GREMLIN Database
Q9HSS6 - Putative heat shock protein
UniProt: Q9HSS6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 128 (109)
Sequences: 4428 (3587)
Seq/√Len: 343.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_D102_S4.2591.00
53_A115_A3.1321.00
50_T53_A2.8571.00
58_A79_V2.7131.00
64_E109_N2.6561.00
45_V58_A2.3311.00
49_E118_R2.2691.00
59_D111_I2.1671.00
45_V92_V2.1591.00
98_V116_F2.0981.00
50_T55_R2.0871.00
64_E67_D2.0121.00
68_I107_Y1.9961.00
60_L107_Y1.9251.00
69_S80_S1.8811.00
80_S89_D1.8461.00
57_I113_E1.7741.00
60_L68_I1.7321.00
76_S91_R1.6871.00
120_E123_T1.6841.00
55_R113_E1.6721.00
99_D119_T1.6491.00
72_C94_L1.6341.00
48_H55_R1.6281.00
76_S93_D1.5511.00
102_S117_D1.5491.00
43_T88_Y1.5201.00
63_V81_A1.4891.00
81_A88_Y1.4881.00
64_E108_N1.4331.00
23_D26_A1.3431.00
46_D57_I1.2951.00
78_T91_R1.2771.00
22_E25_M1.2481.00
72_C103_G1.2301.00
77_V114_V1.2241.00
77_V103_G1.2151.00
65_K109_N1.2021.00
19_R23_D1.1971.00
56_V116_F1.1901.00
16_E21_M1.1901.00
46_D59_D1.1721.00
48_H57_I1.1571.00
106_T113_E1.1181.00
67_D84_G1.1171.00
71_Q78_T1.1151.00
65_K69_S1.0841.00
70_I114_V1.0821.00
18_E21_M1.0551.00
100_A117_D1.0541.00
97_R119_T1.0521.00
94_L116_F1.0341.00
16_E20_M1.0171.00
45_V79_V1.0151.00
106_T115_A1.0151.00
75_T100_A1.0001.00
21_M25_M0.9991.00
41_S81_A0.9901.00
17_I21_M0.9881.00
55_R115_A0.9611.00
54_I96_G0.9391.00
47_V56_V0.9271.00
22_E26_A0.9221.00
60_L81_A0.9181.00
67_D83_S0.9171.00
48_H54_I0.9161.00
19_R24_M0.9021.00
47_V54_I0.9011.00
52_D123_T0.8861.00
54_I97_R0.8831.00
60_L88_Y0.8831.00
16_E19_R0.8711.00
30_R33_R0.8571.00
57_I86_R0.8481.00
63_V83_S0.8401.00
43_T58_A0.8391.00
108_N113_E0.8231.00
97_R118_R0.8191.00
54_I118_R0.8151.00
16_E23_D0.8121.00
56_V92_V0.8101.00
60_L63_V0.7951.00
96_G119_T0.7811.00
54_I103_G0.7781.00
75_T96_G0.7671.00
23_D27_D0.7601.00
95_P98_V0.7551.00
59_D83_S0.7541.00
28_G31_L0.7521.00
70_I105_A0.7451.00
49_E65_K0.7431.00
18_E23_D0.7350.99
19_R22_E0.7290.99
43_T60_L0.7250.99
46_D60_L0.7240.99
22_E27_D0.7240.99
18_E22_E0.7160.99
36_Q40_A0.7160.99
25_M28_G0.7140.99
42_S46_D0.7050.99
21_M24_M0.6940.99
72_C100_A0.6930.99
81_A95_P0.6880.99
83_S90_E0.6880.99
57_I111_I0.6840.99
78_T89_D0.6800.99
28_G32_D0.6620.99
69_S82_Q0.6610.99
43_T95_P0.6470.99
53_A118_R0.6460.99
68_I114_V0.6440.99
43_T81_A0.6390.99
20_M27_D0.6380.99
24_M27_D0.6280.98
18_E26_A0.6280.98
64_E107_Y0.6270.98
71_Q80_S0.6260.98
31_L34_G0.6260.98
63_V68_I0.6250.98
96_G103_G0.6210.98
43_T46_D0.6120.98
20_M24_M0.6080.98
74_G97_R0.6070.98
121_S124_N0.6000.98
21_M26_A0.5970.98
19_R26_A0.5930.98
32_D35_D0.5900.98
38_G41_S0.5870.97
104_A115_A0.5860.97
35_D39_F0.5820.97
17_I23_D0.5760.97
20_M23_D0.5660.97
18_E25_M0.5650.97
44_H78_T0.5610.97
86_R90_E0.5570.97
77_V124_N0.5570.97
65_K107_Y0.5550.96
34_G38_G0.5520.96
31_L35_D0.5510.96
27_D30_R0.5490.96
44_H59_D0.5490.96
46_D93_D0.5390.96
54_I98_V0.5330.96
97_R122_S0.5320.96
24_M28_G0.5320.96
82_Q86_R0.5310.95
49_E53_A0.5290.95
72_C77_V0.5260.95
41_S46_D0.5210.95
99_D120_E0.5210.95
37_S85_H0.5200.95
75_T97_R0.5190.95
77_V116_F0.5160.95
17_I20_M0.5130.95
45_V72_C0.5110.94
28_G37_S0.5110.94
119_T122_S0.5100.94
65_K68_I0.5080.94
75_T93_D0.5070.94
45_V94_L0.5060.94
59_D68_I0.5060.94
32_D37_S0.5020.94
37_S41_S0.5020.94
71_Q92_V0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eldA 4 0.7578 100 0.237 Contact Map
3w1zA 7 0.9375 100 0.269 Contact Map
3aabA 2 0.7734 99.9 0.308 Contact Map
1gmeA 6 0.9766 99.9 0.322 Contact Map
2bolA 2 0.9922 99.9 0.329 Contact Map
4ydzA 4 0.8438 99.9 0.349 Contact Map
2klrA 2 0.5625 99.9 0.357 Contact Map
4jutA 4 0.625 99.9 0.372 Contact Map
3glaA 2 0.6562 99.9 0.374 Contact Map
3l1eA 2 0.6797 99.9 0.38 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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