1.5180.45
29_A79_S1.5160.45
152_L226_V1.5150.45
169_G179_P1.5060.44
239_D330_N1.5020.44
91_G309_N1.4990.44
327_A331_D1.4890.44
82_V289_D1.4810.43
56_D268_D1.4770.43
10_G13_G1.4700.43
134_H317_A1.4630.43
242_A283_G1.4590.42
79_S103_T1.4330.41
279_N299_I1.4220.41
241_L295_C1.4110.40
221_M298_A1.3790.39
156_Y240_V1.3760.39
44_R67_E1.3700.38
184_L292_D1.3680.38
149_L161_V1.3660.38
252_D284_E1.3540.38
164_T225_N1.3500.38
8_G13_G1.3470.37
18_D48_F1.3460.37
119_S138_V1.3410.37
145_L224_I1.3380.37
76_I103_T1.3350.37
28_V121_N1.3340.37
130_A318_G1.3330.37
59_D71_P1.3220.36
61_F219_M1.3190.36
59_D62_P1.3170.36
174_Q304_D1.3070.36
73_D235_A1.2990.35
159_E227_T1.2990.35
120_F209_T1.2930.35
158_I229_E1.2870.35
114_S317_A1.2800.35
26_M314_R1.2790.35
303_S332_A1.2790.35
148_L224_I1.2670.34
253_D335_I1.2620.34
2_I81_V1.2550.34
241_L281_L1.2520.34
131_D318_G1.2440.33
82_V126_F1.2410.33
78_D242_A1.2380.33
279_N304_D1.2360.33
33_K194_H1.2360.33
121_N146_S1.2310.33
268_D277_W1.2240.32
83_V313_V1.2240.32
153_R330_N1.2060.32
55_E60_Q1.1880.31
24_P262_L1.1710.30
23_Q26_M1.1660.30
234_A286_V1.1620.30
104_P133_D1.1590.30
195_G294_Y1.1360.29
113_A195_G1.1350.29
81_V312_A1.1340.29
183_I214_V1.1330.29
50_L250_L1.1300.29
92_A112_D1.1270.29
85_A295_C1.1250.29
181_N282_W1.1200.28
174_Q206_D1.1110.28
56_D74_D1.1090.28
135_V321_D1.1070.28
277_W294_Y1.1050.28
151_P234_A1.1040.28
74_D233_D1.0950.27
41_T50_L1.0940.27
61_F301_Q1.0920.27
149_L163_A1.0820.27
149_L226_V1.0820.27
121_N124_A1.0780.27
117_D258_G1.0770.27
31_V50_L1.0750.27
33_K219_M1.0660.26
158_I299_I1.0650.26
153_R204_D1.0580.26
219_M301_Q1.0560.26
113_A116_A1.0540.26
227_T291_R1.0520.26
212_M221_M1.0510.26
76_I104_P1.0490.26
146_S150_A1.0480.26
50_L53_A1.0470.26
179_P300_H1.0460.26
8_G12_I1.0430.26
27_T290_G1.0410.26
328_T332_A1.0410.26
186_D284_E1.0400.26
189_T221_M1.0400.26
14_K19_A1.0360.25
160_K292_D1.0340.25
58_A235_A1.0320.25
28_V332_A1.0310.25
73_D90_V1.0300.25
59_D102_D1.0270.25
57_R229_E1.0260.25
11_T219_M1.0210.25
319_D322_A1.0210.25
50_L235_A1.0090.24
121_N150_A1.0030.24
166_V296_F0.9990.24
83_V176_D0.9990.24
82_V204_D0.9970.24
314_R325_S0.9950.24
31_V44_R0.9950.24
166_V210_L0.9930.24
4_V12_I0.9830.24
94_N165_L0.9820.24
183_I297_Q0.9810.24
162_R184_L0.9790.23
31_V47_G0.9730.23
267_Q274_G0.9690.23
219_M298_A0.9670.23
297_Q304_D0.9650.23
151_P174_Q0.9640.23
249_L276_L0.9630.23
52_T170_G0.9600.23
2_I335_I0.9590.23
216_A259_T0.9590.23
3_R183_I0.9570.23
163_A303_S0.9550.23
100_A243_G0.9520.23
145_L149_L0.9480.22
119_S136_R0.9480.22
16_V83_V0.9450.22
31_V130_A0.9430.22
216_A298_A0.9410.22
23_Q332_A0.9390.22
310_V332_A0.9360.22
263_K304_D0.9350.22
259_T298_A0.9350.22
181_N303_S0.9330.22
20_V313_V0.9320.22
148_L226_V0.9290.22
68_T90_V0.9280.22
47_G268_D0.9230.22
288_M299_I0.9230.22
279_N295_C0.9150.21
133_D165_L0.9140.21
222_H325_S0.9120.21
216_A301_Q0.9120.21
86_T175_T0.9080.21
102_D281_L0.9070.21
4_V10_G0.9010.21
4_V13_G0.9010.21
95_R100_A0.8990.21
148_L183_I0.8980.21
166_V262_L0.8940.21
174_Q211_G0.8880.21
