GREMLIN Database
RL10E - 50S ribosomal protein L10e
UniProt: Q9HSS4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 176 (167)
Sequences: 338 (175)
Seq/√Len: 13.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_L138_A3.9601.00
91_K133_D3.8851.00
4_K8_M3.1950.98
75_H154_R3.0490.97
17_Y119_F2.9540.97
140_C148_V2.7880.95
80_L84_N2.6270.94
76_L80_L2.5310.92
72_A155_A2.3910.90
89_L136_F2.2960.88
35_K88_Q2.2880.88
16_S95_Q2.0930.82
146_A165_I2.0900.82
88_Q153_R2.0720.82
102_Q111_V1.9980.79
145_A148_V1.9830.79
97_I126_A1.9820.79
100_N111_V1.9820.79
22_Y113_D1.9690.78
62_H125_T1.9680.78
55_Q164_K1.9500.78
1_M5_P1.9100.76
150_E154_R1.9060.76
140_C144_Q1.8590.74
145_A170_G1.7840.71
76_L96_I1.7670.70
35_K86_K1.7580.70
100_N112_S1.6830.66
76_L148_V1.6490.64
4_K118_A1.6460.64
152_F160_T1.6370.64
150_E153_R1.6320.64
80_L87_M1.6290.63
87_M136_F1.6120.63
77_I85_Y1.5860.61
34_H146_A1.5650.60
148_V160_T1.5590.60
4_K123_V1.5380.59
76_L140_C1.5360.59
74_R111_V1.5310.58
31_I34_H1.5250.58
129_I133_D1.5130.58
16_S49_Q1.5090.57
118_A125_T1.4600.55
103_A112_S1.4560.55
103_A111_V1.4310.53
39_L88_Q1.4220.53
98_R116_R1.3940.51
69_R116_R1.3610.49
75_H150_E1.3530.49
25_G56_E1.2880.46
50_I148_V1.2750.45
107_G110_R1.2690.45
8_M112_S1.2530.44
60_L145_A1.2370.43
89_L167_V1.2330.43
4_K24_T1.2330.43
69_R98_R1.2010.41
80_L147_A1.1910.41
48_V60_L1.1870.40
23_V96_I1.1720.40
73_N129_I1.1510.38
138_A148_V1.1490.38
136_F146_A1.1370.38
64_S67_A1.1350.38
3_E10_R1.1240.37
8_M103_A1.1100.36
11_K15_P1.1050.36
11_K14_K1.0780.35
54_P161_P1.0600.34
67_A124_G1.0570.34
87_M148_V1.0550.34
105_G111_V1.0450.33
72_A148_V1.0440.33
72_A140_C1.0430.33
56_E131_P1.0410.33
33_Q103_A1.0320.33
24_T58_C1.0150.32
25_G155_A1.0010.31
13_D30_K1.0010.31
26_I125_T1.0000.31
105_G112_S0.9970.31
16_S39_L0.9910.31
7_S102_Q0.9840.30
3_E15_P0.9800.30
17_Y23_V0.9790.30
4_K7_S0.9730.30
19_R23_V0.9680.30
56_E78_K0.9510.29
32_A122_P0.9470.29
52_L60_L0.9460.29
94_H165_I0.9400.28
52_L98_R0.9370.28
7_S100_N0.9350.28
65_L91_K0.9330.28
12_I57_E0.9310.28
5_P9_Y0.9250.28
52_L151_A0.9160.27
45_D84_N0.9150.27
54_P57_E0.9100.27
94_H149_K0.8980.27
35_K46_Y0.8980.27
73_N127_A0.8840.26
53_V67_A0.8810.26
57_E71_S0.8810.26
45_D89_L0.8720.26
68_A159_I0.8720.26
51_S54_P0.8650.25
8_M104_T0.8580.25
85_Y134_Q0.8560.25
6_A118_A0.8340.24
8_M102_Q0.8330.24
58_C112_S0.8260.24
32_A39_L0.8250.24
29_S125_T0.8240.24
142_V169_R0.8180.23
102_Q112_S0.8120.23
111_V122_P0.8100.23
71_S74_R0.8050.23
36_M165_I0.8020.23
75_H95_Q0.7920.23
96_I170_G0.7910.22
6_A90_R0.7910.22
59_Q66_E0.7820.22
79_E130_Q0.7740.22
100_N116_R0.7730.22
72_A138_A0.7730.22
64_S96_I0.7710.22
60_L136_F0.7640.21
149_K169_R0.7640.21
50_I167_V0.7640.21
65_L68_A0.7620.21
30_K50_I0.7540.21
