GREMLIN Database
Q9HSS5 - Ribosomal protein S6 modification protein
UniProt: Q9HSS5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (254)
Sequences: 29228 (17635)
Seq/√Len: 1106.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_E173_A3.7681.00
222_A226_D3.0671.00
144_D147_S2.9591.00
120_E145_P2.8501.00
243_T246_R2.7991.00
116_R149_G2.5991.00
124_P145_P2.4251.00
104_V121_A2.4211.00
93_L249_V2.3001.00
64_V81_L2.2111.00
108_N114_A2.1741.00
225_V229_A2.1671.00
93_L227_A2.1181.00
192_G195_R2.1121.00
99_P246_R2.1031.00
193_A196_R2.1031.00
191_V196_R2.0451.00
87_A105_Y2.0301.00
270_D274_A2.0241.00
192_G196_R2.0231.00
90_L172_Q2.0071.00
191_V194_V1.9901.00
141_K174_F1.9891.00
145_P149_G1.9631.00
191_V195_R1.9631.00
87_A91_A1.8331.00
64_V68_F1.7341.00
91_A95_D1.7331.00
88_G91_A1.7161.00
143_S147_S1.7101.00
118_V122_L1.7091.00
116_R145_P1.7061.00
94_S102_E1.6861.00
19_P22_E1.6751.00
82_R88_G1.6541.00
181_Y242_A1.6341.00
91_A94_S1.6131.00
95_D230_A1.6101.00
219_R246_R1.6061.00
223_L247_A1.6041.00
228_A236_L1.6001.00
89_A93_L1.5991.00
149_G153_D1.5901.00
85_N131_N1.5861.00
118_V121_A1.5771.00
82_R92_L1.5751.00
20_L27_A1.5721.00
119_F124_P1.5711.00
104_V118_V1.5571.00
96_A230_A1.5431.00
226_D230_A1.5401.00
226_D229_A1.5371.00
52_G71_V1.5291.00
65_V69_I1.5181.00
190_V196_R1.5121.00
81_L88_G1.5031.00
107_S168_S1.4811.00
271_R274_A1.4541.00
219_R223_L1.4391.00
223_L226_D1.4361.00
98_V249_V1.4221.00
140_T154_Y1.4151.00
59_L84_R1.3971.00
99_P223_L1.3861.00
234_S237_G1.3711.00
76_G79_A1.3621.00
219_R222_A1.3621.00
150_G154_Y1.3561.00
78_E82_R1.3551.00
242_A247_A1.3541.00
127_V141_K1.3491.00
87_A131_N1.3491.00
94_S100_V1.3421.00
116_R120_E1.3351.00
126_V171_I1.3221.00
117_G121_A1.3101.00
131_N168_S1.2991.00
92_L230_A1.2891.00
238_V252_T1.2801.00
22_E270_D1.2781.00
152_T156_E1.2691.00
173_A248_V1.2661.00
241_L250_V1.2561.00
143_S176_P1.2561.00
67_A77_R1.2511.00
127_V174_F1.2481.00
109_P153_D1.2361.00
127_V139_V1.2211.00
14_A43_P1.2131.00
92_L95_D1.2121.00
185_V228_A1.2081.00
18_E22_E1.2051.00
221_R225_V1.1961.00
16_M53_F1.1951.00
227_A230_A1.1901.00
92_L96_A1.1901.00
109_P116_R1.1861.00
183_V220_L1.1851.00
266_A271_R1.1711.00
90_L100_V1.1691.00
199_A203_H1.1691.00
156_E167_K1.1591.00
67_A76_G1.1551.00
102_E121_A1.1401.00
186_L235_L1.1381.00
31_T36_V1.1321.00
218_D222_A1.1271.00
243_T248_V1.1181.00
124_P144_D1.1161.00
23_R274_A1.1141.00
122_L126_V1.1081.00
179_T242_A1.1061.00
210_T213_G1.1011.00
114_A117_G1.0971.00
109_P149_G1.0941.00
175_V250_V1.0931.00
227_A231_L1.0921.00
64_V77_R1.0891.00
105_Y168_S1.0851.00
28_E49_F1.0851.00
91_A103_T1.0831.00
40_D45_D1.0731.00
140_T151_V1.0671.00
55_Y59_L1.0661.00
65_V68_F1.0651.00
198_S201_W1.0601.00
190_V195_R1.0591.00
102_E122_L1.0571.00