164_T185_P0.8870.21
55_E96_S0.8860.21
11_T301_Q0.8830.21
172_P217_T0.8790.20
77_A101_H0.8790.20
145_L298_A0.8780.20
76_I79_S0.8760.20
65_G288_M0.8750.20
76_I230_R0.8710.20
46_R276_L0.8700.20
285_S300_H0.8650.20
2_I20_V0.8620.20
322_A330_N0.8610.20
16_V23_Q0.8600.20
178_G192_S0.8600.20
9_Y17_A0.8570.20
236_D253_D0.8560.20
151_P173_G0.8550.20
18_D21_A0.8540.20
3_R63_A0.8520.20
40_A309_N0.8480.19
127_E241_L0.8440.19
194_H298_A0.8440.19
55_E58_A0.8430.19
78_D95_R0.8420.19
77_A127_E0.8410.19
79_S102_D0.8400.19
244_Q299_I0.8370.19
24_P319_D0.8330.19
33_K61_F0.8280.19
122_A310_V0.8260.19
207_I302_E0.8250.19
34_T79_S0.8250.19
96_S99_A0.8240.19
2_I212_M0.8220.19
76_I82_V0.8190.19
38_F144_G0.8160.19
170_G213_K0.8150.19
201_I235_A0.8100.18
37_N76_I0.8090.18
310_V326_I0.8060.18
56_D96_S0.8000.18
96_S101_H0.7990.18
63_A230_R0.7970.18
117_D281_L0.7970.18
151_P247_I0.7970.18
226_V293_F0.7950.18
198_V207_I0.7940.18
42_Q281_L0.7900.18
38_F299_I0.7880.18
21_A46_R0.7860.18
37_N268_D0.7860.18
86_T120_F0.7860.18
179_P296_F0.7850.18
16_V185_P0.7840.18
36_P301_Q0.7800.18
59_D63_A0.7780.18
60_Q239_D0.7750.17
3_R79_S0.7750.17
189_T237_V0.7740.17
179_P285_S0.7740.17
124_A185_P0.7730.17
14_K39_E0.7710.17
132_A202_F0.7680.17
39_E264_E0.7630.17
6_I45_K0.7610.17
170_G212_M0.7610.17
224_I297_Q0.7580.17
106_I281_L0.7570.17
41_T97_R0.7540.17
74_D235_A0.7520.17
27_T203_P0.7510.17
32_A75_L0.7500.17
125_N161_V0.7440.17
194_H198_V0.7440.17
152_L199_N0.7440.17
39_E198_V0.7420.17
139_S197_D0.7380.17
81_V250_L0.7380.17
125_N275_D0.7370.17
127_E131_D0.7370.17
183_I259_T0.7340.16
67_E95_R0.7340.16
183_I233_D0.7340.16
4_V8_G0.7320.16
219_M259_T0.7270.16
262_L265_Y0.7270.16
226_V281_L0.7240.16
108_Q111_E0.7240.16
78_D239_D0.7200.16
99_A316_I0.7200.16
21_A69_A0.7200.16
164_T183_I0.7170.16
234_A293_F0.7170.16
21_A74_D0.7160.16
35_S79_S0.7150.16
123_R202_F0.7150.16
3_R24_P0.7150.16
246_R278_E0.7140.16
120_F314_R0.7130.16
311_D314_R0.7130.16
61_F194_H0.7120.16
77_A133_D0.7110.16
273_R285_S0.7060.16
196_P325_S0.7050.16
74_D242_A0.7040.16
284_E310_V0.7040.16
154_E243_G0.7020.16
23_Q314_R0.7020.16
33_K301_Q0.6990.16
3_R65_G0.6970.16
52_T63_A0.6970.16
251_D280_C0.6940.15
35_S152_L0.6920.15
263_K274_G0.6900.15
156_Y317_A0.6870.15
52_T323_A0.6850.15
22_A31_V0.6850.15
29_A42_Q0.6830.15
57_R236_D0.6820.15
196_P227_T0.6800.15
20_V262_L0.6800.15
161_V224_I0.6780.15
10_G15_R0.6710.15
200_T281_L0.6710.15
121_N219_M0.6700.15
182_D259_T0.6700.15
76_I234_A0.6690.15
148_L277_W0.6690.15
26_M325_S0.6650.15
115_V215_P0.6640.15
72_V75_L0.6610.15
208_D249_L0.6610.15
263_K300_H0.6610.15
75_L205_L0.6590.15
152_L241_L0.6580.15
211_G216_A0.6580.15
41_T45_K0.6570.15
102_D242_A0.6560.15
67_E233_D0.6550.15
88_S144_G0.6540.15
16_V19_A0.6510.14
122_A196_P0.6490.14
239_D242_A0.6480.14
46_R133_D0.6440.14
242_A251_D0.6440.14
113_A135_V0.6440.14
148_L335_I0.6420.14
33_K300_H0.6390.14
235_A257_D0.6360.14
191_P314_R0.6350.14
300_H306_V0.6350.14
85_A276_L0.6350.14
219_M300_H0.6340.14
88_S260_G0.6330.14
170_G177_R0.6310.14