15_P95_Q0.7480.21
69_R120_G0.7440.21
4_K162_P0.7420.21
95_Q125_T0.7400.21
36_M126_A0.7360.20
26_I29_S0.7340.20
94_H103_A0.7330.20
140_C160_T0.7320.20
90_R116_R0.7300.20
35_K163_C0.7270.20
59_Q128_R0.7250.20
122_P154_R0.7230.20
136_F147_A0.7220.20
130_Q150_E0.7200.20
47_P86_K0.7190.20
36_M60_L0.7180.20
94_H167_V0.7170.20
99_E123_V0.7140.20
102_Q156_Y0.7130.20
55_Q159_I0.7100.20
36_M143_E0.7000.19
58_C102_Q0.6990.19
98_R109_D0.6960.19
73_N85_Y0.6960.19
58_C161_P0.6930.19
31_I89_L0.6910.19
67_A139_Y0.6910.19
71_S77_I0.6870.19
90_R162_P0.6850.19
8_M63_G0.6830.19
36_M48_V0.6820.19
60_L71_S0.6790.19
50_I97_I0.6780.19
72_A87_M0.6780.19
14_K128_R0.6780.19
100_N103_A0.6710.18
67_A95_Q0.6700.18
61_R126_A0.6700.18
94_H148_V0.6670.18
151_A160_T0.6590.18
149_K159_I0.6550.18
97_I130_Q0.6520.18
51_S90_R0.6510.18
9_Y100_N0.6490.18
97_I145_A0.6450.17
24_T154_R0.6410.17
15_P62_H0.6350.17
86_K139_Y0.6310.17
4_K161_P0.6310.17
96_I130_Q0.6300.17
70_L73_N0.6290.17
89_L163_C0.6270.17
3_E11_K0.6270.17
106_A110_R0.6210.17
2_S104_T0.6130.17
65_L76_L0.6070.16
98_R108_A0.5990.16
69_R106_A0.5970.16
23_V58_C0.5950.16
134_Q151_A0.5920.16
8_M33_Q0.5890.16
6_A154_R0.5890.16
13_D16_S0.5890.16
5_P114_G0.5880.16
59_Q126_A0.5780.16
78_K96_I0.5740.15
32_A162_P0.5730.15
31_I132_G0.5710.15
23_V119_F0.5710.15
143_E163_C0.5700.15
13_D122_P0.5670.15
80_L138_A0.5660.15
3_E63_G0.5650.15
30_K62_H0.5630.15
81_G153_R0.5600.15
85_Y142_V0.5590.15
91_K97_I0.5590.15
98_R120_G0.5560.15
13_D95_Q0.5550.15
46_Y87_M0.5550.15
106_A109_D0.5550.15
86_K159_I0.5540.15
48_V145_A0.5530.15
6_A83_G0.5490.15
3_E8_M0.5480.15
8_M111_V0.5480.15
88_Q129_I0.5450.15
80_L144_Q0.5450.15
140_C153_R0.5430.15
41_A85_Y0.5420.15
6_A117_Q0.5410.15
109_D114_G0.5400.14
126_A136_F0.5390.14
113_D126_A0.5380.14
20_R23_V0.5370.14
122_P139_Y0.5370.14
31_I167_V0.5370.14
29_S89_L0.5360.14
93_P106_A0.5340.14
148_V165_I0.5330.14
99_E105_G0.5330.14
68_A72_A0.5320.14
4_K98_R0.5310.14
15_P19_R0.5230.14
131_P138_A0.5210.14
22_Y138_A0.5210.14
63_G157_N0.5190.14
7_S122_P0.5190.14
51_S134_Q0.5150.14
26_I121_V0.5140.14
138_A154_R0.5130.14
18_T49_Q0.5080.14
60_L135_L0.5070.14
29_S32_A0.5060.14
68_A160_T0.5050.14
8_M24_T0.5020.14
56_E67_A0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a17H 1 0.9318 100 0.252 Contact Map
3j39I 1 0.9943 100 0.252 Contact Map
3zf7K 1 0.9943 100 0.254 Contact Map
1vx7Q 1 0.9034 100 0.258 Contact Map
4ujqL 1 0.9432 100 0.265 Contact Map
3j21N 1 0.9432 100 0.269 Contact Map
1vq8H 1 0.9034 100 0.29 Contact Map
1ffkF 1 0.892 100 0.383 Contact Map
2pa2A 1 0.6136 100 0.445 Contact Map
3j7yN 1 0.8352 100 0.54 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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