87_A168_S1.0501.00
217_P221_R1.0461.00
216_L219_R1.0411.00
142_V151_V1.0371.00
107_S114_A1.0361.00
23_R270_D1.0321.00
126_V142_V1.0301.00
33_T36_V1.0261.00
154_Y157_L1.0241.00
153_D157_L1.0221.00
99_P248_V1.0201.00
113_D116_R1.0181.00
186_L271_R1.0161.00
183_V224_A1.0151.00
78_E81_L1.0151.00
67_A73_W1.0121.00
19_P270_D1.0101.00
175_V248_V1.0081.00
52_G66_D1.0071.00
173_A243_T0.9961.00
179_T195_R0.9851.00
83_S231_L0.9851.00
190_V194_V0.9851.00
103_T172_Q0.9851.00
218_D221_R0.9811.00
109_P152_T0.9801.00
224_A240_V0.9751.00
185_V224_A0.9731.00
202_K206_H0.9701.00
117_G120_E0.9681.00
215_S218_D0.9601.00
106_V118_V0.9571.00
66_D73_W0.9531.00
155_L169_Y0.9481.00
210_T214_V0.9471.00
85_N132_S0.9421.00
222_A225_V0.9401.00
119_F126_V0.9381.00
223_L227_A0.9351.00
228_A231_L0.9341.00
109_P113_D0.9321.00
80_V254_A0.9211.00
267_E270_D0.9171.00
216_L242_A0.9141.00
181_Y220_L0.9131.00
124_P148_L0.9111.00
190_V193_A0.9111.00
83_S252_T0.9071.00
156_E169_Y0.9071.00
132_S166_D0.9031.00
119_F145_P0.9021.00
235_L255_R0.9011.00
66_D71_V0.8991.00
219_R226_D0.8971.00
94_S103_T0.8961.00
64_V78_E0.8911.00
140_T155_L0.8871.00
20_L273_A0.8871.00
20_L25_V0.8851.00
14_A18_E0.8841.00
17_Q27_A0.8821.00
185_V238_V0.8811.00
203_H206_H0.8811.00
101_P175_V0.8781.00
188_G229_A0.8741.00
211_A214_V0.8741.00
186_L275_L0.8681.00
147_S150_G0.8671.00
183_V221_R0.8651.00
264_Y271_R0.8651.00
268_F271_R0.8641.00
266_A269_Y0.8601.00
36_V39_L0.8551.00
115_V148_L0.8551.00
114_A118_V0.8481.00
176_P244_D0.8401.00
175_V243_T0.8381.00
69_I72_P0.8371.00
150_G153_D0.8351.00
56_P59_L0.8351.00
176_P243_T0.8341.00
220_L223_L0.8311.00
220_L247_A0.8281.00
269_Y273_A0.8241.00
113_D117_G0.8181.00
56_P60_M0.8171.00
106_V115_V0.8161.00
34_G37_T0.8141.00
87_A170_L0.8131.00
128_V171_I0.8101.00
108_N113_D0.8041.00
245_E248_V0.8031.00
85_N168_S0.7911.00
201_W204_N0.7861.00
185_V236_L0.7831.00
273_A276_V0.7761.00
115_V152_T0.7761.00
131_N170_L0.7761.00
238_V249_V0.7761.00
146_D149_G0.7761.00
197_D201_W0.7681.00
40_D44_V0.7681.00
151_V155_L0.7611.00
21_A24_G0.7561.00
242_A245_E0.7501.00
119_F148_L0.7481.00
17_Q21_A0.7461.00
260_D263_K0.7451.00
128_V142_V0.7401.00
63_G73_W0.7381.00
116_R119_F0.7371.00
85_N88_G0.7281.00
220_L240_V0.7241.00
207_Q210_T0.7201.00
264_Y269_Y0.7191.00
204_N207_Q0.7111.00
79_A232_D0.7101.00
99_P219_R0.7091.00
40_D43_P0.7071.00
120_E149_G0.7061.00
32_V36_V0.7031.00
123_E173_A0.7001.00
128_V151_V0.6991.00
146_D150_G0.6971.00
109_P156_E0.6931.00
224_A238_V0.6901.00
205_V208_G0.6871.00
19_P23_R0.6851.00
21_A27_A0.6851.00
62_G66_D0.6841.00
181_Y240_V0.6841.00
93_L252_T0.6831.00
223_L240_V0.6791.00
203_H208_G0.6751.00
51_A74_V0.6731.00
240_V247_A0.6731.00
78_E88_G0.6721.00
188_G192_G0.6681.00
151_V154_Y0.6661.00