94_N306_V0.6280.14
203_P279_N0.6260.14
49_D101_H0.6240.14
251_D254_L0.6230.14
245_S267_Q0.6230.14
257_D261_P0.6230.14
62_P66_I0.6220.14
58_A62_P0.6200.14
105_A273_R0.6190.14
57_R183_I0.6180.14
256_I296_F0.6180.14
59_D237_V0.6180.14
162_R208_D0.6160.14
53_A255_G0.6140.14
200_T285_S0.6140.14
120_F126_F0.6080.14
33_K180_I0.6070.14
12_I15_R0.6050.13
164_T327_A0.6040.13
81_V247_I0.6040.13
305_V309_N0.6040.13
320_A324_E0.6020.13
250_L317_A0.6020.13
28_V117_D0.6020.13
63_A261_P0.6010.13
71_P202_F0.6010.13
60_Q114_S0.6000.13
252_D259_T0.6000.13
46_R96_S0.5990.13
123_R164_T0.5990.13
62_P67_E0.5990.13
122_A222_H0.5980.13
127_E152_L0.5960.13
271_R278_E0.5920.13
160_K275_D0.5920.13
212_M296_F0.5920.13
16_V325_S0.5910.13
231_D235_A0.5900.13
37_N173_G0.5900.13
83_V222_H0.5890.13
162_R264_E0.5870.13
6_I47_G0.5860.13
85_A335_I0.5860.13
31_V53_A0.5860.13
48_F124_A0.5850.13
2_I203_P0.5830.13
123_R245_S0.5740.13
100_A134_H0.5710.13
74_D80_D0.5710.13
56_D114_S0.5690.13
169_G180_I0.5650.13
76_I281_L0.5650.13
88_S216_A0.5630.13
194_H309_N0.5630.13
310_V333_L0.5630.13
14_K293_F0.5600.13
51_Y69_A0.5570.12
187_P285_S0.5560.12
214_V262_L0.5550.12
179_P182_D0.5540.12
29_A327_A0.5530.12
230_R243_G0.5520.12
65_G77_A0.5490.12
210_L261_P0.5490.12
119_S325_S0.5480.12
71_P323_A0.5470.12
34_T75_L0.5450.12
31_V144_G0.5440.12
206_D303_S0.5420.12
129_A190_I0.5410.12
163_A297_Q0.5410.12
156_Y258_G0.5410.12
32_A89_G0.5400.12
168_R171_D0.5400.12
142_T193_H0.5400.12
166_V290_G0.5380.12
277_W295_C0.5370.12
3_R332_A0.5320.12
37_N261_P0.5320.12
170_G180_I0.5320.12
93_E97_R0.5300.12
73_D101_H0.5300.12
267_Q302_E0.5300.12
152_L239_D0.5290.12
161_V165_L0.5280.12
66_I332_A0.5280.12
144_G214_V0.5280.12
73_D161_V0.5270.12
222_H314_R0.5270.12
8_G15_R0.5250.12
89_G101_H0.5250.12
69_A324_E0.5250.12
260_G301_Q0.5240.12
49_D83_V0.5220.12
73_D328_T0.5220.12
235_A332_A0.5220.12
158_I334_G0.5210.12
47_G249_L0.5200.12
21_A41_T0.5200.12
155_Q183_I0.5200.12
253_D327_A0.5190.12
55_E64_A0.5190.12
233_D310_V0.5170.12
84_D98_Y0.5150.12
151_P238_R0.5150.12
72_V79_S0.5130.12
2_I319_D0.5130.12
92_A153_R0.5120.12
36_P91_G0.5120.12
155_Q232_P0.5110.12
224_I279_N0.5110.12
166_V212_M0.5100.12
149_L228_L0.5100.12
286_V290_G0.5100.12
32_A76_I0.5090.12
3_R239_D0.5090.12
235_A239_D0.5090.12
138_V209_T0.5090.12
11_T33_K0.5080.12
106_I189_T0.5070.12
97_R131_D0.5060.12
38_F181_N0.5060.12
194_H296_F0.5060.12
135_V213_K0.5060.12
323_A331_D0.5060.12
103_T177_R0.5050.11
69_A291_R0.5040.11
231_D262_L0.5000.11
21_A316_I0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1cf2P 4 0.997 100 0.534 Contact Map
2yyyA 2 1 100 0.543 Contact Map
2czcA 4 0.9881 100 0.555 Contact Map
1b7gO 4 0.997 100 0.559 Contact Map
4dibA 4 0.8657 99.9 0.821 Contact Map
3docA 4 0.8955 99.9 0.821 Contact Map
3idsC 4 0.9134 99.9 0.824 Contact Map
2d2iA 4 0.8985 99.9 0.828 Contact Map
3hjaA 4 0.8687 99.9 0.828 Contact Map
3h9eO 4 0.8896 99.9 0.83 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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