128_V169_Y0.6611.00
215_S219_R0.6601.00
87_A103_T0.6581.00
64_V67_A0.6571.00
55_Y58_R0.6541.00
17_Q29_H0.6531.00
51_A54_V0.6501.00
51_A276_V0.6481.00
106_V109_P0.6471.00
274_A277_R0.6451.00
152_T169_Y0.6411.00
200_G203_H0.6401.00
256_P268_F0.6391.00
17_Q43_P0.6371.00
101_P248_V0.6361.00
88_G92_L0.6351.00
204_N208_G0.6321.00
233_V236_L0.6311.00
185_V225_V0.6301.00
187_D191_V0.6301.00
143_S174_F0.6301.00
92_L231_L0.6271.00
197_D200_G0.6261.00
91_A105_Y0.6221.00
142_V148_L0.6181.00
200_G207_Q0.6181.00
58_R63_G0.6171.00
173_A246_R0.6161.00
122_L173_A0.6161.00
198_S203_H0.6151.00
203_H207_Q0.6151.00
83_S254_A0.6121.00
98_V226_D0.6111.00
61_E64_V0.6111.00
95_D231_L0.6101.00
209_A212_A0.6101.00
60_M81_L0.6101.00
221_R224_A0.6031.00
174_F241_L0.6031.00
264_Y268_F0.6011.00
273_A277_R0.6001.00
79_A233_V0.5981.00
15_R260_D0.5951.00
25_V277_R0.5951.00
77_R81_L0.5941.00
125_P143_S0.5931.00
98_V223_L0.5931.00
18_E21_A0.5921.00
199_A205_V0.5841.00
201_W205_V0.5821.00
142_V147_S0.5821.00
57_G60_M0.5811.00
33_T37_T0.5801.00
224_A228_A0.5781.00
96_A227_A0.5781.00
72_P277_R0.5771.00
268_F272_L0.5771.00
125_P174_F0.5761.00
100_V103_T0.5731.00
228_A233_V0.5721.00
226_D231_L0.5721.00
183_V240_V0.5721.00
94_S104_V0.5711.00
224_A227_A0.5711.00
206_H209_A0.5691.00
271_R275_L0.5691.00
63_G66_D0.5681.00
31_T34_G0.5681.00
272_L275_L0.5681.00
118_V171_I0.5681.00
228_A238_V0.5671.00
265_E268_F0.5641.00
235_L256_P0.5621.00
90_L103_T0.5621.00
27_A31_T0.5601.00
128_V152_T0.5591.00
33_T39_L0.5581.00
108_N156_E0.5571.00
125_P141_K0.5541.00
92_L227_A0.5521.00
73_W77_R0.5471.00
199_A202_K0.5441.00
202_K205_V0.5441.00
200_G204_N0.5441.00
197_D202_K0.5441.00
176_P179_T0.5421.00
34_G38_R0.5421.00
109_P115_V0.5421.00
132_S168_S0.5401.00
208_G211_A0.5361.00
93_L100_V0.5351.00
57_G62_G0.5341.00
67_A78_E0.5331.00
201_W206_H0.5331.00
119_F123_E0.5301.00
140_T150_G0.5261.00
96_A231_L0.5261.00
176_P241_L0.5241.00
199_A204_N0.5241.00
29_H32_V0.5231.00
119_F125_P0.5211.00
143_S197_D0.5211.00
101_P250_V0.5191.00
15_R18_E0.5181.00
61_E81_L0.5141.00
93_L96_A0.5111.00
35_S38_R0.5101.00
153_D156_E0.5101.00
180_D239_D0.5091.00
266_A272_L0.5081.00
104_V122_L0.5071.00
219_R247_A0.5061.00
184_M235_L0.5041.00
76_G232_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qshA 4 0.7754 100 0.319 Contact Map
1a9xA 3 0.9684 100 0.321 Contact Map
3e5nA 2 0.9158 100 0.321 Contact Map
3u9tA 3 0.9368 100 0.322 Contact Map
4rcnA 6 0.8561 100 0.323 Contact Map
3n6rA 1 0.7509 100 0.323 Contact Map
3hblA 4 0.986 100 0.323 Contact Map
2qf7A 4 0.8246 100 0.323 Contact Map
4iwxA 3 0.9509 100 0.324 Contact Map
3vpdA 3 0.9614 100 0.325 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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